| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 12747827 | SIGNOR-236690 |
| mTORC1 | mTORC1 | – | phosphorylation up-regulates activity | 18372248 | SIGNOR-235518 | |
| mTORC1 | PIP4K2C | Ser324 | GPPALVGsYGTSPEG | phosphorylation up-regulates quantity | 25372051 | SIGNOR-273680 |
| mTORC1 | NRBF2 | Ser120 | SPLSQKYsPSTEKCL | phosphorylation up-regulates activity | 28059666 | SIGNOR-265877 |
| mTORC1 | EIF4EBP1 | Thr45 | PGGTLFStTPGGTRI | phosphorylation down-regulates activity | 9465032 | SIGNOR-217090 |
| mTORC1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 23486913 | SIGNOR-217141 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 10579915 | SIGNOR-217060 |
| mTORC1 | RPS6KB1 | – | phosphorylation up-regulates activity | 35318320 | SIGNOR-273843 | |
| mTORC1 | BTRC | – | phosphorylation up-regulates activity | 33861966 | SIGNOR-267829 | |
| mTORC1 | EEF2K | Ser74 | ERYSSSGsPANSFHF | phosphorylation down-regulates activity | 35513296 | SIGNOR-277907 |
| mTORC1 | EIF4EBP1 | Thr37 | PPGDYSTtPGGTLFS | phosphorylation down-regulates activity | 23486913 | SIGNOR-217110 |
| mTORC1 | GRB10 | – | phosphorylation up-regulates | 21659604 | SIGNOR-217063 | |
| mTORC1 | MAF1 | Ser75 | SPSRLSKsQGGEEEG | phosphorylation down-regulates | 20516213 | SIGNOR-217153 |
| mTORC1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 10942774 | SIGNOR-236702 |
| mTORC1 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 23486913 | SIGNOR-217137 |
| mTORC1 | RPS6K | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255842 |
| mTORC1 | RPS6KB2 | – | phosphorylation up-regulates | 17510057 | SIGNOR-217074 | |
| mTORC1 | PIP4K2C | Ser328 | LVGSYGTsPEGIGGY | phosphorylation up-regulates quantity | 25372051 | SIGNOR-273681 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 15809305 | SIGNOR-217067 |
| mTORC1 | MAF1 | Ser60 | PHVLEALsPPQTSGL | phosphorylation down-regulates | 20516213 | SIGNOR-217149 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 17510057 | SIGNOR-217071 |
| mTORC1 | EIF4EBP1 | Thr37 | PPGDYSTtPGGTLFS | phosphorylation down-regulates activity | 12747827 | SIGNOR-236694 |
| mTORC1 | TFEB | Ser211 | LVGVTSSsCPADLTQ | phosphorylation down-regulates activity | 22692423 | SIGNOR-248274 |
| mTORC1 | MAF1 | Ser68 | PPQTSGLsPSRLSKS | phosphorylation down-regulates | 20516213 | SIGNOR-217145 |
| mTORC1 | EIF4EBP1 | Thr36 | LPPGDYStTPGGTLF | phosphorylation down-regulates activity | 9465032 | SIGNOR-217086 |
| mTORC1 | EEF2K | Ser72 | KSERYSSsGSPANSF | phosphorylation down-regulates activity | 35513296 | SIGNOR-277906 |
| mTORC1 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 23486913 | SIGNOR-217114 |
| mTORC1 | TFEB | Ser142 | AGNSAPNsPMAMLHI | phosphorylation down-regulates activity | 22343943 | SIGNOR-255309 |
| mTORC1 | EEF2K | Ser70 | LTKSERYsSSGSPAN | phosphorylation down-regulates activity | 35513296 | SIGNOR-277908 |
| mTORC1 | RPS6KB1 | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255840 |
| mTORC1 | ULK1 | – | phosphorylation down-regulates | 19690328 | SIGNOR-217133 | |
| mTORC1 | NRBF2 | Ser113 | AEDAEGQsPLSQKYS | phosphorylation up-regulates activity | 28059666 | SIGNOR-265876 |
| mTORC1 | EIF4EBP1 | – | phosphorylation down-regulates activity | 12747827 | SIGNOR-236678 | |
| mTORC1 | ULK1/Atg13/Fip200 | – | phosphorylation down-regulates activity | 23863160 | SIGNOR-209904 | |
| mTORC1 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 18570873 | SIGNOR-217078 |
| mTORC1 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 12747827 | SIGNOR-236698 |
| mTORC1 | EIF4EBP1 | – | phosphorylation down-regulates activity | 20670887 | SIGNOR-235745 | |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 10567431 | SIGNOR-217056 |
| mTORC1 | EEF2K | Tyr69 | NLTKSERySSSGSPA | phosphorylation down-regulates activity | 35513296 | SIGNOR-277909 |
| mTORC1 | EIF4EBP1 | – | phosphorylation down-regulates activity | 17510057 | SIGNOR-235748 | |
| mTORC1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 12747827 | SIGNOR-235964 |
| mTORC1 | JMJD1C | Thr505 | KFVSRPPtPKCVIDI | phosphorylation up-regulates activity | 32034158 | SIGNOR-265168 |
| mTORC1 | ISCU | Ser14 | FRLRRAAsALLLRSP | phosphorylation up-regulates | 23508953 | SIGNOR-217082 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-236690 |
| mTORC1 | phosphorylation up-regulates → | PIP4K2C PSer324 | phosphorylation up-regulates → | PIP4K2C | 25372051 | SIGNOR-273680 |
| mTORC1 | phosphorylation up-regulates → | NRBF2 PSer120 | phosphorylation up-regulates → | NRBF2 | 28059666 | SIGNOR-265877 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr45 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 9465032 | SIGNOR-217090 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217141 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10579915 | SIGNOR-217060 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PSer74 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277907 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr37 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217110 |
| mTORC1 | phosphorylation up-regulates → | MAF1 PSer75 | phosphorylation down-regulates ⊣ | MAF1 | 20516213 | SIGNOR-217153 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-236702 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217137 |
| mTORC1 | phosphorylation up-regulates → | RPS6K PThr390 | phosphorylation up-regulates → | RPS6K | 11914378 | SIGNOR-255842 |
| mTORC1 | phosphorylation up-regulates → | PIP4K2C PSer328 | phosphorylation up-regulates → | PIP4K2C | 25372051 | SIGNOR-273681 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 15809305 | SIGNOR-217067 |
| mTORC1 | phosphorylation up-regulates → | MAF1 PSer60 | phosphorylation down-regulates ⊣ | MAF1 | 20516213 | SIGNOR-217149 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 17510057 | SIGNOR-217071 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr37 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-236694 |
| mTORC1 | phosphorylation up-regulates → | TFEB PSer211 | phosphorylation down-regulates ⊣ | TFEB | 22692423 | SIGNOR-248274 |
| mTORC1 | phosphorylation up-regulates → | MAF1 PSer68 | phosphorylation down-regulates ⊣ | MAF1 | 20516213 | SIGNOR-217145 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr36 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 9465032 | SIGNOR-217086 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PSer72 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277906 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217114 |
| mTORC1 | phosphorylation up-regulates → | TFEB PSer142 | phosphorylation down-regulates ⊣ | TFEB | 22343943 | SIGNOR-255309 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PSer70 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277908 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr390 | phosphorylation up-regulates → | RPS6KB1 | 11914378 | SIGNOR-255840 |
| mTORC1 | phosphorylation up-regulates → | NRBF2 PSer113 | phosphorylation up-regulates → | NRBF2 | 28059666 | SIGNOR-265876 |
| mTORC1 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18570873 | SIGNOR-217078 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-236698 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10567431 | SIGNOR-217056 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PTyr69 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277909 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-235964 |
| mTORC1 | phosphorylation up-regulates → | JMJD1C PThr505 | phosphorylation up-regulates → | JMJD1C | 32034158 | SIGNOR-265168 |
| mTORC1 | phosphorylation up-regulates → | ISCU PSer14 | phosphorylation up-regulates → | ISCU | 23508953 | SIGNOR-217082 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236690 |
| mTORC1 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-235518 |
| mTORC1 | phosphorylation → up-regulates quantity | PIP4K2C | SIGNOR-273680 |
| mTORC1 | phosphorylation → up-regulates activity | NRBF2 | SIGNOR-265877 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217090 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217141 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217060 |
| mTORC1 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-273843 |
| mTORC1 | phosphorylation → up-regulates activity | BTRC | SIGNOR-267829 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277907 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217110 |
| mTORC1 | phosphorylation → up-regulates | GRB10 | SIGNOR-217063 |
| mTORC1 | phosphorylation down-regulates | MAF1 | SIGNOR-217153 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236702 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217137 |
| mTORC1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-255842 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB2 | SIGNOR-217074 |
| mTORC1 | phosphorylation → up-regulates quantity | PIP4K2C | SIGNOR-273681 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217067 |
| mTORC1 | phosphorylation down-regulates | MAF1 | SIGNOR-217149 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217071 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236694 |
| mTORC1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-248274 |
| mTORC1 | phosphorylation down-regulates | MAF1 | SIGNOR-217145 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217086 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277906 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217114 |
| mTORC1 | phosphorylation → down-regulates activity | TFEB | SIGNOR-255309 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277908 |
| mTORC1 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-255840 |
| mTORC1 | phosphorylation down-regulates | ULK1 | SIGNOR-217133 |
| mTORC1 | phosphorylation → up-regulates activity | NRBF2 | SIGNOR-265876 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236678 |
| mTORC1 | phosphorylation → down-regulates activity | ULK1/Atg13/Fip200 | SIGNOR-209904 |
| mTORC1 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-217078 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236698 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-235745 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217056 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277909 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-235748 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-235964 |
| mTORC1 | phosphorylation → up-regulates activity | JMJD1C | SIGNOR-265168 |
| mTORC1 | phosphorylation → up-regulates | ISCU | SIGNOR-217082 |
