Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MEK1/2	TAL1	Ser122	DGRMVQLsPPALAAP	phosphorylation down-regulates	11904294	SIGNOR-244975
MEK1/2	MAPK3	–		phosphorylation up-regulates	12270934	SIGNOR-244798
MEK1/2	MAPK3	Thr202	HDHTGFLtEYVATRW	phosphorylation up-regulates	9677429	SIGNOR-244802
MEK1/2	MAPK3	Tyr204	HTGFLTEyVATRWYR	phosphorylation up-regulates	9677429	SIGNOR-244806
MEK1/2	MAPK3	–		phosphorylation up-regulates activity	11730323	SIGNOR-258991
MEK1/2	MAPK1	–		phosphorylation up-regulates activity	11730323	SIGNOR-258990
MEK1/2	MAPK1	Thr185	HDHTGFLtEYVATRW	phosphorylation up-regulates activity	11971971	SIGNOR-244792
MEK1/2	MAPK1	Tyr187	HTGFLTEyVATRWYR	phosphorylation up-regulates activity	11971971	SIGNOR-244788
MEK1/2	MAPK1	–		phosphorylation up-regulates activity	12270934	SIGNOR-244795
MEK1/2	IRS1	Ser307	TRRSRTEsITATSPA	phosphorylation down-regulates	11160134	SIGNOR-244784
MEK1/2	GSK3B	Tyr216	RGEPNVSyICSRYYR	phosphorylation up-regulates activity	15020233	SIGNOR-244780
MEK1/2	CASP9	–		phosphorylation down-regulates activity	12792650	SIGNOR-270222
MEK1/2	TIAM1	Ser329	DVNAGEGsEFADSGI	phosphorylation down-regulates quantity by destabilization	25124033	SIGNOR-276674
MEK1/2	ERK1/2	–		phosphorylation up-regulates	11971971	SIGNOR-244776
MEK1/2	ERK1/2	–		phosphorylation up-regulates activity	11730323	SIGNOR-258989
MEK1/2	Gbeta	–		phosphorylation up-regulates	12270934	SIGNOR-269913

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MEK1/2	phosphorylation up-regulates →	TAL1 PSer122	phosphorylation down-regulates ⊣	TAL1	11904294	SIGNOR-244975
MEK1/2	phosphorylation up-regulates →	MAPK3 PThr202	phosphorylation up-regulates →	MAPK3	9677429	SIGNOR-244802
MEK1/2	phosphorylation up-regulates →	MAPK3 PTyr204	phosphorylation up-regulates →	MAPK3	9677429	SIGNOR-244806
MEK1/2	phosphorylation up-regulates →	MAPK1 PThr185	phosphorylation up-regulates →	MAPK1	11971971	SIGNOR-244792
MEK1/2	phosphorylation up-regulates →	MAPK1 PTyr187	phosphorylation up-regulates →	MAPK1	11971971	SIGNOR-244788
MEK1/2	phosphorylation up-regulates →	IRS1 PSer307	phosphorylation down-regulates ⊣	IRS1	11160134	SIGNOR-244784
MEK1/2	phosphorylation up-regulates →	GSK3B PTyr216	phosphorylation up-regulates →	GSK3B	15020233	SIGNOR-244780
MEK1/2	phosphorylation up-regulates →	TIAM1 PSer329	phosphorylation down-regulates ⊣	TIAM1	25124033	SIGNOR-276674

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MEK1/2	phosphorylation down-regulates	TAL1	SIGNOR-244975
MEK1/2	phosphorylation → up-regulates	MAPK3	SIGNOR-244798
MEK1/2	phosphorylation → up-regulates	MAPK3	SIGNOR-244802
MEK1/2	phosphorylation → up-regulates	MAPK3	SIGNOR-244806
MEK1/2	phosphorylation → up-regulates activity	MAPK3	SIGNOR-258991
MEK1/2	phosphorylation → up-regulates activity	MAPK1	SIGNOR-258990
MEK1/2	phosphorylation → up-regulates activity	MAPK1	SIGNOR-244792
MEK1/2	phosphorylation → up-regulates activity	MAPK1	SIGNOR-244788
MEK1/2	phosphorylation → up-regulates activity	MAPK1	SIGNOR-244795
MEK1/2	phosphorylation down-regulates	IRS1	SIGNOR-244784
MEK1/2	phosphorylation → up-regulates activity	GSK3B	SIGNOR-244780
MEK1/2	phosphorylation → down-regulates activity	CASP9	SIGNOR-270222
MEK1/2	phosphorylation down-regulates quantity by destabilization	TIAM1	SIGNOR-276674
MEK1/2	phosphorylation → up-regulates	ERK1/2	SIGNOR-244776
MEK1/2	phosphorylation → up-regulates activity	ERK1/2	SIGNOR-258989
MEK1/2	phosphorylation → up-regulates	Gbeta	SIGNOR-269913