| Name | MEK1/2 |
| ID | SIGNOR-PF25 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | MEK1/2 | – | phosphorylation down-regulates activity | 10567369 | SIGNOR-244858 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates | 8668348 | SIGNOR-244843 | |
| RAF1 | MEK1/2 | – | phosphorylation up-regulates | 11018021 | SIGNOR-244952 | |
| RAF1 | MEK1/2 | – | phosphorylation up-regulates activity | 11018021 | SIGNOR-244945 | |
| MAPK1 | MEK1/2 | – | phosphorylation down-regulates activity | 10567369 | SIGNOR-244912 | |
| MAP3K2 | MEK1/2 | – | phosphorylation up-regulates | 11343802 | SIGNOR-244888 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates activity | 8413257 | SIGNOR-244831 | |
| MAP3K8 | MEK1/2 | – | phosphorylation up-regulates | 8131746 | SIGNOR-244892 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates activity | 8131746 | SIGNOR-244827 | |
| ERK1/2 | MEK1/2 | – | phosphorylation down-regulates activity | 14993270 | SIGNOR-244862 | |
| BRAF | MEK1/2 | – | phosphorylation up-regulates activity | 21900390 | SIGNOR-251988 | |
| MAPK1 | MEK1/2 | – | phosphorylation down-regulates activity | 14993270 | SIGNOR-244916 | |
| PDPK1 | MEK1/2 | – | phosphorylation up-regulates | 15175348 | SIGNOR-244938 | |
| ARAF | MEK1/2 | – | phosphorylation up-regulates | 21779497 | SIGNOR-244809 | |
| PDPK1 | MEK1/2 | – | phosphorylation up-regulates activity | 15175348 | SIGNOR-244934 | |
| CDK1 | MEK1/2 | – | phosphorylation down-regulates | 8114697 | SIGNOR-244847 | |
| MAP3K8 | MEK1/2 | – | phosphorylation up-regulates | 15466476 | SIGNOR-244904 | |
| ARAF | MEK1/2 | – | phosphorylation up-regulates | 8621729 | SIGNOR-244813 | |
| PAK | MEK1/2 | – | phosphorylation up-regulates | 16129686 | SIGNOR-244920 | |
| PAK1 | MEK1/2 | – | phosphorylation up-regulates activity | 12876277 | SIGNOR-244924 | |
| MAP3K1 | MEK1/2 | – | phosphorylation up-regulates activity | 8131746 | SIGNOR-244881 | |
| PPP2CA | MEK1/2 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-244941 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → down-regulates activity | MEK1/2 | SIGNOR-244858 |
| BRAF | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244843 |
| RAF1 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244952 |
| RAF1 | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244945 |
| MAPK1 | phosphorylation → down-regulates activity | MEK1/2 | SIGNOR-244912 |
| MAP3K2 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244888 |
| BRAF | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244831 |
| MAP3K8 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244892 |
| BRAF | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244827 |
| ERK1/2 | phosphorylation → down-regulates activity | MEK1/2 | SIGNOR-244862 |
| BRAF | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-251988 |
| MAPK1 | phosphorylation → down-regulates activity | MEK1/2 | SIGNOR-244916 |
| PDPK1 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244938 |
| ARAF | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244809 |
| PDPK1 | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244934 |
| CDK1 | phosphorylation down-regulates | MEK1/2 | SIGNOR-244847 |
| MAP3K8 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244904 |
| ARAF | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244813 |
| PAK | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244920 |
| PAK1 | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244924 |
| MAP3K1 | phosphorylation → up-regulates activity | MEK1/2 | SIGNOR-244881 |
| PPP2CA | dephosphorylation down-regulates | MEK1/2 | SIGNOR-244941 |