| Name | CyclinK/CDK12 |
| ID | SIGNOR-C37 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinK/CDK12 | POLR2A | Ser1616 | TPQSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273104 |
| CyclinK/CDK12 | POLR2A | Ser1623 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273097 |
| CyclinK/CDK12 | POLR2A | Ser1644 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273092 |
| CyclinK/CDK12 | POLR2A | Ser1651 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273090 |
| CyclinK/CDK12 | POLR2A | Ser1665 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273091 |
| CyclinK/CDK12 | POLR2A | Ser1672 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273096 |
| CyclinK/CDK12 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273095 |
| CyclinK/CDK12 | POLR2A | Ser1714 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273094 |
| CyclinK/CDK12 | POLR2A | Ser1721 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273098 |
| CyclinK/CDK12 | POLR2A | Ser1735 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273093 |
| CyclinK/CDK12 | POLR2A | Ser1763 | TPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273108 |
| CyclinK/CDK12 | POLR2A | Ser1784 | TPTSPNYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273107 |
| CyclinK/CDK12 | POLR2A | Ser1861 | TPTSPKYsPTSPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273105 |
| CyclinK/CDK12 | POLR2A | Ser1868 | SPTSPKYsPTSPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273087 |
| CyclinK/CDK12 | POLR2A | Ser1875 | SPTSPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273089 |
| CyclinK/CDK12 | POLR2A | Ser1878 | SPKYSPTsPTYSPTT | phosphorylation up-regulates activity | 32917631 | SIGNOR-273085 |
| CyclinK/CDK12 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273102 |
| CyclinK/CDK12 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273103 |
| CyclinK/CDK12 | POLR2A | Ser1896 | SPTSPTYsPTSPVYT | phosphorylation up-regulates activity | 32917631 | SIGNOR-273101 |
| CyclinK/CDK12 | POLR2A | Ser1910 | TPTSPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273106 |
| CyclinK/CDK12 | POLR2A | Ser1917 | SPTSPTYsPTSPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273100 |
| CyclinK/CDK12 | POLR2A | Ser1924 | SPTSPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273088 |
| CyclinK/CDK12 | POLR2A | Ser1931 | SPTSPTYsPTSPKGS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273099 |
| CyclinK/CDK12 | POLR2A | Ser1941 | SPKGSTYsPTSPGYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273084 |
| CyclinK/CDK12 | POLR2A | Ser1948 | SPTSPGYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273086 |
| CyclinK/CDK12 | PAK2 | Thr134 | LKFYDSNtVKQKYLS | phosphorylation up-regulates activity | 32483448 | SIGNOR-273111 |
| CyclinK/CDK12 | PAK2 | Thr169 | TEAPAVVtEEEDDDE | phosphorylation up-regulates activity | 32483448 | SIGNOR-273112 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1616 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273104 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1623 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273097 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1644 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273092 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1651 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273090 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1665 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273091 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1672 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273096 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1693 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273095 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1714 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273094 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1721 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273098 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1735 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273093 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1763 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273108 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1784 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273107 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1861 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273105 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1868 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273087 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1875 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273089 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1878 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273085 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273102 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273103 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1896 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273101 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1910 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273106 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1917 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273100 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1924 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273088 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1931 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273099 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1941 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273084 |
| CyclinK/CDK12 | phosphorylation up-regulates → | POLR2A PSer1948 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273086 |
| CyclinK/CDK12 | phosphorylation up-regulates → | PAK2 PThr134 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273111 |
| CyclinK/CDK12 | phosphorylation up-regulates → | PAK2 PThr169 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273112 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273104 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273097 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273092 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273090 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273091 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273096 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273095 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273094 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273098 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273093 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273108 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273107 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273105 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273087 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273089 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273085 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273102 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273103 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273101 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273106 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273100 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273088 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273099 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273084 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273086 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273111 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273112 |