| Name | ERK1/2 |
| ID | SIGNOR-PF1 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CCR2 | ERK1/2 | – | phosphorylation up-regulates activity | 20219869 | SIGNOR-255117 | |
| PTPRB | ERK1/2 | – | dephosphorylation up-regulates | 12840032 | SIGNOR-269931 | |
| EML4-ALK | ERK1/2 | – | phosphorylation up-regulates activity | 21415216 | SIGNOR-259174 | |
| GNA13 | ERK1/2 | – | phosphorylation down-regulates activity | 37392861 | SIGNOR-278049 | |
| TLR4 | ERK1/2 | – | phosphorylation up-regulates activity | 28137827 | SIGNOR-261930 | |
| PPP1CA | ERK1/2 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269927 | |
| DUSP5 | ERK1/2 | – | dephosphorylation down-regulates | 10224087 | SIGNOR-269932 | |
| PPP2CA | ERK1/2 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269918 | |
| MEK1/2 | ERK1/2 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258989 | |
| CCR1 | ERK1/2 | – | phosphorylation up-regulates activity | 20219869 | SIGNOR-255118 | |
| RET | ERK1/2 | – | phosphorylation up-regulates | 16153436 | SIGNOR-244643 | |
| DUSP6 | ERK1/2 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269926 | |
| MAP2K1 | ERK1/2 | – | phosphorylation up-regulates activity | 12270934 | SIGNOR-235352 | |
| MAP2K2 | ERK1/2 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258995 | |
| LCK | ERK1/2 | – | phosphorylation up-regulates | 17998336 | SIGNOR-269921 | |
| DUSP3 | ERK1/2 | – | dephosphorylation down-regulates activity | 10224087 | SIGNOR-269928 | |
| PTPRJ | ERK1/2 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-269919 | |
| CCR5 | ERK1/2 | – | phosphorylation up-regulates activity | 20219869 | SIGNOR-255119 | |
| PP1 | ERK1/2 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269923 | |
| MAP2K2 | ERK1/2 | – | phosphorylation up-regulates | 11971971 | SIGNOR-244637 | |
| MAP2K1 | ERK1/2 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258992 | |
| MEK1/2 | ERK1/2 | – | phosphorylation up-regulates | 11971971 | SIGNOR-244776 | |
| DUSP4 | ERK1/2 | – | dephosphorylation down-regulates activity | 7535768 | SIGNOR-269933 | |
| DUSP1 | ERK1/2 | – | dephosphorylation down-regulates | 10617468 | SIGNOR-269930 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CCR2 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-255117 |
| PTPRB | dephosphorylation → up-regulates | ERK1/2 | SIGNOR-269931 |
| EML4-ALK | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-259174 |
| GNA13 | phosphorylation → down-regulates activity | ERK1/2 | SIGNOR-278049 |
| TLR4 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-261930 |
| PPP1CA | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269927 |
| DUSP5 | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269932 |
| PPP2CA | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269918 |
| MEK1/2 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-258989 |
| CCR1 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-255118 |
| RET | phosphorylation → up-regulates | ERK1/2 | SIGNOR-244643 |
| DUSP6 | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269926 |
| MAP2K1 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-235352 |
| MAP2K2 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-258995 |
| LCK | phosphorylation → up-regulates | ERK1/2 | SIGNOR-269921 |
| DUSP3 | dephosphorylation → down-regulates activity | ERK1/2 | SIGNOR-269928 |
| PTPRJ | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269919 |
| CCR5 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-255119 |
| PP1 | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269923 |
| MAP2K2 | phosphorylation → up-regulates | ERK1/2 | SIGNOR-244637 |
| MAP2K1 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-258992 |
| MEK1/2 | phosphorylation → up-regulates | ERK1/2 | SIGNOR-244776 |
| DUSP4 | dephosphorylation → down-regulates activity | ERK1/2 | SIGNOR-269933 |
| DUSP1 | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269930 |