| Name | BCR-ABL |
| ID | SIGNOR-FP6 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BCR-ABL | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 11593427 | SIGNOR-255812 |
| BCR-ABL | BCR | Tyr283 | YQPYQSIyVGGMMEG | phosphorylation down-regulates | 8622703 | SIGNOR-40615 |
| BCR-ABL | BCR | Tyr360 | VSPSPTTyRMFRDKS | phosphorylation down-regulates | 8622703 | SIGNOR-40619 |
| BCR-ABL | BCR | Tyr177 | ADAEKPFyVNVEFHH | phosphorylation down-regulates activity | 8622703 | SIGNOR-40611 |
| BCR-ABL | BCR | Tyr360 | VSPSPTTyRMFRDKS | phosphorylation down-regulates activity | 8622703 | SIGNOR-262530 |
| BCR-ABL | BCR | Tyr328 | YSPRSFEdCGGGYTP | phosphorylation down-regulates activity | 9467953 | SIGNOR-260829 |
| BCR-ABL | BCR | Tyr360 | YSPRSFEdCGGGYTP | phosphorylation down-regulates activity | 9467953 | SIGNOR-260828 |
| BCR-ABL | VAV1 | – | phosphorylation up-regulates | 11790798 | SIGNOR-114094 | |
| BCR-ABL | CSF2RB | – | phosphorylation up-regulates activity | 8758906 | SIGNOR-255814 | |
| BCR-ABL | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation down-regulates | 17318191 | SIGNOR-153435 |
| BCR-ABL | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates | 17318191 | SIGNOR-153431 |
| BCR-ABL | STAT5A | – | phosphorylation up-regulates activity | 8642285 | SIGNOR-255813 | |
| BCR-ABL | RAD52 | Tyr104 | DLNNGKFyVGVCAFV | phosphorylation up-regulates activity | 23836560 | SIGNOR-262531 |
| BCR-ABL | CRKL | Tyr207 | IPEPAHAyAQPQTTT | phosphorylation up-regulates | 9053848 | SIGNOR-46893 |
| BCR-ABL | RHOA | Tyr34 | KDQFPEVyVPTVFEN | phosphorylation down-regulates activity | 23027962 | SIGNOR-271700 |
| BCR-ABL | RHOA | Tyr66 | DTAGQEDyDRLRPLS | phosphorylation down-regulates activity | 23027962 | SIGNOR-271699 |
| BCR-ABL | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation down-regulates | 11726515 | SIGNOR-112354 |
| BCR-ABL | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation down-regulates activity | 20554525 | SIGNOR-246281 |
| BCR-ABL | GRB2 | Tyr37 | EECDQNWyKAELNGK | phosphorylation down-regulates activity | 20554525 | SIGNOR-246289 |
| BCR-ABL | GRB2 | Tyr52 | DGFIPKNyIEMKPHP | phosphorylation down-regulates activity | 20554525 | SIGNOR-246293 |
| BCR-ABL | GRB2 | Tyr7 | yDFKATAD | phosphorylation down-regulates activity | 20554525 | SIGNOR-246285 |
| BCR-ABL | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247146 |
| BCR-ABL | RAD51 | Tyr315 | ETRICKIyDSPCLPE | phosphorylation up-regulates activity | 11684015 | SIGNOR-271707 |
| BCR-ABL | LASP1 | Tyr171 | IPTSAPVyQQPQQQP | phosphorylation unknown | 24913448 | SIGNOR-271703 |
| BCR-ABL | USP7 | Tyr243 | NQLRKAVyMMPTEGD | phosphorylation up-regulates activity | 24317448 | SIGNOR-276532 |
| BCR-ABL | CSF2RA/CSF2RB | – | phosphorylation up-regulates activity | 14500898 | SIGNOR-256123 | |
| BCR-ABL | CSF2RA/CSF2RB | – | phosphorylation up-regulates activity | 8758906 | SIGNOR-255999 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BCR-ABL | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 11593427 | SIGNOR-255812 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr283 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-40615 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr360 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-40619 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr177 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-40611 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr360 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-262530 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr328 | phosphorylation down-regulates ⊣ | BCR | 9467953 | SIGNOR-260829 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr360 | phosphorylation down-regulates ⊣ | BCR | 9467953 | SIGNOR-260828 |
| BCR-ABL | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation down-regulates ⊣ | CTNNB1 | 17318191 | SIGNOR-153435 |
| BCR-ABL | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 17318191 | SIGNOR-153431 |
| BCR-ABL | phosphorylation up-regulates → | RAD52 PTyr104 | phosphorylation up-regulates → | RAD52 | 23836560 | SIGNOR-262531 |
| BCR-ABL | phosphorylation up-regulates → | CRKL PTyr207 | phosphorylation up-regulates → | CRKL | 9053848 | SIGNOR-46893 |
| BCR-ABL | phosphorylation up-regulates → | RHOA PTyr34 | phosphorylation down-regulates ⊣ | RHOA | 23027962 | SIGNOR-271700 |
| BCR-ABL | phosphorylation up-regulates → | RHOA PTyr66 | phosphorylation down-regulates ⊣ | RHOA | 23027962 | SIGNOR-271699 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 11726515 | SIGNOR-112354 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246281 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr37 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246289 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr52 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246293 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr7 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246285 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247146 |
| BCR-ABL | phosphorylation up-regulates → | RAD51 PTyr315 | phosphorylation up-regulates → | RAD51 | 11684015 | SIGNOR-271707 |
| BCR-ABL | phosphorylation up-regulates → | LASP1 PTyr171 | phosphorylation down-regulates ⊣ | LASP1 | 24913448 | SIGNOR-271703 |
| BCR-ABL | phosphorylation up-regulates → | USP7 PTyr243 | phosphorylation up-regulates → | USP7 | 24317448 | SIGNOR-276532 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BCR-ABL | phosphorylation → up-regulates activity | JAK2 | SIGNOR-255812 |
| BCR-ABL | phosphorylation down-regulates | BCR | SIGNOR-40615 |
| BCR-ABL | phosphorylation down-regulates | BCR | SIGNOR-40619 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-40611 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-262530 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-260829 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-260828 |
| BCR-ABL | phosphorylation → up-regulates | VAV1 | SIGNOR-114094 |
| BCR-ABL | phosphorylation → up-regulates activity | CSF2RB | SIGNOR-255814 |
| BCR-ABL | phosphorylation down-regulates | CTNNB1 | SIGNOR-153435 |
| BCR-ABL | phosphorylation → up-regulates | CTNNB1 | SIGNOR-153431 |
| BCR-ABL | phosphorylation → up-regulates activity | STAT5A | SIGNOR-255813 |
| BCR-ABL | phosphorylation → up-regulates activity | RAD52 | SIGNOR-262531 |
| BCR-ABL | phosphorylation → up-regulates | CRKL | SIGNOR-46893 |
| BCR-ABL | phosphorylation → down-regulates activity | RHOA | SIGNOR-271700 |
| BCR-ABL | phosphorylation → down-regulates activity | RHOA | SIGNOR-271699 |
| BCR-ABL | phosphorylation down-regulates | GRB2 | SIGNOR-112354 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246281 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246289 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246293 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246285 |
| BCR-ABL | phosphorylation → unknown | GRB2 | SIGNOR-247146 |
| BCR-ABL | phosphorylation → up-regulates activity | RAD51 | SIGNOR-271707 |
| BCR-ABL | phosphorylation → unknown | LASP1 | SIGNOR-271703 |
| BCR-ABL | phosphorylation → up-regulates activity | USP7 | SIGNOR-276532 |
| BCR-ABL | phosphorylation → up-regulates activity | CSF2RA/CSF2RB | SIGNOR-256123 |
| BCR-ABL | phosphorylation → up-regulates activity | CSF2RA/CSF2RB | SIGNOR-255999 |