Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
TNK2	AKT	Tyr176	EKATGRYyAMKILKK	phosphorylation up-regulates activity	20333297	SIGNOR-252457

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
TNK2	phosphorylation up-regulates →	AKT PTyr176	phosphorylation up-regulates →	AKT	20333297	SIGNOR-252457

Regulator	Mechanism/Effect	Target	SIGNOR-ID
TNK2	phosphorylation → up-regulates activity	AKT	SIGNOR-252457