| Name | AKT |
| ID | SIGNOR-PF24 |
| Role | kinase |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 23457334 | SIGNOR-192260 |
| AKT | RARA | Ser96 | FVCQDKSsGYHYGVS | phosphorylation down-regulates | 16417524 | SIGNOR-143721 |
| AKT | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-266357 |
| AKT | FOXO4 | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates | 16272144 | SIGNOR-141420 |
| AKT | SKI | Thr458 | QPRKRKLtVDTPGAP | phosphorylation down-regulates | 19875456 | SIGNOR-188969 |
| AKT | ESR1 | Ser104 | FPPLNSVsPSPLMLL | phosphorylation up-regulates | 11108261 | SIGNOR-244243 |
| AKT | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-244180 |
| AKT | DLX5 | – | phosphorylation up-regulates | 22298955 | SIGNOR-244228 | |
| AKT | GATA1 | Ser310 | QTRNRKAsGKGKKKR | phosphorylation up-regulates | 16107690 | SIGNOR-244267 |
| AKT | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 12535517 | SIGNOR-97485 |
| AKT | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates | 17470458 | SIGNOR-244140 |
| AKT | ALYREF | Thr219 | GGGTRRGtRGGARGR | phosphorylation up-regulates | 18562279 | SIGNOR-179054 |
| AKT | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 11154276 | SIGNOR-104646 |
| AKT | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201121 |
| AKT | DLX5 | – | phosphorylation up-regulates | 21619873 | SIGNOR-173976 | |
| AKT | ZFP36L1 | Ser92 | RFRDRSFsEGGERLL | phosphorylation down-regulates | 15538381 | SIGNOR-244385 |
| AKT | AKT1S1 | Thr246 | LPRPRLNtSDFQKLK | phosphorylation down-regulates activity | 12524439 | SIGNOR-236929 |
| AKT | FOXO1 | Ser319 | TFRPRTSsNASTISG | phosphorylation down-regulates activity | 11237865 | SIGNOR-252349 |
| AKT | SH3RF1 | Ser304 | KNTKKRHsFTSLTMA | phosphorylation down-regulates | 17535800 | SIGNOR-155229 |
| AKT | HTRA2 | Ser212 | RVRVRLLsGDTYEAV | phosphorylation down-regulates | 17311912 | SIGNOR-153323 |
| AKT | MTOR | Thr2446 | NKRSRTRtDSYSAGQ | phosphorylation unknown | 10910062 | SIGNOR-251482 |
| AKT | RGCC | Ser45 | ERMKRRSsASVSDSS | phosphorylation up-regulates activity | 19162005 | SIGNOR-262629 |
| AKT | AGAP2 | Ser985 | THLSRVRsLDLDDWP | phosphorylation up-regulates | 19176382 | SIGNOR-244132 |
| AKT | CELF1 | Ser28 | GQVPRTWsEKDLREL | phosphorylation up-regulates activity | 18570922 | SIGNOR-262615 |
| AKT | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation down-regulates activity | 11274386 | SIGNOR-105927 |
| AKT | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252823 |
| AKT | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-252826 |
| AKT | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-252346 |
| AKT | GSK3B/Axin/APC | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-227952 | |
| AKT | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-244222 |
| AKT | GSK3B | – | phosphorylation down-regulates | 28712664 | SIGNOR-255488 | |
| AKT | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252827 |
| AKT | ARHGAP22 | Ser16 | ARRARSKsLVMGEQS | phosphorylation up-regulates activity | 21969604 | SIGNOR-262613 |
| AKT | ZNF322 | Thr234 | IVHKRVHtGEKPYKC | phosphorylation up-regulates activity | 31399647 | SIGNOR-276752 |
| AKT | VCP | Ser748 | RFARRSVsDNDIRKY | phosphorylation up-regulates | 16551632 | SIGNOR-145292 |
| AKT | MAP3K11 | Ser674 | PGRERGEsPTTPPTP | phosphorylation down-regulates | 12458207 | SIGNOR-96062 |
| AKT | GAB2 | Ser159 | LLRERKSsAPSHSSQ | phosphorylation down-regulates | 11782427 | SIGNOR-113669 |
| AKT | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20086174 | SIGNOR-244345 |
| AKT | PFKFB3 | Ser461 | NPLMRRNsVTPLASP | phosphorylation up-regulates | 15896703 | SIGNOR-137241 |
| AKT | FANCA | Ser1149 | CLRSRDPsLMVDFIL | phosphorylation unknown | 11855836 | SIGNOR-251476 |
| AKT | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-150140 |
| AKT | BRCA1 | Ser694 | QTSKRHDsDTFPELK | phosphorylation up-regulates | 20085797 | SIGNOR-244164 |
| AKT | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249646 |
| AKT | CFLAR | Ser273 | LLRDTFTsLGYEVQK | phosphorylation down-regulates quantity | 19339247 | SIGNOR-245304 |
| AKT | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-244322 |
| AKT | EDC3 | Ser161 | SFRRRHNsWSSSSRH | phosphorylation down-regulates activity | 20051463 | SIGNOR-262631 |
| AKT | SRPK2 | Thr492 | PSHDRSRtVSASSTG | phosphorylation up-regulates | 19592491 | SIGNOR-244341 |
| AKT | ATG4B | Ser34 | WILGRKYsIFTEKDE | phosphorylation up-regulates activity | 29165041 | SIGNOR-275836 |
| AKT | NIBAN1 | Ser602 | ASPARRAsAILPGVL | phosphorylation unknown | 22510990 | SIGNOR-197053 |
| AKT | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245259 |
| AKT | HK2 | – | phosphorylation up-regulates activity | 31435020 | SIGNOR-259985 | |
| AKT | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 10377430 | SIGNOR-252347 |
| AKT | GATA2 | Ser401 | QTRNRKMsNKSKKSK | phosphorylation down-regulates activity | 15837948 | SIGNOR-244271 |
| AKT | BCL2L11 | Ser87 | FIFMRRSsLLSRSSS | phosphorylation down-regulates activity | 16282323 | SIGNOR-141581 |
| AKT | VCP | Ser746 | AMRFARRsVSDNDIR | phosphorylation up-regulates | 16551632 | SIGNOR-145288 |
| AKT | PDE3B | Ser295 | VIRPRRRsSCVSLGE | phosphorylation up-regulates | 10454575 | SIGNOR-70205 |
| AKT | SP7 | – | phosphorylation up-regulates | 21777568 | SIGNOR-174017 | |
| AKT | ZNF322 | Thr262 | IVHQRVHtGEKPYKC | phosphorylation up-regulates activity | 31399647 | SIGNOR-276753 |
| AKT | PIKFYVE | Ser307 | PARNRSAsITNLSLD | phosphorylation up-regulates | 15546921 | SIGNOR-130920 |
| AKT | CDKN1C | Thr310 | GVGSVEQtPRKRLR | phosphorylation down-regulates | 23421998 | SIGNOR-201046 |
| AKT | CLK2 | Ser34 | HKRRRSRsWSSSSDR | phosphorylation up-regulates | 20682768 | SIGNOR-244214 |
| AKT | FOXO | – | phosphorylation down-regulates quantity by destabilization | 21440011 | SIGNOR-252833 | |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation unknown | 12853467 | SIGNOR-251485 |
| AKT | USP14 | Ser432 | THQGRSSsSGHYVSW | phosphorylation up-regulates activity | 26523394 | SIGNOR-265055 |
| AKT | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-235411 |
| AKT | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11035810 | SIGNOR-83217 |
| AKT | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 9346240 | SIGNOR-244148 |
| AKT | ADRB2 | Ser345 | ELLCLRRsSLKAYGN | phosphorylation down-regulates | 11809767 | SIGNOR-114466 |
| AKT | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 16854453 | SIGNOR-244337 |
| AKT | MAP2K4 | Ser80 | IERLRTHsIESSGKL | phosphorylation down-regulates activity | 11707464 | SIGNOR-275980 |
| AKT | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 12150915 | SIGNOR-244369 |
| AKT | MST1R | Ser1394 | VRRPRPLsEPPRPT | phosphorylation up-regulates | 14505491 | SIGNOR-118053 |
| AKT | NR3C1 | Ser134 | ANLNRSTsVPENPKS | phosphorylation down-regulates | 24291004 | SIGNOR-236216 |
| AKT | CDK2 | Thr39 | LKKIRLDtETEGVPS | phosphorylation up-regulates | 18354084 | SIGNOR-244176 |
| AKT | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates activity | 10217147 | SIGNOR-251477 |
| AKT | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9381178 | SIGNOR-251470 |
| AKT | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 12042314 | SIGNOR-244194 |
| AKT | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252825 |
| AKT | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 11108261 | SIGNOR-244251 |
| AKT | COPS6 | Ser60 | DHWIRMRsQEGRPVQ | phosphorylation up-regulates | 23095642 | SIGNOR-199254 |
| AKT | LARP6 | Ser451 | QEKSPGTsPLLSRKM | phosphorylation up-regulates activity | 26932461 | SIGNOR-273539 |
| AKT | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-183620 |
| AKT | KLHL3 | Ser433 | PMNTRRSsVGVGVVE | phosphorylation up-regulates activity | 26435498 | SIGNOR-273825 |
| AKT | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249647 |
| AKT | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164298 |
| AKT | FOXO | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates | 10377430 | SIGNOR-252831 |
| AKT | TBC1D4 | Ser588 | RMRGRLGsVDSFERS | phosphorylation unknown | 11994271 | SIGNOR-245268 |
| AKT | CCNF | Ser577 | TKRKRENsLQEDRGS | phosphorylation up-regulates activity | 28954236 | SIGNOR-266361 |
| AKT | PEA15 | Ser116 | KDIIRQPsEEEIIKL | phosphorylation up-regulates activity | 12808093 | SIGNOR-244326 |
| AKT | ELK1 | – | phosphorylation up-regulates activity | 22085529 | SIGNOR-259029 | |
| AKT | TAL1 | Thr90 | EARHRVPtTELCRPP | phosphorylation down-regulates | 15930267 | SIGNOR-137942 |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 12853467 | SIGNOR-103462 |
| AKT | ESR1 | Ser106 | PLNSVSPsPLMLLHP | phosphorylation up-regulates | 11108261 | SIGNOR-244247 |
| AKT | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates | 11108261 | SIGNOR-244255 |
| AKT | XIAP | Ser87 | VGRHRKVsPNCRFIN | phosphorylation up-regulates quantity by stabilization | 14645242 | SIGNOR-244377 |
| AKT | BRAF | Thr440 | EDRNRMKtLGRRDSS | phosphorylation down-regulates | 10869359 | SIGNOR-244156 |
| AKT | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation unknown | 11956222 | SIGNOR-244381 |
| AKT | ZNF322 | Ser224 | EKSYRHRsAFIVHKR | phosphorylation up-regulates activity | 31399647 | SIGNOR-276755 |
| AKT | RANBP3 | Ser57 | HGTGHPEsAGEHALE | phosphorylation up-regulates quantity | 18280241 | SIGNOR-276150 |
| AKT | TBC1D7 | Ser124 | GKLPRSPsFPLEPDD | phosphorylation up-regulates quantity by stabilization | 30143532 | SIGNOR-273541 |
| AKT | FOXO | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates | 10377430 | SIGNOR-252832 |
| AKT | ADARB1 | Thr553 | LQGERLLtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-266358 |
| AKT | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 10559253 | SIGNOR-72137 |
| AKT | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252821 |
| AKT | SH2B2 | Ser598 | SARSRSNsAERLLEA | phosphorylation up-regulates activity | 16141217 | SIGNOR-248042 |
| AKT | mTORC1 | – | phosphorylation up-regulates activity | 19593385 | SIGNOR-252817 | |
| AKT | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-244160 |
| AKT | CARHSP1 | Ser52 | TRRTRTFsATVRASQ | phosphorylation unknown | 15910284 | SIGNOR-137430 |
| AKT | CCT2 | Ser260 | GSRVRVDsTAKVAEI | phosphorylation unknown | 19332537 | SIGNOR-244172 |
| AKT | BEX1 | Ser102 | KLREKQLsHSLRAVS | phosphorylation up-regulates quantity by stabilization | 16498402 | SIGNOR-262614 |
| AKT | RAC1 | Ser71 | YDRLRPLsYPQTDVF | phosphorylation down-regulates activity | 10617634 | SIGNOR-248036 |
| AKT | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 19526459 | SIGNOR-186130 |
| AKT | EP300 | – | phosphorylation up-regulates | 17964260 | SIGNOR-244239 | |
| AKT | ARFIP2 | Ser260 | GTRGRLEsAQATFQA | phosphorylation unknown | 15809304 | SIGNOR-135105 |
| AKT | FOXO | Ser319 | TFRPRTSsNASTISG | phosphorylation down-regulates | 11237865 | SIGNOR-252835 |
| AKT | STK4 | Thr120 | IIRLRNKtLTEDEIA | phosphorylation down-regulates | 19940129 | SIGNOR-161829 |
| AKT | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates | 20400976 | SIGNOR-244373 |
| AKT | TKT | Thr382 | GCATRNRtVPFCSTF | phosphorylation up-regulates activity | 24981175 | SIGNOR-265102 |
| AKT | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 12853467 | SIGNOR-248031 |
| AKT | FOXO4 | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates activity | 10217147 | SIGNOR-251478 |
| AKT | POU5F1 | Thr235 | QARKRKRtSIENRVR | phosphorylation up-regulates quantity by stabilization | 23041284 | SIGNOR-242092 |
| AKT | PDE3B | Ser295 | VIRPRRRsSCVSLGE | phosphorylation up-regulates activity | 10454575 | SIGNOR-251483 |
| AKT | LTB4R2 | Thr324 | GGRSREGtMELRTTP | phosphorylation unknown | 22044535 | SIGNOR-177019 |
| AKT | HK2 | Thr473 | QHRARQKtLEHLQLS | phosphorylation up-regulates activity | 25323588 | SIGNOR-267576 |
| AKT | SH2B2 | Ser598 | SARSRSNsAERLLEA | phosphorylation unknown | 16141217 | SIGNOR-251487 |
| AKT | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-251474 |
| AKT | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 12588998 | SIGNOR-244275 |
| AKT | FOXO | – | phosphorylation down-regulates | 21620960 | SIGNOR-252824 | |
| AKT | FOXO | – | phosphorylation down-regulates activity | 18423396 | SIGNOR-252836 | |
| AKT | AR | Ser792 | CVRMRHLsQEFGWLQ | phosphorylation down-regulates activity | 11404460 | SIGNOR-244136 |
| AKT | DLC1 | Ser766 | VTRTRSLsACNKRVG | phosphorylation unknown | 16338927 | SIGNOR-247997 |
| AKT | RPS3 | Thr70 | GRRIRELtAVVQKRF | phosphorylation up-regulates activity | 20605787 | SIGNOR-259816 |
| AKT | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-183616 |
| AKT | BAX | Ser184 | VAGVLTAsLTIWKKM | phosphorylation down-regulates activity | 14766748 | SIGNOR-209651 |
| AKT | FLNC | Ser2233 | LGRERLGsFGSITRQ | phosphorylation up-regulates quantity by stabilization | 32444788 | SIGNOR-262616 |
| AKT | ITGB3 | Thr779 | LYKEATStFTNITYR | phosphorylation down-regulates activity | 10896934 | SIGNOR-251479 |
| AKT | FOXO4 | – | phosphorylation down-regulates | 21620960 | SIGNOR-174021 | |
| AKT | PRPH | Ser59 | SSSVRLGsFRSPRAG | phosphorylation up-regulates activity | 17569669 | SIGNOR-262627 |
| AKT | RNF11 | Thr135 | DWLMRSFtCPSCMEP | phosphorylation down-regulates quantity | 16123141 | SIGNOR-248085 |
| AKT | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 16982699 | SIGNOR-244184 |
| AKT | DNMT1 | Ser143 | RTPRRSKsDGEAKPE | phosphorylation up-regulates | 21151116 | SIGNOR-244232 |
| AKT | TBX3 | Ser719 | AEKEAATsELQSIQR | phosphorylation up-regulates activity | 25595898 | SIGNOR-244353 |
| AKT | FOXO6 | – | phosphorylation down-regulates | 18394876 | SIGNOR-66032 | |
| AKT | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251628 |
| AKT | IRAK1 | Thr100 | LRARDIItAWHPPAP | phosphorylation down-regulates activity | 11976320 | SIGNOR-248008 |
| AKT | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates activity | 12150915 | SIGNOR-244365 |
| AKT | RGCC | Ser47 | MKRRSSAsVSDSSGF | phosphorylation up-regulates activity | 19162005 | SIGNOR-262628 |
| AKT | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 9381178 | SIGNOR-251469 |
| AKT | KHSRP | Ser193 | GLPERSVsLTGAPES | phosphorylation down-regulates activity | 17177604 | SIGNOR-151216 |
| AKT | MTOR | Ser2448 | RSRTRTDsYSAGQSV | phosphorylation unknown | 10910062 | SIGNOR-244311 |
| AKT | ACAP1 | Ser554 | SIRPRPGsLRSKPEP | phosphorylation unknown | 16256741 | SIGNOR-141343 |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 30519351 | SIGNOR-277740 | |
| AKT | ZYX | Ser142 | PQPREKVsSIDLEID | phosphorylation down-regulates | 17572661 | SIGNOR-244389 |
| AKT | STK3 | Thr384 | GTMKRNAtSPQVQRP | phosphorylation down-regulates | 20086174 | SIGNOR-244349 |
| AKT | EZH2 | Ser21 | CWRKRVKsEYMRLRQ | phosphorylation down-regulates activity | 16224021 | SIGNOR-244259 |
| AKT | VIM | Ser39 | TTSTRTYsLGSALRP | phosphorylation up-regulates quantity by stabilization | 20856200 | SIGNOR-167971 |
| AKT | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-141424 |
| AKT | TERT | Ser227 | GARRRGGsASRSLPL | phosphorylation up-regulates | 10224060 | SIGNOR-244361 |
| AKT | TERT | Ser824 | AVRIRGKsYVQCQGI | phosphorylation up-regulates | 10224060 | SIGNOR-244357 |
| AKT | BRAF | Ser364 | FGQRDRSsSAPNVHI | phosphorylation down-regulates | 10869359 | SIGNOR-244152 |
| AKT | HMOX1 | Ser188 | LYRSRMNsLEMTPAV | phosphorylation unknown | 15581622 | SIGNOR-161283 |
| AKT | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-244292 |
| AKT | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates activity | 18570873 | SIGNOR-244202 |
| AKT | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 10529400 | SIGNOR-71480 |
| AKT | FOXO | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates | 16272144 | SIGNOR-252828 |
| AKT | BMI1 | Ser316 | ANRPRKSsVNGSSAT | phosphorylation up-regulates activity | 22505453 | SIGNOR-249581 |
| AKT | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates | 16272144 | SIGNOR-141416 |
| AKT | STK3/4 | – | phosphorylation down-regulates | 20086174 | SIGNOR-269944 | |
| AKT | FOXO | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates activity | 10217147 | SIGNOR-252839 |
| AKT | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 10576741 | SIGNOR-72669 |
| AKT | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates | 11809767 | SIGNOR-114470 |
| AKT | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 9829964 | SIGNOR-247992 |
| AKT | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-244210 |
| AKT | PALLD | Ser1118 | VRRPRSRsRDSGDEN | phosphorylation unknown | 20471940 | SIGNOR-165497 |
| AKT | Histone H3 | – | phosphorylation unknown | 12588998 | SIGNOR-265319 | |
| AKT | FOXO | – | phosphorylation down-regulates | 21798082 | SIGNOR-252820 | |
| AKT | CHEK1 | Ser280 | AKRPRVTsGGVSESP | phosphorylation down-regulates | 15107605 | SIGNOR-244206 |
| AKT | ILF3 | Ser647 | RGRGRGGsIRGRGRG | phosphorylation up-regulates activity | 20870937 | SIGNOR-168169 |
| AKT | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates activity | 15169778 | SIGNOR-244296 |
| AKT | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 10559253 | SIGNOR-72133 |
| AKT | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249645 |
| AKT | IKK-complex | – | phosphorylation up-regulates | 19609947 | SIGNOR-244281 | |
| AKT | RAF1 | – | phosphorylation down-regulates | 14967450 | SIGNOR-244333 | |
| AKT | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 9812896 | SIGNOR-251473 |
| AKT | GSK3B | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-278095 | |
| AKT | EP300 | Ser1834 | MLRRRMAsMQRTGVV | phosphorylation up-regulates | 16926151 | SIGNOR-244236 |
| AKT | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation up-regulates activity | 18356162 | SIGNOR-178063 |
| AKT | ACOT4 | Ser392 | GGEPRAHsKAQEDAW | phosphorylation up-regulates quantity by stabilization | 33148467 | SIGNOR-271821 |
| AKT | YBX1 | Ser102 | NPRKYLRsVGDGETV | phosphorylation up-regulates | 19036157 | SIGNOR-182493 |
| AKT | PDCD4 | Ser457 | RGRKRFVsEGDGGRL | phosphorylation down-regulates | 16357133 | SIGNOR-143098 |
| AKT | PIK3R6 | Thr607 | SHRPREVtVSLRATG | phosphorylation up-regulates activity | 25753393 | SIGNOR-275723 |
| AKT | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 10521487 | SIGNOR-71419 |
| AKT | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation unknown | 12062094 | SIGNOR-89696 |
| AKT | CLK2 | Thr127 | RRRRRSRtFSRSSSQ | phosphorylation up-regulates | 20682768 | SIGNOR-244218 |
| AKT | TBC1D4 | Thr642 | QFRRRAHtFSHPPSS | phosphorylation unknown | 16880201 | SIGNOR-148342 |
| AKT | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 9346240 | SIGNOR-244144 |
| AKT | PDE3B | Ser318 | CKIFRRPsLPCISRE | phosphorylation up-regulates activity | 10454575 | SIGNOR-248027 |
| AKT | BRCA1 | Thr509 | LKRKRRPtSGLHPED | phosphorylation up-regulates | 17428466 | SIGNOR-244168 |
| AKT | GRIN2C | Ser1081 | GSRPRHAsLPSSVAE | phosphorylation up-regulates activity | 19477150 | SIGNOR-262620 |
| AKT | PRKAA1 | – | phosphorylation down-regulates activity | 16340011 | SIGNOR-252740 | |
| AKT | FOXA2 | Thr156 | KTYRRSYtHAKPPYS | phosphorylation down-regulates activity | 14500912 | SIGNOR-254974 |
| AKT | ATXN1 | Ser775 | ATRKRRWsAPESRKL | phosphorylation up-regulates quantity by stabilization | 12757707 | SIGNOR-251468 |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 21440011 | SIGNOR-252348 | |
| AKT | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186772 |
| AKT | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-252830 |
| AKT | TTC3 | Ser378 | AYTPRSLsAPIFTTS | phosphorylation up-regulates | 20059950 | SIGNOR-162984 |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 21798082 | SIGNOR-252352 | |
| AKT | SIK1 | Ser435 | VFRPRPVsPSSLLDT | phosphorylation down-regulates activity | 36806887 | SIGNOR-277835 |
| AKT | FOXO | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates activity | 10217147 | SIGNOR-252838 |
| AKT | HNRNPA1 | Ser199 | SQRGRSGsGNFGGGR | phosphorylation down-regulates | 18562319 | SIGNOR-179059 |
| AKT | MAP2K4 | Ser80 | IERLRTHsIESSGKL | phosphorylation down-regulates | 11707464 | SIGNOR-244285 |
| AKT | NUAK1 | Ser600 | PARQRIRsCVSAENF | phosphorylation up-regulates | 12409306 | SIGNOR-95247 |
| AKT | TBC1D4 | – | phosphorylation down-regulates | 12637568 | SIGNOR-99300 | |
| AKT | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-183612 |
| AKT | S1PR1 | Thr236 | RTRSRRLtFRKNISK | phosphorylation up-regulates activity | 11583630 | SIGNOR-110845 |
| AKT | PHF20 | Ser291 | ELRRRKIsKGCEVPL | phosphorylation down-regulates | 22334668 | SIGNOR-196112 |
| AKT | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245428 |
| AKT | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 18836482 | SIGNOR-181536 |
| AKT | CDKN1C | Ser282 | FFAKRKRsAPEKSSG | phosphorylation down-regulates | 23421998 | SIGNOR-201042 |
| AKT | VCP | Ser352 | AATNRPNsIDPALRR | phosphorylation up-regulates | 16551632 | SIGNOR-145284 |
| AKT | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 9373175 | SIGNOR-242578 |
| AKT | HJURP | Ser486 | GLETRRLsLPSSKAK | phosphorylation up-regulates activity | 17256767 | SIGNOR-262623 |
| AKT | ZNF322 | Thr150 | LVHQRSHtGEKPYLC | phosphorylation up-regulates activity | 31399647 | SIGNOR-276754 |
| AKT | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation unknown | 12853467 | SIGNOR-251484 |
| AKT | CCDC88A | Ser1417 | INRERQKsLTLTPTR | phosphorylation unknown | 16139227 | SIGNOR-140216 |
| AKT | MAP3K8 | Ser413 | LERKRLLsRKELELP | phosphorylation up-regulates activity | 12138205 | SIGNOR-251481 |
| AKT | FOXO1 | – | phosphorylation down-regulates activity | 18423396 | SIGNOR-252350 | |
| AKT | Hexokinase | – | phosphorylation up-regulates activity | 25323588 | SIGNOR-267577 | |
| AKT | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-155532 |
| AKT | TP53RK | Ser250 | RLRGRKRsMVG | phosphorylation up-regulates | 17712528 | SIGNOR-157467 |
| AKT | NCOR1 | Ser1450 | TVRSRHTsVVSSGPS | phosphorylation down-regulates | 23940660 | SIGNOR-244318 |
| AKT | GABRB2 | Ser472 | SRLRRRAsQLKITIP | phosphorylation up-regulates activity | 12818177 | SIGNOR-262619 |
| AKT | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-160982 |
| AKT | METTL1 | Ser27 | YYRQRAHsNPMADHT | phosphorylation down-regulates | 3627513 | SIGNOR-244307 |
| AKT | WNK1 | Thr60 | EYRRRRHtMDKDSRG | phosphorylation up-regulates | 16081417 | SIGNOR-139391 |
| AKT | DOCK6 | Ser1194 | GQRSRLAsMLDSDTE | phosphorylation up-regulates activity | 23462102 | SIGNOR-275667 |
| AKT | MDM2 | Ser188 | RKRHKSDsISLSFDE | phosphorylation up-regulates activity | 15169778 | SIGNOR-244300 |
| AKT | RANBP3 | Ser126 | VKRERTSsLTQFPPS | phosphorylation unknown | 18280241 | SIGNOR-160900 |
| AKT | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252822 |
| AKT | FOXO | – | phosphorylation down-regulates | 18394876 | SIGNOR-252834 | |
| AKT | PLN | Thr17 | SAIRRAStIEMPQQA | phosphorylation down-regulates activity | 19696029 | SIGNOR-252035 |
| AKT | mTORC1 | – | phosphorylation up-regulates activity | 20138985 | SIGNOR-217586 | |
| AKT | MAP3K8 | Ser400 | EDQPRCQsLDSALLE | phosphorylation up-regulates activity | 12138205 | SIGNOR-251480 |
| AKT | CCNF | Thr31 | RRRPRNLtILSLPED | phosphorylation up-regulates activity | 28954236 | SIGNOR-266360 |
| AKT | FOXO3 | – | phosphorylation down-regulates activity | 14981546 | SIGNOR-261526 | |
| AKT | CDCA7 | Thr163 | SRRPRRRtFPGVASR | phosphorylation down-regulates | 23166294 | SIGNOR-199776 |
| AKT | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15531580 | SIGNOR-244263 |
| AKT | TSC | – | phosphorylation down-regulates activity | 19593385 | SIGNOR-251526 | |
| AKT | FOXA2 | – | phosphorylation down-regulates | 14500912 | SIGNOR-254978 | |
| AKT | FOXO | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates | 16272144 | SIGNOR-252829 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 23457334 | SIGNOR-192260 |
| AKT | phosphorylation up-regulates → | RARA PSer96 | phosphorylation down-regulates ⊣ | RARA | 16417524 | SIGNOR-143721 |
| AKT | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-266357 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer262 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141420 |
| AKT | phosphorylation up-regulates → | SKI PThr458 | phosphorylation down-regulates ⊣ | SKI | 19875456 | SIGNOR-188969 |
| AKT | phosphorylation up-regulates → | ESR1 PSer104 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244243 |
| AKT | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-244180 |
| AKT | phosphorylation up-regulates → | GATA1 PSer310 | phosphorylation up-regulates → | GATA1 | 16107690 | SIGNOR-244267 |
| AKT | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 12535517 | SIGNOR-97485 |
| AKT | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 17470458 | SIGNOR-244140 |
| AKT | phosphorylation up-regulates → | ALYREF PThr219 | phosphorylation up-regulates → | ALYREF | 18562279 | SIGNOR-179054 |
| AKT | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 11154276 | SIGNOR-104646 |
| AKT | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201121 |
| AKT | phosphorylation up-regulates → | ZFP36L1 PSer92 | phosphorylation down-regulates ⊣ | ZFP36L1 | 15538381 | SIGNOR-244385 |
| AKT | phosphorylation up-regulates → | AKT1S1 PThr246 | phosphorylation down-regulates ⊣ | AKT1S1 | 12524439 | SIGNOR-236929 |
| AKT | phosphorylation up-regulates → | FOXO1 PSer319 | phosphorylation down-regulates ⊣ | FOXO1 | 11237865 | SIGNOR-252349 |
| AKT | phosphorylation up-regulates → | SH3RF1 PSer304 | phosphorylation down-regulates ⊣ | SH3RF1 | 17535800 | SIGNOR-155229 |
| AKT | phosphorylation up-regulates → | HTRA2 PSer212 | phosphorylation down-regulates ⊣ | HTRA2 | 17311912 | SIGNOR-153323 |
| AKT | phosphorylation up-regulates → | MTOR PThr2446 | phosphorylation down-regulates ⊣ | MTOR | 10910062 | SIGNOR-251482 |
| AKT | phosphorylation up-regulates → | RGCC PSer45 | phosphorylation up-regulates → | RGCC | 19162005 | SIGNOR-262629 |
| AKT | phosphorylation up-regulates → | AGAP2 PSer985 | phosphorylation up-regulates → | AGAP2 | 19176382 | SIGNOR-244132 |
| AKT | phosphorylation up-regulates → | CELF1 PSer28 | phosphorylation up-regulates → | CELF1 | 18570922 | SIGNOR-262615 |
| AKT | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 11274386 | SIGNOR-105927 |
| AKT | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252823 |
| AKT | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252826 |
| AKT | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-252346 |
| AKT | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-244222 |
| AKT | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252827 |
| AKT | phosphorylation up-regulates → | ARHGAP22 PSer16 | phosphorylation up-regulates → | ARHGAP22 | 21969604 | SIGNOR-262613 |
| AKT | phosphorylation up-regulates → | ZNF322 PThr234 | phosphorylation up-regulates → | ZNF322 | 31399647 | SIGNOR-276752 |
| AKT | phosphorylation up-regulates → | VCP PSer748 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-145292 |
| AKT | phosphorylation up-regulates → | MAP3K11 PSer674 | phosphorylation down-regulates ⊣ | MAP3K11 | 12458207 | SIGNOR-96062 |
| AKT | phosphorylation up-regulates → | GAB2 PSer159 | phosphorylation down-regulates ⊣ | GAB2 | 11782427 | SIGNOR-113669 |
| AKT | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-244345 |
| AKT | phosphorylation up-regulates → | PFKFB3 PSer461 | phosphorylation up-regulates → | PFKFB3 | 15896703 | SIGNOR-137241 |
| AKT | phosphorylation up-regulates → | FANCA PSer1149 | phosphorylation down-regulates ⊣ | FANCA | 11855836 | SIGNOR-251476 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-150140 |
| AKT | phosphorylation up-regulates → | BRCA1 PSer694 | phosphorylation up-regulates → | BRCA1 | 20085797 | SIGNOR-244164 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249646 |
| AKT | phosphorylation up-regulates → | CFLAR PSer273 | phosphorylation down-regulates ⊣ | CFLAR | 19339247 | SIGNOR-245304 |
| AKT | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-244322 |
| AKT | phosphorylation up-regulates → | EDC3 PSer161 | phosphorylation down-regulates ⊣ | EDC3 | 20051463 | SIGNOR-262631 |
| AKT | phosphorylation up-regulates → | SRPK2 PThr492 | phosphorylation up-regulates → | SRPK2 | 19592491 | SIGNOR-244341 |
| AKT | phosphorylation up-regulates → | ATG4B PSer34 | phosphorylation up-regulates → | ATG4B | 29165041 | SIGNOR-275836 |
| AKT | phosphorylation up-regulates → | NIBAN1 PSer602 | phosphorylation down-regulates ⊣ | NIBAN1 | 22510990 | SIGNOR-197053 |
| AKT | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245259 |
| AKT | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-252347 |
| AKT | phosphorylation up-regulates → | GATA2 PSer401 | phosphorylation down-regulates ⊣ | GATA2 | 15837948 | SIGNOR-244271 |
| AKT | phosphorylation up-regulates → | BCL2L11 PSer87 | phosphorylation down-regulates ⊣ | BCL2L11 | 16282323 | SIGNOR-141581 |
| AKT | phosphorylation up-regulates → | VCP PSer746 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-145288 |
| AKT | phosphorylation up-regulates → | PDE3B PSer295 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-70205 |
| AKT | phosphorylation up-regulates → | ZNF322 PThr262 | phosphorylation up-regulates → | ZNF322 | 31399647 | SIGNOR-276753 |
| AKT | phosphorylation up-regulates → | PIKFYVE PSer307 | phosphorylation up-regulates → | PIKFYVE | 15546921 | SIGNOR-130920 |
| AKT | phosphorylation up-regulates → | CDKN1C PThr310 | phosphorylation down-regulates ⊣ | CDKN1C | 23421998 | SIGNOR-201046 |
| AKT | phosphorylation up-regulates → | CLK2 PSer34 | phosphorylation up-regulates → | CLK2 | 20682768 | SIGNOR-244214 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-251485 |
| AKT | phosphorylation up-regulates → | USP14 PSer432 | phosphorylation up-regulates → | USP14 | 26523394 | SIGNOR-265055 |
| AKT | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-235411 |
| AKT | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11035810 | SIGNOR-83217 |
| AKT | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-244148 |
| AKT | phosphorylation up-regulates → | ADRB2 PSer345 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-114466 |
| AKT | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 16854453 | SIGNOR-244337 |
| AKT | phosphorylation up-regulates → | MAP2K4 PSer80 | phosphorylation down-regulates ⊣ | MAP2K4 | 11707464 | SIGNOR-275980 |
| AKT | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-244369 |
| AKT | phosphorylation up-regulates → | MST1R PSer1394 | phosphorylation up-regulates → | MST1R | 14505491 | SIGNOR-118053 |
| AKT | phosphorylation up-regulates → | NR3C1 PSer134 | phosphorylation down-regulates ⊣ | NR3C1 | 24291004 | SIGNOR-236216 |
| AKT | phosphorylation up-regulates → | CDK2 PThr39 | phosphorylation up-regulates → | CDK2 | 18354084 | SIGNOR-244176 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-251477 |
| AKT | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-251470 |
| AKT | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 12042314 | SIGNOR-244194 |
| AKT | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252825 |
| AKT | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244251 |
| AKT | phosphorylation up-regulates → | COPS6 PSer60 | phosphorylation up-regulates → | COPS6 | 23095642 | SIGNOR-199254 |
| AKT | phosphorylation up-regulates → | LARP6 PSer451 | phosphorylation up-regulates → | LARP6 | 26932461 | SIGNOR-273539 |
| AKT | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183620 |
| AKT | phosphorylation up-regulates → | KLHL3 PSer433 | phosphorylation up-regulates → | KLHL3 | 26435498 | SIGNOR-273825 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249647 |
| AKT | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164298 |
| AKT | phosphorylation up-regulates → | FOXO PSer256 | phosphorylation down-regulates ⊣ | FOXO | 10377430 | SIGNOR-252831 |
| AKT | phosphorylation up-regulates → | TBC1D4 PSer588 | phosphorylation down-regulates ⊣ | TBC1D4 | 11994271 | SIGNOR-245268 |
| AKT | phosphorylation up-regulates → | CCNF PSer577 | phosphorylation up-regulates → | CCNF | 28954236 | SIGNOR-266361 |
| AKT | phosphorylation up-regulates → | PEA15 PSer116 | phosphorylation up-regulates → | PEA15 | 12808093 | SIGNOR-244326 |
| AKT | phosphorylation up-regulates → | TAL1 PThr90 | phosphorylation down-regulates ⊣ | TAL1 | 15930267 | SIGNOR-137942 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-103462 |
| AKT | phosphorylation up-regulates → | ESR1 PSer106 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244247 |
| AKT | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 11108261 | SIGNOR-244255 |
| AKT | phosphorylation up-regulates → | XIAP PSer87 | phosphorylation up-regulates → | XIAP | 14645242 | SIGNOR-244377 |
| AKT | phosphorylation up-regulates → | BRAF PThr440 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244156 |
| AKT | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 11956222 | SIGNOR-244381 |
| AKT | phosphorylation up-regulates → | ZNF322 PSer224 | phosphorylation up-regulates → | ZNF322 | 31399647 | SIGNOR-276755 |
| AKT | phosphorylation up-regulates → | RANBP3 PSer57 | phosphorylation up-regulates → | RANBP3 | 18280241 | SIGNOR-276150 |
| AKT | phosphorylation up-regulates → | TBC1D7 PSer124 | phosphorylation up-regulates → | TBC1D7 | 30143532 | SIGNOR-273541 |
| AKT | phosphorylation up-regulates → | FOXO PThr24 | phosphorylation down-regulates ⊣ | FOXO | 10377430 | SIGNOR-252832 |
| AKT | phosphorylation up-regulates → | ADARB1 PThr553 | phosphorylation down-regulates ⊣ | ADARB1 | 31095429 | SIGNOR-266358 |
| AKT | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 10559253 | SIGNOR-72137 |
| AKT | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252821 |
| AKT | phosphorylation up-regulates → | SH2B2 PSer598 | phosphorylation up-regulates → | SH2B2 | 16141217 | SIGNOR-248042 |
| AKT | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244160 |
| AKT | phosphorylation up-regulates → | CARHSP1 PSer52 | phosphorylation down-regulates ⊣ | CARHSP1 | 15910284 | SIGNOR-137430 |
| AKT | phosphorylation up-regulates → | CCT2 PSer260 | phosphorylation down-regulates ⊣ | CCT2 | 19332537 | SIGNOR-244172 |
| AKT | phosphorylation up-regulates → | BEX1 PSer102 | phosphorylation up-regulates → | BEX1 | 16498402 | SIGNOR-262614 |
| AKT | phosphorylation up-regulates → | RAC1 PSer71 | phosphorylation down-regulates ⊣ | RAC1 | 10617634 | SIGNOR-248036 |
| AKT | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 19526459 | SIGNOR-186130 |
| AKT | phosphorylation up-regulates → | ARFIP2 PSer260 | phosphorylation down-regulates ⊣ | ARFIP2 | 15809304 | SIGNOR-135105 |
| AKT | phosphorylation up-regulates → | FOXO PSer319 | phosphorylation down-regulates ⊣ | FOXO | 11237865 | SIGNOR-252835 |
| AKT | phosphorylation up-regulates → | STK4 PThr120 | phosphorylation down-regulates ⊣ | STK4 | 19940129 | SIGNOR-161829 |
| AKT | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 20400976 | SIGNOR-244373 |
| AKT | phosphorylation up-regulates → | TKT PThr382 | phosphorylation up-regulates → | TKT | 24981175 | SIGNOR-265102 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-248031 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer262 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-251478 |
| AKT | phosphorylation up-regulates → | POU5F1 PThr235 | phosphorylation up-regulates → | POU5F1 | 23041284 | SIGNOR-242092 |
| AKT | phosphorylation up-regulates → | PDE3B PSer295 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-251483 |
| AKT | phosphorylation up-regulates → | LTB4R2 PThr324 | phosphorylation down-regulates ⊣ | LTB4R2 | 22044535 | SIGNOR-177019 |
| AKT | phosphorylation up-regulates → | HK2 PThr473 | phosphorylation up-regulates → | HK2 | 25323588 | SIGNOR-267576 |
| AKT | phosphorylation up-regulates → | SH2B2 PSer598 | phosphorylation down-regulates ⊣ | SH2B2 | 16141217 | SIGNOR-251487 |
| AKT | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-251474 |
| AKT | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 12588998 | SIGNOR-244275 |
| AKT | phosphorylation up-regulates → | AR PSer792 | phosphorylation down-regulates ⊣ | AR | 11404460 | SIGNOR-244136 |
| AKT | phosphorylation up-regulates → | DLC1 PSer766 | phosphorylation down-regulates ⊣ | DLC1 | 16338927 | SIGNOR-247997 |
| AKT | phosphorylation up-regulates → | RPS3 PThr70 | phosphorylation up-regulates → | RPS3 | 20605787 | SIGNOR-259816 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183616 |
| AKT | phosphorylation up-regulates → | BAX PSer184 | phosphorylation down-regulates ⊣ | BAX | 14766748 | SIGNOR-209651 |
| AKT | phosphorylation up-regulates → | FLNC PSer2233 | phosphorylation up-regulates → | FLNC | 32444788 | SIGNOR-262616 |
| AKT | phosphorylation up-regulates → | ITGB3 PThr779 | phosphorylation down-regulates ⊣ | ITGB3 | 10896934 | SIGNOR-251479 |
| AKT | phosphorylation up-regulates → | PRPH PSer59 | phosphorylation up-regulates → | PRPH | 17569669 | SIGNOR-262627 |
| AKT | phosphorylation up-regulates → | RNF11 PThr135 | phosphorylation down-regulates ⊣ | RNF11 | 16123141 | SIGNOR-248085 |
| AKT | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 16982699 | SIGNOR-244184 |
| AKT | phosphorylation up-regulates → | DNMT1 PSer143 | phosphorylation up-regulates → | DNMT1 | 21151116 | SIGNOR-244232 |
| AKT | phosphorylation up-regulates → | TBX3 PSer719 | phosphorylation up-regulates → | TBX3 | 25595898 | SIGNOR-244353 |
| AKT | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251628 |
| AKT | phosphorylation up-regulates → | IRAK1 PThr100 | phosphorylation down-regulates ⊣ | IRAK1 | 11976320 | SIGNOR-248008 |
| AKT | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-244365 |
| AKT | phosphorylation up-regulates → | RGCC PSer47 | phosphorylation up-regulates → | RGCC | 19162005 | SIGNOR-262628 |
| AKT | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 9381178 | SIGNOR-251469 |
| AKT | phosphorylation up-regulates → | KHSRP PSer193 | phosphorylation down-regulates ⊣ | KHSRP | 17177604 | SIGNOR-151216 |
| AKT | phosphorylation up-regulates → | MTOR PSer2448 | phosphorylation down-regulates ⊣ | MTOR | 10910062 | SIGNOR-244311 |
| AKT | phosphorylation up-regulates → | ACAP1 PSer554 | phosphorylation down-regulates ⊣ | ACAP1 | 16256741 | SIGNOR-141343 |
| AKT | phosphorylation up-regulates → | ZYX PSer142 | phosphorylation down-regulates ⊣ | ZYX | 17572661 | SIGNOR-244389 |
| AKT | phosphorylation up-regulates → | STK3 PThr384 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-244349 |
| AKT | phosphorylation up-regulates → | EZH2 PSer21 | phosphorylation down-regulates ⊣ | EZH2 | 16224021 | SIGNOR-244259 |
| AKT | phosphorylation up-regulates → | VIM PSer39 | phosphorylation up-regulates → | VIM | 20856200 | SIGNOR-167971 |
| AKT | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141424 |
| AKT | phosphorylation up-regulates → | TERT PSer227 | phosphorylation up-regulates → | TERT | 10224060 | SIGNOR-244361 |
| AKT | phosphorylation up-regulates → | TERT PSer824 | phosphorylation up-regulates → | TERT | 10224060 | SIGNOR-244357 |
| AKT | phosphorylation up-regulates → | BRAF PSer364 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-244152 |
| AKT | phosphorylation up-regulates → | HMOX1 PSer188 | phosphorylation down-regulates ⊣ | HMOX1 | 15581622 | SIGNOR-161283 |
| AKT | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-244292 |
| AKT | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-244202 |
| AKT | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 10529400 | SIGNOR-71480 |
| AKT | phosphorylation up-regulates → | FOXO PSer197 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252828 |
| AKT | phosphorylation up-regulates → | BMI1 PSer316 | phosphorylation up-regulates → | BMI1 | 22505453 | SIGNOR-249581 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141416 |
| AKT | phosphorylation up-regulates → | FOXO PSer262 | phosphorylation down-regulates ⊣ | FOXO | 10217147 | SIGNOR-252839 |
| AKT | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 10576741 | SIGNOR-72669 |
| AKT | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-114470 |
| AKT | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-247992 |
| AKT | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-244210 |
| AKT | phosphorylation up-regulates → | PALLD PSer1118 | phosphorylation down-regulates ⊣ | PALLD | 20471940 | SIGNOR-165497 |
| AKT | phosphorylation up-regulates → | CHEK1 PSer280 | phosphorylation down-regulates ⊣ | CHEK1 | 15107605 | SIGNOR-244206 |
| AKT | phosphorylation up-regulates → | ILF3 PSer647 | phosphorylation up-regulates → | ILF3 | 20870937 | SIGNOR-168169 |
| AKT | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-244296 |
| AKT | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 10559253 | SIGNOR-72133 |
| AKT | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249645 |
| AKT | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-251473 |
| AKT | phosphorylation up-regulates → | EP300 PSer1834 | phosphorylation up-regulates → | EP300 | 16926151 | SIGNOR-244236 |
| AKT | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation up-regulates → | MDM4 | 18356162 | SIGNOR-178063 |
| AKT | phosphorylation up-regulates → | ACOT4 PSer392 | phosphorylation up-regulates → | ACOT4 | 33148467 | SIGNOR-271821 |
| AKT | phosphorylation up-regulates → | YBX1 PSer102 | phosphorylation up-regulates → | YBX1 | 19036157 | SIGNOR-182493 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer457 | phosphorylation down-regulates ⊣ | PDCD4 | 16357133 | SIGNOR-143098 |
| AKT | phosphorylation up-regulates → | PIK3R6 PThr607 | phosphorylation up-regulates → | PIK3R6 | 25753393 | SIGNOR-275723 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 10521487 | SIGNOR-71419 |
| AKT | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 12062094 | SIGNOR-89696 |
| AKT | phosphorylation up-regulates → | CLK2 PThr127 | phosphorylation up-regulates → | CLK2 | 20682768 | SIGNOR-244218 |
| AKT | phosphorylation up-regulates → | TBC1D4 PThr642 | phosphorylation down-regulates ⊣ | TBC1D4 | 16880201 | SIGNOR-148342 |
| AKT | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 9346240 | SIGNOR-244144 |
| AKT | phosphorylation up-regulates → | PDE3B PSer318 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-248027 |
| AKT | phosphorylation up-regulates → | BRCA1 PThr509 | phosphorylation up-regulates → | BRCA1 | 17428466 | SIGNOR-244168 |
| AKT | phosphorylation up-regulates → | GRIN2C PSer1081 | phosphorylation up-regulates → | GRIN2C | 19477150 | SIGNOR-262620 |
| AKT | phosphorylation up-regulates → | FOXA2 PThr156 | phosphorylation down-regulates ⊣ | FOXA2 | 14500912 | SIGNOR-254974 |
| AKT | phosphorylation up-regulates → | ATXN1 PSer775 | phosphorylation up-regulates → | ATXN1 | 12757707 | SIGNOR-251468 |
| AKT | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186772 |
| AKT | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252830 |
| AKT | phosphorylation up-regulates → | TTC3 PSer378 | phosphorylation up-regulates → | TTC3 | 20059950 | SIGNOR-162984 |
| AKT | phosphorylation up-regulates → | SIK1 PSer435 | phosphorylation down-regulates ⊣ | SIK1 | 36806887 | SIGNOR-277835 |
| AKT | phosphorylation up-regulates → | FOXO PSer197 | phosphorylation down-regulates ⊣ | FOXO | 10217147 | SIGNOR-252838 |
| AKT | phosphorylation up-regulates → | HNRNPA1 PSer199 | phosphorylation down-regulates ⊣ | HNRNPA1 | 18562319 | SIGNOR-179059 |
| AKT | phosphorylation up-regulates → | MAP2K4 PSer80 | phosphorylation down-regulates ⊣ | MAP2K4 | 11707464 | SIGNOR-244285 |
| AKT | phosphorylation up-regulates → | NUAK1 PSer600 | phosphorylation up-regulates → | NUAK1 | 12409306 | SIGNOR-95247 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183612 |
| AKT | phosphorylation up-regulates → | S1PR1 PThr236 | phosphorylation up-regulates → | S1PR1 | 11583630 | SIGNOR-110845 |
| AKT | phosphorylation up-regulates → | PHF20 PSer291 | phosphorylation down-regulates ⊣ | PHF20 | 22334668 | SIGNOR-196112 |
| AKT | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245428 |
| AKT | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 18836482 | SIGNOR-181536 |
| AKT | phosphorylation up-regulates → | CDKN1C PSer282 | phosphorylation down-regulates ⊣ | CDKN1C | 23421998 | SIGNOR-201042 |
| AKT | phosphorylation up-regulates → | VCP PSer352 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-145284 |
| AKT | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 9373175 | SIGNOR-242578 |
| AKT | phosphorylation up-regulates → | HJURP PSer486 | phosphorylation up-regulates → | HJURP | 17256767 | SIGNOR-262623 |
| AKT | phosphorylation up-regulates → | ZNF322 PThr150 | phosphorylation up-regulates → | ZNF322 | 31399647 | SIGNOR-276754 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-251484 |
| AKT | phosphorylation up-regulates → | CCDC88A PSer1417 | phosphorylation down-regulates ⊣ | CCDC88A | 16139227 | SIGNOR-140216 |
| AKT | phosphorylation up-regulates → | MAP3K8 PSer413 | phosphorylation up-regulates → | MAP3K8 | 12138205 | SIGNOR-251481 |
| AKT | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-155532 |
| AKT | phosphorylation up-regulates → | TP53RK PSer250 | phosphorylation up-regulates → | TP53RK | 17712528 | SIGNOR-157467 |
| AKT | phosphorylation up-regulates → | NCOR1 PSer1450 | phosphorylation down-regulates ⊣ | NCOR1 | 23940660 | SIGNOR-244318 |
| AKT | phosphorylation up-regulates → | GABRB2 PSer472 | phosphorylation up-regulates → | GABRB2 | 12818177 | SIGNOR-262619 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-160982 |
| AKT | phosphorylation up-regulates → | METTL1 PSer27 | phosphorylation down-regulates ⊣ | METTL1 | 3627513 | SIGNOR-244307 |
| AKT | phosphorylation up-regulates → | WNK1 PThr60 | phosphorylation up-regulates → | WNK1 | 16081417 | SIGNOR-139391 |
| AKT | phosphorylation up-regulates → | DOCK6 PSer1194 | phosphorylation up-regulates → | DOCK6 | 23462102 | SIGNOR-275667 |
| AKT | phosphorylation up-regulates → | MDM2 PSer188 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-244300 |
| AKT | phosphorylation up-regulates → | RANBP3 PSer126 | phosphorylation down-regulates ⊣ | RANBP3 | 18280241 | SIGNOR-160900 |
| AKT | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252822 |
| AKT | phosphorylation up-regulates → | PLN PThr17 | phosphorylation down-regulates ⊣ | PLN | 19696029 | SIGNOR-252035 |
| AKT | phosphorylation up-regulates → | MAP3K8 PSer400 | phosphorylation up-regulates → | MAP3K8 | 12138205 | SIGNOR-251480 |
| AKT | phosphorylation up-regulates → | CCNF PThr31 | phosphorylation up-regulates → | CCNF | 28954236 | SIGNOR-266360 |
| AKT | phosphorylation up-regulates → | CDCA7 PThr163 | phosphorylation down-regulates ⊣ | CDCA7 | 23166294 | SIGNOR-199776 |
| AKT | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15531580 | SIGNOR-244263 |
| AKT | phosphorylation up-regulates → | FOXO PSer262 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252829 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-192260 |
| AKT | phosphorylation down-regulates | RARA | SIGNOR-143721 |
| AKT | phosphorylation → down-regulates activity | ADAR | SIGNOR-266357 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141420 |
| AKT | phosphorylation down-regulates | SKI | SIGNOR-188969 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244243 |
| AKT | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-244180 |
| AKT | phosphorylation → up-regulates | DLX5 | SIGNOR-244228 |
| AKT | phosphorylation → up-regulates | GATA1 | SIGNOR-244267 |
| AKT | phosphorylation down-regulates | YAP1 | SIGNOR-97485 |
| AKT | phosphorylation down-regulates | AR | SIGNOR-244140 |
| AKT | phosphorylation → up-regulates | ALYREF | SIGNOR-179054 |
| AKT | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-104646 |
| AKT | phosphorylation down-regulates | STK4 | SIGNOR-201121 |
| AKT | phosphorylation → up-regulates | DLX5 | SIGNOR-173976 |
| AKT | phosphorylation down-regulates | ZFP36L1 | SIGNOR-244385 |
| AKT | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-236929 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252349 |
| AKT | phosphorylation down-regulates | SH3RF1 | SIGNOR-155229 |
| AKT | phosphorylation down-regulates | HTRA2 | SIGNOR-153323 |
| AKT | phosphorylation → unknown | MTOR | SIGNOR-251482 |
| AKT | phosphorylation → up-regulates activity | RGCC | SIGNOR-262629 |
| AKT | phosphorylation → up-regulates | AGAP2 | SIGNOR-244132 |
| AKT | phosphorylation → up-regulates activity | CELF1 | SIGNOR-262615 |
| AKT | phosphorylation → down-regulates activity | NR4A1 | SIGNOR-105927 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252823 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252826 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252346 |
| AKT | phosphorylation → down-regulates activity | GSK3B/Axin/APC | SIGNOR-227952 |
| AKT | phosphorylation → up-regulates | CTNNB1 | SIGNOR-244222 |
| AKT | phosphorylation down-regulates | GSK3B | SIGNOR-255488 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252827 |
| AKT | phosphorylation → up-regulates activity | ARHGAP22 | SIGNOR-262613 |
| AKT | phosphorylation → up-regulates activity | ZNF322 | SIGNOR-276752 |
| AKT | phosphorylation → up-regulates | VCP | SIGNOR-145292 |
| AKT | phosphorylation down-regulates | MAP3K11 | SIGNOR-96062 |
| AKT | phosphorylation down-regulates | GAB2 | SIGNOR-113669 |
| AKT | phosphorylation down-regulates | STK3 | SIGNOR-244345 |
| AKT | phosphorylation → up-regulates | PFKFB3 | SIGNOR-137241 |
| AKT | phosphorylation → unknown | FANCA | SIGNOR-251476 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-150140 |
| AKT | phosphorylation → up-regulates | BRCA1 | SIGNOR-244164 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249646 |
| AKT | phosphorylation → down-regulates quantity | CFLAR | SIGNOR-245304 |
| AKT | phosphorylation → up-regulates | NOS3 | SIGNOR-244322 |
| AKT | phosphorylation → down-regulates activity | EDC3 | SIGNOR-262631 |
| AKT | phosphorylation → up-regulates | SRPK2 | SIGNOR-244341 |
| AKT | phosphorylation → up-regulates activity | ATG4B | SIGNOR-275836 |
| AKT | phosphorylation → unknown | NIBAN1 | SIGNOR-197053 |
| AKT | phosphorylation → unknown | ACLY | SIGNOR-245259 |
| AKT | phosphorylation → up-regulates activity | HK2 | SIGNOR-259985 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252347 |
| AKT | phosphorylation → down-regulates activity | GATA2 | SIGNOR-244271 |
| AKT | phosphorylation → down-regulates activity | BCL2L11 | SIGNOR-141581 |
| AKT | phosphorylation → up-regulates | VCP | SIGNOR-145288 |
| AKT | phosphorylation → up-regulates | PDE3B | SIGNOR-70205 |
| AKT | phosphorylation → up-regulates | SP7 | SIGNOR-174017 |
| AKT | phosphorylation → up-regulates activity | ZNF322 | SIGNOR-276753 |
| AKT | phosphorylation → up-regulates | PIKFYVE | SIGNOR-130920 |
| AKT | phosphorylation down-regulates | CDKN1C | SIGNOR-201046 |
| AKT | phosphorylation → up-regulates | CLK2 | SIGNOR-244214 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252833 |
| AKT | phosphorylation → unknown | PFKFB2 | SIGNOR-251485 |
| AKT | phosphorylation → up-regulates activity | USP14 | SIGNOR-265055 |
| AKT | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-235411 |
| AKT | phosphorylation down-regulates | GSK3A | SIGNOR-83217 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-244148 |
| AKT | phosphorylation down-regulates | ADRB2 | SIGNOR-114466 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-244337 |
| AKT | phosphorylation → down-regulates activity | MAP2K4 | SIGNOR-275980 |
| AKT | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244369 |
| AKT | phosphorylation → up-regulates | MST1R | SIGNOR-118053 |
| AKT | phosphorylation down-regulates | NR3C1 | SIGNOR-236216 |
| AKT | phosphorylation → up-regulates | CDK2 | SIGNOR-244176 |
| AKT | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251477 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-251470 |
| AKT | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-244194 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252825 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244251 |
| AKT | phosphorylation → up-regulates | COPS6 | SIGNOR-199254 |
| AKT | phosphorylation → up-regulates activity | LARP6 | SIGNOR-273539 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183620 |
| AKT | phosphorylation → up-regulates activity | KLHL3 | SIGNOR-273825 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249647 |
| AKT | phosphorylation down-regulates | STK3 | SIGNOR-164298 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252831 |
| AKT | phosphorylation → unknown | TBC1D4 | SIGNOR-245268 |
| AKT | phosphorylation → up-regulates activity | CCNF | SIGNOR-266361 |
| AKT | phosphorylation → up-regulates activity | PEA15 | SIGNOR-244326 |
| AKT | phosphorylation → up-regulates activity | ELK1 | SIGNOR-259029 |
| AKT | phosphorylation down-regulates | TAL1 | SIGNOR-137942 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-103462 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244247 |
| AKT | phosphorylation → up-regulates | ESR1 | SIGNOR-244255 |
| AKT | phosphorylation → up-regulates quantity by stabilization | XIAP | SIGNOR-244377 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244156 |
| AKT | phosphorylation → unknown | YWHAZ | SIGNOR-244381 |
| AKT | phosphorylation → up-regulates activity | ZNF322 | SIGNOR-276755 |
| AKT | phosphorylation → up-regulates quantity | RANBP3 | SIGNOR-276150 |
| AKT | phosphorylation → up-regulates quantity by stabilization | TBC1D7 | SIGNOR-273541 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252832 |
| AKT | phosphorylation → down-regulates activity | ADARB1 | SIGNOR-266358 |
| AKT | phosphorylation → up-regulates | NCF1 | SIGNOR-72137 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252821 |
| AKT | phosphorylation → up-regulates activity | SH2B2 | SIGNOR-248042 |
| AKT | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-252817 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244160 |
| AKT | phosphorylation → unknown | CARHSP1 | SIGNOR-137430 |
| AKT | phosphorylation → unknown | CCT2 | SIGNOR-244172 |
| AKT | phosphorylation → up-regulates quantity by stabilization | BEX1 | SIGNOR-262614 |
| AKT | phosphorylation → down-regulates activity | RAC1 | SIGNOR-248036 |
| AKT | phosphorylation down-regulates | MXD1 | SIGNOR-186130 |
| AKT | phosphorylation → up-regulates | EP300 | SIGNOR-244239 |
| AKT | phosphorylation → unknown | ARFIP2 | SIGNOR-135105 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252835 |
| AKT | phosphorylation down-regulates | STK4 | SIGNOR-161829 |
| AKT | phosphorylation → up-regulates | TWIST1 | SIGNOR-244373 |
| AKT | phosphorylation → up-regulates activity | TKT | SIGNOR-265102 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-248031 |
| AKT | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251478 |
| AKT | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-242092 |
| AKT | phosphorylation → up-regulates activity | PDE3B | SIGNOR-251483 |
| AKT | phosphorylation → unknown | LTB4R2 | SIGNOR-177019 |
| AKT | phosphorylation → up-regulates activity | HK2 | SIGNOR-267576 |
| AKT | phosphorylation → unknown | SH2B2 | SIGNOR-251487 |
| AKT | phosphorylation → up-regulates activity | CREB1 | SIGNOR-251474 |
| AKT | phosphorylation → down-regulates activity | H3-3A | SIGNOR-244275 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252824 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252836 |
| AKT | phosphorylation → down-regulates activity | AR | SIGNOR-244136 |
| AKT | phosphorylation → unknown | DLC1 | SIGNOR-247997 |
| AKT | phosphorylation → up-regulates activity | RPS3 | SIGNOR-259816 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183616 |
| AKT | phosphorylation → down-regulates activity | BAX | SIGNOR-209651 |
| AKT | phosphorylation → up-regulates quantity by stabilization | FLNC | SIGNOR-262616 |
| AKT | phosphorylation → down-regulates activity | ITGB3 | SIGNOR-251479 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-174021 |
| AKT | phosphorylation → up-regulates activity | PRPH | SIGNOR-262627 |
| AKT | phosphorylation → down-regulates quantity | RNF11 | SIGNOR-248085 |
| AKT | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-244184 |
| AKT | phosphorylation → up-regulates | DNMT1 | SIGNOR-244232 |
| AKT | phosphorylation → up-regulates activity | TBX3 | SIGNOR-244353 |
| AKT | phosphorylation down-regulates | FOXO6 | SIGNOR-66032 |
| AKT | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251628 |
| AKT | phosphorylation → down-regulates activity | IRAK1 | SIGNOR-248008 |
| AKT | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244365 |
| AKT | phosphorylation → up-regulates activity | RGCC | SIGNOR-262628 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-251469 |
| AKT | phosphorylation → down-regulates activity | KHSRP | SIGNOR-151216 |
| AKT | phosphorylation → unknown | MTOR | SIGNOR-244311 |
| AKT | phosphorylation → unknown | ACAP1 | SIGNOR-141343 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-277740 |
| AKT | phosphorylation down-regulates | ZYX | SIGNOR-244389 |
| AKT | phosphorylation down-regulates | STK3 | SIGNOR-244349 |
| AKT | phosphorylation → down-regulates activity | EZH2 | SIGNOR-244259 |
| AKT | phosphorylation → up-regulates quantity by stabilization | VIM | SIGNOR-167971 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141424 |
| AKT | phosphorylation → up-regulates | TERT | SIGNOR-244361 |
| AKT | phosphorylation → up-regulates | TERT | SIGNOR-244357 |
| AKT | phosphorylation down-regulates | BRAF | SIGNOR-244152 |
| AKT | phosphorylation → unknown | HMOX1 | SIGNOR-161283 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244292 |
| AKT | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-244202 |
| AKT | phosphorylation → down-regulates activity | CASP9 | SIGNOR-71480 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252828 |
| AKT | phosphorylation → up-regulates activity | BMI1 | SIGNOR-249581 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141416 |
| AKT | phosphorylation down-regulates | STK3/4 | SIGNOR-269944 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252839 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-72669 |
| AKT | phosphorylation down-regulates | ADRB2 | SIGNOR-114470 |
| AKT | phosphorylation → up-regulates activity | CREB1 | SIGNOR-247992 |
| AKT | phosphorylation → up-regulates | CHUK | SIGNOR-244210 |
| AKT | phosphorylation → unknown | PALLD | SIGNOR-165497 |
| AKT | phosphorylation → unknown | Histone H3 | SIGNOR-265319 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252820 |
| AKT | phosphorylation down-regulates | CHEK1 | SIGNOR-244206 |
| AKT | phosphorylation → up-regulates activity | ILF3 | SIGNOR-168169 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244296 |
| AKT | phosphorylation → up-regulates | NCF1 | SIGNOR-72133 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249645 |
| AKT | phosphorylation → up-regulates | IKK-complex | SIGNOR-244281 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-244333 |
| AKT | phosphorylation → down-regulates activity | CASP9 | SIGNOR-251473 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-278095 |
| AKT | phosphorylation → up-regulates | EP300 | SIGNOR-244236 |
| AKT | phosphorylation → up-regulates activity | MDM4 | SIGNOR-178063 |
| AKT | phosphorylation → up-regulates quantity by stabilization | ACOT4 | SIGNOR-271821 |
| AKT | phosphorylation → up-regulates | YBX1 | SIGNOR-182493 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-143098 |
| AKT | phosphorylation → up-regulates activity | PIK3R6 | SIGNOR-275723 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-71419 |
| AKT | phosphorylation → unknown | HTT | SIGNOR-89696 |
| AKT | phosphorylation → up-regulates | CLK2 | SIGNOR-244218 |
| AKT | phosphorylation → unknown | TBC1D4 | SIGNOR-148342 |
| AKT | phosphorylation → down-regulates activity | BAD | SIGNOR-244144 |
| AKT | phosphorylation → up-regulates activity | PDE3B | SIGNOR-248027 |
| AKT | phosphorylation → up-regulates | BRCA1 | SIGNOR-244168 |
| AKT | phosphorylation → up-regulates activity | GRIN2C | SIGNOR-262620 |
| AKT | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-252740 |
| AKT | phosphorylation → down-regulates activity | FOXA2 | SIGNOR-254974 |
| AKT | phosphorylation → up-regulates quantity by stabilization | ATXN1 | SIGNOR-251468 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252348 |
| AKT | phosphorylation down-regulates | HSPB1 | SIGNOR-186772 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252830 |
| AKT | phosphorylation → up-regulates | TTC3 | SIGNOR-162984 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252352 |
| AKT | phosphorylation → down-regulates activity | SIK1 | SIGNOR-277835 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252838 |
| AKT | phosphorylation down-regulates | HNRNPA1 | SIGNOR-179059 |
| AKT | phosphorylation down-regulates | MAP2K4 | SIGNOR-244285 |
| AKT | phosphorylation → up-regulates | NUAK1 | SIGNOR-95247 |
| AKT | phosphorylation down-regulates | TBC1D4 | SIGNOR-99300 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183612 |
| AKT | phosphorylation → up-regulates activity | S1PR1 | SIGNOR-110845 |
| AKT | phosphorylation down-regulates | PHF20 | SIGNOR-196112 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245428 |
| AKT | phosphorylation → up-regulates | EIF4B | SIGNOR-181536 |
| AKT | phosphorylation down-regulates | CDKN1C | SIGNOR-201042 |
| AKT | phosphorylation → up-regulates | VCP | SIGNOR-145284 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-242578 |
| AKT | phosphorylation → up-regulates activity | HJURP | SIGNOR-262623 |
| AKT | phosphorylation → up-regulates activity | ZNF322 | SIGNOR-276754 |
| AKT | phosphorylation → unknown | PFKFB2 | SIGNOR-251484 |
| AKT | phosphorylation → unknown | CCDC88A | SIGNOR-140216 |
| AKT | phosphorylation → up-regulates activity | MAP3K8 | SIGNOR-251481 |
| AKT | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-252350 |
| AKT | phosphorylation → up-regulates activity | Hexokinase | SIGNOR-267577 |
| AKT | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-155532 |
| AKT | phosphorylation → up-regulates | TP53RK | SIGNOR-157467 |
| AKT | phosphorylation down-regulates | NCOR1 | SIGNOR-244318 |
| AKT | phosphorylation → up-regulates activity | GABRB2 | SIGNOR-262619 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-160982 |
| AKT | phosphorylation down-regulates | METTL1 | SIGNOR-244307 |
| AKT | phosphorylation → up-regulates | WNK1 | SIGNOR-139391 |
| AKT | phosphorylation → up-regulates activity | DOCK6 | SIGNOR-275667 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244300 |
| AKT | phosphorylation → unknown | RANBP3 | SIGNOR-160900 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252822 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252834 |
| AKT | phosphorylation → down-regulates activity | PLN | SIGNOR-252035 |
| AKT | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-217586 |
| AKT | phosphorylation → up-regulates activity | MAP3K8 | SIGNOR-251480 |
| AKT | phosphorylation → up-regulates activity | CCNF | SIGNOR-266360 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-261526 |
| AKT | phosphorylation down-regulates | CDCA7 | SIGNOR-199776 |
| AKT | phosphorylation → up-regulates | EZR | SIGNOR-244263 |
| AKT | phosphorylation → down-regulates activity | TSC | SIGNOR-251526 |
| AKT | phosphorylation down-regulates | FOXA2 | SIGNOR-254978 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252829 |