| Name | PIM |
| ID | SIGNOR-PF34 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-259429 |
| PIM | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 18593906 | SIGNOR-259428 |
| PIM | MARK3 | Ser96 | KTQLNPTsLQKLFRE | phosphorylation down-regulates | 15319445 | SIGNOR-259432 |
| PIM | MARK3 | Thr90 | AIKIIDKtQLNPTSL | phosphorylation down-regulates | 15319445 | SIGNOR-259431 |
| PIM | MARK3 | Thr95 | DKTQLNPtSLQKLFR | phosphorylation down-regulates | 15319445 | SIGNOR-259430 |
| PIM | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-259424 |
| PIM | RPS19 | – | phosphorylation up-regulates | 16266891 | SIGNOR-259412 | |
| PIM | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18593906 | SIGNOR-259426 |
| PIM | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18593906 | SIGNOR-259425 |
| PIM | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 17643117 | SIGNOR-259409 |
| PIM | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates | 18467333 | SIGNOR-259433 |
| PIM | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates | 18467333 | SIGNOR-259434 |
| PIM | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 19911008 | SIGNOR-259411 |
| PIM | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10837473 | SIGNOR-259418 |
| PIM | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-259423 |
| PIM | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-259421 |
| PIM | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-259422 |
| PIM | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates | 19749799 | SIGNOR-259410 |
| PIM | FOXO | – | phosphorylation down-regulates | 18593906 | SIGNOR-259427 | |
| PIM | Histone H3 | – | phosphorylation down-regulates activity | 17643117 | SIGNOR-265365 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-259429 |
| PIM | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-259428 |
| PIM | phosphorylation up-regulates → | MARK3 PSer96 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-259432 |
| PIM | phosphorylation up-regulates → | MARK3 PThr90 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-259431 |
| PIM | phosphorylation up-regulates → | MARK3 PThr95 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-259430 |
| PIM | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-259424 |
| PIM | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-259426 |
| PIM | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-259425 |
| PIM | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 17643117 | SIGNOR-259409 |
| PIM | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-259433 |
| PIM | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-259434 |
| PIM | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 19911008 | SIGNOR-259411 |
| PIM | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837473 | SIGNOR-259418 |
| PIM | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259423 |
| PIM | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259421 |
| PIM | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-259422 |
| PIM | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 19749799 | SIGNOR-259410 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM | phosphorylation down-regulates | FOXO3 | SIGNOR-259429 |
| PIM | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-259428 |
| PIM | phosphorylation down-regulates | MARK3 | SIGNOR-259432 |
| PIM | phosphorylation down-regulates | MARK3 | SIGNOR-259431 |
| PIM | phosphorylation down-regulates | MARK3 | SIGNOR-259430 |
| PIM | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-259424 |
| PIM | phosphorylation → up-regulates | RPS19 | SIGNOR-259412 |
| PIM | phosphorylation down-regulates | CDKN1B | SIGNOR-259426 |
| PIM | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-259425 |
| PIM | phosphorylation → down-regulates activity | H3C1 | SIGNOR-259409 |
| PIM | phosphorylation → up-regulates | MDM2 | SIGNOR-259433 |
| PIM | phosphorylation → up-regulates | MDM2 | SIGNOR-259434 |
| PIM | phosphorylation → up-regulates | RELA | SIGNOR-259411 |
| PIM | phosphorylation down-regulates | BAD | SIGNOR-259418 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259423 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259421 |
| PIM | phosphorylation → down-regulates activity | BAD | SIGNOR-259422 |
| PIM | phosphorylation down-regulates | MAP3K5 | SIGNOR-259410 |
| PIM | phosphorylation down-regulates | FOXO | SIGNOR-259427 |
| PIM | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265365 |