| Name | p38 |
| ID | SIGNOR-PF16 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| p38 | EEF2K | – | phosphorylation down-regulates activity | 12171600 | SIGNOR-270127 | |
| p38 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-260443 |
| p38 | TP53 | – | phosphorylation up-regulates | 17254968 | SIGNOR-270126 | |
| p38 | KRT8 | – | phosphorylation up-regulates | 11788583 | SIGNOR-270125 | |
| p38 | FH | Thr90 | GVTERMPtPVIKAFG | phosphorylation up-regulates activity | 30683654 | SIGNOR-266316 |
| p38 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 19336399 | SIGNOR-260450 |
| p38 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171062 |
| p38 | ATF2 | – | phosphorylation up-regulates | 10085140 | SIGNOR-270124 | |
| p38 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates activity | 11333986 | SIGNOR-107412 |
| p38 | CDC25B | Ser375 | ARVLRSKsLCHDEIE | phosphorylation down-regulates activity | 11333986 | SIGNOR-107416 |
| p38 | CDC25B | Ser101 | ASESSLSsESSESSD | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276350 |
| p38 | CDC25B | Ser103 | ESSLSSEsSESSDAG | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276349 |
| p38 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 11333986 | SIGNOR-107420 |
| p38 | DDIT3 | – | phosphorylation up-regulates activity | 8650547 | SIGNOR-260724 | |
| p38 | KRT20 | Ser13 | RSFHRSLsSSLQAPV | phosphorylation up-regulates activity | 20724476 | SIGNOR-263070 |
| p38 | HNF4A | Ser167 | VLSRQITsPVSGING | phosphorylation up-regulates | 16351573 | SIGNOR-143046 |
| p38 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264445 |
| p38 | FOXC1 | Ser241 | PSPPQPLsPAAALGS | phosphorylation up-regulates quantity by stabilization | 31650548 | SIGNOR-275914 |
| p38 | FOXC1 | Ser272 | SSLSSGSsPPGSLPS | phosphorylation up-regulates quantity by stabilization | 31650548 | SIGNOR-275912 |
| p38 | NFATC4 | Ser168 | QGGGAFFsPSPGSSS | phosphorylation down-regulates | 11997522 | SIGNOR-87393 |
| p38 | NFATC4 | Ser170 | GGAFFSPsPGSSSLS | phosphorylation down-regulates | 11997522 | SIGNOR-87397 |
| p38 | CDT1 | Ser391 | LRSAAPSsPGSPRPA | phosphorylation up-regulates quantity by stabilization | 21930785 | SIGNOR-276362 |
| p38 | CDT1 | Ser491 | GSCCTIMsPGEMEKH | phosphorylation up-regulates quantity by stabilization | 21930785 | SIGNOR-276363 |
| p38 | DROSHA | Ser300 | RHRDNRRsPSLERSY | phosphorylation down-regulates activity | 25699712 | SIGNOR-264847 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| p38 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-260443 |
| p38 | phosphorylation up-regulates → | FH PThr90 | phosphorylation up-regulates → | FH | 30683654 | SIGNOR-266316 |
| p38 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 19336399 | SIGNOR-260450 |
| p38 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171062 |
| p38 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 11333986 | SIGNOR-107412 |
| p38 | phosphorylation up-regulates → | CDC25B PSer375 | phosphorylation down-regulates ⊣ | CDC25B | 11333986 | SIGNOR-107416 |
| p38 | phosphorylation up-regulates → | CDC25B PSer101 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276350 |
| p38 | phosphorylation up-regulates → | CDC25B PSer103 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276349 |
| p38 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 11333986 | SIGNOR-107420 |
| p38 | phosphorylation up-regulates → | KRT20 PSer13 | phosphorylation up-regulates → | KRT20 | 20724476 | SIGNOR-263070 |
| p38 | phosphorylation up-regulates → | HNF4A PSer167 | phosphorylation up-regulates → | HNF4A | 16351573 | SIGNOR-143046 |
| p38 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264445 |
| p38 | phosphorylation up-regulates → | FOXC1 PSer241 | phosphorylation up-regulates → | FOXC1 | 31650548 | SIGNOR-275914 |
| p38 | phosphorylation up-regulates → | FOXC1 PSer272 | phosphorylation up-regulates → | FOXC1 | 31650548 | SIGNOR-275912 |
| p38 | phosphorylation up-regulates → | NFATC4 PSer168 | phosphorylation down-regulates ⊣ | NFATC4 | 11997522 | SIGNOR-87393 |
| p38 | phosphorylation up-regulates → | NFATC4 PSer170 | phosphorylation down-regulates ⊣ | NFATC4 | 11997522 | SIGNOR-87397 |
| p38 | phosphorylation up-regulates → | CDT1 PSer391 | phosphorylation up-regulates → | CDT1 | 21930785 | SIGNOR-276362 |
| p38 | phosphorylation up-regulates → | CDT1 PSer491 | phosphorylation up-regulates → | CDT1 | 21930785 | SIGNOR-276363 |
| p38 | phosphorylation up-regulates → | DROSHA PSer300 | phosphorylation down-regulates ⊣ | DROSHA | 25699712 | SIGNOR-264847 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| p38 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-270127 |
| p38 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-260443 |
| p38 | phosphorylation → up-regulates | TP53 | SIGNOR-270126 |
| p38 | phosphorylation → up-regulates | KRT8 | SIGNOR-270125 |
| p38 | phosphorylation → up-regulates activity | FH | SIGNOR-266316 |
| p38 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-260450 |
| p38 | phosphorylation down-regulates | MAPT | SIGNOR-171062 |
| p38 | phosphorylation → up-regulates | ATF2 | SIGNOR-270124 |
| p38 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-107412 |
| p38 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-107416 |
| p38 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276350 |
| p38 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276349 |
| p38 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-107420 |
| p38 | phosphorylation → up-regulates activity | DDIT3 | SIGNOR-260724 |
| p38 | phosphorylation → up-regulates activity | KRT20 | SIGNOR-263070 |
| p38 | phosphorylation → up-regulates | HNF4A | SIGNOR-143046 |
| p38 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264445 |
| p38 | phosphorylation → up-regulates quantity by stabilization | FOXC1 | SIGNOR-275914 |
| p38 | phosphorylation → up-regulates quantity by stabilization | FOXC1 | SIGNOR-275912 |
| p38 | phosphorylation down-regulates | NFATC4 | SIGNOR-87393 |
| p38 | phosphorylation down-regulates | NFATC4 | SIGNOR-87397 |
| p38 | phosphorylation → up-regulates quantity by stabilization | CDT1 | SIGNOR-276362 |
| p38 | phosphorylation → up-regulates quantity by stabilization | CDT1 | SIGNOR-276363 |
| p38 | phosphorylation → down-regulates activity | DROSHA | SIGNOR-264847 |