Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CyclinY/CDK16	PRC1	Thr481	RRGLAPNtPGKARKL	phosphorylation up-regulates activity	35449080	SIGNOR-273013
CyclinY/CDK16	PRKAR1A	Ser83	DSREDEIsPPPPNPV	phosphorylation up-regulates activity	25605337	SIGNOR-273014
CyclinY/CDK16	CDKN1B	Ser10	NVRVSNGsPSLERMD	phosphorylation down-regulates quantity by destabilization	25205104	SIGNOR-273012
CyclinY/CDK16	CDK16	Ser336	PPDILLGsTDYSTQI	phosphorylation up-regulates activity	32723157	SIGNOR-273006

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinY/CDK16	phosphorylation up-regulates →	PRC1 PThr481	phosphorylation up-regulates →	PRC1	35449080	SIGNOR-273013
CyclinY/CDK16	phosphorylation up-regulates →	PRKAR1A PSer83	phosphorylation up-regulates →	PRKAR1A	25605337	SIGNOR-273014
CyclinY/CDK16	phosphorylation up-regulates →	CDKN1B PSer10	phosphorylation down-regulates ⊣	CDKN1B	25205104	SIGNOR-273012
CyclinY/CDK16	phosphorylation up-regulates →	CDK16 PSer336	phosphorylation up-regulates →	CDK16	32723157	SIGNOR-273006

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CyclinY/CDK16	phosphorylation → up-regulates activity	PRC1	SIGNOR-273013
CyclinY/CDK16	phosphorylation → up-regulates activity	PRKAR1A	SIGNOR-273014
CyclinY/CDK16	phosphorylation down-regulates quantity by destabilization	CDKN1B	SIGNOR-273012
CyclinY/CDK16	phosphorylation → up-regulates activity	CDK16	SIGNOR-273006