| Name | ERK1/2 |
| ID | SIGNOR-PF1 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | SREBF2 | – | phosphorylation up-regulates | 14988395 | SIGNOR-270141 | |
| ERK1/2 | CIC | Ser1409 | SAPEDPTsPKRKMRR | phosphorylation down-regulates | 21087211 | SIGNOR-244630 |
| ERK1/2 | THRB | – | phosphorylation down-regulates activity | 12809513 | SIGNOR-270143 | |
| ERK1/2 | MKNK1 | – | phosphorylation up-regulates activity | 9155018 | SIGNOR-253013 | |
| ERK1/2 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-260755 |
| ERK1/2 | CDCA5 | Ser79 | AVQSPRRsPRISFFL | phosphorylation up-regulates activity | 20551060 | SIGNOR-262969 |
| ERK1/2 | MAPKAPK2 | – | phosphorylation up-regulates | 14967450 | SIGNOR-270206 | |
| ERK1/2 | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates | 12359725 | SIGNOR-244614 |
| ERK1/2 | IRS1 | – | phosphorylation down-regulates activity | 12510059 | SIGNOR-270132 | |
| ERK1/2 | NUP50 | Ser315 | TQSKPVSsPFPTKPL | phosphorylation down-regulates activity | 19767751 | SIGNOR-263043 |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-277822 |
| ERK1/2 | TOB1 | – | phosphorylation down-regulates | 12050114 | SIGNOR-270210 | |
| ERK1/2 | EGFR | Thr693 | RELVEPLtPSGEAPN | phosphorylation down-regulates | 10816576 | SIGNOR-244529 |
| ERK1/2 | CDCA5 | Ser209 | DMTLPGIsPPPEKQK | phosphorylation up-regulates activity | 20551060 | SIGNOR-262968 |
| ERK1/2 | PPARG | – | phosphorylation up-regulates quantity by expression | 12270934 | SIGNOR-235334 | |
| ERK1/2 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation up-regulates activity | 21071439 | SIGNOR-174878 |
| ERK1/2 | RRAS | Ser201 | QEQELPPsPPSAPRK | phosphorylation up-regulates activity | 27086924 | SIGNOR-277219 |
| ERK1/2 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-244509 |
| ERK1/2 | MKNK1 | Thr255 | ITTPELTtPCGSAEY | phosphorylation up-regulates activity | 17130135 | SIGNOR-253015 |
| ERK1/2 | RXRA | Ser260 | NMGLNPSsPNDPVTN | phosphorylation down-regulates activity | 17604322 | SIGNOR-244573 |
| ERK1/2 | DUSP6 | – | phosphorylation down-regulates | 15632084 | SIGNOR-270205 | |
| ERK1/2 | BCL6 | – | phosphorylation down-regulates | 9649500 | SIGNOR-270140 | |
| ERK1/2 | RPS6KA1 | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-250558 |
| ERK1/2 | SCRIB | Ser853 | LPLLPPEsPGPLRQR | phosphorylation unknown | 20622900 | SIGNOR-263065 |
| ERK1/2 | SHC4 | Thr159 | GHRATALtPDSCPLP | phosphorylation down-regulates activity | 31121283 | SIGNOR-273669 |
| ERK1/2 | GORASP1 | Ser274 | DPLPGPGsPSHSAPD | phosphorylation down-regulates activity | 18762583 | SIGNOR-260605 |
| ERK1/2 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 12972619 | SIGNOR-251522 |
| ERK1/2 | XBP1 | Ser181 | QQVQAQLsPLQNISP | phosphorylation down-regulates quantity by destabilization | 23277279 | SIGNOR-276439 |
| ERK1/2 | BANP | Thr352 | PSEPMMStPPPASEL | phosphorylation down-regulates activity | 26080397 | SIGNOR-266378 |
| ERK1/2 | SCRIB | Ser1448 | TSRQSPAsPPPLGGG | phosphorylation unknown | 20622900 | SIGNOR-263064 |
| ERK1/2 | CIITA | – | phosphorylation down-regulates | 18245089 | SIGNOR-270173 | |
| ERK1/2 | JUN | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-236767 | |
| ERK1/2 | XBP1 | Ser68 | RQRLTHLsPEEKALR | phosphorylation down-regulates quantity by destabilization | 23277279 | SIGNOR-276438 |
| ERK1/2 | CASP9 | – | phosphorylation down-regulates activity | 12792650 | SIGNOR-270184 | |
| ERK1/2 | SCNN1B | – | phosphorylation down-regulates quantity by destabilization | 11805112 | SIGNOR-270163 | |
| ERK1/2 | RCAN1 | – | phosphorylation up-regulates activity | 12063245 | SIGNOR-270149 | |
| ERK1/2 | MEK1/2 | – | phosphorylation down-regulates activity | 10567369 | SIGNOR-244858 | |
| ERK1/2 | SP3 | – | phosphorylation up-regulates | 17685427 | SIGNOR-270165 | |
| ERK1/2 | MITF | Ser180 | PGSSAPNsPMAMLTL | phosphorylation down-regulates | 10673502 | SIGNOR-249575 |
| ERK1/2 | CSNK2A1 | Thr360 | SGISSVPtPSPLGPL | phosphorylation up-regulates | 19941816 | SIGNOR-244525 |
| ERK1/2 | NCOA1 | – | phosphorylation up-regulates | 12163482 | SIGNOR-270194 | |
| ERK1/2 | MED1 | – | phosphorylation up-regulates | 12356758 | SIGNOR-270199 | |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-277815 |
| ERK1/2 | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 17615152 | SIGNOR-244647 |
| ERK1/2 | PTPN7 | – | phosphorylation up-regulates activity | 16226275 | SIGNOR-270202 | |
| ERK1/2 | RAF1 | Ser301 | SSSPNNLsPTGWSQP | phosphorylation down-regulates | 16407412 | SIGNOR-244685 |
| ERK1/2 | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 17615152 | SIGNOR-244655 |
| ERK1/2 | XPO5 | Thr345 | GADSDVEtPSNFGKY | phosphorylation down-regulates activity | 27846390 | SIGNOR-262986 |
| ERK1/2 | LIMA1 | Ser362 | PVHPKPLsPDSRASS | phosphorylation down-regulates quantity by destabilization | 23188829 | SIGNOR-263062 |
| ERK1/2 | SOX10 | Thr244 | GPPTPPTtPKTELQS | phosphorylation down-regulates activity | 29295999 | SIGNOR-277820 |
| ERK1/2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-244711 |
| ERK1/2 | DUSP1 | – | phosphorylation down-regulates | 16286470 | SIGNOR-270189 | |
| ERK1/2 | WWC1 | – | phosphorylation unknown | 24269383 | SIGNOR-270208 | |
| ERK1/2 | GPHN | Ser268 | ASLSTTPsESPRAQA | phosphorylation down-regulates | 23408424 | SIGNOR-200953 |
| ERK1/2 | SMAD1 | – | phosphorylation down-regulates | 10197981 | SIGNOR-270137 | |
| ERK1/2 | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-244662 | |
| ERK1/2 | MYB | Ser532 | KIKQEVEsPTDKSGN | phosphorylation down-regulates | 8960373 | SIGNOR-244569 |
| ERK1/2 | SMAD3 | – | phosphorylation down-regulates | 10197981 | SIGNOR-270142 | |
| ERK1/2 | RAF1 | Ser296 | SPSALSSsPNNLSPT | phosphorylation down-regulates activity | 15664191 | SIGNOR-244681 |
| ERK1/2 | mTORC1 | – | phosphorylation unknown | 21071439 | SIGNOR-270150 | |
| ERK1/2 | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | phosphorylation up-regulates | 10980595 | SIGNOR-244696 |
| ERK1/2 | CACNB1 | Ser161 | CEVGFIPsPVKLDSL | phosphorylation up-regulates activity | 16406008 | SIGNOR-262966 |
| ERK1/2 | PAK1 | – | phosphorylation down-regulates | 14993270 | SIGNOR-270186 | |
| ERK1/2 | RRAS | Ser186 | S-->L | phosphorylation up-regulates activity | 27086924 | SIGNOR-277220 |
| ERK1/2 | RPS6K | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-252746 |
| ERK1/2 | PDE4D | – | phosphorylation down-regulates | 10828059 | SIGNOR-270174 | |
| ERK1/2 | BANP | Thr352 | PSEPMMStPPPASEL | phosphorylation down-regulates activity | 26080397 | SIGNOR-266204 |
| ERK1/2 | RAF1 | – | phosphorylation down-regulates | 9922370 | SIGNOR-244688 | |
| ERK1/2 | SOS1 | Ser1193 | QPTSKAYsPRYSISD | phosphorylation down-regulates | 20724475 | SIGNOR-244747 |
| ERK1/2 | METTL3 | Ser43 | RNPEAALsPTFRSDS | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265953 |
| ERK1/2 | EWSR1 | – | phosphorylation unknown | 19076070 | SIGNOR-270172 | |
| ERK1/2 | SOS1 | Ser1178 | IMSKHLDsPPAIPPR | phosphorylation down-regulates | 20724475 | SIGNOR-244743 |
| ERK1/2 | EP300 | Ser1038 | STSATQSsPAPGQSK | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276455 |
| ERK1/2 | BAG3 | Ser289 | RSSTPLHsPSPIRVH | phosphorylation up-regulates activity | 27659916 | SIGNOR-274070 |
| ERK1/2 | JUND | – | phosphorylation up-regulates | 22327296 | SIGNOR-270183 | |
| ERK1/2 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 18267068 | SIGNOR-249572 |
| ERK1/2 | ARHGAP31 | Thr789 | PPAPPPPtPLEESTP | phosphorylation up-regulates activity | 16024771 | SIGNOR-263057 |
| ERK1/2 | IL16 | – | phosphorylation up-regulates | 14768064 | SIGNOR-270168 | |
| ERK1/2 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-244618 |
| ERK1/2 | ARRB1 | – | phosphorylation down-regulates | 10347142 | SIGNOR-270190 | |
| ERK1/2 | FOXO3 | – | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-270175 | |
| ERK1/2 | PARP1 | Ser372 | VAATPPPsTASAPAA | phosphorylation up-regulates | 16627622 | SIGNOR-244669 |
| ERK1/2 | BANP | Thr337 | VKSFSRRtPNSSSYC | phosphorylation down-regulates activity | 26080397 | SIGNOR-266377 |
| ERK1/2 | PAPOLA | Ser545 | PTSATKTsPLNSSGS | phosphorylation up-regulates activity | 34048556 | SIGNOR-268342 |
| ERK1/2 | MARS1 | Ser209 | LQKQPQPsPAEGRAV | phosphorylation up-regulates activity | 25097229 | SIGNOR-276671 |
| ERK1/2 | MCL1 | – | phosphorylation up-regulates | 18676833 | SIGNOR-270158 | |
| ERK1/2 | ARHGAP26 | – | phosphorylation unknown | 9525907 | SIGNOR-270170 | |
| ERK1/2 | GAB1 | Thr312 | ISYDIPPtPGNTYQI | phosphorylation up-regulates activity | 15379552 | SIGNOR-129196 |
| ERK1/2 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates quantity by stabilization | 11018017 | SIGNOR-252079 |
| ERK1/2 | TWIST1 | – | phosphorylation up-regulates | 21502402 | SIGNOR-270209 | |
| ERK1/2 | RHOA | Thr100 | ENIPEKWtPEVKHFC | phosphorylation up-regulates activity | 26816343 | SIGNOR-277203 |
| ERK1/2 | MARS1 | Ser209 | LQKQPQPsPAEGRAV | phosphorylation up-regulates activity | 25097229 | SIGNOR-277834 |
| ERK1/2 | PPARA | – | phosphorylation up-regulates activity | 10187842 | SIGNOR-270180 | |
| ERK1/2 | PAX5 | Ser189; Ser283 | SGILGITsPSADTNK;DMKANLAsPTPADIG | phosphorylation down-regulates activity | 22593617 | SIGNOR-269088 |
| ERK1/2 | NFATC4 | – | phosphorylation up-regulates | 15657420 | SIGNOR-270160 | |
| ERK1/2 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 16055710 | SIGNOR-263009 |
| ERK1/2 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264442 |
| ERK1/2 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 18511414 | SIGNOR-244606 |
| ERK1/2 | TSC2 | Ser540 | KVMARSLsPPPELEE | phosphorylation down-regulates activity | 15851026 | SIGNOR-249455 |
| ERK1/2 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244505 |
| ERK1/2 | RPS6KA1 | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-250554 |
| ERK1/2 | MKNK1 | Thr250 | NSCTPITtPELTTPC | phosphorylation up-regulates activity | 17130135 | SIGNOR-253014 |
| ERK1/2 | TSC2 | – | phosphorylation down-regulates activity | 19188143 | SIGNOR-244602 | |
| ERK1/2 | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 17615152 | SIGNOR-244651 |
| ERK1/2 | PLA2G4A | – | phosphorylation up-regulates | 8381049 | SIGNOR-270192 | |
| ERK1/2 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-250553 |
| ERK1/2 | METTL3 | Ser50 | SPTFRSDsPVPTAPT | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265951 |
| ERK1/2 | AP1 | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates | 12972619 | SIGNOR-252357 |
| ERK1/2 | RPS6K | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-252745 |
| ERK1/2 | BCL2L11 | – | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-270152 | |
| ERK1/2 | BCL2 | Thr74 | ARTSPLQtPAAPGAA | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244494 |
| ERK1/2 | CACNA1B | Ser446 | ADLCAVGsPFARASL | phosphorylation up-regulates activity | 16406008 | SIGNOR-262967 |
| ERK1/2 | CDKN1A | Thr57 | NFDFVTEtPLEGDFA | phosphorylation down-regulates quantity by destabilization | 19364816 | SIGNOR-244513 |
| ERK1/2 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates | 7889942 | SIGNOR-252086 |
| ERK1/2 | GSK3B/Axin/APC | – | phosphorylation down-regulates activity | 28646232 | SIGNOR-262519 | |
| ERK1/2 | JUN | – | phosphorylation up-regulates activity | 12509763 | SIGNOR-253214 | |
| ERK1/2 | TFCP2 | – | phosphorylation down-regulates | 19237534 | SIGNOR-270201 | |
| ERK1/2 | AMPH | – | phosphorylation down-regulates | 15262992 | SIGNOR-270197 | |
| ERK1/2 | DIAPH1 | Thr768 | PVLPFGLtPKKLYKP | phosphorylation up-regulates quantity by stabilization | 23325789 | SIGNOR-276483 |
| ERK1/2 | BRAF | Thr401 | STTGLSAtPPASLPG | phosphorylation down-regulates | 21135229 | SIGNOR-170339 |
| ERK1/2 | CAD | Thr456 | KVYFLPItPHYVTQV | phosphorylation up-regulates activity | 17485345 | SIGNOR-267441 |
| ERK1/2 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 25658205 | SIGNOR-275407 |
| ERK1/2 | GJA1 | – | phosphorylation down-regulates activity | 9535909 | SIGNOR-270148 | |
| ERK1/2 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 10197981 | SIGNOR-244727 |
| ERK1/2 | SOS1 | Ser1167 | ESAPAESsPSKIMSK | phosphorylation down-regulates activity | 8816480 | SIGNOR-244584 |
| ERK1/2 | RPS6K | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-252744 |
| ERK1/2 | CDKN1B | Ser178 | EENVSDGsPNAGSVE | phosphorylation up-regulates | 10831586 | SIGNOR-244517 |
| ERK1/2 | SOS1 | – | phosphorylation down-regulates activity | 20724475 | SIGNOR-244591 | |
| ERK1/2 | RPS6K | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-252743 |
| ERK1/2 | METTL3 | Ser525 | YGMIERLsPGTRKIE | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265952 |
| ERK1/2 | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-252741 |
| ERK1/2 | EP300 | Ser2366 | MEQGHFAsPDQNSML | phosphorylation up-regulates | 17623675 | SIGNOR-244537 |
| ERK1/2 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates | 12058067 | SIGNOR-89614 |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-277801 |
| ERK1/2 | KRT8 | – | phosphorylation unknown | 16554440 | SIGNOR-270135 | |
| ERK1/2 | PTPRR | – | phosphorylation up-regulates activity | 11493009 | SIGNOR-270147 | |
| ERK1/2 | CEBPB | Thr235 | SSSSPPGtPSPADAK | phosphorylation up-regulates activity | 19723873 | SIGNOR-238303 |
| ERK1/2 | ARRB2 | Thr276 | FCKVYTItPLLSDNR | phosphorylation up-regulates activity | 26324936 | SIGNOR-274019 |
| ERK1/2 | HIF1A | – | phosphorylation up-regulates | 18519666 | SIGNOR-270191 | |
| ERK1/2 | ELK1 | Ser324 | RDLELPLsPSLLGGP | phosphorylation up-regulates | 7889942 | SIGNOR-252085 |
| ERK1/2 | PTTG1 | – | phosphorylation up-regulates | 10906323 | SIGNOR-270155 | |
| ERK1/2 | APBB1 | – | phosphorylation unknown | 14697653 | SIGNOR-270166 | |
| ERK1/2 | TSC2 | Ser664 | KKTSGPLsPPTGPPG | phosphorylation down-regulates | 15851026 | SIGNOR-244765 |
| ERK1/2 | ARHGEF2 | – | phosphorylation up-regulates | 18211802 | SIGNOR-270138 | |
| ERK1/2 | STMN1 | – | phosphorylation down-regulates activity | 9731215 | SIGNOR-270182 | |
| ERK1/2 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 12972619 | SIGNOR-251523 |
| ERK1/2 | MEK1/2 | – | phosphorylation down-regulates activity | 14993270 | SIGNOR-244862 | |
| ERK1/2 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-249574 |
| ERK1/2 | EP300 | Ser2039 | GLGQVGIsPLKPGTV | phosphorylation down-regulates quantity by destabilization | 24530506 | SIGNOR-276458 |
| ERK1/2 | TCF3 | – | phosphorylation down-regulates quantity by destabilization | 14592976 | SIGNOR-270139 | |
| ERK1/2 | RPS6KB1 | – | phosphorylation up-regulates activity | 14967450 | SIGNOR-270198 | |
| ERK1/2 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-250557 |
| ERK1/2 | MAP2K1 | Thr386 | IGLNQPStPTHAAGV | phosphorylation down-regulates activity | 10567369 | SIGNOR-244561 |
| ERK1/2 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10980595 | SIGNOR-244692 |
| ERK1/2 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 10197981 | SIGNOR-244719 |
| ERK1/2 | CTTN | – | phosphorylation up-regulates | 20444238 | SIGNOR-270164 | |
| ERK1/2 | MKNK2 | – | phosphorylation up-regulates | 9155017 | SIGNOR-270204 | |
| ERK1/2 | RPS6K | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-252742 |
| ERK1/2 | BAD | – | phosphorylation down-regulates activity | 8929531 | SIGNOR-244497 | |
| ERK1/2 | HECTD3 | Thr157 | ARLVPIDtPNHLQRQ | phosphorylation up-regulates activity | 28716524 | SIGNOR-272330 |
| ERK1/2 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-129200 |
| ERK1/2 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-244703 |
| ERK1/2 | CAPN2 | – | phosphorylation up-regulates | 14993287 | SIGNOR-270179 | |
| ERK1/2 | MCRIP1 | – | phosphorylation down-regulates activity | 25728771 | SIGNOR-270188 | |
| ERK1/2 | KLC1 | – | phosphorylation down-regulates | 21385839 | SIGNOR-270176 | |
| ERK1/2 | LIPE | – | phosphorylation up-regulates activity | 11581251 | SIGNOR-270207 | |
| ERK1/2 | ELK1 | Thr336 | GGPGPERtPGSGSGS | phosphorylation up-regulates | 7889942 | SIGNOR-252082 |
| ERK1/2 | MFN1 | Thr562 | LPRSLASTPTAPTTP | phosphorylation up-regulates activity | 25801171 | SIGNOR-274134 |
| ERK1/2 | AP1 | Thr232 | GGLPEVAtPESEEAF | phosphorylation up-regulates | 7816602 | SIGNOR-252359 |
| ERK1/2 | PAPOLA | Ser537 | DNSMSVPsPTSATKT | phosphorylation up-regulates activity | 34048556 | SIGNOR-268341 |
| ERK1/2 | FOS | – | phosphorylation up-regulates | 21561061 | SIGNOR-260762 | |
| ERK1/2 | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation up-regulates activity | 11733495 | SIGNOR-232236 |
| ERK1/2 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates | 16046550 | SIGNOR-244715 |
| ERK1/2 | RAF1 | Ser289 | RSHSESAsPSALSSS | phosphorylation down-regulates activity | 15664191 | SIGNOR-244677 |
| ERK1/2 | STAT5A | – | phosphorylation up-regulates | 10194762 | SIGNOR-270136 | |
| ERK1/2 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-244731 |
| ERK1/2 | HDAC6 | Ser1035 | DHQTPPTsPVQGTTP | phosphorylation up-regulates | 24089523 | SIGNOR-244545 |
| ERK1/2 | HDAC6 | Thr1031 | ASSTDHQtPPTSPVQ | phosphorylation up-regulates | 24089523 | SIGNOR-244549 |
| ERK1/2 | PCYT1A | – | phosphorylation down-regulates | 15788406 | SIGNOR-270151 | |
| ERK1/2 | ELK1 | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-233520 | |
| ERK1/2 | MARS1 | Ser825 | GGGQAKTsPKPAVVE | phosphorylation up-regulates activity | 25097229 | SIGNOR-277833 |
| ERK1/2 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | phosphorylation up-regulates | 10197981 | SIGNOR-244723 |
| ERK1/2 | SOS1 | Ser1197 | KAYSPRYsISDRTSI | phosphorylation down-regulates activity | 8816480 | SIGNOR-244588 |
| ERK1/2 | GAB1 | Ser597 | VPMNPNLsSEDPNLF | phosphorylation up-regulates activity | 15379552 | SIGNOR-129192 |
| ERK1/2 | RAMAC | Ser36 | YLKRPPEsPPIVEEW | phosphorylation down-regulates quantity by destabilization | 27452456 | SIGNOR-277267 |
| ERK1/2 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates | 16046550 | SIGNOR-244707 |
| ERK1/2 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates | 11259409 | SIGNOR-105754 |
| ERK1/2 | EP300 | Ser2279 | PVQPNPMsPQQHMLP | phosphorylation up-regulates | 17623675 | SIGNOR-244533 |
| ERK1/2 | MAPK3 | Thr207 | FLTEYVAtRWYRAPE | phosphorylation up-regulates activity | 19060905 | SIGNOR-244565 |
| ERK1/2 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 9199329 | SIGNOR-93554 |
| ERK1/2 | BRAF | Ser151 | VARSNPKsPQKPIVR | phosphorylation down-regulates activity | 21478863 | SIGNOR-259919 |
| ERK1/2 | POLR2A | – | phosphorylation down-regulates | 14662762 | SIGNOR-270156 | |
| ERK1/2 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 16055710 | SIGNOR-263010 |
| ERK1/2 | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 12670876 | SIGNOR-264443 |
| ERK1/2 | MARS1 | Ser825 | GGGQAKTsPKPAVVE | phosphorylation up-regulates activity | 25097229 | SIGNOR-276670 |
| ERK1/2 | SMAD4 | Thr277 | GSRTAPYtPNLPHHQ | phosphorylation up-regulates | 12801888 | SIGNOR-244739 |
| ERK1/2 | FOS | Thr232 | GGLPEVAtPESEEAF | phosphorylation up-regulates | 7816602 | SIGNOR-251525 |
| ERK1/2 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 12972619 | SIGNOR-251524 |
| ERK1/2 | PAPOLA | Ser558 | GSSQGRNsPAPAVTA | phosphorylation up-regulates activity | 34048556 | SIGNOR-268343 |
| ERK1/2 | GRIP1 | Ser734 | SLKGKPLsEAIHLLQ | phosphorylation up-regulates activity | 11301320 | SIGNOR-263056 |
| ERK1/2 | RPS6KA1 | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-250556 |
| ERK1/2 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10677502 | SIGNOR-244501 |
| ERK1/2 | NCF1 | – | phosphorylation up-regulates | 16778989 | SIGNOR-270187 | |
| ERK1/2 | MBP | – | phosphorylation down-regulates | 16401070 | SIGNOR-270195 | |
| ERK1/2 | TSC1 | – | phosphorylation down-regulates | 15851026 | SIGNOR-244761 | |
| ERK1/2 | RPS6KA1 | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-250555 |
| ERK1/2 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 10831586 | SIGNOR-244622 |
| ERK1/2 | SREBF1 | Ser117 | YPSMPAFsPGPGIKE | phosphorylation up-regulates | 10915800 | SIGNOR-244754 |
| ERK1/2 | RAMAC | Ser36 | YLKRPPEsPPIVEEW | phosphorylation down-regulates quantity by destabilization | 27452456 | SIGNOR-277819 |
| ERK1/2 | SPHK2 | – | phosphorylation up-regulates | 17311928 | SIGNOR-270154 | |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-266376 |
| ERK1/2 | E2F1 | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-233526 | |
| ERK1/2 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates activity | 19767751 | SIGNOR-188131 |
| ERK1/2 | NOXA1 | – | phosphorylation down-regulates | 20230789 | SIGNOR-270203 | |
| ERK1/2 | PCBP2 | Ser173 | MLETLSQsPPKGVTI | phosphorylation up-regulates quantity by stabilization | 17475908 | SIGNOR-262668 |
| ERK1/2 | RHOA | Ser88 | LMCFSIDsPDSLENI | phosphorylation up-regulates activity | 26816343 | SIGNOR-277202 |
| ERK1/2 | ETV6 | Ser213 | DNMIRRLsPAERAQG | phosphorylation down-regulates | 15060146 | SIGNOR-260084 |
| ERK1/2 | PPP2R5C | – | phosphorylation down-regulates | 16456541 | SIGNOR-270196 | |
| ERK1/2 | GABBR1 | Ser868 | ITRGEWQsEAQDTMK | phosphorylation down-regulates quantity by destabilization | 37686242 | SIGNOR-277853 |
| ERK1/2 | GABBR1 | Thr873 | WQSEAQDtMKTGSST | phosphorylation down-regulates quantity by destabilization | 37686242 | SIGNOR-277852 |
| ERK1/2 | SCNN1G | – | phosphorylation down-regulates quantity by destabilization | 11805112 | SIGNOR-270171 | |
| ERK1/2 | SOS1 | Ser1132 | TLPHGPRsASVSSIS | phosphorylation down-regulates activity | 8816480 | SIGNOR-244580 |
| ERK1/2 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262522 |
| ERK1/2 | CALD1 | – | phosphorylation down-regulates | 10514499 | SIGNOR-270162 | |
| ERK1/2 | H3-3A | Ser29 | ATKAARKsAPSTGGV | phosphorylation down-regulates activity | 11278789 | SIGNOR-263068 |
| ERK1/2 | CSNK2A1 | Ser362 | ISSVPTPsPLGPLAG | phosphorylation up-regulates | 19941816 | SIGNOR-244521 |
| ERK1/2 | GAB2 | – | phosphorylation up-regulates | 15356145 | SIGNOR-270133 | |
| ERK1/2 | MRTFA | – | phosphorylation down-regulates | 18694962 | SIGNOR-270131 | |
| ERK1/2 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244610 |
| ERK1/2 | PARP1 | Thr373 | AATPPPStASAPAAV | phosphorylation up-regulates | 16627622 | SIGNOR-244673 |
| ERK1/2 | FGFR1 | Ser777 | SMPLDQYsPSFPDTR | phosphorylation down-regulates | 23405013 | SIGNOR-244541 |
| ERK1/2 | PGR | – | phosphorylation down-regulates | 10655479 | SIGNOR-270157 | |
| ERK1/2 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262995 |
| ERK1/2 | AP1 | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates | 12972619 | SIGNOR-252358 |
| ERK1/2 | MAP2K1 | Thr292 | ETPPRPRtPGRPLSS | phosphorylation down-regulates activity | 14993270 | SIGNOR-244557 |
| ERK1/2 | LCK | – | phosphorylation up-regulates activity | 8618896 | SIGNOR-270177 | |
| ERK1/2 | GTF2I | – | phosphorylation up-regulates | 10648599 | SIGNOR-270169 | |
| ERK1/2 | GRB10 | – | phosphorylation up-regulates | 15952796 | SIGNOR-270178 | |
| ERK1/2 | XPO5 | Ser416 | GFPSKTDsPSCEYSR | phosphorylation down-regulates activity | 27846390 | SIGNOR-262980 |
| ERK1/2 | ARRB2 | Ser14 | TRVFKKSsPNCKLTV | phosphorylation up-regulates activity | 26324936 | SIGNOR-274018 |
| ERK1/2 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 12193595 | SIGNOR-244735 |
| ERK1/2 | RPS6KA3 | – | phosphorylation up-regulates | 19282669 | SIGNOR-244699 | |
| ERK1/2 | CACNB1 | Ser348 | IVYIKITsPKVLQRL | phosphorylation up-regulates activity | 16406008 | SIGNOR-262965 |
| ERK1/2 | SP1 | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-233523 | |
| ERK1/2 | XPO5 | Ser497 | GSLCSVFsPSFVQWE | phosphorylation down-regulates activity | 27846390 | SIGNOR-262983 |
| ERK1/2 | IRX2 | – | phosphorylation up-regulates activity | 15133517 | SIGNOR-270193 | |
| ERK1/2 | SOX10 | Thr240 | GQSHGPPtPPTTPKT | phosphorylation down-regulates activity | 29295999 | SIGNOR-277821 |
| ERK1/2 | BAG3 | Thr285 | GSPARSStPLHSPSP | phosphorylation up-regulates activity | 27659916 | SIGNOR-274071 |
| ERK1/2 | AP1 | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates | 12972619 | SIGNOR-252353 |
| ERK1/2 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-244595 |
| ERK1/2 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 7889942 | SIGNOR-252083 |
| ERK1/2 | NUP153 | – | phosphorylation unknown | 19767751 | SIGNOR-270159 | |
| ERK1/2 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-244553 |
| ERK1/2 | ASB2 | Ser371 | RIRRSGVsPLHLAAE | phosphorylation up-regulates activity | 24044920 | SIGNOR-272239 |
| ERK1/2 | RPS3 | – | phosphorylation unknown | 15950189 | SIGNOR-270145 | |
| ERK1/2 | ELK1 | – | phosphorylation up-regulates | 7618106 | SIGNOR-252081 | |
| ERK1/2 | LIMA1 | Ser604 | FQSTSVKsPKTVSPP | phosphorylation down-regulates quantity by destabilization | 23188829 | SIGNOR-263063 |
| ERK1/2 | GAB1 | Ser454 | YVPMNPNsPPRQHSS | phosphorylation up-regulates activity | 15379552 | SIGNOR-129188 |
| ERK1/2 | SPHK1 | Ser225 | VGSKTPAsPVVVQQG | phosphorylation up-regulates | 14532121 | SIGNOR-118542 |
| ERK1/2 | BANP | Thr337 | VKSFSRRtPNSSSYC | phosphorylation down-regulates activity | 26080397 | SIGNOR-266203 |
| ERK1/2 | PLCB1 | – | phosphorylation up-regulates activity | 11287604 | SIGNOR-270200 | |
| ERK1/2 | UBTF | – | phosphorylation down-regulates | 11741541 | SIGNOR-270181 | |
| ERK1/2 | LIFR | – | phosphorylation down-regulates | 7777512 | SIGNOR-270134 | |
| ERK1/2 | RXRA | Thr82 | HSMSVPTtPTLGFST | phosphorylation down-regulates activity | 17604322 | SIGNOR-262960 |
| ERK1/2 | EP300 | Ser2315 | RSPQPVPsPRPQSQP | phosphorylation up-regulates | 17623675 | SIGNOR-244634 |
| ERK1/2 | ELK1 | Ser422 | LSTPVVLsPGPQKP | phosphorylation up-regulates | 7889942 | SIGNOR-252084 |
| ERK1/2 | POU5F1 | – | phosphorylation down-regulates | 23024368 | SIGNOR-270185 | |
| ERK1/2 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 18267068 | SIGNOR-249573 |
| ERK1/2 | RPS6KA2 | – | phosphorylation up-regulates | 8939914 | SIGNOR-270144 | |
| ERK1/2 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 26194464 | SIGNOR-255020 |
| ERK1/2 | FOXO | – | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-270146 | |
| ERK1/2 | PML | – | phosphorylation up-regulates | 15093545 | SIGNOR-270153 | |
| ERK1/2 | SMAD2 | – | phosphorylation down-regulates | 10197981 | SIGNOR-244576 | |
| ERK1/2 | ABI1 | – | phosphorylation up-regulates | 21419341 | SIGNOR-270161 | |
| ERK1/2 | TH | – | phosphorylation up-regulates | 7901013 | SIGNOR-270167 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | CIC PSer1409 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-244630 |
| ERK1/2 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-260755 |
| ERK1/2 | phosphorylation up-regulates → | CDCA5 PSer79 | phosphorylation up-regulates → | CDCA5 | 20551060 | SIGNOR-262969 |
| ERK1/2 | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 12359725 | SIGNOR-244614 |
| ERK1/2 | phosphorylation up-regulates → | NUP50 PSer315 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-263043 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-277822 |
| ERK1/2 | phosphorylation up-regulates → | EGFR PThr693 | phosphorylation down-regulates ⊣ | EGFR | 10816576 | SIGNOR-244529 |
| ERK1/2 | phosphorylation up-regulates → | CDCA5 PSer209 | phosphorylation up-regulates → | CDCA5 | 20551060 | SIGNOR-262968 |
| ERK1/2 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation up-regulates → | RPTOR | 21071439 | SIGNOR-174878 |
| ERK1/2 | phosphorylation up-regulates → | RRAS PSer201 | phosphorylation up-regulates → | RRAS | 27086924 | SIGNOR-277219 |
| ERK1/2 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-244509 |
| ERK1/2 | phosphorylation up-regulates → | MKNK1 PThr255 | phosphorylation up-regulates → | MKNK1 | 17130135 | SIGNOR-253015 |
| ERK1/2 | phosphorylation up-regulates → | RXRA PSer260 | phosphorylation down-regulates ⊣ | RXRA | 17604322 | SIGNOR-244573 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PThr573 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250558 |
| ERK1/2 | phosphorylation up-regulates → | SCRIB PSer853 | phosphorylation down-regulates ⊣ | SCRIB | 20622900 | SIGNOR-263065 |
| ERK1/2 | phosphorylation up-regulates → | SHC4 PThr159 | phosphorylation down-regulates ⊣ | SHC4 | 31121283 | SIGNOR-273669 |
| ERK1/2 | phosphorylation up-regulates → | GORASP1 PSer274 | phosphorylation down-regulates ⊣ | GORASP1 | 18762583 | SIGNOR-260605 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-251522 |
| ERK1/2 | phosphorylation up-regulates → | XBP1 PSer181 | phosphorylation down-regulates ⊣ | XBP1 | 23277279 | SIGNOR-276439 |
| ERK1/2 | phosphorylation up-regulates → | BANP PThr352 | phosphorylation down-regulates ⊣ | BANP | 26080397 | SIGNOR-266378 |
| ERK1/2 | phosphorylation up-regulates → | SCRIB PSer1448 | phosphorylation down-regulates ⊣ | SCRIB | 20622900 | SIGNOR-263064 |
| ERK1/2 | phosphorylation up-regulates → | XBP1 PSer68 | phosphorylation down-regulates ⊣ | XBP1 | 23277279 | SIGNOR-276438 |
| ERK1/2 | phosphorylation up-regulates → | MITF PSer180 | phosphorylation down-regulates ⊣ | MITF | 10673502 | SIGNOR-249575 |
| ERK1/2 | phosphorylation up-regulates → | CSNK2A1 PThr360 | phosphorylation up-regulates → | CSNK2A1 | 19941816 | SIGNOR-244525 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-277815 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244647 |
| ERK1/2 | phosphorylation up-regulates → | RAF1 PSer301 | phosphorylation down-regulates ⊣ | RAF1 | 16407412 | SIGNOR-244685 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244655 |
| ERK1/2 | phosphorylation up-regulates → | XPO5 PThr345 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262986 |
| ERK1/2 | phosphorylation up-regulates → | LIMA1 PSer362 | phosphorylation down-regulates ⊣ | LIMA1 | 23188829 | SIGNOR-263062 |
| ERK1/2 | phosphorylation up-regulates → | SOX10 PThr244 | phosphorylation down-regulates ⊣ | SOX10 | 29295999 | SIGNOR-277820 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244711 |
| ERK1/2 | phosphorylation up-regulates → | GPHN PSer268 | phosphorylation down-regulates ⊣ | GPHN | 23408424 | SIGNOR-200953 |
| ERK1/2 | phosphorylation up-regulates → | MYB PSer532 | phosphorylation down-regulates ⊣ | MYB | 8960373 | SIGNOR-244569 |
| ERK1/2 | phosphorylation up-regulates → | RAF1 PSer296 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-244681 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA3 PThr577 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-244696 |
| ERK1/2 | phosphorylation up-regulates → | CACNB1 PSer161 | phosphorylation up-regulates → | CACNB1 | 16406008 | SIGNOR-262966 |
| ERK1/2 | phosphorylation up-regulates → | RRAS PSer186 | phosphorylation up-regulates → | RRAS | 27086924 | SIGNOR-277220 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer380 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252746 |
| ERK1/2 | phosphorylation up-regulates → | BANP PThr352 | phosphorylation down-regulates ⊣ | BANP | 26080397 | SIGNOR-266204 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1193 | phosphorylation down-regulates ⊣ | SOS1 | 20724475 | SIGNOR-244747 |
| ERK1/2 | phosphorylation up-regulates → | METTL3 PSer43 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265953 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1178 | phosphorylation down-regulates ⊣ | SOS1 | 20724475 | SIGNOR-244743 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer1038 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276455 |
| ERK1/2 | phosphorylation up-regulates → | BAG3 PSer289 | phosphorylation up-regulates → | BAG3 | 27659916 | SIGNOR-274070 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-249572 |
| ERK1/2 | phosphorylation up-regulates → | ARHGAP31 PThr789 | phosphorylation up-regulates → | ARHGAP31 | 16024771 | SIGNOR-263057 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-244618 |
| ERK1/2 | phosphorylation up-regulates → | PARP1 PSer372 | phosphorylation up-regulates → | PARP1 | 16627622 | SIGNOR-244669 |
| ERK1/2 | phosphorylation up-regulates → | BANP PThr337 | phosphorylation down-regulates ⊣ | BANP | 26080397 | SIGNOR-266377 |
| ERK1/2 | phosphorylation up-regulates → | PAPOLA PSer545 | phosphorylation up-regulates → | PAPOLA | 34048556 | SIGNOR-268342 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer209 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-276671 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PThr312 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129196 |
| ERK1/2 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 11018017 | SIGNOR-252079 |
| ERK1/2 | phosphorylation up-regulates → | RHOA PThr100 | phosphorylation up-regulates → | RHOA | 26816343 | SIGNOR-277203 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer209 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-277834 |
| ERK1/2 | phosphorylation up-regulates → | PAX5 PSer189; Ser283 | phosphorylation down-regulates ⊣ | PAX5 | 22593617 | SIGNOR-269088 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263009 |
| ERK1/2 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264442 |
| ERK1/2 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 18511414 | SIGNOR-244606 |
| ERK1/2 | phosphorylation up-regulates → | TSC2 PSer540 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-249455 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244505 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer363 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250554 |
| ERK1/2 | phosphorylation up-regulates → | MKNK1 PThr250 | phosphorylation up-regulates → | MKNK1 | 17130135 | SIGNOR-253014 |
| ERK1/2 | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 17615152 | SIGNOR-244651 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250553 |
| ERK1/2 | phosphorylation up-regulates → | METTL3 PSer50 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265951 |
| ERK1/2 | phosphorylation up-regulates → | AP1 PThr325 | phosphorylation up-regulates → | AP1 | 12972619 | SIGNOR-252357 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PThr359 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252745 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PThr74 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244494 |
| ERK1/2 | phosphorylation up-regulates → | CACNA1B PSer446 | phosphorylation up-regulates → | CACNA1B | 16406008 | SIGNOR-262967 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1A PThr57 | phosphorylation down-regulates ⊣ | CDKN1A | 19364816 | SIGNOR-244513 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252086 |
| ERK1/2 | phosphorylation up-regulates → | DIAPH1 PThr768 | phosphorylation up-regulates → | DIAPH1 | 23325789 | SIGNOR-276483 |
| ERK1/2 | phosphorylation up-regulates → | BRAF PThr401 | phosphorylation down-regulates ⊣ | BRAF | 21135229 | SIGNOR-170339 |
| ERK1/2 | phosphorylation up-regulates → | CAD PThr456 | phosphorylation up-regulates → | CAD | 17485345 | SIGNOR-267441 |
| ERK1/2 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 25658205 | SIGNOR-275407 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244727 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1167 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244584 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer732 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252744 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1B PSer178 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-244517 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PThr573 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252743 |
| ERK1/2 | phosphorylation up-regulates → | METTL3 PSer525 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265952 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252741 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2366 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-244537 |
| ERK1/2 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 12058067 | SIGNOR-89614 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-277801 |
| ERK1/2 | phosphorylation up-regulates → | CEBPB PThr235 | phosphorylation up-regulates → | CEBPB | 19723873 | SIGNOR-238303 |
| ERK1/2 | phosphorylation up-regulates → | ARRB2 PThr276 | phosphorylation up-regulates → | ARRB2 | 26324936 | SIGNOR-274019 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer324 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252085 |
| ERK1/2 | phosphorylation up-regulates → | TSC2 PSer664 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-244765 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-251523 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-249574 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2039 | phosphorylation down-regulates ⊣ | EP300 | 24530506 | SIGNOR-276458 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250557 |
| ERK1/2 | phosphorylation up-regulates → | MAP2K1 PThr386 | phosphorylation down-regulates ⊣ | MAP2K1 | 10567369 | SIGNOR-244561 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-244692 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244719 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer363 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252742 |
| ERK1/2 | phosphorylation up-regulates → | HECTD3 PThr157 | phosphorylation up-regulates → | HECTD3 | 28716524 | SIGNOR-272330 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129200 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244703 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PThr336 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252082 |
| ERK1/2 | phosphorylation up-regulates → | MFN1 PThr562 | phosphorylation up-regulates → | MFN1 | 25801171 | SIGNOR-274134 |
| ERK1/2 | phosphorylation up-regulates → | AP1 PThr232 | phosphorylation up-regulates → | AP1 | 7816602 | SIGNOR-252359 |
| ERK1/2 | phosphorylation up-regulates → | PAPOLA PSer537 | phosphorylation up-regulates → | PAPOLA | 34048556 | SIGNOR-268341 |
| ERK1/2 | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation up-regulates → | PPARG | 11733495 | SIGNOR-232236 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244715 |
| ERK1/2 | phosphorylation up-regulates → | RAF1 PSer289 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-244677 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-244731 |
| ERK1/2 | phosphorylation up-regulates → | HDAC6 PSer1035 | phosphorylation up-regulates → | HDAC6 | 24089523 | SIGNOR-244545 |
| ERK1/2 | phosphorylation up-regulates → | HDAC6 PThr1031 | phosphorylation up-regulates → | HDAC6 | 24089523 | SIGNOR-244549 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer825 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-277833 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer250 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244723 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1197 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244588 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PSer597 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129192 |
| ERK1/2 | phosphorylation up-regulates → | RAMAC PSer36 | phosphorylation down-regulates ⊣ | RAMAC | 27452456 | SIGNOR-277267 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244707 |
| ERK1/2 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105754 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2279 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-244533 |
| ERK1/2 | phosphorylation up-regulates → | MAPK3 PThr207 | phosphorylation up-regulates → | MAPK3 | 19060905 | SIGNOR-244565 |
| ERK1/2 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-93554 |
| ERK1/2 | phosphorylation up-regulates → | BRAF PSer151 | phosphorylation down-regulates ⊣ | BRAF | 21478863 | SIGNOR-259919 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263010 |
| ERK1/2 | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264443 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer825 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-276670 |
| ERK1/2 | phosphorylation up-regulates → | SMAD4 PThr277 | phosphorylation up-regulates → | SMAD4 | 12801888 | SIGNOR-244739 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr232 | phosphorylation up-regulates → | FOS | 7816602 | SIGNOR-251525 |
| ERK1/2 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-251524 |
| ERK1/2 | phosphorylation up-regulates → | PAPOLA PSer558 | phosphorylation up-regulates → | PAPOLA | 34048556 | SIGNOR-268343 |
| ERK1/2 | phosphorylation up-regulates → | GRIP1 PSer734 | phosphorylation up-regulates → | GRIP1 | 11301320 | SIGNOR-263056 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer732 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250556 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10677502 | SIGNOR-244501 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer380 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250555 |
| ERK1/2 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 10831586 | SIGNOR-244622 |
| ERK1/2 | phosphorylation up-regulates → | SREBF1 PSer117 | phosphorylation up-regulates → | SREBF1 | 10915800 | SIGNOR-244754 |
| ERK1/2 | phosphorylation up-regulates → | RAMAC PSer36 | phosphorylation down-regulates ⊣ | RAMAC | 27452456 | SIGNOR-277819 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-266376 |
| ERK1/2 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188131 |
| ERK1/2 | phosphorylation up-regulates → | PCBP2 PSer173 | phosphorylation up-regulates → | PCBP2 | 17475908 | SIGNOR-262668 |
| ERK1/2 | phosphorylation up-regulates → | RHOA PSer88 | phosphorylation up-regulates → | RHOA | 26816343 | SIGNOR-277202 |
| ERK1/2 | phosphorylation up-regulates → | ETV6 PSer213 | phosphorylation down-regulates ⊣ | ETV6 | 15060146 | SIGNOR-260084 |
| ERK1/2 | phosphorylation up-regulates → | GABBR1 PSer868 | phosphorylation down-regulates ⊣ | GABBR1 | 37686242 | SIGNOR-277853 |
| ERK1/2 | phosphorylation up-regulates → | GABBR1 PThr873 | phosphorylation down-regulates ⊣ | GABBR1 | 37686242 | SIGNOR-277852 |
| ERK1/2 | phosphorylation up-regulates → | SOS1 PSer1132 | phosphorylation down-regulates ⊣ | SOS1 | 8816480 | SIGNOR-244580 |
| ERK1/2 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262522 |
| ERK1/2 | phosphorylation up-regulates → | H3-3A PSer29 | phosphorylation down-regulates ⊣ | H3-3A | 11278789 | SIGNOR-263068 |
| ERK1/2 | phosphorylation up-regulates → | CSNK2A1 PSer362 | phosphorylation up-regulates → | CSNK2A1 | 19941816 | SIGNOR-244521 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244610 |
| ERK1/2 | phosphorylation up-regulates → | PARP1 PThr373 | phosphorylation up-regulates → | PARP1 | 16627622 | SIGNOR-244673 |
| ERK1/2 | phosphorylation up-regulates → | FGFR1 PSer777 | phosphorylation down-regulates ⊣ | FGFR1 | 23405013 | SIGNOR-244541 |
| ERK1/2 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262995 |
| ERK1/2 | phosphorylation up-regulates → | AP1 PSer374 | phosphorylation up-regulates → | AP1 | 12972619 | SIGNOR-252358 |
| ERK1/2 | phosphorylation up-regulates → | MAP2K1 PThr292 | phosphorylation down-regulates ⊣ | MAP2K1 | 14993270 | SIGNOR-244557 |
| ERK1/2 | phosphorylation up-regulates → | XPO5 PSer416 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262980 |
| ERK1/2 | phosphorylation up-regulates → | ARRB2 PSer14 | phosphorylation up-regulates → | ARRB2 | 26324936 | SIGNOR-274018 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-244735 |
| ERK1/2 | phosphorylation up-regulates → | CACNB1 PSer348 | phosphorylation up-regulates → | CACNB1 | 16406008 | SIGNOR-262965 |
| ERK1/2 | phosphorylation up-regulates → | XPO5 PSer497 | phosphorylation down-regulates ⊣ | XPO5 | 27846390 | SIGNOR-262983 |
| ERK1/2 | phosphorylation up-regulates → | SOX10 PThr240 | phosphorylation down-regulates ⊣ | SOX10 | 29295999 | SIGNOR-277821 |
| ERK1/2 | phosphorylation up-regulates → | BAG3 PThr285 | phosphorylation up-regulates → | BAG3 | 27659916 | SIGNOR-274071 |
| ERK1/2 | phosphorylation up-regulates → | AP1 PThr331 | phosphorylation up-regulates → | AP1 | 12972619 | SIGNOR-252353 |
| ERK1/2 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-244595 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252083 |
| ERK1/2 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-244553 |
| ERK1/2 | phosphorylation up-regulates → | ASB2 PSer371 | phosphorylation up-regulates → | ASB2 | 24044920 | SIGNOR-272239 |
| ERK1/2 | phosphorylation up-regulates → | LIMA1 PSer604 | phosphorylation down-regulates ⊣ | LIMA1 | 23188829 | SIGNOR-263063 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PSer454 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129188 |
| ERK1/2 | phosphorylation up-regulates → | SPHK1 PSer225 | phosphorylation up-regulates → | SPHK1 | 14532121 | SIGNOR-118542 |
| ERK1/2 | phosphorylation up-regulates → | BANP PThr337 | phosphorylation down-regulates ⊣ | BANP | 26080397 | SIGNOR-266203 |
| ERK1/2 | phosphorylation up-regulates → | RXRA PThr82 | phosphorylation down-regulates ⊣ | RXRA | 17604322 | SIGNOR-262960 |
| ERK1/2 | phosphorylation up-regulates → | EP300 PSer2315 | phosphorylation up-regulates → | EP300 | 17623675 | SIGNOR-244634 |
| ERK1/2 | phosphorylation up-regulates → | ELK1 PSer422 | phosphorylation up-regulates → | ELK1 | 7889942 | SIGNOR-252084 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-249573 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 26194464 | SIGNOR-255020 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → up-regulates | SREBF2 | SIGNOR-270141 |
| ERK1/2 | phosphorylation down-regulates | CIC | SIGNOR-244630 |
| ERK1/2 | phosphorylation → down-regulates activity | THRB | SIGNOR-270143 |
| ERK1/2 | phosphorylation → up-regulates activity | MKNK1 | SIGNOR-253013 |
| ERK1/2 | phosphorylation → up-regulates | ATF2 | SIGNOR-260755 |
| ERK1/2 | phosphorylation → up-regulates activity | CDCA5 | SIGNOR-262969 |
| ERK1/2 | phosphorylation → up-regulates | MAPKAPK2 | SIGNOR-270206 |
| ERK1/2 | phosphorylation → up-regulates | CDK2 | SIGNOR-244614 |
| ERK1/2 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-270132 |
| ERK1/2 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-263043 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-277822 |
| ERK1/2 | phosphorylation down-regulates | TOB1 | SIGNOR-270210 |
| ERK1/2 | phosphorylation down-regulates | EGFR | SIGNOR-244529 |
| ERK1/2 | phosphorylation → up-regulates activity | CDCA5 | SIGNOR-262968 |
| ERK1/2 | phosphorylation → up-regulates quantity by expression | PPARG | SIGNOR-235334 |
| ERK1/2 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-174878 |
| ERK1/2 | phosphorylation → up-regulates activity | RRAS | SIGNOR-277219 |
| ERK1/2 | phosphorylation down-regulates | CASP8 | SIGNOR-244509 |
| ERK1/2 | phosphorylation → up-regulates activity | MKNK1 | SIGNOR-253015 |
| ERK1/2 | phosphorylation → down-regulates activity | RXRA | SIGNOR-244573 |
| ERK1/2 | phosphorylation down-regulates | DUSP6 | SIGNOR-270205 |
| ERK1/2 | phosphorylation down-regulates | BCL6 | SIGNOR-270140 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250558 |
| ERK1/2 | phosphorylation → unknown | SCRIB | SIGNOR-263065 |
| ERK1/2 | phosphorylation → down-regulates activity | SHC4 | SIGNOR-273669 |
| ERK1/2 | phosphorylation → down-regulates activity | GORASP1 | SIGNOR-260605 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-251522 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | XBP1 | SIGNOR-276439 |
| ERK1/2 | phosphorylation → down-regulates activity | BANP | SIGNOR-266378 |
| ERK1/2 | phosphorylation → unknown | SCRIB | SIGNOR-263064 |
| ERK1/2 | phosphorylation down-regulates | CIITA | SIGNOR-270173 |
| ERK1/2 | phosphorylation → up-regulates activity | JUN | SIGNOR-236767 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | XBP1 | SIGNOR-276438 |
| ERK1/2 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-270184 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | SCNN1B | SIGNOR-270163 |
| ERK1/2 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-270149 |
| ERK1/2 | phosphorylation → down-regulates activity | MEK1/2 | SIGNOR-244858 |
| ERK1/2 | phosphorylation → up-regulates | SP3 | SIGNOR-270165 |
| ERK1/2 | phosphorylation down-regulates | MITF | SIGNOR-249575 |
| ERK1/2 | phosphorylation → up-regulates | CSNK2A1 | SIGNOR-244525 |
| ERK1/2 | phosphorylation → up-regulates | NCOA1 | SIGNOR-270194 |
| ERK1/2 | phosphorylation → up-regulates | MED1 | SIGNOR-270199 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-277815 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244647 |
| ERK1/2 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-270202 |
| ERK1/2 | phosphorylation down-regulates | RAF1 | SIGNOR-244685 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244655 |
| ERK1/2 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262986 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | LIMA1 | SIGNOR-263062 |
| ERK1/2 | phosphorylation → down-regulates activity | SOX10 | SIGNOR-277820 |
| ERK1/2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-244711 |
| ERK1/2 | phosphorylation down-regulates | DUSP1 | SIGNOR-270189 |
| ERK1/2 | phosphorylation → unknown | WWC1 | SIGNOR-270208 |
| ERK1/2 | phosphorylation down-regulates | GPHN | SIGNOR-200953 |
| ERK1/2 | phosphorylation down-regulates | SMAD1 | SIGNOR-270137 |
| ERK1/2 | phosphorylation → up-regulates | LRP6 | SIGNOR-244662 |
| ERK1/2 | phosphorylation down-regulates | MYB | SIGNOR-244569 |
| ERK1/2 | phosphorylation down-regulates | SMAD3 | SIGNOR-270142 |
| ERK1/2 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-244681 |
| ERK1/2 | phosphorylation → unknown | mTORC1 | SIGNOR-270150 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244696 |
| ERK1/2 | phosphorylation → up-regulates activity | CACNB1 | SIGNOR-262966 |
| ERK1/2 | phosphorylation down-regulates | PAK1 | SIGNOR-270186 |
| ERK1/2 | phosphorylation → up-regulates activity | RRAS | SIGNOR-277220 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252746 |
| ERK1/2 | phosphorylation down-regulates | PDE4D | SIGNOR-270174 |
| ERK1/2 | phosphorylation → down-regulates activity | BANP | SIGNOR-266204 |
| ERK1/2 | phosphorylation down-regulates | RAF1 | SIGNOR-244688 |
| ERK1/2 | phosphorylation down-regulates | SOS1 | SIGNOR-244747 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265953 |
| ERK1/2 | phosphorylation → unknown | EWSR1 | SIGNOR-270172 |
| ERK1/2 | phosphorylation down-regulates | SOS1 | SIGNOR-244743 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | EP300 | SIGNOR-276455 |
| ERK1/2 | phosphorylation → up-regulates activity | BAG3 | SIGNOR-274070 |
| ERK1/2 | phosphorylation → up-regulates | JUND | SIGNOR-270183 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-249572 |
| ERK1/2 | phosphorylation → up-regulates activity | ARHGAP31 | SIGNOR-263057 |
| ERK1/2 | phosphorylation → up-regulates | IL16 | SIGNOR-270168 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-244618 |
| ERK1/2 | phosphorylation down-regulates | ARRB1 | SIGNOR-270190 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-270175 |
| ERK1/2 | phosphorylation → up-regulates | PARP1 | SIGNOR-244669 |
| ERK1/2 | phosphorylation → down-regulates activity | BANP | SIGNOR-266377 |
| ERK1/2 | phosphorylation → up-regulates activity | PAPOLA | SIGNOR-268342 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-276671 |
| ERK1/2 | phosphorylation → up-regulates | MCL1 | SIGNOR-270158 |
| ERK1/2 | phosphorylation → unknown | ARHGAP26 | SIGNOR-270170 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129196 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-252079 |
| ERK1/2 | phosphorylation → up-regulates | TWIST1 | SIGNOR-270209 |
| ERK1/2 | phosphorylation → up-regulates activity | RHOA | SIGNOR-277203 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-277834 |
| ERK1/2 | phosphorylation → up-regulates activity | PPARA | SIGNOR-270180 |
| ERK1/2 | phosphorylation → down-regulates activity | PAX5 | SIGNOR-269088 |
| ERK1/2 | phosphorylation → up-regulates | NFATC4 | SIGNOR-270160 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-263009 |
| ERK1/2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264442 |
| ERK1/2 | phosphorylation down-regulates | AR | SIGNOR-244606 |
| ERK1/2 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-249455 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244505 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250554 |
| ERK1/2 | phosphorylation → up-regulates activity | MKNK1 | SIGNOR-253014 |
| ERK1/2 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244602 |
| ERK1/2 | phosphorylation → up-regulates | ESR1 | SIGNOR-244651 |
| ERK1/2 | phosphorylation → up-regulates | PLA2G4A | SIGNOR-270192 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250553 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265951 |
| ERK1/2 | phosphorylation → up-regulates | AP1 | SIGNOR-252357 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252745 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-270152 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244494 |
| ERK1/2 | phosphorylation → up-regulates activity | CACNA1B | SIGNOR-262967 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-244513 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252086 |
| ERK1/2 | phosphorylation → down-regulates activity | GSK3B/Axin/APC | SIGNOR-262519 |
| ERK1/2 | phosphorylation → up-regulates activity | JUN | SIGNOR-253214 |
| ERK1/2 | phosphorylation down-regulates | TFCP2 | SIGNOR-270201 |
| ERK1/2 | phosphorylation down-regulates | AMPH | SIGNOR-270197 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | DIAPH1 | SIGNOR-276483 |
| ERK1/2 | phosphorylation down-regulates | BRAF | SIGNOR-170339 |
| ERK1/2 | phosphorylation → up-regulates activity | CAD | SIGNOR-267441 |
| ERK1/2 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-275407 |
| ERK1/2 | phosphorylation → down-regulates activity | GJA1 | SIGNOR-270148 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244727 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244584 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252744 |
| ERK1/2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-244517 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244591 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252743 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265952 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252741 |
| ERK1/2 | phosphorylation → up-regulates | EP300 | SIGNOR-244537 |
| ERK1/2 | phosphorylation → up-regulates | ADAM17 | SIGNOR-89614 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-277801 |
| ERK1/2 | phosphorylation → unknown | KRT8 | SIGNOR-270135 |
| ERK1/2 | phosphorylation → up-regulates activity | PTPRR | SIGNOR-270147 |
| ERK1/2 | phosphorylation → up-regulates activity | CEBPB | SIGNOR-238303 |
| ERK1/2 | phosphorylation → up-regulates activity | ARRB2 | SIGNOR-274019 |
| ERK1/2 | phosphorylation → up-regulates | HIF1A | SIGNOR-270191 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252085 |
| ERK1/2 | phosphorylation → up-regulates | PTTG1 | SIGNOR-270155 |
| ERK1/2 | phosphorylation → unknown | APBB1 | SIGNOR-270166 |
| ERK1/2 | phosphorylation down-regulates | TSC2 | SIGNOR-244765 |
| ERK1/2 | phosphorylation → up-regulates | ARHGEF2 | SIGNOR-270138 |
| ERK1/2 | phosphorylation → down-regulates activity | STMN1 | SIGNOR-270182 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-251523 |
| ERK1/2 | phosphorylation → down-regulates activity | MEK1/2 | SIGNOR-244862 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-249574 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | EP300 | SIGNOR-276458 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | TCF3 | SIGNOR-270139 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-270198 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250557 |
| ERK1/2 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-244561 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244692 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244719 |
| ERK1/2 | phosphorylation → up-regulates | CTTN | SIGNOR-270164 |
| ERK1/2 | phosphorylation → up-regulates | MKNK2 | SIGNOR-270204 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252742 |
| ERK1/2 | phosphorylation → down-regulates activity | BAD | SIGNOR-244497 |
| ERK1/2 | phosphorylation → up-regulates activity | HECTD3 | SIGNOR-272330 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129200 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244703 |
| ERK1/2 | phosphorylation → up-regulates | CAPN2 | SIGNOR-270179 |
| ERK1/2 | phosphorylation → down-regulates activity | MCRIP1 | SIGNOR-270188 |
| ERK1/2 | phosphorylation down-regulates | KLC1 | SIGNOR-270176 |
| ERK1/2 | phosphorylation → up-regulates activity | LIPE | SIGNOR-270207 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252082 |
| ERK1/2 | phosphorylation → up-regulates activity | MFN1 | SIGNOR-274134 |
| ERK1/2 | phosphorylation → up-regulates | AP1 | SIGNOR-252359 |
| ERK1/2 | phosphorylation → up-regulates activity | PAPOLA | SIGNOR-268341 |
| ERK1/2 | phosphorylation → up-regulates | FOS | SIGNOR-260762 |
| ERK1/2 | phosphorylation → up-regulates activity | PPARG | SIGNOR-232236 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244715 |
| ERK1/2 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-244677 |
| ERK1/2 | phosphorylation → up-regulates | STAT5A | SIGNOR-270136 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244731 |
| ERK1/2 | phosphorylation → up-regulates | HDAC6 | SIGNOR-244545 |
| ERK1/2 | phosphorylation → up-regulates | HDAC6 | SIGNOR-244549 |
| ERK1/2 | phosphorylation down-regulates | PCYT1A | SIGNOR-270151 |
| ERK1/2 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-233520 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-277833 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244723 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244588 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129192 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | RAMAC | SIGNOR-277267 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244707 |
| ERK1/2 | phosphorylation → up-regulates | HNRNPK | SIGNOR-105754 |
| ERK1/2 | phosphorylation → up-regulates | EP300 | SIGNOR-244533 |
| ERK1/2 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-244565 |
| ERK1/2 | phosphorylation down-regulates | NR3C1 | SIGNOR-93554 |
| ERK1/2 | phosphorylation → down-regulates activity | BRAF | SIGNOR-259919 |
| ERK1/2 | phosphorylation down-regulates | POLR2A | SIGNOR-270156 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-263010 |
| ERK1/2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264443 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-276670 |
| ERK1/2 | phosphorylation → up-regulates | SMAD4 | SIGNOR-244739 |
| ERK1/2 | phosphorylation → up-regulates | FOS | SIGNOR-251525 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-251524 |
| ERK1/2 | phosphorylation → up-regulates activity | PAPOLA | SIGNOR-268343 |
| ERK1/2 | phosphorylation → up-regulates activity | GRIP1 | SIGNOR-263056 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250556 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244501 |
| ERK1/2 | phosphorylation → up-regulates | NCF1 | SIGNOR-270187 |
| ERK1/2 | phosphorylation down-regulates | MBP | SIGNOR-270195 |
| ERK1/2 | phosphorylation down-regulates | TSC1 | SIGNOR-244761 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250555 |
| ERK1/2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-244622 |
| ERK1/2 | phosphorylation → up-regulates | SREBF1 | SIGNOR-244754 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | RAMAC | SIGNOR-277819 |
| ERK1/2 | phosphorylation → up-regulates | SPHK2 | SIGNOR-270154 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-266376 |
| ERK1/2 | phosphorylation → up-regulates activity | E2F1 | SIGNOR-233526 |
| ERK1/2 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-188131 |
| ERK1/2 | phosphorylation down-regulates | NOXA1 | SIGNOR-270203 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | PCBP2 | SIGNOR-262668 |
| ERK1/2 | phosphorylation → up-regulates activity | RHOA | SIGNOR-277202 |
| ERK1/2 | phosphorylation down-regulates | ETV6 | SIGNOR-260084 |
| ERK1/2 | phosphorylation down-regulates | PPP2R5C | SIGNOR-270196 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | GABBR1 | SIGNOR-277853 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | GABBR1 | SIGNOR-277852 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | SCNN1G | SIGNOR-270171 |
| ERK1/2 | phosphorylation → down-regulates activity | SOS1 | SIGNOR-244580 |
| ERK1/2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262522 |
| ERK1/2 | phosphorylation down-regulates | CALD1 | SIGNOR-270162 |
| ERK1/2 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-263068 |
| ERK1/2 | phosphorylation → up-regulates | CSNK2A1 | SIGNOR-244521 |
| ERK1/2 | phosphorylation → up-regulates | GAB2 | SIGNOR-270133 |
| ERK1/2 | phosphorylation down-regulates | MRTFA | SIGNOR-270131 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244610 |
| ERK1/2 | phosphorylation → up-regulates | PARP1 | SIGNOR-244673 |
| ERK1/2 | phosphorylation down-regulates | FGFR1 | SIGNOR-244541 |
| ERK1/2 | phosphorylation down-regulates | PGR | SIGNOR-270157 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-262995 |
| ERK1/2 | phosphorylation → up-regulates | AP1 | SIGNOR-252358 |
| ERK1/2 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-244557 |
| ERK1/2 | phosphorylation → up-regulates activity | LCK | SIGNOR-270177 |
| ERK1/2 | phosphorylation → up-regulates | GTF2I | SIGNOR-270169 |
| ERK1/2 | phosphorylation → up-regulates | GRB10 | SIGNOR-270178 |
| ERK1/2 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262980 |
| ERK1/2 | phosphorylation → up-regulates activity | ARRB2 | SIGNOR-274018 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244735 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244699 |
| ERK1/2 | phosphorylation → up-regulates activity | CACNB1 | SIGNOR-262965 |
| ERK1/2 | phosphorylation → up-regulates activity | SP1 | SIGNOR-233523 |
| ERK1/2 | phosphorylation → down-regulates activity | XPO5 | SIGNOR-262983 |
| ERK1/2 | phosphorylation → up-regulates activity | IRX2 | SIGNOR-270193 |
| ERK1/2 | phosphorylation → down-regulates activity | SOX10 | SIGNOR-277821 |
| ERK1/2 | phosphorylation → up-regulates activity | BAG3 | SIGNOR-274071 |
| ERK1/2 | phosphorylation → up-regulates | AP1 | SIGNOR-252353 |
| ERK1/2 | phosphorylation → down-regulates activity | STK11 | SIGNOR-244595 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252083 |
| ERK1/2 | phosphorylation → unknown | NUP153 | SIGNOR-270159 |
| ERK1/2 | phosphorylation down-regulates | JAK2 | SIGNOR-244553 |
| ERK1/2 | phosphorylation → up-regulates activity | ASB2 | SIGNOR-272239 |
| ERK1/2 | phosphorylation → unknown | RPS3 | SIGNOR-270145 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252081 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | LIMA1 | SIGNOR-263063 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129188 |
| ERK1/2 | phosphorylation → up-regulates | SPHK1 | SIGNOR-118542 |
| ERK1/2 | phosphorylation → down-regulates activity | BANP | SIGNOR-266203 |
| ERK1/2 | phosphorylation → up-regulates activity | PLCB1 | SIGNOR-270200 |
| ERK1/2 | phosphorylation down-regulates | UBTF | SIGNOR-270181 |
| ERK1/2 | phosphorylation down-regulates | LIFR | SIGNOR-270134 |
| ERK1/2 | phosphorylation → down-regulates activity | RXRA | SIGNOR-262960 |
| ERK1/2 | phosphorylation → up-regulates | EP300 | SIGNOR-244634 |
| ERK1/2 | phosphorylation → up-regulates | ELK1 | SIGNOR-252084 |
| ERK1/2 | phosphorylation down-regulates | POU5F1 | SIGNOR-270185 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-249573 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA2 | SIGNOR-270144 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-255020 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-270146 |
| ERK1/2 | phosphorylation → up-regulates | PML | SIGNOR-270153 |
| ERK1/2 | phosphorylation down-regulates | SMAD2 | SIGNOR-244576 |
| ERK1/2 | phosphorylation → up-regulates | ABI1 | SIGNOR-270161 |
| ERK1/2 | phosphorylation → up-regulates | TH | SIGNOR-270167 |