| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | mTORC1 | – | phosphorylation down-regulates activity | 20083114 | SIGNOR-216422 | |
| AMPK | mTORC1 | – | phosphorylation down-regulates activity | 23863160 | SIGNOR-209862 | |
| MAPK1 | mTORC1 | – | phosphorylation unknown | 21071439 | SIGNOR-217574 | |
| AKT1 | mTORC1 | – | phosphorylation up-regulates activity | 17130464 | SIGNOR-252540 | |
| MAPK11 | mTORC1 | – | phosphorylation unknown | 21757713 | SIGNOR-217580 | |
| AKT2 | mTORC1 | – | phosphorylation up-regulates activity | 17277771 | SIGNOR-235967 | |
| MAPK3 | mTORC1 | – | phosphorylation up-regulates | 19864431 | SIGNOR-217559 | |
| CILK1 | mTORC1 | – | phosphorylation up-regulates | 22356909 | SIGNOR-217562 | |
| MAPK3 | mTORC1 | – | phosphorylation up-regulates | 19346248 | SIGNOR-217556 | |
| ULK1/Atg13/Fip200 | mTORC1 | – | phosphorylation down-regulates activity | 23863160 | SIGNOR-209910 | |
| AKT1 | mTORC1 | – | phosphorylation up-regulates | 15829723 | SIGNOR-255844 | |
| AKT | mTORC1 | – | phosphorylation up-regulates activity | 20138985 | SIGNOR-217586 | |
| RPS6K | mTORC1 | – | phosphorylation up-regulates | 18722121 | SIGNOR-252794 | |
| AMPK | mTORC1 | – | phosphorylation down-regulates activity | 18439900 | SIGNOR-216430 | |
| AKT1 | mTORC1 | – | phosphorylation up-regulates activity | 20138985 | SIGNOR-252539 | |
| RPS6KA1 | mTORC1 | – | phosphorylation up-regulates | 18722121 | SIGNOR-217553 | |
| RPS6K | mTORC1 | – | phosphorylation up-regulates activity | 15342917 | SIGNOR-252796 | |
| AKT2 | mTORC1 | – | phosphorylation up-regulates activity | 17386266 | SIGNOR-236705 | |
| MAPK3 | mTORC1 | – | phosphorylation up-regulates | 21757713 | SIGNOR-217544 | |
| MAPK3 | mTORC1 | – | phosphorylation up-regulates activity | 19143636 | SIGNOR-209859 | |
| MAPK3 | mTORC1 | – | phosphorylation unknown | 21071439 | SIGNOR-217577 | |
| DYRK3 | mTORC1 | – | phosphorylation down-regulates | 23415227 | SIGNOR-217571 | |
| AMPK | mTORC1 | – | phosphorylation down-regulates activity | 21460634 | SIGNOR-216418 | |
| ERK1/2 | mTORC1 | – | phosphorylation unknown | 21071439 | SIGNOR-270150 | |
| Gbeta | mTORC1 | – | phosphorylation unknown | 21071439 | SIGNOR-270027 | |
| AKT | mTORC1 | – | phosphorylation up-regulates activity | 19593385 | SIGNOR-252817 | |
| mTORC1 | mTORC1 | – | phosphorylation up-regulates activity | 18372248 | SIGNOR-235518 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → down-regulates activity | mTORC1 | SIGNOR-216422 |
| AMPK | phosphorylation → down-regulates activity | mTORC1 | SIGNOR-209862 |
| MAPK1 | phosphorylation → unknown | mTORC1 | SIGNOR-217574 |
| AKT1 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-252540 |
| MAPK11 | phosphorylation → unknown | mTORC1 | SIGNOR-217580 |
| AKT2 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-235967 |
| MAPK3 | phosphorylation → up-regulates | mTORC1 | SIGNOR-217559 |
| CILK1 | phosphorylation → up-regulates | mTORC1 | SIGNOR-217562 |
| MAPK3 | phosphorylation → up-regulates | mTORC1 | SIGNOR-217556 |
| ULK1/Atg13/Fip200 | phosphorylation → down-regulates activity | mTORC1 | SIGNOR-209910 |
| AKT1 | phosphorylation → up-regulates | mTORC1 | SIGNOR-255844 |
| AKT | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-217586 |
| RPS6K | phosphorylation → up-regulates | mTORC1 | SIGNOR-252794 |
| AMPK | phosphorylation → down-regulates activity | mTORC1 | SIGNOR-216430 |
| AKT1 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-252539 |
| RPS6KA1 | phosphorylation → up-regulates | mTORC1 | SIGNOR-217553 |
| RPS6K | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-252796 |
| AKT2 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-236705 |
| MAPK3 | phosphorylation → up-regulates | mTORC1 | SIGNOR-217544 |
| MAPK3 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-209859 |
| MAPK3 | phosphorylation → unknown | mTORC1 | SIGNOR-217577 |
| DYRK3 | phosphorylation down-regulates | mTORC1 | SIGNOR-217571 |
| AMPK | phosphorylation → down-regulates activity | mTORC1 | SIGNOR-216418 |
| ERK1/2 | phosphorylation → unknown | mTORC1 | SIGNOR-270150 |
| Gbeta | phosphorylation → unknown | mTORC1 | SIGNOR-270027 |
| AKT | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-252817 |
| mTORC1 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-235518 |
