| Name | PKA |
| ID | SIGNOR-PF17 |
| Role | phosphatase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | ABCB1 | Ser667 | SSLIRKRsTRRSVRG | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272508 |
| PKA | ABCB1 | Ser671 | RKRSTRRsVRGSQAQ | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272509 |
| PKA | ABCB1 | Ser683 | QAQDRKLsTKEALDE | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272510 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer667 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272508 |
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer671 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272509 |
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer683 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272510 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272508 |
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272509 |
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272510 |