| Name | AKT |
| ID | SIGNOR-PF24 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC2 | AKT | – | phosphorylation up-regulates activity | 21592956 | SIGNOR-251983 | |
| PPP1CA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248559 |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 12808134 | SIGNOR-134477 |
| ILK | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 9736715 | SIGNOR-60115 |
| PPP2CA | AKT | – | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248655 | |
| PIK3CA | AKT | – | phosphorylation up-regulates activity | 12167717 | SIGNOR-244429 | |
| MTOR | AKT | – | phosphorylation up-regulates activity | 21592956 | SIGNOR-244417 | |
| GSK3A | AKT | Thr312 | TMKTFCGtPEYLAPE | phosphorylation down-regulates activity | 23142783 | SIGNOR-252455 |
| MTOR | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-134185 |
| CSNK2A1 | AKT | Ser129 | SGSPSDNsGAEEMEV | phosphorylation up-regulates | 21735093 | SIGNOR-174691 |
| PP1 | AKT | – | dephosphorylation down-regulates activity | 14633703 | SIGNOR-264659 | |
| LRRK2 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 24916379 | SIGNOR-205115 |
| PPP2CA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248627 |
| CAMKK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 10833263 | SIGNOR-250714 |
| PPP2CB | AKT | – | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248614 | |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 15718470 | SIGNOR-243203 |
| PPP1CB | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248575 |
| SRC | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates activity | 11445557 | SIGNOR-246368 |
| PP2CA_R1A_R2A | AKT | – | dephosphorylation down-regulates activity | 18042541 | SIGNOR-243530 | |
| LRRK2 | AKT | – | phosphorylation up-regulates | 21658387 | SIGNOR-244410 | |
| PDPK1 | AKT | – | phosphorylation up-regulates activity | 15743829 | SIGNOR-244469 | |
| PHLPP1 | AKT | – | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248331 | |
| PTK6 | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-138437 |
| mTORC2 | AKT | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252454 |
| CCN4 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 11782444 | SIGNOR-256269 |
| FLT3 | AKT | – | phosphorylation up-regulates activity | 14981546 | SIGNOR-261522 | |
| PHLPP2 | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-135046 |
| mTORC2 | AKT | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252451 |
| mTORC2 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-217008 |
| PPP1CA | AKT | – | dephosphorylation down-regulates | 20186153 | SIGNOR-244436 | |
| TBK1 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21329883 | SIGNOR-172132 |
| PTPN1 | AKT | – | dephosphorylation down-regulates | 15632081 | SIGNOR-132959 | |
| ACP1 | AKT | – | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248458 | |
| PDPK2P | AKT | – | phosphorylation up-regulates | 15505410 | SIGNOR-129965 | |
| PTK6 | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 20606012 | SIGNOR-166506 |
| PPP2CA | AKT | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 11839802 | SIGNOR-114767 |
| PTPA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 21159657 | SIGNOR-170699 |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 10226025 | SIGNOR-244421 |
| PPP2CA | AKT | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248629 |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 9512493 | SIGNOR-244480 |
| PDPK1 | AKT | – | phosphorylation up-regulates | 21798082 | SIGNOR-244396 | |
| TNK2 | AKT | Tyr176 | EKATGRYyAMKILKK | phosphorylation up-regulates activity | 20333297 | SIGNOR-252457 |
| PHLPP1 | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-135005 |
| RET | AKT | – | phosphorylation up-regulates | 12242309 | SIGNOR-244443 | |
| mTORC2 | AKT | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 18566586 | SIGNOR-252448 |
| CSNK2A1 | AKT | – | phosphorylation up-regulates | 15818404 | SIGNOR-244400 | |
| PPP2R5B | AKT | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates | 16495456 | SIGNOR-144808 |
| PI3K | AKT | – | phosphorylation up-regulates activity | 15526160 | SIGNOR-254950 | |
| SRC | AKT | Tyr326 | EVLEDNDyGRAVDWW | phosphorylation up-regulates activity | 11445557 | SIGNOR-246377 |
| CyclinA2/CDK2 | AKT | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252450 |
| PHLPP2 | AKT | – | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248732 | |
| PPP1CC | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248502 |
| PRKDC | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 18439899 | SIGNOR-252447 |
| ILK | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 11313365 | SIGNOR-250261 |
| SRC | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates activity | 12600984 | SIGNOR-246373 |
| CyclinA2/CDK2 | AKT | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252453 |
| PPP2CB | AKT | – | dephosphorylation down-regulates | 8650155 | SIGNOR-42050 | |
| PTK6 | AKT | Tyr326 | EVLEDNDyGRAVDWW | phosphorylation up-regulates | 20606012 | SIGNOR-166510 |
| mTORC2 | AKT | – | phosphorylation up-regulates activity | 21157483 | SIGNOR-251982 | |
| RET | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-166514 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248559 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 12808134 | SIGNOR-134477 |
| ILK | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 9736715 | SIGNOR-60115 |
| GSK3A | phosphorylation up-regulates → | AKT PThr312 | phosphorylation down-regulates ⊣ | AKT | 23142783 | SIGNOR-252455 |
| MTOR | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-134185 |
| CSNK2A1 | phosphorylation up-regulates → | AKT PSer129 | phosphorylation up-regulates → | AKT | 21735093 | SIGNOR-174691 |
| LRRK2 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 24916379 | SIGNOR-205115 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15367694 | SIGNOR-248627 |
| CAMKK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 10833263 | SIGNOR-250714 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-243203 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248575 |
| SRC | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 11445557 | SIGNOR-246368 |
| PTK6 | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 15994200 | SIGNOR-138437 |
| mTORC2 | phosphorylation up-regulates → | AKT PThr479 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252454 |
| CCN4 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 11782444 | SIGNOR-256269 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15808505 | SIGNOR-135046 |
| mTORC2 | phosphorylation up-regulates → | AKT PSer477 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252451 |
| mTORC2 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-217008 |
| TBK1 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 21329883 | SIGNOR-172132 |
| PTK6 | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 20606012 | SIGNOR-166506 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PThr450 | dephosphorylation up-regulates → | AKT | 11839802 | SIGNOR-114767 |
| PTPA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 21159657 | SIGNOR-170699 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 10226025 | SIGNOR-244421 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PThr308 | dephosphorylation up-regulates → | AKT | 15367694 | SIGNOR-248629 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 9512493 | SIGNOR-244480 |
| TNK2 | phosphorylation up-regulates → | AKT PTyr176 | phosphorylation up-regulates → | AKT | 20333297 | SIGNOR-252457 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15808505 | SIGNOR-135005 |
| mTORC2 | phosphorylation up-regulates → | AKT PThr450 | phosphorylation up-regulates → | AKT | 18566586 | SIGNOR-252448 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | AKT PThr308 | dephosphorylation up-regulates → | AKT | 16495456 | SIGNOR-144808 |
| SRC | phosphorylation up-regulates → | AKT PTyr326 | phosphorylation up-regulates → | AKT | 11445557 | SIGNOR-246377 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT PSer477 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252450 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248502 |
| PRKDC | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 18439899 | SIGNOR-252447 |
| ILK | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 11313365 | SIGNOR-250261 |
| SRC | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 12600984 | SIGNOR-246373 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT PThr479 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252453 |
| PTK6 | phosphorylation up-regulates → | AKT PTyr326 | phosphorylation up-regulates → | AKT | 20606012 | SIGNOR-166510 |
| RET | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 15994200 | SIGNOR-166514 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-251983 |
| PPP1CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248559 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-134477 |
| ILK | phosphorylation → up-regulates | AKT | SIGNOR-60115 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248655 |
| PIK3CA | phosphorylation → up-regulates activity | AKT | SIGNOR-244429 |
| MTOR | phosphorylation → up-regulates activity | AKT | SIGNOR-244417 |
| GSK3A | phosphorylation → down-regulates activity | AKT | SIGNOR-252455 |
| MTOR | phosphorylation → up-regulates activity | AKT | SIGNOR-134185 |
| CSNK2A1 | phosphorylation → up-regulates | AKT | SIGNOR-174691 |
| PP1 | dephosphorylation → down-regulates activity | AKT | SIGNOR-264659 |
| LRRK2 | phosphorylation → up-regulates | AKT | SIGNOR-205115 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248627 |
| CAMKK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-250714 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT | SIGNOR-248614 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-243203 |
| PPP1CB | dephosphorylation → down-regulates activity | AKT | SIGNOR-248575 |
| SRC | phosphorylation → up-regulates activity | AKT | SIGNOR-246368 |
| PP2CA_R1A_R2A | dephosphorylation → down-regulates activity | AKT | SIGNOR-243530 |
| LRRK2 | phosphorylation → up-regulates | AKT | SIGNOR-244410 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-244469 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT | SIGNOR-248331 |
| PTK6 | phosphorylation → up-regulates | AKT | SIGNOR-138437 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252454 |
| CCN4 | phosphorylation → up-regulates activity | AKT | SIGNOR-256269 |
| FLT3 | phosphorylation → up-regulates activity | AKT | SIGNOR-261522 |
| PHLPP2 | dephosphorylation down-regulates | AKT | SIGNOR-135046 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252451 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-217008 |
| PPP1CA | dephosphorylation down-regulates | AKT | SIGNOR-244436 |
| TBK1 | phosphorylation → up-regulates | AKT | SIGNOR-172132 |
| PTPN1 | dephosphorylation down-regulates | AKT | SIGNOR-132959 |
| ACP1 | dephosphorylation → down-regulates activity | AKT | SIGNOR-248458 |
| PDPK2P | phosphorylation → up-regulates | AKT | SIGNOR-129965 |
| PTK6 | phosphorylation → up-regulates | AKT | SIGNOR-166506 |
| PPP2CA | dephosphorylation down-regulates | AKT | SIGNOR-114767 |
| PTPA | dephosphorylation down-regulates | AKT | SIGNOR-170699 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-244421 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248629 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-244480 |
| PDPK1 | phosphorylation → up-regulates | AKT | SIGNOR-244396 |
| TNK2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252457 |
| PHLPP1 | dephosphorylation down-regulates | AKT | SIGNOR-135005 |
| RET | phosphorylation → up-regulates | AKT | SIGNOR-244443 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252448 |
| CSNK2A1 | phosphorylation → up-regulates | AKT | SIGNOR-244400 |
| PPP2R5B | dephosphorylation down-regulates | AKT | SIGNOR-144808 |
| PI3K | phosphorylation → up-regulates activity | AKT | SIGNOR-254950 |
| SRC | phosphorylation → up-regulates activity | AKT | SIGNOR-246377 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252450 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT | SIGNOR-248732 |
| PPP1CC | dephosphorylation → down-regulates activity | AKT | SIGNOR-248502 |
| PRKDC | phosphorylation → up-regulates activity | AKT | SIGNOR-252447 |
| ILK | phosphorylation → up-regulates activity | AKT | SIGNOR-250261 |
| SRC | phosphorylation → up-regulates activity | AKT | SIGNOR-246373 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252453 |
| PPP2CB | dephosphorylation down-regulates | AKT | SIGNOR-42050 |
| PTK6 | phosphorylation → up-regulates | AKT | SIGNOR-166510 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-251982 |
| RET | phosphorylation → up-regulates | AKT | SIGNOR-166514 |