Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PP1	AURKA	–		dephosphorylation down-regulates	11551964	SIGNOR-264651
PP1	AXIN1	Ser217	YTRTGSEsPKVCSDQ	dephosphorylation down-regulates activity	17318175	SIGNOR-264660
PP1	AHCYL1	Ser68	RSLSRSIsQSSTDSY	dephosphorylation unknown	17635105	SIGNOR-264657
PP1	TP53	Ser15	PSVEPPLsQETFSDL	dephosphorylation down-regulates activity	16501611	SIGNOR-264670
PP1	PYGL	Ser15	QEKRRQIsIRGIVGV	dephosphorylation down-regulates activity	22225877	SIGNOR-267403
PP1	SP1	–		dephosphorylation down-regulates activity	12684058	SIGNOR-264669
PP1	PYGM	Ser15	QEKRKQIsVRGLAGV	dephosphorylation down-regulates activity	22225877	SIGNOR-267402
PP1	CFTR	–		dephosphorylation up-regulates activity	21317537	SIGNOR-264646
PP1	MAPK3	–		dephosphorylation down-regulates	12840032	SIGNOR-264665
PP1	CAD	Ser1406	GAGGRRLsSFVTKGY	dephosphorylation down-regulates activity	4092695	SIGNOR-264653
PP1	MAPK1	–		dephosphorylation down-regulates	12840032	SIGNOR-264664
PP1	NOS3	Thr495	TGITRKKtFKEVANA	dephosphorylation up-regulates activity	19036824	SIGNOR-264668
PP1	CCND3	Thr283	QGPSQTStPTDVTAI	dephosphorylation up-regulates	16331257	SIGNOR-264662
PP1	AKT1	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates activity	14633703	SIGNOR-264658
PP1	CASP2	Ser164	STDTVEHsLDNKDGP	dephosphorylation up-regulates activity	19531356	SIGNOR-264661
PP1	GSK3B	Ser9	SGRPRTTsFAESCKP	dephosphorylation up-regulates activity	26088133	SIGNOR-264820
PP1	CDK9	Ser175	FGLARAFsLAKNSQP	dephosphorylation up-regulates	21533037	SIGNOR-264671
PP1	NEK2	–		dephosphorylation down-regulates	17283141	SIGNOR-264667
PP1	MDM2	Ser370	KKTIVNDsRESCVEE	dephosphorylation up-regulates quantity by stabilization	23277204	SIGNOR-264666
PP1	SP3	–		dephosphorylation down-regulates activity	12684058	SIGNOR-264652
PP1	IKZF1	–		dephosphorylation up-regulates	21750978	SIGNOR-264663
PP1	SLC4A4	–		dephosphorylation up-regulates activity	21317537	SIGNOR-264647
PP1	ERK1/2	–		dephosphorylation down-regulates	12840032	SIGNOR-269923
PP1	AKT	–		dephosphorylation down-regulates activity	14633703	SIGNOR-264659
PP1	Gbeta	–		dephosphorylation down-regulates	12840032	SIGNOR-269901
PP1	PYG	–		dephosphorylation down-regulates activity	22225877	SIGNOR-267961

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PP1	dephosphorylation down-regulates ⊣	AXIN1 PSer217	dephosphorylation up-regulates →	AXIN1	17318175	SIGNOR-264660
PP1	dephosphorylation down-regulates ⊣	AHCYL1 PSer68	dephosphorylation up-regulates →	AHCYL1	17635105	SIGNOR-264657
PP1	dephosphorylation down-regulates ⊣	TP53 PSer15	dephosphorylation up-regulates →	TP53	16501611	SIGNOR-264670
PP1	dephosphorylation down-regulates ⊣	PYGL PSer15	dephosphorylation up-regulates →	PYGL	22225877	SIGNOR-267403
PP1	dephosphorylation down-regulates ⊣	PYGM PSer15	dephosphorylation up-regulates →	PYGM	22225877	SIGNOR-267402
PP1	dephosphorylation down-regulates ⊣	CAD PSer1406	dephosphorylation up-regulates →	CAD	4092695	SIGNOR-264653
PP1	dephosphorylation down-regulates ⊣	NOS3 PThr495	dephosphorylation down-regulates ⊣	NOS3	19036824	SIGNOR-264668
PP1	dephosphorylation down-regulates ⊣	CCND3 PThr283	dephosphorylation down-regulates ⊣	CCND3	16331257	SIGNOR-264662
PP1	dephosphorylation down-regulates ⊣	AKT1 PSer473	dephosphorylation up-regulates →	AKT1	14633703	SIGNOR-264658
PP1	dephosphorylation down-regulates ⊣	CASP2 PSer164	dephosphorylation down-regulates ⊣	CASP2	19531356	SIGNOR-264661
PP1	dephosphorylation down-regulates ⊣	GSK3B PSer9	dephosphorylation down-regulates ⊣	GSK3B	26088133	SIGNOR-264820
PP1	dephosphorylation down-regulates ⊣	CDK9 PSer175	dephosphorylation down-regulates ⊣	CDK9	21533037	SIGNOR-264671
PP1	dephosphorylation down-regulates ⊣	MDM2 PSer370	dephosphorylation down-regulates ⊣	MDM2	23277204	SIGNOR-264666

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PP1	dephosphorylation down-regulates	AURKA	SIGNOR-264651
PP1	dephosphorylation → down-regulates activity	AXIN1	SIGNOR-264660
PP1	dephosphorylation → unknown	AHCYL1	SIGNOR-264657
PP1	dephosphorylation → down-regulates activity	TP53	SIGNOR-264670
PP1	dephosphorylation → down-regulates activity	PYGL	SIGNOR-267403
PP1	dephosphorylation → down-regulates activity	SP1	SIGNOR-264669
PP1	dephosphorylation → down-regulates activity	PYGM	SIGNOR-267402
PP1	dephosphorylation → up-regulates activity	CFTR	SIGNOR-264646
PP1	dephosphorylation down-regulates	MAPK3	SIGNOR-264665
PP1	dephosphorylation → down-regulates activity	CAD	SIGNOR-264653
PP1	dephosphorylation down-regulates	MAPK1	SIGNOR-264664
PP1	dephosphorylation → up-regulates activity	NOS3	SIGNOR-264668
PP1	dephosphorylation → up-regulates	CCND3	SIGNOR-264662
PP1	dephosphorylation → down-regulates activity	AKT1	SIGNOR-264658
PP1	dephosphorylation → up-regulates activity	CASP2	SIGNOR-264661
PP1	dephosphorylation → up-regulates activity	GSK3B	SIGNOR-264820
PP1	dephosphorylation → up-regulates	CDK9	SIGNOR-264671
PP1	dephosphorylation down-regulates	NEK2	SIGNOR-264667
PP1	dephosphorylation → up-regulates quantity by stabilization	MDM2	SIGNOR-264666
PP1	dephosphorylation → down-regulates activity	SP3	SIGNOR-264652
PP1	dephosphorylation → up-regulates	IKZF1	SIGNOR-264663
PP1	dephosphorylation → up-regulates activity	SLC4A4	SIGNOR-264647
PP1	dephosphorylation down-regulates	ERK1/2	SIGNOR-269923
PP1	dephosphorylation → down-regulates activity	AKT	SIGNOR-264659
PP1	dephosphorylation down-regulates	Gbeta	SIGNOR-269901
PP1	dephosphorylation → down-regulates activity	PYG	SIGNOR-267961