Entity Details

Name Gbeta
ID SIGNOR-PF4
Role kinase
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GbetaRPS6KA2phosphorylation
up-regulates
8939914SIGNOR-270018
GbetaPCYT1Aphosphorylation
down-regulates
15788406SIGNOR-270028
GbetaGJA1phosphorylation
down-regulates activity
9535909SIGNOR-270025
GbetaGAB2phosphorylation
up-regulates
15356145SIGNOR-270000
GbetaMKNK2phosphorylation
up-regulates
9155017SIGNOR-270115
GbetaCASP8phosphorylation
down-regulates
24342355SIGNOR-270118
GbetaMETTL3phosphorylation
up-regulates quantity by stabilization
33217317SIGNOR-270035
GbetaTFCP2phosphorylation
down-regulates
19237534SIGNOR-270110
GbetaPTTG1phosphorylation
up-regulates
10906323SIGNOR-270038
GbetaEGFRphosphorylation
down-regulates
1651322SIGNOR-270017
GbetaTOB1phosphorylation
down-regulates
12050114SIGNOR-270123
GbetaRCAN1phosphorylation
up-regulates activity
12063245SIGNOR-270026
GbetaSPHK2phosphorylation
up-regulates
17311928SIGNOR-270036
GbetaETV6phosphorylation
down-regulates
15060146SIGNOR-270120
GbetaSREBF2phosphorylation
up-regulates
14988395SIGNOR-270012
GbetaMED1phosphorylation
up-regulates
12356758SIGNOR-270106
GbetaRPS6Kphosphorylation
up-regulates activity
12832467SIGNOR-270006
GbetaKLC1phosphorylation
down-regulates
21385839SIGNOR-270072
GbetaSPHK1phosphorylation
up-regulates
14532121SIGNOR-270063
GbetaFOXO3phosphorylation
down-regulates quantity by destabilization
19282669SIGNOR-270070
GbetaARHGEF2phosphorylation
up-regulates
18211802SIGNOR-270007
GbetaJUNDphosphorylation
up-regulates
22327296SIGNOR-270083
GbetaCASP9phosphorylation
down-regulates activity
12792650SIGNOR-270084
GbetaSMAD4phosphorylation
up-regulates
12801888SIGNOR-270107
GbetaSP1phosphorylation
up-regulates
11904305SIGNOR-270104
GbetaSTK11phosphorylation
down-regulates activity
25846811SIGNOR-270071
GbetaCALD1phosphorylation
down-regulates
10514499SIGNOR-270049
GbetaBCL2L11phosphorylation
down-regulates quantity by destabilization
15486195SIGNOR-270031
GbetaSOS1phosphorylation
down-regulates
8816480SIGNOR-270112
GbetaCDKN1Bphosphorylation
down-regulates
10931950SIGNOR-270087
GbetaTSC2phosphorylation
down-regulates activity
15851026SIGNOR-270108
GbetaPAK1phosphorylation
down-regulates
14993270SIGNOR-270086
GbetaBCL6phosphorylation
down-regulates
9649500SIGNOR-270011
GbetaMAPKAPK2phosphorylation
up-regulates
14967450SIGNOR-270117
GbetaSCNN1Bphosphorylation
down-regulates quantity by destabilization
11805112SIGNOR-270050
GbetaMRTFAphosphorylation
down-regulates
18694962SIGNOR-269996
GbetaCIITAphosphorylation
down-regulates
18245089SIGNOR-270067
GbetaLIPEphosphorylation
up-regulates activity
11581251SIGNOR-270119
GbetaFOXOphosphorylation
down-regulates quantity by destabilization
19282669SIGNOR-270020
GbetaSTMN1phosphorylation
down-regulates activity
9731215SIGNOR-270082
GbetaLCKphosphorylation
up-regulates activity
8618896SIGNOR-270074
GbetaNUP153phosphorylation
unknown
19767751SIGNOR-270044
GbetaBADphosphorylation
down-regulates
19777442SIGNOR-270037
GbetaSCNN1Gphosphorylation
down-regulates quantity by destabilization
11805112SIGNOR-270061
GbetaJAK2phosphorylation
down-regulates
16705159SIGNOR-270046
GbetaDUSP6phosphorylation
down-regulates
15632084SIGNOR-270116
GbetamTORC1phosphorylation
unknown
21071439SIGNOR-270027
GbetaMYBphosphorylation
down-regulates
8798443SIGNOR-270089
GbetaMKNK1phosphorylation
up-regulates
9155018SIGNOR-270022
GbetaCEBPAphosphorylation
down-regulates
14701740SIGNOR-270066
GbetaRPTORphosphorylation
up-regulates activity
21071439SIGNOR-270032
GbetaCEBPBphosphorylation
up-regulates
19327116SIGNOR-270045
GbetaARHGAP26phosphorylation
unknown
9525907SIGNOR-270058
GbetaCICphosphorylation
down-regulates
21087211SIGNOR-270090
GbetaARRB1phosphorylation
down-regulates
10347142SIGNOR-270094
GbetaPTPRRphosphorylation
up-regulates activity
11493009SIGNOR-270021
GbetaESR1phosphorylation
up-regulates
17615152SIGNOR-270023
GbetaTWIST1phosphorylation
up-regulates
21502402SIGNOR-270122
GbetaKRT8phosphorylation
unknown
16554440SIGNOR-270003
GbetaALOX5phosphorylation
up-regulates activity
12670876SIGNOR-270088
GbetaMCRIP1phosphorylation
down-regulates activity
25728771SIGNOR-270092
GbetaBCL2phosphorylation
up-regulates
10669763SIGNOR-270064
GbetaMYCphosphorylation
up-regulates activity
32482868SIGNOR-270030
GbetaSMAD2phosphorylation
up-regulates
10197981SIGNOR-270065
GbetaAMPHphosphorylation
down-regulates
15262992SIGNOR-270102
GbetaNUP50phosphorylation
down-regulates
19767751SIGNOR-270041
GbetaRPS3phosphorylation
unknown
15950189SIGNOR-270019
GbetaTHRBphosphorylation
down-regulates activity
12809513SIGNOR-270016
GbetaGSK3B/Axin/APCphosphorylation
down-regulates activity
28646232SIGNOR-270068
GbetaCADphosphorylation
up-regulates
15890648SIGNOR-269998
GbetaTCF3phosphorylation
down-regulates quantity by destabilization
14592976SIGNOR-270009
GbetaATF2phosphorylation
up-regulates
12110590SIGNOR-270073
GbetaHIF1Aphosphorylation
up-regulates
18519666SIGNOR-270095
GbetaSP3phosphorylation
up-regulates
17685427SIGNOR-270053
GbetaIRX2phosphorylation
up-regulates activity
15133517SIGNOR-270097
GbetaNCOA1phosphorylation
up-regulates
12163482SIGNOR-270099
GbetaRPS6KB1phosphorylation
up-regulates activity
14967450SIGNOR-270103
GbetaPCBP2Thr213SASFPHTtPSMCLNPphosphorylation
up-regulates quantity by stabilization
17475908SIGNOR-262671
GbetaRPS6KA1phosphorylation
up-regulates activity
8387505SIGNOR-270002
GbetaPMLphosphorylation
up-regulates
15093545SIGNOR-270034
GbetaAPBB1phosphorylation
unknown
14697653SIGNOR-270054
GbetaMITFphosphorylation
down-regulates quantity by destabilization
10841026SIGNOR-270029
GbetaBRAFphosphorylation
down-regulates
16508002SIGNOR-270043
GbetaGSK3Bphosphorylation
down-regulates
16039586SIGNOR-270059
GbetaPDE4Dphosphorylation
down-regulates
10828059SIGNOR-270069
GbetaLIFRphosphorylation
down-regulates
7777512SIGNOR-270001
GbetaIRS1phosphorylation
down-regulates activity
12510059SIGNOR-269997
GbetaABI1phosphorylation
up-regulates
21419341SIGNOR-270048
GbetaPPARAphosphorylation
up-regulates activity
10187842SIGNOR-270079
GbetaNFATC4phosphorylation
up-regulates
15657420SIGNOR-270047
GbetaRAF1phosphorylation
down-regulates
16407412SIGNOR-270010
GbetaMBPphosphorylation
down-regulates
16401070SIGNOR-270100
GbetaGRB10phosphorylation
up-regulates
15952796SIGNOR-270077
GbetaSREBF1phosphorylation
up-regulates activity
10915800SIGNOR-270081
GbetaCAPN2phosphorylation
up-regulates
14993287SIGNOR-270078
GbetaPPP2R5Cphosphorylation
down-regulates
16456541SIGNOR-270101
GbetaJUNphosphorylation
up-regulates
12169099SIGNOR-270033
GbetaSMAD1phosphorylation
down-regulates
10197981SIGNOR-270005
GbetaNOXA1phosphorylation
down-regulates
20230789SIGNOR-270114
GbetaCTTNphosphorylation
up-regulates
20444238SIGNOR-270051
GbetaDUSP1phosphorylation
down-regulates
16286470SIGNOR-270093
GbetaWWC1phosphorylation
unknown
24269383SIGNOR-270121
GbetaPOLR2Aphosphorylation
down-regulates
14662762SIGNOR-270039
GbetaNR3C1phosphorylation
down-regulates
9199329SIGNOR-270098
GbetaIL16phosphorylation
up-regulates
14768064SIGNOR-270056
GbetaGAB1phosphorylation
up-regulates activity
15379552SIGNOR-270060
GbetaEWSR1phosphorylation
unknown
19076070SIGNOR-270062
GbetaRPS6KA5phosphorylation
up-regulates
15568999SIGNOR-270076
GbetaPGRphosphorylation
down-regulates
10655479SIGNOR-270040
GbetaRXRAphosphorylation
down-regulates activity
17604322SIGNOR-269995
GbetaNCF1phosphorylation
up-regulates
16778989SIGNOR-270091
GbetaFOSphosphorylation
up-regulates
7816602SIGNOR-270105
GbetaFGFR1phosphorylation
down-regulates
23405013SIGNOR-270013
GbetaUBTFphosphorylation
down-regulates
11741541SIGNOR-270080
GbetaRPS6KA3phosphorylation
up-regulates
10980595SIGNOR-270014
GbetaSMAD3phosphorylation
down-regulates
10197981SIGNOR-270015
GbetaSTAT5Aphosphorylation
up-regulates
10194762SIGNOR-270004
GbetaTHphosphorylation
up-regulates
7901013SIGNOR-270055
GbetaPLA2G4Aphosphorylation
up-regulates
8381049SIGNOR-270096
GbetaPTPN7phosphorylation
up-regulates activity
16226275SIGNOR-270111
GbetaELK1phosphorylation
up-regulates
7889942SIGNOR-270075
GbetaPOU5F1phosphorylation
down-regulates
23024368SIGNOR-270085
GbetaXPO5phosphorylation
down-regulates activity
27846390SIGNOR-269999
GbetaGTF2Iphosphorylation
up-regulates
10648599SIGNOR-270057
GbetaPLCB1phosphorylation
up-regulates activity
11287604SIGNOR-270109
GbetaMCL1phosphorylation
up-regulates
18676833SIGNOR-270042
GbetaLRP6phosphorylation
up-regulates
20974802SIGNOR-270024
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Gbetaphosphorylation
up-regulates
PCBP2
PThr213
phosphorylation
up-regulates
PCBP217475908SIGNOR-262671
Regulator Mechanism/Effect Target SIGNOR-ID
Gbetaphosphorylation

up-regulates
RPS6KA2SIGNOR-270018
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PCYT1ASIGNOR-270028
Gbetaphosphorylation

down-regulates activity
GJA1SIGNOR-270025
Gbetaphosphorylation

up-regulates
GAB2SIGNOR-270000
Gbetaphosphorylation

up-regulates
MKNK2SIGNOR-270115
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CASP8SIGNOR-270118
Gbetaphosphorylation

up-regulates quantity by stabilization
METTL3SIGNOR-270035
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
TFCP2SIGNOR-270110
Gbetaphosphorylation

up-regulates
PTTG1SIGNOR-270038
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
EGFRSIGNOR-270017
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
TOB1SIGNOR-270123
Gbetaphosphorylation

up-regulates activity
RCAN1SIGNOR-270026
Gbetaphosphorylation

up-regulates
SPHK2SIGNOR-270036
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
ETV6SIGNOR-270120
Gbetaphosphorylation

up-regulates
SREBF2SIGNOR-270012
Gbetaphosphorylation

up-regulates
MED1SIGNOR-270106
Gbetaphosphorylation

up-regulates activity
RPS6KSIGNOR-270006
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
KLC1SIGNOR-270072
Gbetaphosphorylation

up-regulates
SPHK1SIGNOR-270063
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FOXO3SIGNOR-270070
Gbetaphosphorylation

up-regulates
ARHGEF2SIGNOR-270007
Gbetaphosphorylation

up-regulates
JUNDSIGNOR-270083
Gbetaphosphorylation

down-regulates activity
CASP9SIGNOR-270084
Gbetaphosphorylation

up-regulates
SMAD4SIGNOR-270107
Gbetaphosphorylation

up-regulates
SP1SIGNOR-270104
Gbetaphosphorylation

down-regulates activity
STK11SIGNOR-270071
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CALD1SIGNOR-270049
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
BCL2L11SIGNOR-270031
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
SOS1SIGNOR-270112
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CDKN1BSIGNOR-270087
Gbetaphosphorylation

down-regulates activity
TSC2SIGNOR-270108
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PAK1SIGNOR-270086
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
BCL6SIGNOR-270011
Gbetaphosphorylation

up-regulates
MAPKAPK2SIGNOR-270117
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SCNN1BSIGNOR-270050
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
MRTFASIGNOR-269996
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CIITASIGNOR-270067
Gbetaphosphorylation

up-regulates activity
LIPESIGNOR-270119
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FOXOSIGNOR-270020
Gbetaphosphorylation

down-regulates activity
STMN1SIGNOR-270082
Gbetaphosphorylation

up-regulates activity
LCKSIGNOR-270074
Gbetaphosphorylation

unknown
NUP153SIGNOR-270044
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-270037
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SCNN1GSIGNOR-270061
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
JAK2SIGNOR-270046
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
DUSP6SIGNOR-270116
Gbetaphosphorylation

unknown
mTORC1SIGNOR-270027
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
MYBSIGNOR-270089
Gbetaphosphorylation

up-regulates
MKNK1SIGNOR-270022
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CEBPASIGNOR-270066
Gbetaphosphorylation

up-regulates activity
RPTORSIGNOR-270032
Gbetaphosphorylation

up-regulates
CEBPBSIGNOR-270045
Gbetaphosphorylation

unknown
ARHGAP26SIGNOR-270058
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
CICSIGNOR-270090
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
ARRB1SIGNOR-270094
Gbetaphosphorylation

up-regulates activity
PTPRRSIGNOR-270021
Gbetaphosphorylation

up-regulates
ESR1SIGNOR-270023
Gbetaphosphorylation

up-regulates
TWIST1SIGNOR-270122
Gbetaphosphorylation

unknown
KRT8SIGNOR-270003
Gbetaphosphorylation

up-regulates activity
ALOX5SIGNOR-270088
Gbetaphosphorylation

down-regulates activity
MCRIP1SIGNOR-270092
Gbetaphosphorylation

up-regulates
BCL2SIGNOR-270064
Gbetaphosphorylation

up-regulates activity
MYCSIGNOR-270030
Gbetaphosphorylation

up-regulates
SMAD2SIGNOR-270065
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
AMPHSIGNOR-270102
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
NUP50SIGNOR-270041
Gbetaphosphorylation

unknown
RPS3SIGNOR-270019
Gbetaphosphorylation

down-regulates activity
THRBSIGNOR-270016
Gbetaphosphorylation

down-regulates activity
GSK3B/Axin/APCSIGNOR-270068
Gbetaphosphorylation

up-regulates
CADSIGNOR-269998
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TCF3SIGNOR-270009
Gbetaphosphorylation

up-regulates
ATF2SIGNOR-270073
Gbetaphosphorylation

up-regulates
HIF1ASIGNOR-270095
Gbetaphosphorylation

up-regulates
SP3SIGNOR-270053
Gbetaphosphorylation

up-regulates activity
IRX2SIGNOR-270097
Gbetaphosphorylation

up-regulates
NCOA1SIGNOR-270099
Gbetaphosphorylation

up-regulates activity
RPS6KB1SIGNOR-270103
Gbetaphosphorylation

up-regulates quantity by stabilization
PCBP2SIGNOR-262671
Gbetaphosphorylation

up-regulates activity
RPS6KA1SIGNOR-270002
Gbetaphosphorylation

up-regulates
PMLSIGNOR-270034
Gbetaphosphorylation

unknown
APBB1SIGNOR-270054
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
MITFSIGNOR-270029
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
BRAFSIGNOR-270043
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
GSK3BSIGNOR-270059
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PDE4DSIGNOR-270069
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
LIFRSIGNOR-270001
Gbetaphosphorylation

down-regulates activity
IRS1SIGNOR-269997
Gbetaphosphorylation

up-regulates
ABI1SIGNOR-270048
Gbetaphosphorylation

up-regulates activity
PPARASIGNOR-270079
Gbetaphosphorylation

up-regulates
NFATC4SIGNOR-270047
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
RAF1SIGNOR-270010
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
MBPSIGNOR-270100
Gbetaphosphorylation

up-regulates
GRB10SIGNOR-270077
Gbetaphosphorylation

up-regulates activity
SREBF1SIGNOR-270081
Gbetaphosphorylation

up-regulates
CAPN2SIGNOR-270078
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PPP2R5CSIGNOR-270101
Gbetaphosphorylation

up-regulates
JUNSIGNOR-270033
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
SMAD1SIGNOR-270005
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
NOXA1SIGNOR-270114
Gbetaphosphorylation

up-regulates
CTTNSIGNOR-270051
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
DUSP1SIGNOR-270093
Gbetaphosphorylation

unknown
WWC1SIGNOR-270121
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
POLR2ASIGNOR-270039
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
NR3C1SIGNOR-270098
Gbetaphosphorylation

up-regulates
IL16SIGNOR-270056
Gbetaphosphorylation

up-regulates activity
GAB1SIGNOR-270060
Gbetaphosphorylation

unknown
EWSR1SIGNOR-270062
Gbetaphosphorylation

up-regulates
RPS6KA5SIGNOR-270076
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
PGRSIGNOR-270040
Gbetaphosphorylation

down-regulates activity
RXRASIGNOR-269995
Gbetaphosphorylation

up-regulates
NCF1SIGNOR-270091
Gbetaphosphorylation

up-regulates
FOSSIGNOR-270105
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-270013
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
UBTFSIGNOR-270080
Gbetaphosphorylation

up-regulates
RPS6KA3SIGNOR-270014
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
SMAD3SIGNOR-270015
Gbetaphosphorylation

up-regulates
STAT5ASIGNOR-270004
Gbetaphosphorylation

up-regulates
THSIGNOR-270055
Gbetaphosphorylation

up-regulates
PLA2G4ASIGNOR-270096
Gbetaphosphorylation

up-regulates activity
PTPN7SIGNOR-270111
Gbetaphosphorylation

up-regulates
ELK1SIGNOR-270075
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
POU5F1SIGNOR-270085
Gbetaphosphorylation

down-regulates activity
XPO5SIGNOR-269999
Gbetaphosphorylation

up-regulates
GTF2ISIGNOR-270057
Gbetaphosphorylation

up-regulates activity
PLCB1SIGNOR-270109
Gbetaphosphorylation

up-regulates
MCL1SIGNOR-270042
Gbetaphosphorylation

up-regulates
LRP6SIGNOR-270024