| Name | AKT_Thr450 |
| ID | SIGNOR-PF24 |
| Role | residue |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | AKT | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 11839802 | SIGNOR-114767 |
| mTORC2 | AKT | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 18566586 | SIGNOR-252448 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PThr450 | dephosphorylation up-regulates → | AKT | 11839802 | SIGNOR-114767 |
| mTORC2 | phosphorylation up-regulates → | AKT PThr450 | phosphorylation up-regulates → | AKT | 18566586 | SIGNOR-252448 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates | AKT | SIGNOR-114767 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252448 |