| Name | CyclinD3/CDK6 |
| ID | SIGNOR-C234 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK6 | PFKM | – | phosphorylation down-regulates activity | 28607489 | SIGNOR-276452 | |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-276453 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-273032 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-276454 |
| CyclinD3/CDK6 | PFKL | – | phosphorylation down-regulates activity | 28607489 | SIGNOR-276451 | |
| CyclinD3/CDK6 | CDC25A | Ser40 | ASAAGGLsPVTNLTV | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277343 |
| CyclinD3/CDK6 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277341 |
| CyclinD3/CDK6 | RUNX1 | Ser21 | TPPSTALsPGKMSEA | phosphorylation up-regulates activity | 21059642 | SIGNOR-273031 |
| CyclinD3/CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 21059642 | SIGNOR-273029 |
| CyclinD3/CDK6 | RUNX1 | Ser397 | SMVGGERsPPRILPP | phosphorylation up-regulates activity | 21059642 | SIGNOR-273030 |
| CyclinD3/CDK6 | PFKP | Ser679 | MQQGGAPsPFDRNFG | phosphorylation down-regulates activity | 28607489 | SIGNOR-273033 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-276453 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-273032 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-276454 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | CDC25A PSer40 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277343 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277341 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer21 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273031 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273029 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer397 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273030 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PFKP PSer679 | phosphorylation down-regulates ⊣ | PFKP | 28607489 | SIGNOR-273033 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PFKM | SIGNOR-276452 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-276453 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-273032 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-276454 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PFKL | SIGNOR-276451 |
| CyclinD3/CDK6 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277343 |
| CyclinD3/CDK6 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277341 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273031 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273029 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273030 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PFKP | SIGNOR-273033 |