| Name | CKM complex |
| ID | SIGNOR-C406 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CKM complex | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 29239838 | SIGNOR-273182 |
| CKM complex | NOTCH1 | – | phosphorylation down-regulates quantity by destabilization | 15546612 | SIGNOR-273150 | |
| CKM complex | NOTCH1 | – | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273158 | |
| CKM complex | NOTCH1 | – | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273160 | |
| CKM complex | NOTCH1 | – | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273159 | |
| CKM complex | CCNH | Ser304 | YEDDDYVsKKSKHEE | phosphorylation down-regulates activity | 10993082 | SIGNOR-273141 |
| CKM complex | CCNH | Ser5 | sSQKRHWT | phosphorylation down-regulates activity | 10993082 | SIGNOR-273139 |
| CKM complex | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273170 |
| CKM complex | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-273151 |
| CKM complex | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273147 |
| CKM complex | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273142 |
| CKM complex | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273146 |
| CKM complex | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273172 |
| CKM complex | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates activity | 18794899 | SIGNOR-273149 |
| CKM complex | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates activity | 22945643 | SIGNOR-273138 |
| CKM complex | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273145 |
| CKM complex | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273140 |
| CKM complex | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273144 |
| CKM complex | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273148 |
| CKM complex | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273152 |
| CKM complex | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273143 |
| CKM complex | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273174 |
| CKM complex | NOTCH | – | phosphorylation down-regulates quantity by destabilization | 15546612 | SIGNOR-273153 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CKM complex | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 29239838 | SIGNOR-273182 |
| CKM complex | phosphorylation up-regulates → | CCNH PSer304 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-273141 |
| CKM complex | phosphorylation up-regulates → | CCNH PSer5 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-273139 |
| CKM complex | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 18418385 | SIGNOR-273170 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273151 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273147 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273142 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-273146 |
| CKM complex | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 18418385 | SIGNOR-273172 |
| CKM complex | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 18794899 | SIGNOR-273149 |
| CKM complex | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 22945643 | SIGNOR-273138 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273145 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273140 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273144 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273148 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-273152 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-273143 |
| CKM complex | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 18418385 | SIGNOR-273174 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CKM complex | phosphorylation → up-regulates activity | STAT1 | SIGNOR-273182 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273150 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273158 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273160 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273159 |
| CKM complex | phosphorylation → down-regulates activity | CCNH | SIGNOR-273141 |
| CKM complex | phosphorylation → down-regulates activity | CCNH | SIGNOR-273139 |
| CKM complex | phosphorylation → down-regulates activity | H3C1 | SIGNOR-273170 |
| CKM complex | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-273151 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273147 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273142 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273146 |
| CKM complex | phosphorylation → down-regulates activity | H3-3A | SIGNOR-273172 |
| CKM complex | phosphorylation → down-regulates activity | E2F1 | SIGNOR-273149 |
| CKM complex | phosphorylation → down-regulates activity | E2F1 | SIGNOR-273138 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273145 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273140 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273144 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273148 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273152 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273143 |
| CKM complex | phosphorylation → down-regulates activity | H3-4 | SIGNOR-273174 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | NOTCH | SIGNOR-273153 |