Entity Details

Name CyclinC/CDK3
ID SIGNOR-C545
Role kinase
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinC/CDK3RB1Ser811IYISPLKsPYKISEGphosphorylation
down-regulates activity		15084261SIGNOR-273181
CyclinC/CDK3NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273165
CyclinC/CDK3NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273166
CyclinC/CDK3NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273164
CyclinC/CDK3TFCP2Ser309SLGEGNGsPNHQPEPphosphorylation
down-regulates activity		19237534SIGNOR-273180
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinC/CDK3phosphorylation
up-regulates
→
RB1
PSer811		phosphorylation
down-regulates
⊣		RB115084261SIGNOR-273181
CyclinC/CDK3phosphorylation
up-regulates
→
TFCP2
PSer309		phosphorylation
down-regulates
⊣		TFCP219237534SIGNOR-273180
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinC/CDK3phosphorylation
→
down-regulates activity 		RB1SIGNOR-273181
CyclinC/CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273165
CyclinC/CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273166
CyclinC/CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273164
CyclinC/CDK3phosphorylation
→
down-regulates activity 		TFCP2SIGNOR-273180