| Name | RPS6K |
| ID | SIGNOR-PF26 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 11500364 | SIGNOR-252775 |
| RPS6K | MITF | Ser409 | HGLSLIPsTGLCSPD | phosphorylation down-regulates | 10673502 | SIGNOR-252791 |
| RPS6K | MITF | Ser409 | HGLSLIPsTGLCSPD | phosphorylation down-regulates | 21749389 | SIGNOR-252795 |
| RPS6K | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 16055710 | SIGNOR-262998 |
| RPS6K | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-252789 |
| RPS6K | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-252807 |
| RPS6K | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates activity | 10558990 | SIGNOR-252782 |
| RPS6K | SLC9A1 | Ser703 | MSRARIGsDPLAYEP | phosphorylation up-regulates | 10400637 | SIGNOR-252792 |
| RPS6K | FLNA | Ser2152 | TRRRRAPsVANVGSH | phosphorylation up-regulates | 15024089 | SIGNOR-252790 |
| RPS6K | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 15071500 | SIGNOR-252783 |
| RPS6K | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation up-regulates activity | 23429703 | SIGNOR-267197 |
| RPS6K | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 23708659 | SIGNOR-252793 |
| RPS6K | CDC25A | Ser295 | TKRRKSMsGASPKES | phosphorylation down-regulates | 23708659 | SIGNOR-252776 |
| RPS6K | CDC25B | Ser353 | VQNKRRRsVTPPEEQ | phosphorylation up-regulates | 23708659 | SIGNOR-252781 |
| RPS6K | CDC25B | Thr355 | NKRRRSVtPPEEQQE | phosphorylation up-regulates | 23708659 | SIGNOR-252779 |
| RPS6K | L1CAM | Ser1152 | RSKGGKYsVKDKEDT | phosphorylation up-regulates activity | 8663493 | SIGNOR-252766 |
| RPS6K | IRS1 | – | phosphorylation down-regulates quantity by destabilization | 21798082 | SIGNOR-252787 | |
| RPS6K | MTOR | Ser2448 | RSRTRTDsYSAGQSV | phosphorylation down-regulates activity | 15905173 | SIGNOR-137251 |
| RPS6K | MTOR | Thr2446 | NKRSRTRtDSYSAGQ | phosphorylation down-regulates activity | 15905173 | SIGNOR-137255 |
| RPS6K | TSC2 | Ser1798 | GQRKRLIsSVEDFTE | phosphorylation down-regulates | 15342917 | SIGNOR-252801 |
| RPS6K | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 11584304 | SIGNOR-252788 |
| RPS6K | ETV1 | Ser191 | HRFRRQLsEPCNSFP | phosphorylation up-regulates activity | 12213813 | SIGNOR-252768 |
| RPS6K | ETV1 | Ser216 | PMYQRQMsEPNIPFP | phosphorylation up-regulates activity | 12213813 | SIGNOR-252769 |
| RPS6K | VASP | Thr278 | LARRRKAtQVGEKTP | phosphorylation down-regulates | 21423205 | SIGNOR-252802 |
| RPS6K | RPS6 | Ser235 | IAKRRRLsSLRASTS | phosphorylation up-regulates | 17360704 | SIGNOR-252813 |
| RPS6K | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation up-regulates | 17360704 | SIGNOR-252812 |
| RPS6K | RPS6 | Ser240 | RLSSLRAsTSKSESS | phosphorylation up-regulates | 21233202 | SIGNOR-252765 |
| RPS6K | RPS6 | Ser244 | LRASTSKsESSQK | phosphorylation up-regulates | 21233202 | SIGNOR-252764 |
| RPS6K | YBX1 | Ser102 | NPRKYLRsVGDGETV | phosphorylation up-regulates | 19036157 | SIGNOR-252804 |
| RPS6K | CCT2 | Ser260 | GSRVRVDsTAKVAEI | phosphorylation up-regulates | 21440620 | SIGNOR-252780 |
| RPS6K | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-252815 |
| RPS6K | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-252806 |
| RPS6K | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-252808 |
| RPS6K | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-252811 |
| RPS6K | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-252805 |
| RPS6K | PPP1R3A | Ser46 | PQPSRRGsDSSEDIY | phosphorylation up-regulates activity | 10648825 | SIGNOR-252777 |
| RPS6K | WWC1 | Ser947 | CRLNRSDsDSSTLSK | phosphorylation up-regulates | 24269383 | SIGNOR-252809 |
| RPS6K | WWC1 | Thr929 | STIIRSKtFSPGPQS | phosphorylation up-regulates | 24269383 | SIGNOR-252810 |
| RPS6K | RPTOR | Ser719 | PCTPRLRsVSSYGNI | phosphorylation up-regulates | 18722121 | SIGNOR-252772 |
| RPS6K | RPTOR | Ser721 | TPRLRSVsSYGNIRA | phosphorylation up-regulates | 18722121 | SIGNOR-252774 |
| RPS6K | RPTOR | Ser722 | PRLRSVSsYGNIRAV | phosphorylation up-regulates | 18722121 | SIGNOR-252773 |
| RPS6K | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-252797 |
| RPS6K | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-252798 |
| RPS6K | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-252799 |
| RPS6K | NR4A3 | Ser376 | GRRGRLPsKPKSPLQ | phosphorylation down-regulates activity | 16223362 | SIGNOR-252771 |
| RPS6K | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-252786 |
| RPS6K | BAD | Ser153 | SWTRVFQsWWDRNLG | phosphorylation down-regulates activity | 10837486 | SIGNOR-252767 |
| RPS6K | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 18246127 | SIGNOR-252784 |
| RPS6K | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-252778 |
| RPS6K | RANBP3 | Ser126 | VKRERTSsLTQFPPS | phosphorylation unknown | 18280241 | SIGNOR-252770 |
| RPS6K | METTL1 | Ser27 | YYRQRAHsNPMADHT | phosphorylation down-regulates | 15861136 | SIGNOR-252800 |
| RPS6K | CARHSP1 | Ser52 | TRRTRTFsATVRASQ | phosphorylation unknown | 15910284 | SIGNOR-252814 |
| RPS6K | TSC | – | phosphorylation down-regulates activity | 15342917 | SIGNOR-256311 | |
| RPS6K | mTORC1 | – | phosphorylation up-regulates | 18722121 | SIGNOR-252794 | |
| RPS6K | mTORC1 | – | phosphorylation up-regulates activity | 15342917 | SIGNOR-252796 | |
| RPS6K | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 20048145 | SIGNOR-252785 |
| RPS6K | Histone H3 | – | phosphorylation down-regulates activity | 10464286 | SIGNOR-265345 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 11500364 | SIGNOR-252775 |
| RPS6K | phosphorylation up-regulates → | MITF PSer409 | phosphorylation down-regulates ⊣ | MITF | 10673502 | SIGNOR-252791 |
| RPS6K | phosphorylation up-regulates → | MITF PSer409 | phosphorylation down-regulates ⊣ | MITF | 21749389 | SIGNOR-252795 |
| RPS6K | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262998 |
| RPS6K | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-252789 |
| RPS6K | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-252807 |
| RPS6K | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 10558990 | SIGNOR-252782 |
| RPS6K | phosphorylation up-regulates → | SLC9A1 PSer703 | phosphorylation up-regulates → | SLC9A1 | 10400637 | SIGNOR-252792 |
| RPS6K | phosphorylation up-regulates → | FLNA PSer2152 | phosphorylation up-regulates → | FLNA | 15024089 | SIGNOR-252790 |
| RPS6K | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 15071500 | SIGNOR-252783 |
| RPS6K | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation up-regulates → | CAD | 23429703 | SIGNOR-267197 |
| RPS6K | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-252793 |
| RPS6K | phosphorylation up-regulates → | CDC25A PSer295 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-252776 |
| RPS6K | phosphorylation up-regulates → | CDC25B PSer353 | phosphorylation up-regulates → | CDC25B | 23708659 | SIGNOR-252781 |
| RPS6K | phosphorylation up-regulates → | CDC25B PThr355 | phosphorylation up-regulates → | CDC25B | 23708659 | SIGNOR-252779 |
| RPS6K | phosphorylation up-regulates → | L1CAM PSer1152 | phosphorylation up-regulates → | L1CAM | 8663493 | SIGNOR-252766 |
| RPS6K | phosphorylation up-regulates → | MTOR PSer2448 | phosphorylation down-regulates ⊣ | MTOR | 15905173 | SIGNOR-137251 |
| RPS6K | phosphorylation up-regulates → | MTOR PThr2446 | phosphorylation down-regulates ⊣ | MTOR | 15905173 | SIGNOR-137255 |
| RPS6K | phosphorylation up-regulates → | TSC2 PSer1798 | phosphorylation down-regulates ⊣ | TSC2 | 15342917 | SIGNOR-252801 |
| RPS6K | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 11584304 | SIGNOR-252788 |
| RPS6K | phosphorylation up-regulates → | ETV1 PSer191 | phosphorylation up-regulates → | ETV1 | 12213813 | SIGNOR-252768 |
| RPS6K | phosphorylation up-regulates → | ETV1 PSer216 | phosphorylation up-regulates → | ETV1 | 12213813 | SIGNOR-252769 |
| RPS6K | phosphorylation up-regulates → | VASP PThr278 | phosphorylation down-regulates ⊣ | VASP | 21423205 | SIGNOR-252802 |
| RPS6K | phosphorylation up-regulates → | RPS6 PSer235 | phosphorylation up-regulates → | RPS6 | 17360704 | SIGNOR-252813 |
| RPS6K | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation up-regulates → | RPS6 | 17360704 | SIGNOR-252812 |
| RPS6K | phosphorylation up-regulates → | RPS6 PSer240 | phosphorylation up-regulates → | RPS6 | 21233202 | SIGNOR-252765 |
| RPS6K | phosphorylation up-regulates → | RPS6 PSer244 | phosphorylation up-regulates → | RPS6 | 21233202 | SIGNOR-252764 |
| RPS6K | phosphorylation up-regulates → | YBX1 PSer102 | phosphorylation up-regulates → | YBX1 | 19036157 | SIGNOR-252804 |
| RPS6K | phosphorylation up-regulates → | CCT2 PSer260 | phosphorylation up-regulates → | CCT2 | 21440620 | SIGNOR-252780 |
| RPS6K | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 10464286 | SIGNOR-252815 |
| RPS6K | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 14625384 | SIGNOR-252806 |
| RPS6K | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15994958 | SIGNOR-252808 |
| RPS6K | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-252811 |
| RPS6K | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-252805 |
| RPS6K | phosphorylation up-regulates → | PPP1R3A PSer46 | phosphorylation up-regulates → | PPP1R3A | 10648825 | SIGNOR-252777 |
| RPS6K | phosphorylation up-regulates → | WWC1 PSer947 | phosphorylation up-regulates → | WWC1 | 24269383 | SIGNOR-252809 |
| RPS6K | phosphorylation up-regulates → | WWC1 PThr929 | phosphorylation up-regulates → | WWC1 | 24269383 | SIGNOR-252810 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer719 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252772 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer721 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252774 |
| RPS6K | phosphorylation up-regulates → | RPTOR PSer722 | phosphorylation up-regulates → | RPTOR | 18722121 | SIGNOR-252773 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252797 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252798 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252799 |
| RPS6K | phosphorylation up-regulates → | NR4A3 PSer376 | phosphorylation down-regulates ⊣ | NR4A3 | 16223362 | SIGNOR-252771 |
| RPS6K | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-252786 |
| RPS6K | phosphorylation up-regulates → | BAD PSer153 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-252767 |
| RPS6K | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 18246127 | SIGNOR-252784 |
| RPS6K | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-252778 |
| RPS6K | phosphorylation up-regulates → | RANBP3 PSer126 | phosphorylation down-regulates ⊣ | RANBP3 | 18280241 | SIGNOR-252770 |
| RPS6K | phosphorylation up-regulates → | METTL1 PSer27 | phosphorylation down-regulates ⊣ | METTL1 | 15861136 | SIGNOR-252800 |
| RPS6K | phosphorylation up-regulates → | CARHSP1 PSer52 | phosphorylation down-regulates ⊣ | CARHSP1 | 15910284 | SIGNOR-252814 |
| RPS6K | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 20048145 | SIGNOR-252785 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation → down-regulates activity | EEF2K | SIGNOR-252775 |
| RPS6K | phosphorylation down-regulates | MITF | SIGNOR-252791 |
| RPS6K | phosphorylation down-regulates | MITF | SIGNOR-252795 |
| RPS6K | phosphorylation → up-regulates activity | FOS | SIGNOR-262998 |
| RPS6K | phosphorylation → up-regulates activity | FOS | SIGNOR-252789 |
| RPS6K | phosphorylation → up-regulates | ESR1 | SIGNOR-252807 |
| RPS6K | phosphorylation → up-regulates activity | CREB1 | SIGNOR-252782 |
| RPS6K | phosphorylation → up-regulates | SLC9A1 | SIGNOR-252792 |
| RPS6K | phosphorylation → up-regulates | FLNA | SIGNOR-252790 |
| RPS6K | phosphorylation → up-regulates | EIF4B | SIGNOR-252783 |
| RPS6K | phosphorylation → up-regulates activity | CAD | SIGNOR-267197 |
| RPS6K | phosphorylation down-regulates | CDC25A | SIGNOR-252793 |
| RPS6K | phosphorylation down-regulates | CDC25A | SIGNOR-252776 |
| RPS6K | phosphorylation → up-regulates | CDC25B | SIGNOR-252781 |
| RPS6K | phosphorylation → up-regulates | CDC25B | SIGNOR-252779 |
| RPS6K | phosphorylation → up-regulates activity | L1CAM | SIGNOR-252766 |
| RPS6K | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-252787 |
| RPS6K | phosphorylation → down-regulates activity | MTOR | SIGNOR-137251 |
| RPS6K | phosphorylation → down-regulates activity | MTOR | SIGNOR-137255 |
| RPS6K | phosphorylation down-regulates | TSC2 | SIGNOR-252801 |
| RPS6K | phosphorylation down-regulates | GSK3B | SIGNOR-252788 |
| RPS6K | phosphorylation → up-regulates activity | ETV1 | SIGNOR-252768 |
| RPS6K | phosphorylation → up-regulates activity | ETV1 | SIGNOR-252769 |
| RPS6K | phosphorylation down-regulates | VASP | SIGNOR-252802 |
| RPS6K | phosphorylation → up-regulates | RPS6 | SIGNOR-252813 |
| RPS6K | phosphorylation → up-regulates | RPS6 | SIGNOR-252812 |
| RPS6K | phosphorylation → up-regulates | RPS6 | SIGNOR-252765 |
| RPS6K | phosphorylation → up-regulates | RPS6 | SIGNOR-252764 |
| RPS6K | phosphorylation → up-regulates | YBX1 | SIGNOR-252804 |
| RPS6K | phosphorylation → up-regulates | CCT2 | SIGNOR-252780 |
| RPS6K | phosphorylation → down-regulates activity | H3-3A | SIGNOR-252815 |
| RPS6K | phosphorylation → down-regulates activity | H3-3A | SIGNOR-252806 |
| RPS6K | phosphorylation → down-regulates activity | H3-3A | SIGNOR-252808 |
| RPS6K | phosphorylation down-regulates | MXD1 | SIGNOR-252811 |
| RPS6K | phosphorylation → down-regulates activity | STK11 | SIGNOR-252805 |
| RPS6K | phosphorylation → up-regulates activity | PPP1R3A | SIGNOR-252777 |
| RPS6K | phosphorylation → up-regulates | WWC1 | SIGNOR-252809 |
| RPS6K | phosphorylation → up-regulates | WWC1 | SIGNOR-252810 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252772 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252774 |
| RPS6K | phosphorylation → up-regulates | RPTOR | SIGNOR-252773 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252797 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252798 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252799 |
| RPS6K | phosphorylation → down-regulates activity | NR4A3 | SIGNOR-252771 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252786 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252767 |
| RPS6K | phosphorylation → down-regulates activity | BAD | SIGNOR-252784 |
| RPS6K | phosphorylation down-regulates | CIC | SIGNOR-252778 |
| RPS6K | phosphorylation → unknown | RANBP3 | SIGNOR-252770 |
| RPS6K | phosphorylation down-regulates | METTL1 | SIGNOR-252800 |
| RPS6K | phosphorylation → unknown | CARHSP1 | SIGNOR-252814 |
| RPS6K | phosphorylation → down-regulates activity | TSC | SIGNOR-256311 |
| RPS6K | phosphorylation → up-regulates | mTORC1 | SIGNOR-252794 |
| RPS6K | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-252796 |
| RPS6K | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252785 |
| RPS6K | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265345 |