Entity Details

Name Gbeta
ID SIGNOR-PF4
Role kinase
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GbetaARHGAP26–phosphorylation
unknown
9525907SIGNOR-270058
GbetaEGFR–phosphorylation
down-regulates
1651322SIGNOR-270017
GbetaIRX2–phosphorylation
up-regulates activity
15133517SIGNOR-270097
GbetaTOB1–phosphorylation
down-regulates
12050114SIGNOR-270123
GbetaNR3C1–phosphorylation
down-regulates
9199329SIGNOR-270098
GbetaIL16–phosphorylation
up-regulates
14768064SIGNOR-270056
GbetaRPS6K–phosphorylation
up-regulates activity
12832467SIGNOR-270006
GbetaRPS6KA3–phosphorylation
up-regulates
10980595SIGNOR-270014
GbetaELK1–phosphorylation
up-regulates
7889942SIGNOR-270075
GbetaMED1–phosphorylation
up-regulates
12356758SIGNOR-270106
GbetaNFATC4–phosphorylation
up-regulates
15657420SIGNOR-270047
GbetaFOXO–phosphorylation
down-regulates quantity by destabilization
19282669SIGNOR-270020
GbetaTSC2–phosphorylation
down-regulates activity
15851026SIGNOR-270108
GbetaFGFR1–phosphorylation
down-regulates
23405013SIGNOR-270013
GbetaGRB10–phosphorylation
up-regulates
15952796SIGNOR-270077
GbetaSP1–phosphorylation
up-regulates
11904305SIGNOR-270104
GbetaCDKN1B–phosphorylation
down-regulates
10931950SIGNOR-270087
GbetaSMAD1–phosphorylation
down-regulates
10197981SIGNOR-270005
GbetaPML–phosphorylation
up-regulates
15093545SIGNOR-270034
GbetaTCF3–phosphorylation
down-regulates quantity by destabilization
14592976SIGNOR-270009
GbetaSREBF2–phosphorylation
up-regulates
14988395SIGNOR-270012
GbetaTFCP2–phosphorylation
down-regulates
19237534SIGNOR-270110
GbetaGJA1–phosphorylation
down-regulates activity
9535909SIGNOR-270025
GbetaSREBF1–phosphorylation
up-regulates activity
10915800SIGNOR-270081
GbetaJUN–phosphorylation
up-regulates
12169099SIGNOR-270033
GbetaPCBP2Thr213SASFPHTtPSMCLNPphosphorylation
up-regulates quantity by stabilization
17475908SIGNOR-262671
GbetaALOX5–phosphorylation
up-regulates activity
12670876SIGNOR-270088
GbetaCTTN–phosphorylation
up-regulates
20444238SIGNOR-270051
GbetaBCL2L11–phosphorylation
down-regulates quantity by destabilization
15486195SIGNOR-270031
GbetaPTPRR–phosphorylation
up-regulates activity
11493009SIGNOR-270021
GbetaPOLR2A–phosphorylation
down-regulates
14662762SIGNOR-270039
GbetaFOS–phosphorylation
up-regulates
7816602SIGNOR-270105
GbetaNCOA1–phosphorylation
up-regulates
12163482SIGNOR-270099
GbetaMAPKAPK2–phosphorylation
up-regulates
14967450SIGNOR-270117
GbetaRPS6KA5–phosphorylation
up-regulates
15568999SIGNOR-270076
GbetaRAF1–phosphorylation
down-regulates
16407412SIGNOR-270010
GbetaMRTFA–phosphorylation
down-regulates
18694962SIGNOR-269996
GbetaXPO5–phosphorylation
down-regulates activity
27846390SIGNOR-269999
GbetaKLC1–phosphorylation
down-regulates
21385839SIGNOR-270072
GbetaPDE4D–phosphorylation
down-regulates
10828059SIGNOR-270069
GbetaLIPE–phosphorylation
up-regulates activity
11581251SIGNOR-270119
GbetaPGR–phosphorylation
down-regulates
10655479SIGNOR-270040
GbetaSCNN1B–phosphorylation
down-regulates quantity by destabilization
11805112SIGNOR-270050
GbetaGSK3B/Axin/APC–phosphorylation
down-regulates activity
28646232SIGNOR-270068
GbetaGTF2I–phosphorylation
up-regulates
10648599SIGNOR-270057
GbetaRPS6KB1–phosphorylation
up-regulates activity
14967450SIGNOR-270103
GbetaMYC–phosphorylation
up-regulates activity
32482868SIGNOR-270030
GbetaUBTF–phosphorylation
down-regulates
11741541SIGNOR-270080
GbetaHIF1A–phosphorylation
up-regulates
18519666SIGNOR-270095
GbetaPCYT1A–phosphorylation
down-regulates
15788406SIGNOR-270028
GbetaIRS1–phosphorylation
down-regulates activity
12510059SIGNOR-269997
GbetaEWSR1–phosphorylation
unknown
19076070SIGNOR-270062
GbetaPPP2R5C–phosphorylation
down-regulates
16456541SIGNOR-270101
GbetamTORC1–phosphorylation
unknown
21071439SIGNOR-270027
GbetaSCNN1G–phosphorylation
down-regulates quantity by destabilization
11805112SIGNOR-270061
GbetaBCL6–phosphorylation
down-regulates
9649500SIGNOR-270011
GbetaPAK1–phosphorylation
down-regulates
14993270SIGNOR-270086
GbetaCEBPA–phosphorylation
down-regulates
14701740SIGNOR-270066
GbetaMKNK1–phosphorylation
up-regulates
9155018SIGNOR-270022
GbetaMKNK2–phosphorylation
up-regulates
9155017SIGNOR-270115
GbetaPTPN7–phosphorylation
up-regulates activity
16226275SIGNOR-270111
GbetaTH–phosphorylation
up-regulates
7901013SIGNOR-270055
GbetaSTMN1–phosphorylation
down-regulates activity
9731215SIGNOR-270082
GbetaMETTL3–phosphorylation
up-regulates quantity by stabilization
33217317SIGNOR-270035
GbetaLRP6–phosphorylation
up-regulates
20974802SIGNOR-270024
GbetaDUSP6–phosphorylation
down-regulates
15632084SIGNOR-270116
GbetaPTTG1–phosphorylation
up-regulates
10906323SIGNOR-270038
GbetaSMAD4–phosphorylation
up-regulates
12801888SIGNOR-270107
GbetaCEBPB–phosphorylation
up-regulates
19327116SIGNOR-270045
GbetaRPS6KA1–phosphorylation
up-regulates activity
8387505SIGNOR-270002
GbetaARHGEF2–phosphorylation
up-regulates
18211802SIGNOR-270007
GbetaCAPN2–phosphorylation
up-regulates
14993287SIGNOR-270078
GbetaDUSP1–phosphorylation
down-regulates
16286470SIGNOR-270093
GbetaRCAN1–phosphorylation
up-regulates activity
12063245SIGNOR-270026
GbetaARRB1–phosphorylation
down-regulates
10347142SIGNOR-270094
GbetaSMAD2–phosphorylation
up-regulates
10197981SIGNOR-270065
GbetaESR1–phosphorylation
up-regulates
17615152SIGNOR-270023
GbetaFOXO3–phosphorylation
down-regulates quantity by destabilization
19282669SIGNOR-270070
GbetaLIFR–phosphorylation
down-regulates
7777512SIGNOR-270001
GbetaCASP8–phosphorylation
down-regulates
24342355SIGNOR-270118
GbetaCIITA–phosphorylation
down-regulates
18245089SIGNOR-270067
GbetaMCRIP1–phosphorylation
down-regulates activity
25728771SIGNOR-270092
GbetaBCL2–phosphorylation
up-regulates
10669763SIGNOR-270064
GbetaTWIST1–phosphorylation
up-regulates
21502402SIGNOR-270122
GbetaMITF–phosphorylation
down-regulates quantity by destabilization
10841026SIGNOR-270029
GbetaNUP50–phosphorylation
down-regulates
19767751SIGNOR-270041
GbetaAMPH–phosphorylation
down-regulates
15262992SIGNOR-270102
GbetaMYB–phosphorylation
down-regulates
8798443SIGNOR-270089
GbetaMBP–phosphorylation
down-regulates
16401070SIGNOR-270100
GbetaRPTOR–phosphorylation
up-regulates activity
21071439SIGNOR-270032
GbetaSTK11–phosphorylation
down-regulates activity
25846811SIGNOR-270071
GbetaRPS6KA2–phosphorylation
up-regulates
8939914SIGNOR-270018
GbetaCAD–phosphorylation
up-regulates
15890648SIGNOR-269998
GbetaCIC–phosphorylation
down-regulates
21087211SIGNOR-270090
GbetaAPBB1–phosphorylation
unknown
14697653SIGNOR-270054
GbetaLCK–phosphorylation
up-regulates activity
8618896SIGNOR-270074
GbetaSOS1–phosphorylation
down-regulates
8816480SIGNOR-270112
GbetaETV6–phosphorylation
down-regulates
15060146SIGNOR-270120
GbetaWWC1–phosphorylation
unknown
24269383SIGNOR-270121
GbetaGSK3B–phosphorylation
down-regulates
16039586SIGNOR-270059
GbetaBRAF–phosphorylation
down-regulates
16508002SIGNOR-270043
GbetaABI1–phosphorylation
up-regulates
21419341SIGNOR-270048
GbetaPPARA–phosphorylation
up-regulates activity
10187842SIGNOR-270079
GbetaNOXA1–phosphorylation
down-regulates
20230789SIGNOR-270114
GbetaJAK2–phosphorylation
down-regulates
16705159SIGNOR-270046
GbetaRXRA–phosphorylation
down-regulates activity
17604322SIGNOR-269995
GbetaGAB1–phosphorylation
up-regulates activity
15379552SIGNOR-270060
GbetaNCF1–phosphorylation
up-regulates
16778989SIGNOR-270091
GbetaSMAD3–phosphorylation
down-regulates
10197981SIGNOR-270015
GbetaSTAT5A–phosphorylation
up-regulates
10194762SIGNOR-270004
GbetaPLA2G4A–phosphorylation
up-regulates
8381049SIGNOR-270096
GbetaJUND–phosphorylation
up-regulates
22327296SIGNOR-270083
GbetaATF2–phosphorylation
up-regulates
12110590SIGNOR-270073
GbetaKRT8–phosphorylation
unknown
16554440SIGNOR-270003
GbetaMCL1–phosphorylation
up-regulates
18676833SIGNOR-270042
GbetaTHRB–phosphorylation
down-regulates activity
12809513SIGNOR-270016
GbetaPLCB1–phosphorylation
up-regulates activity
11287604SIGNOR-270109
GbetaNUP153–phosphorylation
unknown
19767751SIGNOR-270044
GbetaPOU5F1–phosphorylation
down-regulates
23024368SIGNOR-270085
GbetaCALD1–phosphorylation
down-regulates
10514499SIGNOR-270049
GbetaBAD–phosphorylation
down-regulates
19777442SIGNOR-270037
GbetaGAB2–phosphorylation
up-regulates
15356145SIGNOR-270000
GbetaSP3–phosphorylation
up-regulates
17685427SIGNOR-270053
GbetaSPHK2–phosphorylation
up-regulates
17311928SIGNOR-270036
GbetaCASP9–phosphorylation
down-regulates activity
12792650SIGNOR-270084
GbetaRPS3–phosphorylation
unknown
15950189SIGNOR-270019
GbetaSPHK1–phosphorylation
up-regulates
14532121SIGNOR-270063
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Gbetaphosphorylation
up-regulates
→
PCBP2
PThr213
phosphorylation
up-regulates
→
PCBP217475908SIGNOR-262671
Regulator Mechanism/Effect Target SIGNOR-ID
Gbetaphosphorylation
→
unknown
ARHGAP26SIGNOR-270058
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
EGFRSIGNOR-270017
Gbetaphosphorylation
→
up-regulates activity
IRX2SIGNOR-270097
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-270123
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
NR3C1SIGNOR-270098
Gbetaphosphorylation
→
up-regulates
IL16SIGNOR-270056
Gbetaphosphorylation
→
up-regulates activity
RPS6KSIGNOR-270006
Gbetaphosphorylation
→
up-regulates
RPS6KA3SIGNOR-270014
Gbetaphosphorylation
→
up-regulates
ELK1SIGNOR-270075
Gbetaphosphorylation
→
up-regulates
MED1SIGNOR-270106
Gbetaphosphorylation
→
up-regulates
NFATC4SIGNOR-270047
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FOXOSIGNOR-270020
Gbetaphosphorylation
→
down-regulates activity
TSC2SIGNOR-270108
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-270013
Gbetaphosphorylation
→
up-regulates
GRB10SIGNOR-270077
Gbetaphosphorylation
→
up-regulates
SP1SIGNOR-270104
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CDKN1BSIGNOR-270087
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
SMAD1SIGNOR-270005
Gbetaphosphorylation
→
up-regulates
PMLSIGNOR-270034
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TCF3SIGNOR-270009
Gbetaphosphorylation
→
up-regulates
SREBF2SIGNOR-270012
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
TFCP2SIGNOR-270110
Gbetaphosphorylation
→
down-regulates activity
GJA1SIGNOR-270025
Gbetaphosphorylation
→
up-regulates activity
SREBF1SIGNOR-270081
Gbetaphosphorylation
→
up-regulates
JUNSIGNOR-270033
Gbetaphosphorylation
→
up-regulates quantity by stabilization
PCBP2SIGNOR-262671
Gbetaphosphorylation
→
up-regulates activity
ALOX5SIGNOR-270088
Gbetaphosphorylation
→
up-regulates
CTTNSIGNOR-270051
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
BCL2L11SIGNOR-270031
Gbetaphosphorylation
→
up-regulates activity
PTPRRSIGNOR-270021
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
POLR2ASIGNOR-270039
Gbetaphosphorylation
→
up-regulates
FOSSIGNOR-270105
Gbetaphosphorylation
→
up-regulates
NCOA1SIGNOR-270099
Gbetaphosphorylation
→
up-regulates
MAPKAPK2SIGNOR-270117
Gbetaphosphorylation
→
up-regulates
RPS6KA5SIGNOR-270076
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
RAF1SIGNOR-270010
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
MRTFASIGNOR-269996
Gbetaphosphorylation
→
down-regulates activity
XPO5SIGNOR-269999
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
KLC1SIGNOR-270072
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PDE4DSIGNOR-270069
Gbetaphosphorylation
→
up-regulates activity
LIPESIGNOR-270119
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PGRSIGNOR-270040
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SCNN1BSIGNOR-270050
Gbetaphosphorylation
→
down-regulates activity
GSK3B/Axin/APCSIGNOR-270068
Gbetaphosphorylation
→
up-regulates
GTF2ISIGNOR-270057
Gbetaphosphorylation
→
up-regulates activity
RPS6KB1SIGNOR-270103
Gbetaphosphorylation
→
up-regulates activity
MYCSIGNOR-270030
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
UBTFSIGNOR-270080
Gbetaphosphorylation
→
up-regulates
HIF1ASIGNOR-270095
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PCYT1ASIGNOR-270028
Gbetaphosphorylation
→
down-regulates activity
IRS1SIGNOR-269997
Gbetaphosphorylation
→
unknown
EWSR1SIGNOR-270062
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PPP2R5CSIGNOR-270101
Gbetaphosphorylation
→
unknown
mTORC1SIGNOR-270027
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SCNN1GSIGNOR-270061
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
BCL6SIGNOR-270011
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PAK1SIGNOR-270086
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CEBPASIGNOR-270066
Gbetaphosphorylation
→
up-regulates
MKNK1SIGNOR-270022
Gbetaphosphorylation
→
up-regulates
MKNK2SIGNOR-270115
Gbetaphosphorylation
→
up-regulates activity
PTPN7SIGNOR-270111
Gbetaphosphorylation
→
up-regulates
THSIGNOR-270055
Gbetaphosphorylation
→
down-regulates activity
STMN1SIGNOR-270082
Gbetaphosphorylation
→
up-regulates quantity by stabilization
METTL3SIGNOR-270035
Gbetaphosphorylation
→
up-regulates
LRP6SIGNOR-270024
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
DUSP6SIGNOR-270116
Gbetaphosphorylation
→
up-regulates
PTTG1SIGNOR-270038
Gbetaphosphorylation
→
up-regulates
SMAD4SIGNOR-270107
Gbetaphosphorylation
→
up-regulates
CEBPBSIGNOR-270045
Gbetaphosphorylation
→
up-regulates activity
RPS6KA1SIGNOR-270002
Gbetaphosphorylation
→
up-regulates
ARHGEF2SIGNOR-270007
Gbetaphosphorylation
→
up-regulates
CAPN2SIGNOR-270078
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
DUSP1SIGNOR-270093
Gbetaphosphorylation
→
up-regulates activity
RCAN1SIGNOR-270026
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
ARRB1SIGNOR-270094
Gbetaphosphorylation
→
up-regulates
SMAD2SIGNOR-270065
Gbetaphosphorylation
→
up-regulates
ESR1SIGNOR-270023
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FOXO3SIGNOR-270070
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
LIFRSIGNOR-270001
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CASP8SIGNOR-270118
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CIITASIGNOR-270067
Gbetaphosphorylation
→
down-regulates activity
MCRIP1SIGNOR-270092
Gbetaphosphorylation
→
up-regulates
BCL2SIGNOR-270064
Gbetaphosphorylation
→
up-regulates
TWIST1SIGNOR-270122
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
MITFSIGNOR-270029
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
NUP50SIGNOR-270041
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
AMPHSIGNOR-270102
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
MYBSIGNOR-270089
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
MBPSIGNOR-270100
Gbetaphosphorylation
→
up-regulates activity
RPTORSIGNOR-270032
Gbetaphosphorylation
→
down-regulates activity
STK11SIGNOR-270071
Gbetaphosphorylation
→
up-regulates
RPS6KA2SIGNOR-270018
Gbetaphosphorylation
→
up-regulates
CADSIGNOR-269998
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CICSIGNOR-270090
Gbetaphosphorylation
→
unknown
APBB1SIGNOR-270054
Gbetaphosphorylation
→
up-regulates activity
LCKSIGNOR-270074
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
SOS1SIGNOR-270112
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
ETV6SIGNOR-270120
Gbetaphosphorylation
→
unknown
WWC1SIGNOR-270121
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
GSK3BSIGNOR-270059
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
BRAFSIGNOR-270043
Gbetaphosphorylation
→
up-regulates
ABI1SIGNOR-270048
Gbetaphosphorylation
→
up-regulates activity
PPARASIGNOR-270079
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
NOXA1SIGNOR-270114
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
JAK2SIGNOR-270046
Gbetaphosphorylation
→
down-regulates activity
RXRASIGNOR-269995
Gbetaphosphorylation
→
up-regulates activity
GAB1SIGNOR-270060
Gbetaphosphorylation
→
up-regulates
NCF1SIGNOR-270091
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
SMAD3SIGNOR-270015
Gbetaphosphorylation
→
up-regulates
STAT5ASIGNOR-270004
Gbetaphosphorylation
→
up-regulates
PLA2G4ASIGNOR-270096
Gbetaphosphorylation
→
up-regulates
JUNDSIGNOR-270083
Gbetaphosphorylation
→
up-regulates
ATF2SIGNOR-270073
Gbetaphosphorylation
→
unknown
KRT8SIGNOR-270003
Gbetaphosphorylation
→
up-regulates
MCL1SIGNOR-270042
Gbetaphosphorylation
→
down-regulates activity
THRBSIGNOR-270016
Gbetaphosphorylation
→
up-regulates activity
PLCB1SIGNOR-270109
Gbetaphosphorylation
→
unknown
NUP153SIGNOR-270044
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
POU5F1SIGNOR-270085
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CALD1SIGNOR-270049
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-270037
Gbetaphosphorylation
→
up-regulates
GAB2SIGNOR-270000
Gbetaphosphorylation
→
up-regulates
SP3SIGNOR-270053
Gbetaphosphorylation
→
up-regulates
SPHK2SIGNOR-270036
Gbetaphosphorylation
→
down-regulates activity
CASP9SIGNOR-270084
Gbetaphosphorylation
→
unknown
RPS3SIGNOR-270019
Gbetaphosphorylation
→
up-regulates
SPHK1SIGNOR-270063