| Name | AKT_Thr308 |
| ID | SIGNOR-PF24 |
| Role | residue |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 15718470 | SIGNOR-243203 |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 10226025 | SIGNOR-244421 |
| PPP2R5B | AKT | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates | 16495456 | SIGNOR-144808 |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 12808134 | SIGNOR-134477 |
| PDPK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 9512493 | SIGNOR-244480 |
| CAMKK1 | AKT | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 10833263 | SIGNOR-250714 |
| PPP2CA | AKT | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248629 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-243203 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 10226025 | SIGNOR-244421 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | AKT PThr308 | dephosphorylation up-regulates → | AKT | 16495456 | SIGNOR-144808 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 12808134 | SIGNOR-134477 |
| PDPK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 9512493 | SIGNOR-244480 |
| CAMKK1 | phosphorylation up-regulates → | AKT PThr308 | phosphorylation up-regulates → | AKT | 10833263 | SIGNOR-250714 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PThr308 | dephosphorylation up-regulates → | AKT | 15367694 | SIGNOR-248629 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-243203 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-244421 |
| PPP2R5B | dephosphorylation down-regulates | AKT | SIGNOR-144808 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-134477 |
| PDPK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-244480 |
| CAMKK1 | phosphorylation → up-regulates activity | AKT | SIGNOR-250714 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248629 |