| Name | PHLPP1_Ser473 |
| ID | SIGNOR-PF24 |
| Role | residue |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-134185 |
| PPP1CB | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248575 |
| PPP1CA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248559 |
| PPP1CC | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248502 |
| PRKDC | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 18439899 | SIGNOR-252447 |
| PPP2CA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248627 |
| ILK | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 9736715 | SIGNOR-60115 |
| CCN4 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 11782444 | SIGNOR-256269 |
| PHLPP2 | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-135046 |
| mTORC2 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-217008 |
| PHLPP1 | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-135005 |
| LRRK2 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 24916379 | SIGNOR-205115 |
| ILK | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 11313365 | SIGNOR-250261 |
| TBK1 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21329883 | SIGNOR-172132 |
| PTPA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 21159657 | SIGNOR-170699 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-134185 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248575 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248559 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248502 |
| PRKDC | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 18439899 | SIGNOR-252447 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15367694 | SIGNOR-248627 |
| ILK | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 9736715 | SIGNOR-60115 |
| CCN4 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 11782444 | SIGNOR-256269 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15808505 | SIGNOR-135046 |
| mTORC2 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-217008 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15808505 | SIGNOR-135005 |
| LRRK2 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 24916379 | SIGNOR-205115 |
| ILK | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 11313365 | SIGNOR-250261 |
| TBK1 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 21329883 | SIGNOR-172132 |
| PTPA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 21159657 | SIGNOR-170699 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → up-regulates activity | AKT | SIGNOR-134185 |
| PPP1CB | dephosphorylation → down-regulates activity | AKT | SIGNOR-248575 |
| PPP1CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248559 |
| PPP1CC | dephosphorylation → down-regulates activity | AKT | SIGNOR-248502 |
| PRKDC | phosphorylation → up-regulates activity | AKT | SIGNOR-252447 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248627 |
| ILK | phosphorylation → up-regulates | AKT | SIGNOR-60115 |
| CCN4 | phosphorylation → up-regulates activity | AKT | SIGNOR-256269 |
| PHLPP2 | dephosphorylation down-regulates | AKT | SIGNOR-135046 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-217008 |
| PHLPP1 | dephosphorylation down-regulates | AKT | SIGNOR-135005 |
| LRRK2 | phosphorylation → up-regulates | AKT | SIGNOR-205115 |
| ILK | phosphorylation → up-regulates activity | AKT | SIGNOR-250261 |
| TBK1 | phosphorylation → up-regulates | AKT | SIGNOR-172132 |
| PTPA | dephosphorylation down-regulates | AKT | SIGNOR-170699 |