Entity Details

Name ERK1/2_Ser221
ID SIGNOR-PF26
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PDPK1RPS6KSer221DHEKKAYsFCGTVEYphosphorylation
up-regulates activity		10480933SIGNOR-252763
MAPK1RPS6KSer221DHEKKAYsFCGTVEYphosphorylation
up-regulates activity		9430688SIGNOR-252750
ERK1/2RPS6KSer221DHEKKAYsFCGTVEYphosphorylation
up-regulates activity		9430688SIGNOR-252741
MAPK3RPS6KSer221DHEKKAYsFCGTVEYphosphorylation
up-regulates activity		9430688SIGNOR-252758
RPS6KRPS6KSer221DHEKKAYsFCGTVEYphosphorylation
up-regulates activity		20048145SIGNOR-252785
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDPK1phosphorylation
up-regulates
→
RPS6K
PSer221		phosphorylation
up-regulates
→		RPS6K10480933SIGNOR-252763
MAPK1phosphorylation
up-regulates
→
RPS6K
PSer221		phosphorylation
up-regulates
→		RPS6K9430688SIGNOR-252750
ERK1/2phosphorylation
up-regulates
→
RPS6K
PSer221		phosphorylation
up-regulates
→		RPS6K9430688SIGNOR-252741
MAPK3phosphorylation
up-regulates
→
RPS6K
PSer221		phosphorylation
up-regulates
→		RPS6K9430688SIGNOR-252758
RPS6Kphosphorylation
up-regulates
→
RPS6K
PSer221		phosphorylation
up-regulates
→		RPS6K20048145SIGNOR-252785
Regulator Mechanism/Effect Target SIGNOR-ID
PDPK1phosphorylation
→
up-regulates activity 		RPS6KSIGNOR-252763
MAPK1phosphorylation
→
up-regulates activity 		RPS6KSIGNOR-252750
ERK1/2phosphorylation
→
up-regulates activity 		RPS6KSIGNOR-252741
MAPK3phosphorylation
→
up-regulates activity 		RPS6KSIGNOR-252758
RPS6Kphosphorylation
→
up-regulates activity 		RPS6KSIGNOR-252785