AMPK Signaling

Pathway ID: SIGNOR-AMPKView in NDEx

Description: Maintaining a balanced level of ATP (the immediate source of cellular energy) is essential for the proper functioning of all living cells. AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis: AMP-activated protein kinase (AMPK) is activated in response to a fall in ATP (concomitant with a rise in ADP and AMP) level, resulting in the activation of catabolic processes and the inhibition of anabolic processes.

Curated by: Livia Perfetto

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

26 Seed Entities

Organism:
Name Primary ID
EIF4EBP1 Q13541
STK11 Q15831
Autophagy SIGNOR-PH31
AMPK SIGNOR-C15
RHEB Q15382
SIRT1 Q96EB6
CREB1 P16220
Starvation SIGNOR-ST4
gluconeogenesis SIGNOR-PH35
ULK1/Atg13/Fip200 SIGNOR-C100
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
Cell Growth SIGNOR-PH33
mTORC1 SIGNOR-C3
TSC1/TSC2 SIGNOR-C101
INSR P06213
INS P01308
IRS1 P35568
PIK3CA P42336
FOXO3 O43524
PPARGC1A Q9UBK2
PFKFB2 O60825
RPS6KA1 Q15418
ERK1/2 SIGNOR-PF1
glycolysis SIGNOR-PH34
PDPK1 O15530
AKT SIGNOR-PF24