Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CyclinD3/CDK11A	SPDEF	Ser238	SEESWTDsEVDSSCS	phosphorylation down-regulates quantity by destabilization	26885618	SIGNOR-273121
CyclinD3/CDK11A	SPDEF	Ser242	WTDSEVDsSCSGQPI	phosphorylation down-regulates quantity by destabilization	26885618	SIGNOR-273122
CyclinD3/CDK11A	SPDEF	Ser243	TDSEVDSsCSGQPIH	phosphorylation down-regulates quantity by destabilization	26885618	SIGNOR-273123
CyclinD3/CDK11A	AR	Ser310	TEDTAEYsPFKGGYT	phosphorylation down-regulates quantity by destabilization	17698582	SIGNOR-273125
CyclinD3/CDK11A	PAK1	Ser174	TPAVPPVsEDEDDDD	phosphorylation up-regulates activity	19520772	SIGNOR-273124

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinD3/CDK11A	phosphorylation up-regulates →	SPDEF PSer238	phosphorylation down-regulates ⊣	SPDEF	26885618	SIGNOR-273121
CyclinD3/CDK11A	phosphorylation up-regulates →	SPDEF PSer242	phosphorylation down-regulates ⊣	SPDEF	26885618	SIGNOR-273122
CyclinD3/CDK11A	phosphorylation up-regulates →	SPDEF PSer243	phosphorylation down-regulates ⊣	SPDEF	26885618	SIGNOR-273123
CyclinD3/CDK11A	phosphorylation up-regulates →	AR PSer310	phosphorylation down-regulates ⊣	AR	17698582	SIGNOR-273125
CyclinD3/CDK11A	phosphorylation up-regulates →	PAK1 PSer174	phosphorylation up-regulates →	PAK1	19520772	SIGNOR-273124

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CyclinD3/CDK11A	phosphorylation down-regulates quantity by destabilization	SPDEF	SIGNOR-273121
CyclinD3/CDK11A	phosphorylation down-regulates quantity by destabilization	SPDEF	SIGNOR-273122
CyclinD3/CDK11A	phosphorylation down-regulates quantity by destabilization	SPDEF	SIGNOR-273123
CyclinD3/CDK11A	phosphorylation down-regulates quantity by destabilization	AR	SIGNOR-273125
CyclinD3/CDK11A	phosphorylation → up-regulates activity	PAK1	SIGNOR-273124