| Name | CyclinA2/CDK2 |
| ID | SIGNOR-C83 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | MYBL2 | Ser577 | RKPGLRRsPIKKVRK | phosphorylation up-regulates | 9840932 | SIGNOR-217252 |
| CyclinA2/CDK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates | 14640983 | SIGNOR-217300 |
| CyclinA2/CDK2 | AKT | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252453 |
| CyclinA2/CDK2 | CDH1 | Thr40 | DAESYTFtVPRRHLE | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274052 |
| CyclinA2/CDK2 | TSPYL2 | Thr340 | GRLVSHStPIRWHRG | phosphorylation up-regulates activity | 11395479 | SIGNOR-250753 |
| CyclinA2/CDK2 | MYBL2 | Thr494 | TPLHRDKtPLHQKHA | phosphorylation up-regulates | 9840932 | SIGNOR-217264 |
| CyclinA2/CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates activity | 17015473 | SIGNOR-217340 |
| CyclinA2/CDK2 | BLM | Ser175 | SFVTPPQsHFVRVST | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276910 |
| CyclinA2/CDK2 | MCM4 | Thr110 | PRSGVRGtPVRQRPD | phosphorylation down-regulates | 12714602 | SIGNOR-217352 |
| CyclinA2/CDK2 | CDC6 | Ser74 | TPHLPPCsPPKQGKK | phosphorylation down-regulates activity | 9889196 | SIGNOR-217332 |
| CyclinA2/CDK2 | CEP76 | Ser83 | VEQELPSsPKQPICF | phosphorylation down-regulates activity | 27065328 | SIGNOR-262730 |
| CyclinA2/CDK2 | MYBL2 | Thr487 | SQKVVVTtPLHRDKT | phosphorylation up-regulates | 9840932 | SIGNOR-217260 |
| CyclinA2/CDK2 | CDC7 | Thr376 | QVAPRAGtPGFRAPE | phosphorylation up-regulates activity | 10846177 | SIGNOR-250725 |
| CyclinA2/CDK2 | RB1 | Thr821 | KISEGLPtPTKMTPR | phosphorylation down-regulates | 9139732 | SIGNOR-217324 |
| CyclinA2/CDK2 | CEP76 | Ser83 | VEQELPSsPKQPICF | phosphorylation down-regulates activity | 27065328 | SIGNOR-262603 |
| CyclinA2/CDK2 | UBTF | Ser389 | INKKQATsPASKKPA | phosphorylation up-regulates | 11698641 | SIGNOR-217304 |
| CyclinA2/CDK2 | AKT | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252450 |
| CyclinA2/CDK2 | CDH1 | Ser36 | HPGFDAEsYTFTVPR | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274051 |
| CyclinA2/CDK2 | MASTL | Thr194 | NMMDILTtPSMAKPR | phosphorylation up-regulates activity | 24391510 | SIGNOR-276614 |
| CyclinA2/CDK2 | BLM | Thr171 | ETSKSFVtPPQSHFV | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276907 |
| CyclinA2/CDK2 | POLM | Ser372 | HQHSCCEsPTRLAQQ | phosphorylation down-regulates activity | 23933132 | SIGNOR-273596 |
| CyclinA2/CDK2 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 10428798 | SIGNOR-217288 |
| CyclinA2/CDK2 | POLL | Thr553 | GPGRVLPtPTEKDVF | phosphorylation up-regulates quantity by stabilization | 18688254 | SIGNOR-273595 |
| CyclinA2/CDK2 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276088 |
| CyclinA2/CDK2 | CDC6 | Ser74 | TPHLPPCsPPKQGKK | phosphorylation down-regulates activity | 10339564 | SIGNOR-217280 |
| CyclinA2/CDK2 | SLBP | Thr62 | RRPESFTtPEGPKPR | phosphorylation down-regulates quantity by destabilization | 18490441 | SIGNOR-265259 |
| CyclinA2/CDK2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 10428798 | SIGNOR-217292 |
| CyclinA2/CDK2 | ORC2 | Thr116 | LASELAKtPQKSVSF | phosphorylation up-regulates | 11931757 | SIGNOR-217296 |
| CyclinA2/CDK2 | RRM1 | Ser559 | PYETYEGsPVSKGIL | phosphorylation up-regulates activity | 32712628 | SIGNOR-277522 |
| CyclinA2/CDK2 | ID2 | Ser5 | sPVRSVRK | phosphorylation down-regulates | 9029153 | SIGNOR-217320 |
| CyclinA2/CDK2 | UNG | Ser64 | EPGTPPSsPLSAEQL | phosphorylation up-regulates activity | 18079698 | SIGNOR-276090 |
| CyclinA2/CDK2 | IDH2 | Thr197 | GTFKMVFtPKDGSGV | phosphorylation down-regulates quantity by destabilization | 34929314 | SIGNOR-267622 |
| CyclinA2/CDK2 | CDC6 | Ser106 | DNQLTIKsPSKRELA | phosphorylation up-regulates | 10339564 | SIGNOR-217272 |
| CyclinA2/CDK2 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276091 |
| CyclinA2/CDK2 | INCA1 | Ser191 | GRAQLLWsPWSPLDQ | phosphorylation unknown | 15159402 | SIGNOR-273592 |
| CyclinA2/CDK2 | POLM | Ser12 | RRRARVGsPSGDAAS | phosphorylation down-regulates activity | 23933132 | SIGNOR-273597 |
| CyclinA2/CDK2 | INCA1 | Ser23 | CSRVVSRsPPPRLPS | phosphorylation unknown | 15159402 | SIGNOR-273593 |
| CyclinA2/CDK2 | AKT1 | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252443 |
| CyclinA2/CDK2 | RBBP8 | Ser327 | ELPTRVSsPVFGATS | phosphorylation up-regulates activity | 15485915 | SIGNOR-263227 |
| CyclinA2/CDK2 | MCM4 | Ser54 | ELQPMPTsPGVDLQS | phosphorylation down-regulates | 12714602 | SIGNOR-217348 |
| CyclinA2/CDK2 | AKT1 | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252440 |
| CyclinA2/CDK2 | ORC2 | Thr226 | SAPVGKEtPSKRMKR | phosphorylation up-regulates | 11931757 | SIGNOR-217308 |
| CyclinA2/CDK2 | IDH1 | Thr157 | GKVEITYtPSDGTQK | phosphorylation down-regulates quantity by destabilization | 34929314 | SIGNOR-267621 |
| CyclinA2/CDK2 | MCM4 | Ser32 | RSEDARSsPSQRRRG | phosphorylation down-regulates | 12714602 | SIGNOR-217344 |
| CyclinA2/CDK2 | RAD9A | Ser328 | VLPSISLsPGPQPPK | phosphorylation unknown | 23028682 | SIGNOR-217268 |
| CyclinA2/CDK2 | CDK7 | Ser164 | GLAKSFGsPNRAYTH | phosphorylation up-regulates activity | 11113184 | SIGNOR-270807 |
| CyclinA2/CDK2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 10428798 | SIGNOR-217284 |
| CyclinA2/CDK2 | CEBPB | Thr235 | SSSSPPGtPSPADAK | phosphorylation up-regulates | 22369944 | SIGNOR-217316 |
| CyclinA2/CDK2 | USP37 | Ser628 | MVNSCITsPSTPSKK | phosphorylation up-regulates activity | 21596315 | SIGNOR-265046 |
| CyclinA2/CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 9889196 | SIGNOR-217328 |
| CyclinA2/CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 10339564 | SIGNOR-217276 |
| CyclinA2/CDK2 | POLM | Thr21 | SGDAASStPPSTRFP | phosphorylation down-regulates activity | 23933132 | SIGNOR-273598 |
| CyclinA2/CDK2 | CEBPB | Thr235 | SSSSPPGtPSPADAK | phosphorylation up-regulates | 17601773 | SIGNOR-217312 |
| CyclinA2/CDK2 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276089 |
| CyclinA2/CDK2 | TSPYL2 | Ser20 | RRLSSSEsPQRDPPP | phosphorylation up-regulates activity | 11395479 | SIGNOR-250752 |
| CyclinA2/CDK2 | CDK7 | Thr170 | GSPNRAYtHQVVTRW | phosphorylation up-regulates activity | 11113184 | SIGNOR-270806 |
| CyclinA2/CDK2 | MYBL2 | Thr444 | NSLTPKStPVKTLPF | phosphorylation up-regulates | 9840932 | SIGNOR-217256 |
| CyclinA2/CDK2 | SP1 | Ser59 | GGQESQPsPLALLAA | phosphorylation up-regulates activity | 11598016 | SIGNOR-248240 |
| CyclinA2/CDK2 | TP53 | Ser392 | FKTEGPDsD | phosphorylation unknown | 10884347 | SIGNOR-250751 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PSer577 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217252 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 14640983 | SIGNOR-217300 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT PThr479 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252453 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDH1 PThr40 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274052 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TSPYL2 PThr340 | phosphorylation up-regulates → | TSPYL2 | 11395479 | SIGNOR-250753 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PThr494 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217264 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-217340 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | BLM PSer175 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276910 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MCM4 PThr110 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-217352 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer74 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-217332 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CEP76 PSer83 | phosphorylation down-regulates ⊣ | CEP76 | 27065328 | SIGNOR-262730 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PThr487 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217260 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC7 PThr376 | phosphorylation up-regulates → | CDC7 | 10846177 | SIGNOR-250725 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RB1 PThr821 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-217324 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CEP76 PSer83 | phosphorylation down-regulates ⊣ | CEP76 | 27065328 | SIGNOR-262603 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UBTF PSer389 | phosphorylation up-regulates → | UBTF | 11698641 | SIGNOR-217304 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT PSer477 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252450 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDH1 PSer36 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274051 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MASTL PThr194 | phosphorylation up-regulates → | MASTL | 24391510 | SIGNOR-276614 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | BLM PThr171 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276907 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | POLM PSer372 | phosphorylation down-regulates ⊣ | POLM | 23933132 | SIGNOR-273596 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217288 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | POLL PThr553 | phosphorylation up-regulates → | POLL | 18688254 | SIGNOR-273595 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276088 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer74 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-217280 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | SLBP PThr62 | phosphorylation down-regulates ⊣ | SLBP | 18490441 | SIGNOR-265259 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217292 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ORC2 PThr116 | phosphorylation up-regulates → | ORC2 | 11931757 | SIGNOR-217296 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RRM1 PSer559 | phosphorylation up-regulates → | RRM1 | 32712628 | SIGNOR-277522 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ID2 PSer5 | phosphorylation down-regulates ⊣ | ID2 | 9029153 | SIGNOR-217320 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer64 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276090 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | IDH2 PThr197 | phosphorylation down-regulates ⊣ | IDH2 | 34929314 | SIGNOR-267622 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer106 | phosphorylation up-regulates → | CDC6 | 10339564 | SIGNOR-217272 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276091 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | INCA1 PSer191 | phosphorylation down-regulates ⊣ | INCA1 | 15159402 | SIGNOR-273592 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | POLM PSer12 | phosphorylation down-regulates ⊣ | POLM | 23933132 | SIGNOR-273597 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | INCA1 PSer23 | phosphorylation down-regulates ⊣ | INCA1 | 15159402 | SIGNOR-273593 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT1 PThr479 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252443 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RBBP8 PSer327 | phosphorylation up-regulates → | RBBP8 | 15485915 | SIGNOR-263227 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MCM4 PSer54 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-217348 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT1 PSer477 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252440 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ORC2 PThr226 | phosphorylation up-regulates → | ORC2 | 11931757 | SIGNOR-217308 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | IDH1 PThr157 | phosphorylation down-regulates ⊣ | IDH1 | 34929314 | SIGNOR-267621 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MCM4 PSer32 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-217344 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RAD9A PSer328 | phosphorylation down-regulates ⊣ | RAD9A | 23028682 | SIGNOR-217268 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDK7 PSer164 | phosphorylation up-regulates → | CDK7 | 11113184 | SIGNOR-270807 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 10428798 | SIGNOR-217284 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CEBPB PThr235 | phosphorylation up-regulates → | CEBPB | 22369944 | SIGNOR-217316 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | USP37 PSer628 | phosphorylation up-regulates → | USP37 | 21596315 | SIGNOR-265046 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-217328 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-217276 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | POLM PThr21 | phosphorylation down-regulates ⊣ | POLM | 23933132 | SIGNOR-273598 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CEBPB PThr235 | phosphorylation up-regulates → | CEBPB | 17601773 | SIGNOR-217312 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276089 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TSPYL2 PSer20 | phosphorylation up-regulates → | TSPYL2 | 11395479 | SIGNOR-250752 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDK7 PThr170 | phosphorylation up-regulates → | CDK7 | 11113184 | SIGNOR-270806 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PThr444 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217256 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | SP1 PSer59 | phosphorylation up-regulates → | SP1 | 11598016 | SIGNOR-248240 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation down-regulates ⊣ | TP53 | 10884347 | SIGNOR-250751 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217252 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | TP53 | SIGNOR-217300 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252453 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274052 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | TSPYL2 | SIGNOR-250753 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217264 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | RUNX1 | SIGNOR-217340 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276910 |
| CyclinA2/CDK2 | phosphorylation down-regulates | MCM4 | SIGNOR-217352 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217332 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CEP76 | SIGNOR-262730 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217260 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | CDC7 | SIGNOR-250725 |
| CyclinA2/CDK2 | phosphorylation down-regulates | RB1 | SIGNOR-217324 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CEP76 | SIGNOR-262603 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | UBTF | SIGNOR-217304 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252450 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274051 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | MASTL | SIGNOR-276614 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276907 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | POLM | SIGNOR-273596 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217288 |
| CyclinA2/CDK2 | phosphorylation → up-regulates quantity by stabilization | POLL | SIGNOR-273595 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276088 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217280 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | SLBP | SIGNOR-265259 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217292 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-217296 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | RRM1 | SIGNOR-277522 |
| CyclinA2/CDK2 | phosphorylation down-regulates | ID2 | SIGNOR-217320 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276090 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | IDH2 | SIGNOR-267622 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | CDC6 | SIGNOR-217272 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276091 |
| CyclinA2/CDK2 | phosphorylation → unknown | INCA1 | SIGNOR-273592 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | POLM | SIGNOR-273597 |
| CyclinA2/CDK2 | phosphorylation → unknown | INCA1 | SIGNOR-273593 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252443 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | RBBP8 | SIGNOR-263227 |
| CyclinA2/CDK2 | phosphorylation down-regulates | MCM4 | SIGNOR-217348 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252440 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-217308 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | IDH1 | SIGNOR-267621 |
| CyclinA2/CDK2 | phosphorylation down-regulates | MCM4 | SIGNOR-217344 |
| CyclinA2/CDK2 | phosphorylation → unknown | RAD9A | SIGNOR-217268 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | CDK7 | SIGNOR-270807 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ESR1 | SIGNOR-217284 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | CEBPB | SIGNOR-217316 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | USP37 | SIGNOR-265046 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217328 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217276 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | POLM | SIGNOR-273598 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | CEBPB | SIGNOR-217312 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276089 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | TSPYL2 | SIGNOR-250752 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | CDK7 | SIGNOR-270806 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217256 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | SP1 | SIGNOR-248240 |
| CyclinA2/CDK2 | phosphorylation → unknown | TP53 | SIGNOR-250751 |