| Name | RPS6K |
| ID | SIGNOR-PF26 |
| Role | substrate |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | RPS6K | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-252757 |
| MAPK1 | RPS6K | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-252747 |
| GSK3B | RPS6K | – | phosphorylation up-regulates activity | 33081032 | SIGNOR-263513 | |
| PDPK1 | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 10480933 | SIGNOR-252763 |
| MTOR | RPS6K | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255841 |
| MAPK3 | RPS6K | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-252761 |
| Gbeta | RPS6K | – | phosphorylation up-regulates activity | 12832467 | SIGNOR-270006 | |
| MAPK1 | RPS6K | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-252748 |
| MAPK3 | RPS6K | – | phosphorylation up-regulates activity | 12832467 | SIGNOR-252760 | |
| MAPK3 | RPS6K | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-252755 |
| mTORC1 | RPS6K | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255842 |
| ERK1/2 | RPS6K | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-252746 |
| MAPK1 | RPS6K | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9687510 | SIGNOR-252753 |
| MAPK1 | RPS6K | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-252754 |
| ERK1/2 | RPS6K | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-252745 |
| MAPK1 | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-252750 |
| MAPK1 | RPS6K | – | phosphorylation up-regulates activity | 12832467 | SIGNOR-252749 | |
| ERK1/2 | RPS6K | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-252744 |
| ERK1/2 | RPS6K | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-252743 |
| ERK1/2 | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-252741 |
| MAPK3 | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-252758 |
| MAPK3 | RPS6K | – | phosphorylation up-regulates activity | 8387505 | SIGNOR-252762 | |
| RPS6K | RPS6K | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 20048145 | SIGNOR-252785 |
| ERK1/2 | RPS6K | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-252742 |
| MAPK3 | RPS6K | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-252759 |
| MAPK3 | RPS6K | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-252756 |
| MAPK1 | RPS6K | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-252751 |
| MAPK1 | RPS6K | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-252752 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | RPS6K PThr573 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252757 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PSer732 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252747 |
| PDPK1 | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 10480933 | SIGNOR-252763 |
| MTOR | phosphorylation up-regulates → | RPS6K PThr390 | phosphorylation up-regulates → | RPS6K | 11914378 | SIGNOR-255841 |
| MAPK3 | phosphorylation up-regulates → | RPS6K PSer732 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252761 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PSer380 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252748 |
| MAPK3 | phosphorylation up-regulates → | RPS6K PThr359 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252755 |
| mTORC1 | phosphorylation up-regulates → | RPS6K PThr390 | phosphorylation up-regulates → | RPS6K | 11914378 | SIGNOR-255842 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer380 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252746 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PThr573 | phosphorylation up-regulates → | RPS6K | 9687510 | SIGNOR-252753 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PSer363 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252754 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PThr359 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252745 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252750 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer732 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252744 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PThr573 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252743 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252741 |
| MAPK3 | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252758 |
| RPS6K | phosphorylation up-regulates → | RPS6K PSer221 | phosphorylation up-regulates → | RPS6K | 20048145 | SIGNOR-252785 |
| ERK1/2 | phosphorylation up-regulates → | RPS6K PSer363 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252742 |
| MAPK3 | phosphorylation up-regulates → | RPS6K PSer363 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252759 |
| MAPK3 | phosphorylation up-regulates → | RPS6K PSer380 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252756 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PThr359 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252751 |
| MAPK1 | phosphorylation up-regulates → | RPS6K PThr573 | phosphorylation up-regulates → | RPS6K | 9430688 | SIGNOR-252752 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252757 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252747 |
| GSK3B | phosphorylation → up-regulates activity | RPS6K | SIGNOR-263513 |
| PDPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252763 |
| MTOR | phosphorylation → up-regulates activity | RPS6K | SIGNOR-255841 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252761 |
| Gbeta | phosphorylation → up-regulates activity | RPS6K | SIGNOR-270006 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252748 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252760 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252755 |
| mTORC1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-255842 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252746 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252753 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252754 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252745 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252750 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252749 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252744 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252743 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252741 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252758 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252762 |
| RPS6K | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252785 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252742 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252759 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252756 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252751 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6K | SIGNOR-252752 |