| Name | PKC |
| ID | SIGNOR-PF53 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | GSTA4 | Thr193 | VKLSNIPtIKRFLEP | phosphorylation up-regulates activity | 12646569 | SIGNOR-264795 |
| PKC | SUN1 | Ser113 | HVSRQVTsSGVSHGG | phosphorylation down-regulates activity | 28831067 | SIGNOR-263281 |
| PKC | MBD4 | Ser165 | CSMAALTsHLQNQSN | phosphorylation up-regulates activity | 23195996 | SIGNOR-275675 |
| PKC | MBD4 | Ser262 | SGFVQSDsKRESVCN | phosphorylation up-regulates activity | 23195996 | SIGNOR-275674 |
| PKC | NOS3 | – | phosphorylation down-regulates activity | 24379783 | SIGNOR-269971 | |
| PKC | GRM5 | – | phosphorylation up-regulates activity | 15894802 | SIGNOR-269972 | |
| PKC | KCNJ1 | Ser201 | FSKNAVIsKRGGKLC | phosphorylation up-regulates activity | 12221079 | SIGNOR-275990 |
| PKC | KCNJ1 | Ser4 | sSRNVFDT | phosphorylation up-regulates activity | 12221079 | SIGNOR-275989 |
| PKC | AQP4 | Ser180 | TIFASCDsKRTDVTG | phosphorylation down-regulates activity | 19761816 | SIGNOR-276260 |
| PKC | GAD2 | – | phosphorylation up-regulates activity | 15147202 | SIGNOR-276010 | |
| PKC | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272164 |
| PKC | ARHGEF6 | Ser684 | GSSTRKDsIPQVLLP | phosphorylation down-regulates activity | 26507661 | SIGNOR-272161 |
| PKC | ARHGAP17 | Ser702 | LSAPRRYsSSLSPIQ | phosphorylation down-regulates activity | 26507661 | SIGNOR-272157 |
| PKC | NOXO1 | Ser159 | SRAAGRLsIHSLEAQ | phosphorylation up-regulates activity | 28336130 | SIGNOR-264728 |
| PKC | PPP1R14B | Thr57 | VRRQGKVtVKYDRKE | phosphorylation up-regulates activity | 10606530 | SIGNOR-265740 |
| PKC | SLITRK1 | Ser695 | DCGSHSLsD | phosphorylation up-regulates activity | 19640509 | SIGNOR-273635 |
| PKC | SCN2A | – | phosphorylation down-regulates activity | 32599005 | SIGNOR-275750 | |
| PKC | TRPV4 | Ser162 | FDIVSRGsTADLDGL | phosphorylation up-regulates activity | 19661060 | SIGNOR-276229 |
| PKC | TRPV4 | Ser189 | DEEFREPsTGKTCLP | phosphorylation up-regulates activity | 19661060 | SIGNOR-276230 |
| PKC | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-276228 |
| PKC | KCNK9 | Thr341 | IEEISPStLKNSLFP | phosphorylation down-regulates activity | 17374744 | SIGNOR-276059 |
| PKC | KLHL3 | Ser433 | PMNTRRSsVGVGVVE | phosphorylation up-regulates quantity by stabilization | 25313067 | SIGNOR-273780 |
| PKC | GNE | – | phosphorylation up-regulates activity | 10745088 | SIGNOR-266072 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | phosphorylation up-regulates → | GSTA4 PThr193 | phosphorylation up-regulates → | GSTA4 | 12646569 | SIGNOR-264795 |
| PKC | phosphorylation up-regulates → | SUN1 PSer113 | phosphorylation down-regulates ⊣ | SUN1 | 28831067 | SIGNOR-263281 |
| PKC | phosphorylation up-regulates → | MBD4 PSer165 | phosphorylation up-regulates → | MBD4 | 23195996 | SIGNOR-275675 |
| PKC | phosphorylation up-regulates → | MBD4 PSer262 | phosphorylation up-regulates → | MBD4 | 23195996 | SIGNOR-275674 |
| PKC | phosphorylation up-regulates → | KCNJ1 PSer201 | phosphorylation up-regulates → | KCNJ1 | 12221079 | SIGNOR-275990 |
| PKC | phosphorylation up-regulates → | KCNJ1 PSer4 | phosphorylation up-regulates → | KCNJ1 | 12221079 | SIGNOR-275989 |
| PKC | phosphorylation up-regulates → | AQP4 PSer180 | phosphorylation down-regulates ⊣ | AQP4 | 19761816 | SIGNOR-276260 |
| PKC | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272164 |
| PKC | phosphorylation up-regulates → | ARHGEF6 PSer684 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272161 |
| PKC | phosphorylation up-regulates → | ARHGAP17 PSer702 | phosphorylation down-regulates ⊣ | ARHGAP17 | 26507661 | SIGNOR-272157 |
| PKC | phosphorylation up-regulates → | NOXO1 PSer159 | phosphorylation up-regulates → | NOXO1 | 28336130 | SIGNOR-264728 |
| PKC | phosphorylation up-regulates → | PPP1R14B PThr57 | phosphorylation up-regulates → | PPP1R14B | 10606530 | SIGNOR-265740 |
| PKC | phosphorylation up-regulates → | SLITRK1 PSer695 | phosphorylation up-regulates → | SLITRK1 | 19640509 | SIGNOR-273635 |
| PKC | phosphorylation up-regulates → | TRPV4 PSer162 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276229 |
| PKC | phosphorylation up-regulates → | TRPV4 PSer189 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276230 |
| PKC | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276228 |
| PKC | phosphorylation up-regulates → | KCNK9 PThr341 | phosphorylation down-regulates ⊣ | KCNK9 | 17374744 | SIGNOR-276059 |
| PKC | phosphorylation up-regulates → | KLHL3 PSer433 | phosphorylation up-regulates → | KLHL3 | 25313067 | SIGNOR-273780 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKC | phosphorylation → up-regulates activity | GSTA4 | SIGNOR-264795 |
| PKC | phosphorylation → down-regulates activity | SUN1 | SIGNOR-263281 |
| PKC | phosphorylation → up-regulates activity | MBD4 | SIGNOR-275675 |
| PKC | phosphorylation → up-regulates activity | MBD4 | SIGNOR-275674 |
| PKC | phosphorylation → down-regulates activity | NOS3 | SIGNOR-269971 |
| PKC | phosphorylation → up-regulates activity | GRM5 | SIGNOR-269972 |
| PKC | phosphorylation → up-regulates activity | KCNJ1 | SIGNOR-275990 |
| PKC | phosphorylation → up-regulates activity | KCNJ1 | SIGNOR-275989 |
| PKC | phosphorylation → down-regulates activity | AQP4 | SIGNOR-276260 |
| PKC | phosphorylation → up-regulates activity | GAD2 | SIGNOR-276010 |
| PKC | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272164 |
| PKC | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272161 |
| PKC | phosphorylation → down-regulates activity | ARHGAP17 | SIGNOR-272157 |
| PKC | phosphorylation → up-regulates activity | NOXO1 | SIGNOR-264728 |
| PKC | phosphorylation → up-regulates activity | PPP1R14B | SIGNOR-265740 |
| PKC | phosphorylation → up-regulates activity | SLITRK1 | SIGNOR-273635 |
| PKC | phosphorylation → down-regulates activity | SCN2A | SIGNOR-275750 |
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276229 |
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276230 |
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276228 |
| PKC | phosphorylation → down-regulates activity | KCNK9 | SIGNOR-276059 |
| PKC | phosphorylation → up-regulates quantity by stabilization | KLHL3 | SIGNOR-273780 |
| PKC | phosphorylation → up-regulates activity | GNE | SIGNOR-266072 |