| Name | CyclinD3/CDK11B |
| ID | SIGNOR-C543 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK11B | EIF3F | Ser46 | PAAAPASsSDPAAAA | phosphorylation up-regulates activity | 19245811 | SIGNOR-273134 |
| CyclinD3/CDK11B | EIF3F | Thr119 | GAARVIGtLLGTVDK | phosphorylation up-regulates activity | 19245811 | SIGNOR-273132 |
| CyclinD3/CDK11B | SPDEF | Ser238 | SEESWTDsEVDSSCS | phosphorylation down-regulates quantity by destabilization | 26885618 | SIGNOR-273126 |
| CyclinD3/CDK11B | SPDEF | Ser242 | WTDSEVDsSCSGQPI | phosphorylation down-regulates quantity by destabilization | 26885618 | SIGNOR-273127 |
| CyclinD3/CDK11B | SPDEF | Ser243 | TDSEVDSsCSGQPIH | phosphorylation down-regulates quantity by destabilization | 26885618 | SIGNOR-273128 |
| CyclinD3/CDK11B | AR | Ser310 | TEDTAEYsPFKGGYT | phosphorylation down-regulates quantity by destabilization | 17698582 | SIGNOR-273130 |
| CyclinD3/CDK11B | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation up-regulates activity | 19520772 | SIGNOR-273129 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK11B | phosphorylation up-regulates → | EIF3F PSer46 | phosphorylation up-regulates → | EIF3F | 19245811 | SIGNOR-273134 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | EIF3F PThr119 | phosphorylation up-regulates → | EIF3F | 19245811 | SIGNOR-273132 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | SPDEF PSer238 | phosphorylation down-regulates ⊣ | SPDEF | 26885618 | SIGNOR-273126 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | SPDEF PSer242 | phosphorylation down-regulates ⊣ | SPDEF | 26885618 | SIGNOR-273127 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | SPDEF PSer243 | phosphorylation down-regulates ⊣ | SPDEF | 26885618 | SIGNOR-273128 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | AR PSer310 | phosphorylation down-regulates ⊣ | AR | 17698582 | SIGNOR-273130 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation up-regulates → | PAK1 | 19520772 | SIGNOR-273129 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinD3/CDK11B | phosphorylation → up-regulates activity | EIF3F | SIGNOR-273134 |
| CyclinD3/CDK11B | phosphorylation → up-regulates activity | EIF3F | SIGNOR-273132 |
| CyclinD3/CDK11B | phosphorylation down-regulates quantity by destabilization | SPDEF | SIGNOR-273126 |
| CyclinD3/CDK11B | phosphorylation down-regulates quantity by destabilization | SPDEF | SIGNOR-273127 |
| CyclinD3/CDK11B | phosphorylation down-regulates quantity by destabilization | SPDEF | SIGNOR-273128 |
| CyclinD3/CDK11B | phosphorylation down-regulates quantity by destabilization | AR | SIGNOR-273130 |
| CyclinD3/CDK11B | phosphorylation → up-regulates activity | PAK1 | SIGNOR-273129 |