| Name | PP2B |
| ID | SIGNOR-PF18 |
| Role | phosphatase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP2B | DNM1L | – | dephosphorylation up-regulates activity | 18838687 | SIGNOR-269994 | |
| PP2B | JUN | Ser243 | PGETPPLsPIDMESQ | dephosphorylation up-regulates | 17215518 | SIGNOR-152006 |
| PP2B | MAPT | Ser516 | GDRSGYSsPGSPGTP | dephosphorylation up-regulates | 20308788 | SIGNOR-164659 |
| PP2B | MAPT | Ser579 | NVKSKIGsTENLKHQ | dephosphorylation up-regulates | 20308788 | SIGNOR-164663 |
| PP2B | MAPT | Ser721 | PVVSGDTsPRHLSNV | dephosphorylation up-regulates | 20308788 | SIGNOR-164667 |
| PP2B | MAPT | Thr522 | SSPGSPGtPGSRSRT | dephosphorylation up-regulates | 20308788 | SIGNOR-164671 |
| PP2B | MAPT | Thr529 | TPGSRSRtPSLPTPP | dephosphorylation up-regulates | 20308788 | SIGNOR-164675 |
| PP2B | FLNA | – | dephosphorylation down-regulates quantity by destabilization | 16442073 | SIGNOR-269986 | |
| PP2B | DNM2 | – | dephosphorylation unknown | 20496096 | SIGNOR-269990 | |
| PP2B | NFATC2 | – | dephosphorylation up-regulates | 18676376 | SIGNOR-269988 | |
| PP2B | PPP1R1A | – | dephosphorylation unknown | 11278334 | SIGNOR-269991 | |
| PP2B | BAD | – | dephosphorylation up-regulates activity | 10195903 | SIGNOR-269992 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP2B | dephosphorylation down-regulates ⊣ | JUN PSer243 | dephosphorylation down-regulates ⊣ | JUN | 17215518 | SIGNOR-152006 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer516 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164659 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer579 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164663 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer721 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164667 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PThr522 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164671 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PThr529 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164675 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PP2B | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-269994 |
| PP2B | dephosphorylation → up-regulates | JUN | SIGNOR-152006 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164659 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164663 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164667 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164671 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164675 |
| PP2B | dephosphorylation down-regulates quantity by destabilization | FLNA | SIGNOR-269986 |
| PP2B | dephosphorylation → unknown | DNM2 | SIGNOR-269990 |
| PP2B | dephosphorylation → up-regulates | NFATC2 | SIGNOR-269988 |
| PP2B | dephosphorylation → unknown | PPP1R1A | SIGNOR-269991 |
| PP2B | dephosphorylation → up-regulates activity | BAD | SIGNOR-269992 |