Entity Details

Name PKA
ID SIGNOR-PF17
Role kinase
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PKASCN5ASer525TSMKPRSsRGSIFTFphosphorylation
up-regulates activity
33410863SIGNOR-275766
PKAEVL–phosphorylation
up-regulates activity
15066263SIGNOR-268287
PKADIAPH1Thr768PVLPFGLtPKKLYKPphosphorylation
up-regulates quantity by stabilization
23325789SIGNOR-276484
PKAPRKD3Ser731ARIIGEKsFRRSVVGphosphorylation
up-regulates activity
18692497SIGNOR-275924
PKAARHGEF6Ser684GSSTRKDsIPQVLLPphosphorylation
down-regulates activity
26507661SIGNOR-272160
PKAGRIN2BSer1166SDDFKRDsVSGGGPCphosphorylation
up-regulates activity
24431445SIGNOR-276617
PKATRPV4Thr175GLLPFLLtHKKRLTDphosphorylation
up-regulates activity
19661060SIGNOR-260881
PKABRSK2Thr260VDAARRLtLEHIQKHphosphorylation
up-regulates activity
16870137SIGNOR-276056
PKACAMKK2Ser100HLSGRKLsLQERSQGphosphorylation
down-regulates activity
32913128SIGNOR-277239
PKAKCNA4Thr601LKKFRSStSSSLGDKphosphorylation
down-regulates quantity by destabilization
15955806SIGNOR-276037
PKASCN5ASer525TSMKPRSsRGSIFTFphosphorylation
up-regulates activity
12242273SIGNOR-275991
PKAFRAT1Ser188RLQQRRGsQPETRTGphosphorylation
down-regulates activity
16982607SIGNOR-276058
PKASMN complex–phosphorylation
up-regulates quantity by stabilization
19103745SIGNOR-253122
PKANKD2Ser223SAHVRRPsTDPQPCSphosphorylation
up-regulates quantity by stabilization
30941853SIGNOR-273782
PKAGRK7Ser23YLQARKPsDCDSKELphosphorylation
down-regulates activity
15946941SIGNOR-276036
PKASLC4A4Ser1026KKKKKKGsLDSDNDDphosphorylation
up-regulates activity
11744745SIGNOR-263158
PKACAMKK2Ser495KTMIRKRsFGNPFEGphosphorylation
down-regulates activity
32913128SIGNOR-277238
PKAPPM1BSer195MIQRVNGsLAVSRALphosphorylation
down-regulates quantity by destabilization
23756813SIGNOR-277825
PKAPDE4BSer133GHSQRREsFLYRSDSphosphorylation
up-regulates activity
12023945SIGNOR-273940
PKAGATA3Ser308IKPKRRLsAARRAGTphosphorylation
up-regulates activity
16109788SIGNOR-276042
PKASLC9A3Ser555AEGERRGsLAFIRSPphosphorylation
down-regulates activity
38047302SIGNOR-277847
PKAPDE4BSer133GHSQRREsFLYRSDSphosphorylation
up-regulates activity
12023945SIGNOR-275986
PKAPRKD2Ser706ARIIGEKsFRRSVVGphosphorylation
up-regulates activity
12058027SIGNOR-275952
PKASEC14L2Ser289VQISRGSsHQVEYEIphosphorylation
up-regulates activity
15680919SIGNOR-276028
PKAKLHL3Ser433PMNTRRSsVGVGVVEphosphorylation
up-regulates activity
26435498SIGNOR-273824
PKACHKBSer39TPKRRRAsSLSRDAEphosphorylation
up-regulates activity
27149373SIGNOR-275632
PKATRPV4Thr175GLLPFLLtHKKRLTDphosphorylation
up-regulates activity
19661060SIGNOR-276231
PKATRPV4Ser162FDIVSRGsTADLDGLphosphorylation
up-regulates activity
19661060SIGNOR-260885
PKAGRK7Ser23YLQARKPsDCDSKELphosphorylation
down-regulates activity
15946941SIGNOR-260839
PKAMYOM1Ser618ARLKSRPsAPWTGQIphosphorylation
down-regulates activity
9029142SIGNOR-263156
PKASCN5ASer36AEKQARGsTTLQESRphosphorylation
up-regulates activity
33410863SIGNOR-275765
PKACREB1Ser119EILSRRPsYRKILNDphosphorylation
up-regulates activity
8386317SIGNOR-263653
PKAARHGEF6Ser640RKTERKPsEEEYVIRphosphorylation
down-regulates activity
26507661SIGNOR-272163
PKASISer7sGLEISLIphosphorylation
unknown
8521865SIGNOR-263157
PKAABCC8–phosphorylation
down-regulates activity
35065096SIGNOR-278147
PKASCN2A–phosphorylation
down-regulates activity
32599005SIGNOR-275749
PKASLITRK1Ser695DCGSHSLsDphosphorylation
up-regulates activity
19640509SIGNOR-273634
PKALRP6Thr1548YAPSRRMtSVATAKGphosphorylation
up-regulates activity
21406690SIGNOR-275416
PKATRPC5Ser796GARAKSKsVSFNLGCphosphorylation
down-regulates activity
21734191SIGNOR-276339
PKAmTORC2–phosphorylation
up-regulates activity
35065096SIGNOR-278149
PKAGLI1Thr374PGCTKRYtDPSSLRKphosphorylation
down-regulates activity
16293631SIGNOR-276044
PKACAMKK2Ser511RREERSLsAPGNLLTphosphorylation
down-regulates
22778263SIGNOR-198154
PKAHDAC4–phosphorylation
up-regulates activity
30661366SIGNOR-277425
PKACADSer1406GAGGRRLsSFVTKGYphosphorylation
down-regulates activity
17485345SIGNOR-267442
PKAMFN2Ser442AEEIRRLSVLVDDYQphosphorylation
up-regulates activity
20303493SIGNOR-274137
PKAPHF2Ser1056FLTQRRPsASSPNNNphosphorylation
up-regulates activity
21532585SIGNOR-264513
PKATRPC5Ser796GARAKSKsVSFNLGCphosphorylation
down-regulates quantity
21734191SIGNOR-277824
PKANLRP3Ser295HKIVRKPsRILFLMDphosphorylation
down-regulates activity
27548431SIGNOR-277274
PKAPHKA1–phosphorylation
down-regulates activity
10487978SIGNOR-267409
PKAPHF2Ser954QKSKKKKsAKRKLTPphosphorylation
up-regulates activity
21532585SIGNOR-264512
PKAPSMD2Ser361ENNRFGGsGSQVDSAphosphorylation
up-regulates activity
31843888SIGNOR-273898
PKATRPV4Ser189DEEFREPsTGKTCLPphosphorylation
up-regulates activity
19661060SIGNOR-260883
PKAGABA-A–phosphorylation
up-regulates quantity
25600368SIGNOR-264991
PKATENT2–phosphorylation
down-regulates activity
31057087SIGNOR-270130
PKASYN2–phosphorylation
down-regulates activity
10571231SIGNOR-264109
PKAPRKD1Ser742GEKSFRRsVVGTPAYphosphorylation
up-regulates activity
18692497SIGNOR-275925
PKAKCNK18Ser252QAMERSNsCPELVLGphosphorylation
down-regulates activity
18397886SIGNOR-263154
PKAHDAC4Ser584EPGQRQPsEQELLFRphosphorylation
up-regulates activity
30661366SIGNOR-277423
PKANR5A2Ser510LPEIRAIsMQAEEYLphosphorylation
up-regulates activity
16109788SIGNOR-276041
PKASEC14L2Ser289VQISRGSsHQVEYEIphosphorylation
up-regulates activity
15680919SIGNOR-273788
PKAPIK3CGThr1024YLALRHHtNLLIILFphosphorylation
down-regulates activity
21474070SIGNOR-276321
PKATRPV4Ser189DEEFREPsTGKTCLPphosphorylation
up-regulates activity
19661060SIGNOR-276233
PKAATG16L1Ser269RAATKRLsQPAGGLLphosphorylation
down-regulates quantity by destabilization
31580256SIGNOR-277488
PKAPDE4CSer14GEGAEACsRLSRSRGphosphorylation
up-regulates activity
12023945SIGNOR-275987
PKAGRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity
15946941SIGNOR-260841
PKAGRK7Ser36ELQRRRRsLALPGLQphosphorylation
up-regulates activity
18803695SIGNOR-263152
PKAPDE4CSer14GEGAEACsRLSRSRGphosphorylation
up-regulates activity
12023945SIGNOR-273938
PKASCN5ASer528KPRSSRGsIFTFRRRphosphorylation
up-regulates activity
33410863SIGNOR-275764
PKAGSK3BSer9SGRPRTTsFAESCKPphosphorylation
down-regulates activity
26088133SIGNOR-264819
PKATRPC5Ser794SGGARAKsKSVSFNLphosphorylation
down-regulates activity
21734191SIGNOR-276340
PKAHSPB8Ser57DWALPRLsSAWPGTLphosphorylation
down-regulates quantity by destabilization
18298377SIGNOR-276151
PKAPHKA2–phosphorylation
down-regulates activity
10487978SIGNOR-267408
PKASLC2A2Ser491VPETKGKsFEEIAAEphosphorylation
down-regulates activity
8626492SIGNOR-250049
PKAPHF2Ser899RSKKRKGsDDAPYSPphosphorylation
up-regulates activity
21532585SIGNOR-264511
PKASLC8B1Ser258YQRQRRGsLFCPMPVphosphorylation
up-regulates activity
36476859SIGNOR-275728
PKAAQP5Ser156STDSRRTsPVGSPALphosphorylation
up-regulates activity
26569106SIGNOR-272087
PKAGATA4Ser262IKPQRRLsASRRVGLphosphorylation
up-regulates activity
16109788SIGNOR-276043
PKATRPC5Ser796GARAKSKsVSFNLGCphosphorylation
down-regulates activity
21734191SIGNOR-273789
PKACAMKK2Ser100HLSGRKLsLQERSQGphosphorylation
down-regulates
22778263SIGNOR-198146
PKAPDE11ASer162RALLRKAsSLPPTTAphosphorylation
up-regulates activity
18312413SIGNOR-276179
PKAGRK7Ser23YLQARKPsDCDSKELphosphorylation
down-regulates activity
15946941SIGNOR-274081
PKAPIK3R1Ser83YIGRKKIsPPTPKPRphosphorylation
up-regulates activity
21743495SIGNOR-276343
PKAPDE4ASer145ATSQRREsFLYRSDSphosphorylation
up-regulates activity
12023945SIGNOR-275985
PKAGRK7Ser36ELQRRRRsLALPGLQphosphorylation
down-regulates activity
15946941SIGNOR-276035
PKAPRKD2Ser876QGLAERIsVLphosphorylation
up-regulates activity
12058027SIGNOR-275950
PKASYN1–phosphorylation
down-regulates activity
10571231SIGNOR-264108
PKADNM1LSer637VPVARKLsAREQRDCphosphorylation
down-regulates activity
31063459SIGNOR-262551
PKAKCNJ2Ser425PRPLRREsEIphosphorylation
down-regulates activity
19843922SIGNOR-273779
PKAKCNA4Thr601LKKFRSStSSSLGDKphosphorylation
down-regulates activity
15955806SIGNOR-273778
PKAPPP1R1BThr34MIRRRRPtPAMLFRLphosphorylation
up-regulates activity
10604473SIGNOR-264956
PKAGSTA4Ser189QEYTVKLsNIPTIKRphosphorylation
up-regulates activity
12646569SIGNOR-264796
PKAPPM1BSer195MIQRVNGsLAVSRALphosphorylation
down-regulates quantity by destabilization
23756813SIGNOR-276494
PKASYN3–phosphorylation
down-regulates activity
10571231SIGNOR-264110
PKAIQGAP2Thr716EYMHRRQtFIDNTDSphosphorylation
up-regulates activity
21776420SIGNOR-273742
PKAARHGAP17Ser702LSAPRRYsSSLSPIQphosphorylation
down-regulates activity
26507661SIGNOR-272156
PKAPDZK1Ser505MAKERAHsTASHSSSphosphorylation
up-regulates activity
16174736SIGNOR-273784
PKAGNMTSer10DSVYRTRsLGVAAEGphosphorylation
unknown
12697024SIGNOR-263151
PKAPDE4ASer89TRMSWPSsFHGTGTGphosphorylation
up-regulates activity
12023945SIGNOR-273937
PKAPDE11ASer117GNLQRRAsQKELRKSphosphorylation
up-regulates activity
18312413SIGNOR-276153
PKAHSPB8Ser24RRDPFRDsPLSSRLLphosphorylation
down-regulates quantity by destabilization
18298377SIGNOR-276152
PKATRPV4Ser162FDIVSRGsTADLDGLphosphorylation
up-regulates activity
19661060SIGNOR-276232
PKANOXA1Ser461VPAGPRMsGAPGRLPphosphorylation
down-regulates activity
20943948SIGNOR-264713
PKARAP1ASer180KKKPKKKsCLLLphosphorylation
up-regulates activity
17068197SIGNOR-278057
PKABAD–phosphorylation
down-regulates
10230396SIGNOR-270129
PKAGRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity
15946941SIGNOR-276034
PKAPHF2Ser757NARVKKEsGSSAAGIphosphorylation
up-regulates activity
21532585SIGNOR-264510
PKAPRKD2Ser710GEKSFRRsVVGTPAYphosphorylation
up-regulates activity
12058027SIGNOR-275951
PKACHKBSer40PKRRRASsLSRDAERphosphorylation
up-regulates activity
27149373SIGNOR-275631
PKATRPC5Ser794SGGARAKsKSVSFNLphosphorylation
down-regulates activity
21734191SIGNOR-273790
PKALIPESer950EGFHPRRsSQGATQMphosphorylation
up-regulates activity
19018281SIGNOR-276174
PKAMYBPC3–phosphorylation
up-regulates
20151718SIGNOR-270128
PKACAMKK2Ser511RREERSLsAPGNLLTphosphorylation
down-regulates activity
32913128SIGNOR-277240
PKAKCNA1Ser446SDLSRRSsSTMSKSEphosphorylation
down-regulates quantity
23774215SIGNOR-273777
PKAMOSSer73LGAGGFGsVYKATYRphosphorylation
down-regulates activity
8622681SIGNOR-260819
PKAHDAC4–phosphorylation
up-regulates activity
30661366SIGNOR-277424
PKAGRK7Ser36ELQRRRRsLALPGLQphosphorylation
down-regulates activity
15946941SIGNOR-274080
PKAGAD1Thr91RDARFRRtETDFSNLphosphorylation
down-regulates activity
15147202SIGNOR-276009
PKAKCNJ4Ser443NISYRREsAIphosphorylation
up-regulates activity
19635485SIGNOR-263153
PKAPDE4DSer125CRAMDRTsYAVETGHphosphorylation
up-regulates activity
12023945SIGNOR-275988
PKAPTPN11Ser189GGGERFDsLTDLVEHphosphorylation
down-regulates activity
25802336SIGNOR-276894
PKAABCC8–phosphorylation
down-regulates activity
35065096SIGNOR-278146
PKALIPESer951GFHPRRSsQGATQMPphosphorylation
up-regulates activity
19018281SIGNOR-276175
PKACDK18Ser14KNFKRRFsLSVPRTEphosphorylation
up-regulates activity
28361970SIGNOR-264559
PKAPTPN11Thr73YGGEKFAtLAELVQYphosphorylation
down-regulates activity
25802336SIGNOR-276893
PKACAMKK2Ser495KTMIRKRsFGNPFEGphosphorylation
down-regulates
22778263SIGNOR-198150
PKAAQP2Ser256REVRRRQsVELHSPQphosphorylation
up-regulates activity
12194985SIGNOR-264563
PKASMN1–phosphorylation
up-regulates quantity by stabilization
19103745SIGNOR-253114
PKANOXA1Ser172DQVQRRGsLPPRQVPphosphorylation
down-regulates activity
20943948SIGNOR-264712
PKAATG16L1Ser268SRAATRRsVSSFPVPphosphorylation
down-regulates quantity by destabilization
31580256SIGNOR-277489
PKAGRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity
15946941SIGNOR-274079
PKAENAH–phosphorylation
up-regulates activity
15066263SIGNOR-268285
PKAVASP–phosphorylation
up-regulates activity
15066263SIGNOR-268286
PKAPDE8ASer359HKDRRKGsLDVKAVAphosphorylation
up-regulates activity
22673573SIGNOR-276416
PKASNAI2Ser247KYQCKNCsKTFSRMSphosphorylation
down-regulates quantity by destabilization
37596321SIGNOR-277905
PKAGRK7Ser36ELQRRRRsLALPGLQphosphorylation
down-regulates activity
15946941SIGNOR-260840
PKASCN5ASer528KPRSSRGsIFTFRRRphosphorylation
up-regulates activity
12242273SIGNOR-275992
PKAPDE8ASer359HKDRRKGsLDVKAVAphosphorylation
up-regulates activity
22673573SIGNOR-273783
PKAPDE4DSer125CRAMDRTsYAVETGHphosphorylation
up-regulates activity
12023945SIGNOR-273939
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PKAphosphorylation
up-regulates
→
SCN5A
PSer525
phosphorylation
up-regulates
→
SCN5A33410863SIGNOR-275766
PKAphosphorylation
up-regulates
→
DIAPH1
PThr768
phosphorylation
up-regulates
→
DIAPH123325789SIGNOR-276484
PKAphosphorylation
up-regulates
→
PRKD3
PSer731
phosphorylation
up-regulates
→
PRKD318692497SIGNOR-275924
PKAphosphorylation
up-regulates
→
ARHGEF6
PSer684
phosphorylation
down-regulates
⊣
ARHGEF626507661SIGNOR-272160
PKAphosphorylation
up-regulates
→
GRIN2B
PSer1166
phosphorylation
up-regulates
→
GRIN2B24431445SIGNOR-276617
PKAphosphorylation
up-regulates
→
TRPV4
PThr175
phosphorylation
up-regulates
→
TRPV419661060SIGNOR-260881
PKAphosphorylation
up-regulates
→
BRSK2
PThr260
phosphorylation
up-regulates
→
BRSK216870137SIGNOR-276056
PKAphosphorylation
up-regulates
→
CAMKK2
PSer100
phosphorylation
down-regulates
⊣
CAMKK232913128SIGNOR-277239
PKAphosphorylation
up-regulates
→
KCNA4
PThr601
phosphorylation
down-regulates
⊣
KCNA415955806SIGNOR-276037
PKAphosphorylation
up-regulates
→
SCN5A
PSer525
phosphorylation
up-regulates
→
SCN5A12242273SIGNOR-275991
PKAphosphorylation
up-regulates
→
FRAT1
PSer188
phosphorylation
down-regulates
⊣
FRAT116982607SIGNOR-276058
PKAphosphorylation
up-regulates
→
NKD2
PSer223
phosphorylation
up-regulates
→
NKD230941853SIGNOR-273782
PKAphosphorylation
up-regulates
→
GRK7
PSer23
phosphorylation
down-regulates
⊣
GRK715946941SIGNOR-276036
PKAphosphorylation
up-regulates
→
SLC4A4
PSer1026
phosphorylation
up-regulates
→
SLC4A411744745SIGNOR-263158
PKAphosphorylation
up-regulates
→
CAMKK2
PSer495
phosphorylation
down-regulates
⊣
CAMKK232913128SIGNOR-277238
PKAphosphorylation
up-regulates
→
PPM1B
PSer195
phosphorylation
down-regulates
⊣
PPM1B23756813SIGNOR-277825
PKAphosphorylation
up-regulates
→
PDE4B
PSer133
phosphorylation
up-regulates
→
PDE4B12023945SIGNOR-273940
PKAphosphorylation
up-regulates
→
GATA3
PSer308
phosphorylation
up-regulates
→
GATA316109788SIGNOR-276042
PKAphosphorylation
up-regulates
→
SLC9A3
PSer555
phosphorylation
down-regulates
⊣
SLC9A338047302SIGNOR-277847
PKAphosphorylation
up-regulates
→
PDE4B
PSer133
phosphorylation
up-regulates
→
PDE4B12023945SIGNOR-275986
PKAphosphorylation
up-regulates
→
PRKD2
PSer706
phosphorylation
up-regulates
→
PRKD212058027SIGNOR-275952
PKAphosphorylation
up-regulates
→
SEC14L2
PSer289
phosphorylation
up-regulates
→
SEC14L215680919SIGNOR-276028
PKAphosphorylation
up-regulates
→
KLHL3
PSer433
phosphorylation
up-regulates
→
KLHL326435498SIGNOR-273824
PKAphosphorylation
up-regulates
→
CHKB
PSer39
phosphorylation
up-regulates
→
CHKB27149373SIGNOR-275632
PKAphosphorylation
up-regulates
→
TRPV4
PThr175
phosphorylation
up-regulates
→
TRPV419661060SIGNOR-276231
PKAphosphorylation
up-regulates
→
TRPV4
PSer162
phosphorylation
up-regulates
→
TRPV419661060SIGNOR-260885
PKAphosphorylation
up-regulates
→
GRK7
PSer23
phosphorylation
down-regulates
⊣
GRK715946941SIGNOR-260839
PKAphosphorylation
up-regulates
→
MYOM1
PSer618
phosphorylation
down-regulates
⊣
MYOM19029142SIGNOR-263156
PKAphosphorylation
up-regulates
→
SCN5A
PSer36
phosphorylation
up-regulates
→
SCN5A33410863SIGNOR-275765
PKAphosphorylation
up-regulates
→
CREB1
PSer119
phosphorylation
up-regulates
→
CREB18386317SIGNOR-263653
PKAphosphorylation
up-regulates
→
ARHGEF6
PSer640
phosphorylation
down-regulates
⊣
ARHGEF626507661SIGNOR-272163
PKAphosphorylation
up-regulates
→
SI
PSer7
phosphorylation
down-regulates
⊣
SI8521865SIGNOR-263157
PKAphosphorylation
up-regulates
→
SLITRK1
PSer695
phosphorylation
up-regulates
→
SLITRK119640509SIGNOR-273634
PKAphosphorylation
up-regulates
→
LRP6
PThr1548
phosphorylation
up-regulates
→
LRP621406690SIGNOR-275416
PKAphosphorylation
up-regulates
→
TRPC5
PSer796
phosphorylation
down-regulates
⊣
TRPC521734191SIGNOR-276339
PKAphosphorylation
up-regulates
→
GLI1
PThr374
phosphorylation
down-regulates
⊣
GLI116293631SIGNOR-276044
PKAphosphorylation
up-regulates
→
CAMKK2
PSer511
phosphorylation
down-regulates
⊣
CAMKK222778263SIGNOR-198154
PKAphosphorylation
up-regulates
→
CAD
PSer1406
phosphorylation
down-regulates
⊣
CAD17485345SIGNOR-267442
PKAphosphorylation
up-regulates
→
MFN2
PSer442
phosphorylation
up-regulates
→
MFN220303493SIGNOR-274137
PKAphosphorylation
up-regulates
→
PHF2
PSer1056
phosphorylation
up-regulates
→
PHF221532585SIGNOR-264513
PKAphosphorylation
up-regulates
→
TRPC5
PSer796
phosphorylation
down-regulates
⊣
TRPC521734191SIGNOR-277824
PKAphosphorylation
up-regulates
→
NLRP3
PSer295
phosphorylation
down-regulates
⊣
NLRP327548431SIGNOR-277274
PKAphosphorylation
up-regulates
→
PHF2
PSer954
phosphorylation
up-regulates
→
PHF221532585SIGNOR-264512
PKAphosphorylation
up-regulates
→
PSMD2
PSer361
phosphorylation
up-regulates
→
PSMD231843888SIGNOR-273898
PKAphosphorylation
up-regulates
→
TRPV4
PSer189
phosphorylation
up-regulates
→
TRPV419661060SIGNOR-260883
PKAphosphorylation
up-regulates
→
PRKD1
PSer742
phosphorylation
up-regulates
→
PRKD118692497SIGNOR-275925
PKAphosphorylation
up-regulates
→
KCNK18
PSer252
phosphorylation
down-regulates
⊣
KCNK1818397886SIGNOR-263154
PKAphosphorylation
up-regulates
→
HDAC4
PSer584
phosphorylation
up-regulates
→
HDAC430661366SIGNOR-277423
PKAphosphorylation
up-regulates
→
NR5A2
PSer510
phosphorylation
up-regulates
→
NR5A216109788SIGNOR-276041
PKAphosphorylation
up-regulates
→
SEC14L2
PSer289
phosphorylation
up-regulates
→
SEC14L215680919SIGNOR-273788
PKAphosphorylation
up-regulates
→
PIK3CG
PThr1024
phosphorylation
down-regulates
⊣
PIK3CG21474070SIGNOR-276321
PKAphosphorylation
up-regulates
→
TRPV4
PSer189
phosphorylation
up-regulates
→
TRPV419661060SIGNOR-276233
PKAphosphorylation
up-regulates
→
ATG16L1
PSer269
phosphorylation
down-regulates
⊣
ATG16L131580256SIGNOR-277488
PKAphosphorylation
up-regulates
→
PDE4C
PSer14
phosphorylation
up-regulates
→
PDE4C12023945SIGNOR-275987
PKAphosphorylation
up-regulates
→
GRK1
PSer21
phosphorylation
down-regulates
⊣
GRK115946941SIGNOR-260841
PKAphosphorylation
up-regulates
→
GRK7
PSer36
phosphorylation
up-regulates
→
GRK718803695SIGNOR-263152
PKAphosphorylation
up-regulates
→
PDE4C
PSer14
phosphorylation
up-regulates
→
PDE4C12023945SIGNOR-273938
PKAphosphorylation
up-regulates
→
SCN5A
PSer528
phosphorylation
up-regulates
→
SCN5A33410863SIGNOR-275764
PKAphosphorylation
up-regulates
→
GSK3B
PSer9
phosphorylation
down-regulates
⊣
GSK3B26088133SIGNOR-264819
PKAphosphorylation
up-regulates
→
TRPC5
PSer794
phosphorylation
down-regulates
⊣
TRPC521734191SIGNOR-276340
PKAphosphorylation
up-regulates
→
HSPB8
PSer57
phosphorylation
down-regulates
⊣
HSPB818298377SIGNOR-276151
PKAphosphorylation
up-regulates
→
SLC2A2
PSer491
phosphorylation
down-regulates
⊣
SLC2A28626492SIGNOR-250049
PKAphosphorylation
up-regulates
→
PHF2
PSer899
phosphorylation
up-regulates
→
PHF221532585SIGNOR-264511
PKAphosphorylation
up-regulates
→
SLC8B1
PSer258
phosphorylation
up-regulates
→
SLC8B136476859SIGNOR-275728
PKAphosphorylation
up-regulates
→
AQP5
PSer156
phosphorylation
up-regulates
→
AQP526569106SIGNOR-272087
PKAphosphorylation
up-regulates
→
GATA4
PSer262
phosphorylation
up-regulates
→
GATA416109788SIGNOR-276043
PKAphosphorylation
up-regulates
→
TRPC5
PSer796
phosphorylation
down-regulates
⊣
TRPC521734191SIGNOR-273789
PKAphosphorylation
up-regulates
→
CAMKK2
PSer100
phosphorylation
down-regulates
⊣
CAMKK222778263SIGNOR-198146
PKAphosphorylation
up-regulates
→
PDE11A
PSer162
phosphorylation
up-regulates
→
PDE11A18312413SIGNOR-276179
PKAphosphorylation
up-regulates
→
GRK7
PSer23
phosphorylation
down-regulates
⊣
GRK715946941SIGNOR-274081
PKAphosphorylation
up-regulates
→
PIK3R1
PSer83
phosphorylation
up-regulates
→
PIK3R121743495SIGNOR-276343
PKAphosphorylation
up-regulates
→
PDE4A
PSer145
phosphorylation
up-regulates
→
PDE4A12023945SIGNOR-275985
PKAphosphorylation
up-regulates
→
GRK7
PSer36
phosphorylation
down-regulates
⊣
GRK715946941SIGNOR-276035
PKAphosphorylation
up-regulates
→
PRKD2
PSer876
phosphorylation
up-regulates
→
PRKD212058027SIGNOR-275950
PKAphosphorylation
up-regulates
→
DNM1L
PSer637
phosphorylation
down-regulates
⊣
DNM1L31063459SIGNOR-262551
PKAphosphorylation
up-regulates
→
KCNJ2
PSer425
phosphorylation
down-regulates
⊣
KCNJ219843922SIGNOR-273779
PKAphosphorylation
up-regulates
→
KCNA4
PThr601
phosphorylation
down-regulates
⊣
KCNA415955806SIGNOR-273778
PKAphosphorylation
up-regulates
→
PPP1R1B
PThr34
phosphorylation
up-regulates
→
PPP1R1B10604473SIGNOR-264956
PKAphosphorylation
up-regulates
→
GSTA4
PSer189
phosphorylation
up-regulates
→
GSTA412646569SIGNOR-264796
PKAphosphorylation
up-regulates
→
PPM1B
PSer195
phosphorylation
down-regulates
⊣
PPM1B23756813SIGNOR-276494
PKAphosphorylation
up-regulates
→
IQGAP2
PThr716
phosphorylation
up-regulates
→
IQGAP221776420SIGNOR-273742
PKAphosphorylation
up-regulates
→
ARHGAP17
PSer702
phosphorylation
down-regulates
⊣
ARHGAP1726507661SIGNOR-272156
PKAphosphorylation
up-regulates
→
PDZK1
PSer505
phosphorylation
up-regulates
→
PDZK116174736SIGNOR-273784
PKAphosphorylation
up-regulates
→
GNMT
PSer10
phosphorylation
down-regulates
⊣
GNMT12697024SIGNOR-263151
PKAphosphorylation
up-regulates
→
PDE4A
PSer89
phosphorylation
up-regulates
→
PDE4A12023945SIGNOR-273937
PKAphosphorylation
up-regulates
→
PDE11A
PSer117
phosphorylation
up-regulates
→
PDE11A18312413SIGNOR-276153
PKAphosphorylation
up-regulates
→
HSPB8
PSer24
phosphorylation
down-regulates
⊣
HSPB818298377SIGNOR-276152
PKAphosphorylation
up-regulates
→
TRPV4
PSer162
phosphorylation
up-regulates
→
TRPV419661060SIGNOR-276232
PKAphosphorylation
up-regulates
→
NOXA1
PSer461
phosphorylation
down-regulates
⊣
NOXA120943948SIGNOR-264713
PKAphosphorylation
up-regulates
→
RAP1A
PSer180
phosphorylation
up-regulates
→
RAP1A17068197SIGNOR-278057
PKAphosphorylation
up-regulates
→
GRK1
PSer21
phosphorylation
down-regulates
⊣
GRK115946941SIGNOR-276034
PKAphosphorylation
up-regulates
→
PHF2
PSer757
phosphorylation
up-regulates
→
PHF221532585SIGNOR-264510
PKAphosphorylation
up-regulates
→
PRKD2
PSer710
phosphorylation
up-regulates
→
PRKD212058027SIGNOR-275951
PKAphosphorylation
up-regulates
→
CHKB
PSer40
phosphorylation
up-regulates
→
CHKB27149373SIGNOR-275631
PKAphosphorylation
up-regulates
→
TRPC5
PSer794
phosphorylation
down-regulates
⊣
TRPC521734191SIGNOR-273790
PKAphosphorylation
up-regulates
→
LIPE
PSer950
phosphorylation
up-regulates
→
LIPE19018281SIGNOR-276174
PKAphosphorylation
up-regulates
→
CAMKK2
PSer511
phosphorylation
down-regulates
⊣
CAMKK232913128SIGNOR-277240
PKAphosphorylation
up-regulates
→
KCNA1
PSer446
phosphorylation
down-regulates
⊣
KCNA123774215SIGNOR-273777
PKAphosphorylation
up-regulates
→
MOS
PSer73
phosphorylation
down-regulates
⊣
MOS8622681SIGNOR-260819
PKAphosphorylation
up-regulates
→
GRK7
PSer36
phosphorylation
down-regulates
⊣
GRK715946941SIGNOR-274080
PKAphosphorylation
up-regulates
→
GAD1
PThr91
phosphorylation
down-regulates
⊣
GAD115147202SIGNOR-276009
PKAphosphorylation
up-regulates
→
KCNJ4
PSer443
phosphorylation
up-regulates
→
KCNJ419635485SIGNOR-263153
PKAphosphorylation
up-regulates
→
PDE4D
PSer125
phosphorylation
up-regulates
→
PDE4D12023945SIGNOR-275988
PKAphosphorylation
up-regulates
→
PTPN11
PSer189
phosphorylation
down-regulates
⊣
PTPN1125802336SIGNOR-276894
PKAphosphorylation
up-regulates
→
LIPE
PSer951
phosphorylation
up-regulates
→
LIPE19018281SIGNOR-276175
PKAphosphorylation
up-regulates
→
CDK18
PSer14
phosphorylation
up-regulates
→
CDK1828361970SIGNOR-264559
PKAphosphorylation
up-regulates
→
PTPN11
PThr73
phosphorylation
down-regulates
⊣
PTPN1125802336SIGNOR-276893
PKAphosphorylation
up-regulates
→
CAMKK2
PSer495
phosphorylation
down-regulates
⊣
CAMKK222778263SIGNOR-198150
PKAphosphorylation
up-regulates
→
AQP2
PSer256
phosphorylation
up-regulates
→
AQP212194985SIGNOR-264563
PKAphosphorylation
up-regulates
→
NOXA1
PSer172
phosphorylation
down-regulates
⊣
NOXA120943948SIGNOR-264712
PKAphosphorylation
up-regulates
→
ATG16L1
PSer268
phosphorylation
down-regulates
⊣
ATG16L131580256SIGNOR-277489
PKAphosphorylation
up-regulates
→
GRK1
PSer21
phosphorylation
down-regulates
⊣
GRK115946941SIGNOR-274079
PKAphosphorylation
up-regulates
→
PDE8A
PSer359
phosphorylation
up-regulates
→
PDE8A22673573SIGNOR-276416
PKAphosphorylation
up-regulates
→
SNAI2
PSer247
phosphorylation
down-regulates
⊣
SNAI237596321SIGNOR-277905
PKAphosphorylation
up-regulates
→
GRK7
PSer36
phosphorylation
down-regulates
⊣
GRK715946941SIGNOR-260840
PKAphosphorylation
up-regulates
→
SCN5A
PSer528
phosphorylation
up-regulates
→
SCN5A12242273SIGNOR-275992
PKAphosphorylation
up-regulates
→
PDE8A
PSer359
phosphorylation
up-regulates
→
PDE8A22673573SIGNOR-273783
PKAphosphorylation
up-regulates
→
PDE4D
PSer125
phosphorylation
up-regulates
→
PDE4D12023945SIGNOR-273939
Regulator Mechanism/Effect Target SIGNOR-ID
PKAphosphorylation
→
up-regulates activity
SCN5ASIGNOR-275766
PKAphosphorylation
→
up-regulates activity
EVLSIGNOR-268287
PKAphosphorylation
→
up-regulates quantity by stabilization
DIAPH1SIGNOR-276484
PKAphosphorylation
→
up-regulates activity
PRKD3SIGNOR-275924
PKAphosphorylation
→
down-regulates activity
ARHGEF6SIGNOR-272160
PKAphosphorylation
→
up-regulates activity
GRIN2BSIGNOR-276617
PKAphosphorylation
→
up-regulates activity
TRPV4SIGNOR-260881
PKAphosphorylation
→
up-regulates activity
BRSK2SIGNOR-276056
PKAphosphorylation
→
down-regulates activity
CAMKK2SIGNOR-277239
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
KCNA4SIGNOR-276037
PKAphosphorylation
→
up-regulates activity
SCN5ASIGNOR-275991
PKAphosphorylation
→
down-regulates activity
FRAT1SIGNOR-276058
PKAphosphorylation
→
up-regulates quantity by stabilization
SMN complexSIGNOR-253122
PKAphosphorylation
→
up-regulates quantity by stabilization
NKD2SIGNOR-273782
PKAphosphorylation
→
down-regulates activity
GRK7SIGNOR-276036
PKAphosphorylation
→
up-regulates activity
SLC4A4SIGNOR-263158
PKAphosphorylation
→
down-regulates activity
CAMKK2SIGNOR-277238
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PPM1BSIGNOR-277825
PKAphosphorylation
→
up-regulates activity
PDE4BSIGNOR-273940
PKAphosphorylation
→
up-regulates activity
GATA3SIGNOR-276042
PKAphosphorylation
→
down-regulates activity
SLC9A3SIGNOR-277847
PKAphosphorylation
→
up-regulates activity
PDE4BSIGNOR-275986
PKAphosphorylation
→
up-regulates activity
PRKD2SIGNOR-275952
PKAphosphorylation
→
up-regulates activity
SEC14L2SIGNOR-276028
PKAphosphorylation
→
up-regulates activity
KLHL3SIGNOR-273824
PKAphosphorylation
→
up-regulates activity
CHKBSIGNOR-275632
PKAphosphorylation
→
up-regulates activity
TRPV4SIGNOR-276231
PKAphosphorylation
→
up-regulates activity
TRPV4SIGNOR-260885
PKAphosphorylation
→
down-regulates activity
GRK7SIGNOR-260839
PKAphosphorylation
→
down-regulates activity
MYOM1SIGNOR-263156
PKAphosphorylation
→
up-regulates activity
SCN5ASIGNOR-275765
PKAphosphorylation
→
up-regulates activity
CREB1SIGNOR-263653
PKAphosphorylation
→
down-regulates activity
ARHGEF6SIGNOR-272163
PKAphosphorylation
→
unknown
SISIGNOR-263157
PKAphosphorylation
→
down-regulates activity
ABCC8SIGNOR-278147
PKAphosphorylation
→
down-regulates activity
SCN2ASIGNOR-275749
PKAphosphorylation
→
up-regulates activity
SLITRK1SIGNOR-273634
PKAphosphorylation
→
up-regulates activity
LRP6SIGNOR-275416
PKAphosphorylation
→
down-regulates activity
TRPC5SIGNOR-276339
PKAphosphorylation
→
up-regulates activity
mTORC2SIGNOR-278149
PKAphosphorylation
→
down-regulates activity
GLI1SIGNOR-276044
PKAphosphorylation
img/direct_inhibition.png
down-regulates
CAMKK2SIGNOR-198154
PKAphosphorylation
→
up-regulates activity
HDAC4SIGNOR-277425
PKAphosphorylation
→
down-regulates activity
CADSIGNOR-267442
PKAphosphorylation
→
up-regulates activity
MFN2SIGNOR-274137
PKAphosphorylation
→
up-regulates activity
PHF2SIGNOR-264513
PKAphosphorylation
→
down-regulates quantity
TRPC5SIGNOR-277824
PKAphosphorylation
→
down-regulates activity
NLRP3SIGNOR-277274
PKAphosphorylation
→
down-regulates activity
PHKA1SIGNOR-267409
PKAphosphorylation
→
up-regulates activity
PHF2SIGNOR-264512
PKAphosphorylation
→
up-regulates activity
PSMD2SIGNOR-273898
PKAphosphorylation
→
up-regulates activity
TRPV4SIGNOR-260883
PKAphosphorylation
→
up-regulates quantity
GABA-ASIGNOR-264991
PKAphosphorylation
→
down-regulates activity
TENT2SIGNOR-270130
PKAphosphorylation
→
down-regulates activity
SYN2SIGNOR-264109
PKAphosphorylation
→
up-regulates activity
PRKD1SIGNOR-275925
PKAphosphorylation
→
down-regulates activity
KCNK18SIGNOR-263154
PKAphosphorylation
→
up-regulates activity
HDAC4SIGNOR-277423
PKAphosphorylation
→
up-regulates activity
NR5A2SIGNOR-276041
PKAphosphorylation
→
up-regulates activity
SEC14L2SIGNOR-273788
PKAphosphorylation
→
down-regulates activity
PIK3CGSIGNOR-276321
PKAphosphorylation
→
up-regulates activity
TRPV4SIGNOR-276233
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
ATG16L1SIGNOR-277488
PKAphosphorylation
→
up-regulates activity
PDE4CSIGNOR-275987
PKAphosphorylation
→
down-regulates activity
GRK1SIGNOR-260841
PKAphosphorylation
→
up-regulates activity
GRK7SIGNOR-263152
PKAphosphorylation
→
up-regulates activity
PDE4CSIGNOR-273938
PKAphosphorylation
→
up-regulates activity
SCN5ASIGNOR-275764
PKAphosphorylation
→
down-regulates activity
GSK3BSIGNOR-264819
PKAphosphorylation
→
down-regulates activity
TRPC5SIGNOR-276340
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
HSPB8SIGNOR-276151
PKAphosphorylation
→
down-regulates activity
PHKA2SIGNOR-267408
PKAphosphorylation
→
down-regulates activity
SLC2A2SIGNOR-250049
PKAphosphorylation
→
up-regulates activity
PHF2SIGNOR-264511
PKAphosphorylation
→
up-regulates activity
SLC8B1SIGNOR-275728
PKAphosphorylation
→
up-regulates activity
AQP5SIGNOR-272087
PKAphosphorylation
→
up-regulates activity
GATA4SIGNOR-276043
PKAphosphorylation
→
down-regulates activity
TRPC5SIGNOR-273789
PKAphosphorylation
img/direct_inhibition.png
down-regulates
CAMKK2SIGNOR-198146
PKAphosphorylation
→
up-regulates activity
PDE11ASIGNOR-276179
PKAphosphorylation
→
down-regulates activity
GRK7SIGNOR-274081
PKAphosphorylation
→
up-regulates activity
PIK3R1SIGNOR-276343
PKAphosphorylation
→
up-regulates activity
PDE4ASIGNOR-275985
PKAphosphorylation
→
down-regulates activity
GRK7SIGNOR-276035
PKAphosphorylation
→
up-regulates activity
PRKD2SIGNOR-275950
PKAphosphorylation
→
down-regulates activity
SYN1SIGNOR-264108
PKAphosphorylation
→
down-regulates activity
DNM1LSIGNOR-262551
PKAphosphorylation
→
down-regulates activity
KCNJ2SIGNOR-273779
PKAphosphorylation
→
down-regulates activity
KCNA4SIGNOR-273778
PKAphosphorylation
→
up-regulates activity
PPP1R1BSIGNOR-264956
PKAphosphorylation
→
up-regulates activity
GSTA4SIGNOR-264796
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PPM1BSIGNOR-276494
PKAphosphorylation
→
down-regulates activity
SYN3SIGNOR-264110
PKAphosphorylation
→
up-regulates activity
IQGAP2SIGNOR-273742
PKAphosphorylation
→
down-regulates activity
ARHGAP17SIGNOR-272156
PKAphosphorylation
→
up-regulates activity
PDZK1SIGNOR-273784
PKAphosphorylation
→
unknown
GNMTSIGNOR-263151
PKAphosphorylation
→
up-regulates activity
PDE4ASIGNOR-273937
PKAphosphorylation
→
up-regulates activity
PDE11ASIGNOR-276153
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
HSPB8SIGNOR-276152
PKAphosphorylation
→
up-regulates activity
TRPV4SIGNOR-276232
PKAphosphorylation
→
down-regulates activity
NOXA1SIGNOR-264713
PKAphosphorylation
→
up-regulates activity
RAP1ASIGNOR-278057
PKAphosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-270129
PKAphosphorylation
→
down-regulates activity
GRK1SIGNOR-276034
PKAphosphorylation
→
up-regulates activity
PHF2SIGNOR-264510
PKAphosphorylation
→
up-regulates activity
PRKD2SIGNOR-275951
PKAphosphorylation
→
up-regulates activity
CHKBSIGNOR-275631
PKAphosphorylation
→
down-regulates activity
TRPC5SIGNOR-273790
PKAphosphorylation
→
up-regulates activity
LIPESIGNOR-276174
PKAphosphorylation
→
up-regulates
MYBPC3SIGNOR-270128
PKAphosphorylation
→
down-regulates activity
CAMKK2SIGNOR-277240
PKAphosphorylation
→
down-regulates quantity
KCNA1SIGNOR-273777
PKAphosphorylation
→
down-regulates activity
MOSSIGNOR-260819
PKAphosphorylation
→
up-regulates activity
HDAC4SIGNOR-277424
PKAphosphorylation
→
down-regulates activity
GRK7SIGNOR-274080
PKAphosphorylation
→
down-regulates activity
GAD1SIGNOR-276009
PKAphosphorylation
→
up-regulates activity
KCNJ4SIGNOR-263153
PKAphosphorylation
→
up-regulates activity
PDE4DSIGNOR-275988
PKAphosphorylation
→
down-regulates activity
PTPN11SIGNOR-276894
PKAphosphorylation
→
down-regulates activity
ABCC8SIGNOR-278146
PKAphosphorylation
→
up-regulates activity
LIPESIGNOR-276175
PKAphosphorylation
→
up-regulates activity
CDK18SIGNOR-264559
PKAphosphorylation
→
down-regulates activity
PTPN11SIGNOR-276893
PKAphosphorylation
img/direct_inhibition.png
down-regulates
CAMKK2SIGNOR-198150
PKAphosphorylation
→
up-regulates activity
AQP2SIGNOR-264563
PKAphosphorylation
→
up-regulates quantity by stabilization
SMN1SIGNOR-253114
PKAphosphorylation
→
down-regulates activity
NOXA1SIGNOR-264712
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
ATG16L1SIGNOR-277489
PKAphosphorylation
→
down-regulates activity
GRK1SIGNOR-274079
PKAphosphorylation
→
up-regulates activity
ENAHSIGNOR-268285
PKAphosphorylation
→
up-regulates activity
VASPSIGNOR-268286
PKAphosphorylation
→
up-regulates activity
PDE8ASIGNOR-276416
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SNAI2SIGNOR-277905
PKAphosphorylation
→
down-regulates activity
GRK7SIGNOR-260840
PKAphosphorylation
→
up-regulates activity
SCN5ASIGNOR-275992
PKAphosphorylation
→
up-regulates activity
PDE8ASIGNOR-273783
PKAphosphorylation
→
up-regulates activity
PDE4DSIGNOR-273939