| Name | Histone H3 |
| ID | SIGNOR-PF69 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TLK1 | Histone H3 | – | phosphorylation up-regulates activity | 11314006 | SIGNOR-265370 | |
| RPS6KA1 | Histone H3 | – | phosphorylation down-regulates activity | 14625384 | SIGNOR-265346 | |
| VRK1 | Histone H3 | – | phosphorylation unknown | 17938195 | SIGNOR-265371 | |
| AKT | Histone H3 | – | phosphorylation unknown | 12588998 | SIGNOR-265319 | |
| MAPK14 | Histone H3 | – | phosphorylation unknown | 10806218 | SIGNOR-265338 | |
| RPS6K | Histone H3 | – | phosphorylation down-regulates activity | 10464286 | SIGNOR-265345 | |
| PAK1 | Histone H3 | – | phosphorylation unknown | 12151336 | SIGNOR-265363 | |
| PIM1 | Histone H3 | – | phosphorylation down-regulates activity | 17643117 | SIGNOR-265366 | |
| TGM2 | Histone H3 | – | phosphorylation unknown | 16407273 | SIGNOR-265369 | |
| PRKCD | Histone H3 | – | phosphorylation up-regulates activity | 19363025 | SIGNOR-265368 | |
| AKT1 | Histone H3 | – | phosphorylation unknown | 12588998 | SIGNOR-265320 | |
| CHEK1 | Histone H3 | – | phosphorylation down-regulates activity | 18243098 | SIGNOR-265326 | |
| PRKACA | Histone H3 | – | phosphorylation up-regulates | 10464286 | SIGNOR-265344 | |
| AURKA | Histone H3 | – | phosphorylation unknown | 12234980 | SIGNOR-265356 | |
| RPS6KA4 | Histone H3 | – | phosphorylation unknown | 12773393 | SIGNOR-265355 | |
| RPS6KA5 | Histone H3 | – | phosphorylation down-regulates activity | 10464286 | SIGNOR-265348 | |
| FYN | Histone H3 | – | phosphorylation unknown | 15537652 | SIGNOR-265330 | |
| PIM | Histone H3 | – | phosphorylation down-regulates activity | 17643117 | SIGNOR-265365 | |
| RPS6KA3 | Histone H3 | – | phosphorylation down-regulates activity | 10464286 | SIGNOR-265347 | |
| AURKB | Histone H3 | – | phosphorylation up-regulates | 10464286 | SIGNOR-265321 | |
| AURKC | Histone H3 | – | phosphorylation up-regulates | 12588998 | SIGNOR-265357 | |
| PBK | Histone H3 | – | phosphorylation unknown | 16982762 | SIGNOR-265364 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TLK1 | phosphorylation → up-regulates activity | Histone H3 | SIGNOR-265370 |
| RPS6KA1 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265346 |
| VRK1 | phosphorylation → unknown | Histone H3 | SIGNOR-265371 |
| AKT | phosphorylation → unknown | Histone H3 | SIGNOR-265319 |
| MAPK14 | phosphorylation → unknown | Histone H3 | SIGNOR-265338 |
| RPS6K | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265345 |
| PAK1 | phosphorylation → unknown | Histone H3 | SIGNOR-265363 |
| PIM1 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265366 |
| TGM2 | phosphorylation → unknown | Histone H3 | SIGNOR-265369 |
| PRKCD | phosphorylation → up-regulates activity | Histone H3 | SIGNOR-265368 |
| AKT1 | phosphorylation → unknown | Histone H3 | SIGNOR-265320 |
| CHEK1 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265326 |
| PRKACA | phosphorylation → up-regulates | Histone H3 | SIGNOR-265344 |
| AURKA | phosphorylation → unknown | Histone H3 | SIGNOR-265356 |
| RPS6KA4 | phosphorylation → unknown | Histone H3 | SIGNOR-265355 |
| RPS6KA5 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265348 |
| FYN | phosphorylation → unknown | Histone H3 | SIGNOR-265330 |
| PIM | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265365 |
| RPS6KA3 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265347 |
| AURKB | phosphorylation → up-regulates | Histone H3 | SIGNOR-265321 |
| AURKC | phosphorylation → up-regulates | Histone H3 | SIGNOR-265357 |
| PBK | phosphorylation → unknown | Histone H3 | SIGNOR-265364 |