| Name | JNK |
| ID | SIGNOR-PF15 |
| Role | kinase |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | BCL2L11 | Thr116 | SCDKSTQtPSPPCQA | phosphorylation up-regulates | 12591950 | SIGNOR-98392 |
| JNK | BCL2L11 | Ser118 | DKSTQTPsPPCQAFN | phosphorylation up-regulates | 12591950 | SIGNOR-98388 |
| JNK | CDC25C | – | phosphorylation down-regulates | 20220133 | SIGNOR-269983 | |
| JNK | SMAD3 | – | phosphorylation up-regulates activity | 10601313 | SIGNOR-236113 | |
| JNK | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates activity | 11323415 | SIGNOR-261133 |
| JNK | SFN | – | phosphorylation down-regulates | 15071501 | SIGNOR-269979 | |
| JNK | KIF5C | Ser176 | CTERFVSsPEEVMDV | phosphorylation up-regulates activity | 27013971 | SIGNOR-264063 |
| JNK | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 19667122 | SIGNOR-187578 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 9405416 | SIGNOR-53788 |
| JNK | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 20959475 | SIGNOR-168766 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 12040039 | SIGNOR-236149 |
| JNK | FOXO4 | Thr227 | PAPPEGAtPTSPVGH | phosphorylation up-regulates | 20959475 | SIGNOR-168758 |
| JNK | YAP1 | Ser138 | SLQLGAVsPGTLTPT | phosphorylation up-regulates activity | 21364637 | SIGNOR-277642 |
| JNK | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 20959475 | SIGNOR-168762 |
| JNK | MAPK8IP3 | – | phosphorylation up-regulates | 15767678 | SIGNOR-269984 | |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 17158707 | SIGNOR-36466 |
| JNK | STMN1 | – | phosphorylation down-regulates | 20630875 | SIGNOR-269982 | |
| JNK | YAP1 | Ser367 | GTQNPVSsPGMSQEL | phosphorylation up-regulates activity | 21364637 | SIGNOR-277644 |
| JNK | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 15916964 | SIGNOR-137631 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 12040039 | SIGNOR-236130 |
| JNK | FOXO | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 20959475 | SIGNOR-252956 |
| JNK | FOXO | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 20959475 | SIGNOR-252955 |
| JNK | BCL2L11 | Ser104 | FSFDTDRsPAPMSCD | phosphorylation up-regulates | 12591950 | SIGNOR-98384 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 21561061 | SIGNOR-260758 |
| JNK | YAP1 | Thr154 | VVSGPAAtPTAQHLR | phosphorylation up-regulates activity | 21364637 | SIGNOR-277643 |
| JNK | PPM1J | – | phosphorylation down-regulates | 18553930 | SIGNOR-269981 | |
| JNK | ATN1 | – | phosphorylation down-regulates activity | 12812981 | SIGNOR-269978 | |
| JNK | YAP1 | Thr119 | AGTAGALtPQHVRAH | phosphorylation up-regulates activity | 21364637 | SIGNOR-277641 |
| JNK | TP53 | – | phosphorylation up-regulates | 14699954 | SIGNOR-269985 | |
| JNK | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates | 11259409 | SIGNOR-105762 |
| JNK | FOXO | Ser230 | PEGATPTsPVGHFAK | phosphorylation up-regulates | 20959475 | SIGNOR-252953 |
| JNK | BCL2L1 | Thr115 | LTSQLHItPGTAYQS | phosphorylation down-regulates | 10617621 | SIGNOR-73638 |
| JNK | YWHAZ | – | phosphorylation down-regulates | 15071501 | SIGNOR-269980 | |
| JNK | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates quantity by destabilization | 12510059 | SIGNOR-235777 |
| JNK | FOXO4 | Ser230 | PEGATPTsPVGHFAK | phosphorylation up-regulates | 20959475 | SIGNOR-168754 |
| JNK | BCL2L1 | Ser62 | PSWHLADsPAVNGAT | phosphorylation down-regulates | 12633850 | SIGNOR-99215 |
| JNK | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates | 19667122 | SIGNOR-187582 |
| JNK | BCL2L1 | Thr47 | GTESEMEtPSAINGN | phosphorylation down-regulates | 10617621 | SIGNOR-73642 |
| JNK | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 15916964 | SIGNOR-137627 |
| JNK | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 20419129 | SIGNOR-165026 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 17158707 | SIGNOR-53784 |
| JNK | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation up-regulates activity | 21364637 | SIGNOR-277645 |
| JNK | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates | 11259409 | SIGNOR-105758 |
| JNK | FOXO | Thr227 | PAPPEGAtPTSPVGH | phosphorylation up-regulates | 20959475 | SIGNOR-252954 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | phosphorylation up-regulates → | BCL2L11 PThr116 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98392 |
| JNK | phosphorylation up-regulates → | BCL2L11 PSer118 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98388 |
| JNK | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 11323415 | SIGNOR-261133 |
| JNK | phosphorylation up-regulates → | KIF5C PSer176 | phosphorylation up-regulates → | KIF5C | 27013971 | SIGNOR-264063 |
| JNK | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19667122 | SIGNOR-187578 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 9405416 | SIGNOR-53788 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168766 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-236149 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr227 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168758 |
| JNK | phosphorylation up-regulates → | YAP1 PSer138 | phosphorylation up-regulates → | YAP1 | 21364637 | SIGNOR-277642 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168762 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 17158707 | SIGNOR-36466 |
| JNK | phosphorylation up-regulates → | YAP1 PSer367 | phosphorylation up-regulates → | YAP1 | 21364637 | SIGNOR-277644 |
| JNK | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137631 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-236130 |
| JNK | phosphorylation up-regulates → | FOXO PThr455 | phosphorylation up-regulates → | FOXO | 20959475 | SIGNOR-252956 |
| JNK | phosphorylation up-regulates → | FOXO PThr451 | phosphorylation up-regulates → | FOXO | 20959475 | SIGNOR-252955 |
| JNK | phosphorylation up-regulates → | BCL2L11 PSer104 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98384 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 21561061 | SIGNOR-260758 |
| JNK | phosphorylation up-regulates → | YAP1 PThr154 | phosphorylation up-regulates → | YAP1 | 21364637 | SIGNOR-277643 |
| JNK | phosphorylation up-regulates → | YAP1 PThr119 | phosphorylation up-regulates → | YAP1 | 21364637 | SIGNOR-277641 |
| JNK | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105762 |
| JNK | phosphorylation up-regulates → | FOXO PSer230 | phosphorylation up-regulates → | FOXO | 20959475 | SIGNOR-252953 |
| JNK | phosphorylation up-regulates → | BCL2L1 PThr115 | phosphorylation down-regulates ⊣ | BCL2L1 | 10617621 | SIGNOR-73638 |
| JNK | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-235777 |
| JNK | phosphorylation up-regulates → | FOXO4 PSer230 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168754 |
| JNK | phosphorylation up-regulates → | BCL2L1 PSer62 | phosphorylation down-regulates ⊣ | BCL2L1 | 12633850 | SIGNOR-99215 |
| JNK | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19667122 | SIGNOR-187582 |
| JNK | phosphorylation up-regulates → | BCL2L1 PThr47 | phosphorylation down-regulates ⊣ | BCL2L1 | 10617621 | SIGNOR-73642 |
| JNK | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 15916964 | SIGNOR-137627 |
| JNK | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 20419129 | SIGNOR-165026 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 17158707 | SIGNOR-53784 |
| JNK | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation up-regulates → | YAP1 | 21364637 | SIGNOR-277645 |
| JNK | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105758 |
| JNK | phosphorylation up-regulates → | FOXO PThr227 | phosphorylation up-regulates → | FOXO | 20959475 | SIGNOR-252954 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JNK | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98392 |
| JNK | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98388 |
| JNK | phosphorylation down-regulates | CDC25C | SIGNOR-269983 |
| JNK | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-236113 |
| JNK | phosphorylation → up-regulates activity | BCL2 | SIGNOR-261133 |
| JNK | phosphorylation down-regulates | SFN | SIGNOR-269979 |
| JNK | phosphorylation → up-regulates activity | KIF5C | SIGNOR-264063 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-187578 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-53788 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168766 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-236149 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168758 |
| JNK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277642 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168762 |
| JNK | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-269984 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-36466 |
| JNK | phosphorylation down-regulates | STMN1 | SIGNOR-269982 |
| JNK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277644 |
| JNK | phosphorylation → up-regulates | ATF2 | SIGNOR-137631 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-236130 |
| JNK | phosphorylation → up-regulates | FOXO | SIGNOR-252956 |
| JNK | phosphorylation → up-regulates | FOXO | SIGNOR-252955 |
| JNK | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98384 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-260758 |
| JNK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277643 |
| JNK | phosphorylation down-regulates | PPM1J | SIGNOR-269981 |
| JNK | phosphorylation → down-regulates activity | ATN1 | SIGNOR-269978 |
| JNK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277641 |
| JNK | phosphorylation → up-regulates | TP53 | SIGNOR-269985 |
| JNK | phosphorylation → up-regulates | HNRNPK | SIGNOR-105762 |
| JNK | phosphorylation → up-regulates | FOXO | SIGNOR-252953 |
| JNK | phosphorylation down-regulates | BCL2L1 | SIGNOR-73638 |
| JNK | phosphorylation down-regulates | YWHAZ | SIGNOR-269980 |
| JNK | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-235777 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168754 |
| JNK | phosphorylation down-regulates | BCL2L1 | SIGNOR-99215 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-187582 |
| JNK | phosphorylation down-regulates | BCL2L1 | SIGNOR-73642 |
| JNK | phosphorylation → up-regulates | ATF2 | SIGNOR-137627 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-165026 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-53784 |
| JNK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277645 |
| JNK | phosphorylation → up-regulates | HNRNPK | SIGNOR-105758 |
| JNK | phosphorylation → up-regulates | FOXO | SIGNOR-252954 |