| Name | CyclinK/CDK13 |
| ID | SIGNOR-C38 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinK/CDK13 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates activity | 36882522 | SIGNOR-273116 |
| CyclinK/CDK13 | POLR2A | Ser1616 | TPQSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273079 |
| CyclinK/CDK13 | POLR2A | Ser1623 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273072 |
| CyclinK/CDK13 | POLR2A | Ser1644 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273067 |
| CyclinK/CDK13 | POLR2A | Ser1651 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273065 |
| CyclinK/CDK13 | POLR2A | Ser1665 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273066 |
| CyclinK/CDK13 | POLR2A | Ser1672 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273071 |
| CyclinK/CDK13 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273070 |
| CyclinK/CDK13 | POLR2A | Ser1714 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273069 |
| CyclinK/CDK13 | POLR2A | Ser1721 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273073 |
| CyclinK/CDK13 | POLR2A | Ser1735 | SPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273068 |
| CyclinK/CDK13 | POLR2A | Ser1763 | TPTSPSYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273083 |
| CyclinK/CDK13 | POLR2A | Ser1784 | TPTSPNYsPTSPSYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273082 |
| CyclinK/CDK13 | POLR2A | Ser1861 | TPTSPKYsPTSPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273080 |
| CyclinK/CDK13 | POLR2A | Ser1868 | SPTSPKYsPTSPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273062 |
| CyclinK/CDK13 | POLR2A | Ser1875 | SPTSPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273064 |
| CyclinK/CDK13 | POLR2A | Ser1878 | SPKYSPTsPTYSPTT | phosphorylation up-regulates activity | 32917631 | SIGNOR-273060 |
| CyclinK/CDK13 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273077 |
| CyclinK/CDK13 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273078 |
| CyclinK/CDK13 | POLR2A | Ser1896 | SPTSPTYsPTSPVYT | phosphorylation up-regulates activity | 32917631 | SIGNOR-273076 |
| CyclinK/CDK13 | POLR2A | Ser1910 | TPTSPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273081 |
| CyclinK/CDK13 | POLR2A | Ser1917 | SPTSPTYsPTSPKYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273075 |
| CyclinK/CDK13 | POLR2A | Ser1924 | SPTSPKYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273063 |
| CyclinK/CDK13 | POLR2A | Ser1931 | SPTSPTYsPTSPKGS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273074 |
| CyclinK/CDK13 | POLR2A | Ser1941 | SPKGSTYsPTSPGYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273059 |
| CyclinK/CDK13 | POLR2A | Ser1948 | SPTSPGYsPTSPTYS | phosphorylation up-regulates activity | 32917631 | SIGNOR-273061 |
| CyclinK/CDK13 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation up-regulates activity | 36882522 | SIGNOR-273114 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinK/CDK13 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 36882522 | SIGNOR-273116 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1616 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273079 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1623 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273072 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1644 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273067 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1651 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273065 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1665 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273066 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1672 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273071 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1693 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273070 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1714 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273069 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1721 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273073 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1735 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273068 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1763 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273083 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1784 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273082 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1861 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273080 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1868 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273062 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1875 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273064 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1878 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273060 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273077 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273078 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1896 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273076 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1910 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273081 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1917 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273075 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1924 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273063 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1931 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273074 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1941 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273059 |
| CyclinK/CDK13 | phosphorylation up-regulates → | POLR2A PSer1948 | phosphorylation up-regulates → | POLR2A | 32917631 | SIGNOR-273061 |
| CyclinK/CDK13 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation up-regulates → | EIF4EBP1 | 36882522 | SIGNOR-273114 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinK/CDK13 | phosphorylation → up-regulates activity | EIF4B | SIGNOR-273116 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273079 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273072 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273067 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273065 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273066 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273071 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273070 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273069 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273073 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273068 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273083 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273082 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273080 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273062 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273064 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273060 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273077 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273078 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273076 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273081 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273075 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273063 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273074 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273059 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-273061 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | EIF4EBP1 | SIGNOR-273114 |