| Name | BCR-ABL |
| ID | SIGNOR-FP6 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | BCR-ABL | Tyr832 | LRYEGRVyHYRINTA | phosphorylation up-regulates activity | 16912036 | SIGNOR-260814 |
| HCK | BCR-ABL | Tyr775 | QGWVPSNyITPVNSL | phosphorylation up-regulates activity | 16912036 | SIGNOR-260811 |
| HCK | BCR-ABL | Tyr177 | ADAEKPFyVNVEFHH | phosphorylation up-regulates | 9407116 | SIGNOR-53964 |
| HCK | BCR-ABL | Tyr845 | TASDGKLyVSSESRF | phosphorylation up-regulates activity | 16912036 | SIGNOR-260815 |
| HCK | BCR-ABL | Tyr730 | PNLFVALyDFVASGD | phosphorylation up-regulates activity | 16912036 | SIGNOR-260810 |
| HCK | BCR-ABL | Tyr875 | GLITTLHyPAPKRNK | phosphorylation up-regulates activity | 16912036 | SIGNOR-260816 |
| HCK | BCR-ABL | Tyr788 | SLEKHSWyHGPVSRN | phosphorylation up-regulates activity | 16912036 | SIGNOR-260813 |
| PTPN1 | BCR-ABL | – | dephosphorylation down-regulates | 9566916 | SIGNOR-56822 | |
| HCK | BCR-ABL | Tyr798 | VSRNAAEyLLSSGIN | phosphorylation up-regulates activity | 16912036 | SIGNOR-260812 |
| PTEN | BCR-ABL | – | dephosphorylation down-regulates activity | 31374292 | SIGNOR-260080 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr832 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260814 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr775 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260811 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr177 | phosphorylation up-regulates → | BCR-ABL | 9407116 | SIGNOR-53964 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr845 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260815 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr730 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260810 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr875 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260816 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr788 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260813 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr798 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260812 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260814 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260811 |
| HCK | phosphorylation → up-regulates | BCR-ABL | SIGNOR-53964 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260815 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260810 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260816 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260813 |
| PTPN1 | dephosphorylation down-regulates | BCR-ABL | SIGNOR-56822 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260812 |
| PTEN | dephosphorylation → down-regulates activity | BCR-ABL | SIGNOR-260080 |