Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PAK	VIM	–		phosphorylation down-regulates activity	11895474	SIGNOR-269975
PAK	SYN1	–		phosphorylation unknown	12237306	SIGNOR-269974
PAK	NF2	–		phosphorylation down-regulates	18071304	SIGNOR-269976
PAK	MAP2K1	Ser298	RTPGRPLsSYGMDSR	phosphorylation up-regulates	16129686	SIGNOR-140039
PAK	MYLK	–		phosphorylation down-regulates activity	10748018	SIGNOR-269973
PAK	MEK1/2	–		phosphorylation up-regulates	16129686	SIGNOR-244920

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PAK	phosphorylation up-regulates →	MAP2K1 PSer298	phosphorylation up-regulates →	MAP2K1	16129686	SIGNOR-140039

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PAK	phosphorylation → down-regulates activity	VIM	SIGNOR-269975
PAK	phosphorylation → unknown	SYN1	SIGNOR-269974
PAK	phosphorylation down-regulates	NF2	SIGNOR-269976
PAK	phosphorylation → up-regulates	MAP2K1	SIGNOR-140039
PAK	phosphorylation → down-regulates activity	MYLK	SIGNOR-269973
PAK	phosphorylation → up-regulates	MEK1/2	SIGNOR-244920