| Name | TFIIH |
| ID | SIGNOR-C457 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TFIIH | POLR2A | Ser1934 | SPTYSPTsPKGSTYS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269359 |
| TFIIH | POLR2A | Ser1871 | SPKYSPTsPKYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269337 |
| TFIIH | POLR2A | Ser1724 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269334 |
| TFIIH | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates | 10428966 | SIGNOR-269354 |
| TFIIH | POLR2A | Ser1724 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269365 |
| TFIIH | POLR2A | Ser1951 | SPGYSPTsPTYSLTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269372 |
| TFIIH | POLR2A | Ser1913 | SPKYSPTsPTYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269345 |
| TFIIH | POLR2A | Ser1626 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269379 |
| TFIIH | POLR2A | Ser1766 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269381 |
| TFIIH | RARA | Ser77 | EIVPSPPsPPPLPRI | phosphorylation unknown | 11955452 | SIGNOR-269332 |
| TFIIH | POLR2A | Ser1619 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269351 |
| TFIIH | POLR2A | Ser1654 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269369 |
| TFIIH | POLR2A | Ser1654 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269338 |
| TFIIH | POLR2A | Ser1892 | TPKYSPTsPTYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269346 |
| TFIIH | POLR2A | Ser1717 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269384 |
| TFIIH | POLR2A | Ser1717 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269357 |
| TFIIH | POLR2A | Ser1951 | SPGYSPTsPTYSLTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269341 |
| TFIIH | POLR2A | Ser1738 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269340 |
| TFIIH | POLR2A | Ser1787 | SPNYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269336 |
| TFIIH | POLR2A | Ser1920 | SPTYSPTsPKYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269366 |
| TFIIH | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269349 |
| TFIIH | POLR2A | Ser1647 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269339 |
| TFIIH | POLR2A | Ser1864 | SPKYSPTsPKYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269358 |
| TFIIH | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269380 |
| TFIIH | POLR2A | Ser1892 | TPKYSPTsPTYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269377 |
| TFIIH | NR5A1 | Ser203 | EYPEPYAsPPQPGLP | phosphorylation up-regulates | 17901130 | SIGNOR-269355 |
| TFIIH | POLR2A | Ser1696 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269342 |
| TFIIH | POLR2A | Ser1626 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269348 |
| TFIIH | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269347 |
| TFIIH | POLR2A | Ser1675 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269343 |
| TFIIH | POLR2A | Ser1927 | SPKYSPTsPTYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269375 |
| TFIIH | POLR2A | Ser1871 | SPKYSPTsPKYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269368 |
| TFIIH | E2F1 | Ser403 | PEEFISLsPPHEALD | phosphorylation down-regulates | 10428966 | SIGNOR-269353 |
| TFIIH | POLR2A | Ser1899 | SPTYSPTsPVYTPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269378 |
| TFIIH | POLR2A | Ser1927 | SPKYSPTsPTYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269344 |
| TFIIH | POLR2A | Ser1934 | SPTYSPTsPKGSTYS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269386 |
| TFIIH | POLR2A | Ser1913 | SPKYSPTsPTYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269376 |
| TFIIH | POLR2A | Ser1787 | SPNYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269367 |
| TFIIH | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269333 |
| TFIIH | POLR2A | Ser1619 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269382 |
| TFIIH | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269364 |
| TFIIH | POLR2A | Ser1647 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269370 |
| TFIIH | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 21157430 | SIGNOR-269331 |
| TFIIH | POLR2A | Ser1944 | GSTYSPTsPGYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269383 |
| TFIIH | POLR2A | Ser1864 | SPKYSPTsPKYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269385 |
| TFIIH | POLR2A | Ser1696 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269373 |
| TFIIH | POLR2A | Ser1944 | GSTYSPTsPGYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269352 |
| TFIIH | POLR2A | Ser1738 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269371 |
| TFIIH | POLR2A | Ser1920 | SPTYSPTsPKYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269335 |
| TFIIH | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10949034 | SIGNOR-269356 |
| TFIIH | POLR2A | Ser1675 | SPSYSPTsPSYSPTS | phosphorylation up-regulates activity | 24746699 | SIGNOR-269374 |
| TFIIH | POLR2A | Ser1766 | SPSYSPTsPSYSPTS | phosphorylation down-regulates quantity by destabilization | 14662762 | SIGNOR-269350 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1934 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269359 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1871 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269337 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1724 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269334 |
| TFIIH | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-269354 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1724 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269365 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1951 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269372 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1913 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269345 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1626 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269379 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1766 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269381 |
| TFIIH | phosphorylation up-regulates → | RARA PSer77 | phosphorylation down-regulates ⊣ | RARA | 11955452 | SIGNOR-269332 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1619 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269351 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1654 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269369 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1654 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269338 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1892 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269346 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1717 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269384 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1717 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269357 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1951 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269341 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1738 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269340 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1787 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269336 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1920 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269366 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269349 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1647 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269339 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1864 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269358 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269380 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1892 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269377 |
| TFIIH | phosphorylation up-regulates → | NR5A1 PSer203 | phosphorylation up-regulates → | NR5A1 | 17901130 | SIGNOR-269355 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1696 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269342 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1626 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269348 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269347 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1675 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269343 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1927 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269375 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1871 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269368 |
| TFIIH | phosphorylation up-regulates → | E2F1 PSer403 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-269353 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1899 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269378 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1927 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269344 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1934 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269386 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1913 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269376 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1787 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269367 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269333 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1619 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269382 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1668 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269364 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1647 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269370 |
| TFIIH | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 21157430 | SIGNOR-269331 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1944 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269383 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1864 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269385 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1696 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269373 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1944 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269352 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1738 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269371 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1920 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269335 |
| TFIIH | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10949034 | SIGNOR-269356 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1675 | phosphorylation up-regulates → | POLR2A | 24746699 | SIGNOR-269374 |
| TFIIH | phosphorylation up-regulates → | POLR2A PSer1766 | phosphorylation down-regulates ⊣ | POLR2A | 14662762 | SIGNOR-269350 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269359 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269337 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269334 |
| TFIIH | phosphorylation down-regulates | E2F1 | SIGNOR-269354 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269365 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269372 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269345 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269379 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269381 |
| TFIIH | phosphorylation → unknown | RARA | SIGNOR-269332 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269351 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269369 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269338 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269346 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269384 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269357 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269341 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269340 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269336 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269366 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269349 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269339 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269358 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269380 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269377 |
| TFIIH | phosphorylation → up-regulates | NR5A1 | SIGNOR-269355 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269342 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269348 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269347 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269343 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269375 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269368 |
| TFIIH | phosphorylation down-regulates | E2F1 | SIGNOR-269353 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269378 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269344 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269386 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269376 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269367 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269333 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269382 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269364 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269370 |
| TFIIH | phosphorylation down-regulates | AR | SIGNOR-269331 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269383 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269385 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269373 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269352 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269371 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269335 |
| TFIIH | phosphorylation → up-regulates | ESR1 | SIGNOR-269356 |
| TFIIH | phosphorylation → up-regulates activity | POLR2A | SIGNOR-269374 |
| TFIIH | phosphorylation down-regulates quantity by destabilization | POLR2A | SIGNOR-269350 |