| Name | Gbeta |
| ID | SIGNOR-PF4 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP3 | Gbeta | – | dephosphorylation down-regulates activity | 10224087 | SIGNOR-269907 | |
| PTPRB | Gbeta | – | dephosphorylation up-regulates | 12840032 | SIGNOR-269911 | |
| PTPRJ | Gbeta | – | dephosphorylation down-regulates | 12771128 | SIGNOR-269897 | |
| DUSP4 | Gbeta | – | dephosphorylation down-regulates activity | 7535768 | SIGNOR-269914 | |
| PRKAA2 | Gbeta | – | phosphorylation up-regulates | 20647423 | SIGNOR-166905 | |
| MAP2K2 | Gbeta | – | phosphorylation up-regulates | 1411546 | SIGNOR-269895 | |
| MAP2K1 | Gbeta | – | phosphorylation up-regulates | 12270934 | SIGNOR-269909 | |
| LCK | Gbeta | – | phosphorylation up-regulates | 17998336 | SIGNOR-269899 | |
| PPP1CA | Gbeta | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269906 | |
| PPP2CA | Gbeta | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269896 | |
| RET | Gbeta | – | phosphorylation up-regulates | 16153436 | SIGNOR-269894 | |
| DUSP5 | Gbeta | – | dephosphorylation down-regulates | 10224087 | SIGNOR-269912 | |
| DUSP6 | Gbeta | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269905 | |
| MEK1/2 | Gbeta | – | phosphorylation up-regulates | 12270934 | SIGNOR-269913 | |
| PP1 | Gbeta | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269901 | |
| AMPK | Gbeta | – | phosphorylation up-regulates | 20647423 | SIGNOR-216471 | |
| DUSP1 | Gbeta | – | dephosphorylation down-regulates | 10617468 | SIGNOR-269910 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP3 | dephosphorylation → down-regulates activity | Gbeta | SIGNOR-269907 |
| PTPRB | dephosphorylation → up-regulates | Gbeta | SIGNOR-269911 |
| PTPRJ | dephosphorylation down-regulates | Gbeta | SIGNOR-269897 |
| DUSP4 | dephosphorylation → down-regulates activity | Gbeta | SIGNOR-269914 |
| PRKAA2 | phosphorylation → up-regulates | Gbeta | SIGNOR-166905 |
| MAP2K2 | phosphorylation → up-regulates | Gbeta | SIGNOR-269895 |
| MAP2K1 | phosphorylation → up-regulates | Gbeta | SIGNOR-269909 |
| LCK | phosphorylation → up-regulates | Gbeta | SIGNOR-269899 |
| PPP1CA | dephosphorylation down-regulates | Gbeta | SIGNOR-269906 |
| PPP2CA | dephosphorylation down-regulates | Gbeta | SIGNOR-269896 |
| RET | phosphorylation → up-regulates | Gbeta | SIGNOR-269894 |
| DUSP5 | dephosphorylation down-regulates | Gbeta | SIGNOR-269912 |
| DUSP6 | dephosphorylation down-regulates | Gbeta | SIGNOR-269905 |
| MEK1/2 | phosphorylation → up-regulates | Gbeta | SIGNOR-269913 |
| PP1 | dephosphorylation down-regulates | Gbeta | SIGNOR-269901 |
| AMPK | phosphorylation → up-regulates | Gbeta | SIGNOR-216471 |
| DUSP1 | dephosphorylation down-regulates | Gbeta | SIGNOR-269910 |