Entity Details

Name P-TEFb
ID SIGNOR-C238
Role kinase
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
P-TEFbPOLR2A–phosphorylation
up-regulates activity		32048991SIGNOR-261039
P-TEFbMLLT3–phosphorylation
down-regulates quantity by destabilization		17135274SIGNOR-266800
P-TEFbAFF2–phosphorylation
down-regulates quantity by destabilization		17135274SIGNOR-266798
P-TEFbMLLT1–phosphorylation
down-regulates quantity by destabilization		17135274SIGNOR-266799
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Regulator Mechanism/Effect Target SIGNOR-ID
P-TEFbphosphorylation
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up-regulates activity 		POLR2ASIGNOR-261039
P-TEFbphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MLLT3SIGNOR-266800
P-TEFbphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		AFF2SIGNOR-266798
P-TEFbphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MLLT1SIGNOR-266799