Inhibition of Apoptosis

Pathway ID: SIGNOR-IOAView in NDEx

Description: For a cell to survive, apoptosis needs to be tightly regulated. Survival signals such as growth factors are able to induce activation of pathways that inhibits pro-apoptotic proteins and activates anti-apoptotic factors.

Curated by: Alessandra Silvestri

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

31 Seed Entities

Organism:
Name Primary ID
NfKb-p65/p50 SIGNOR-C13
CASP9 P55211
BRAF P15056
Survival Factors SIGNOR-ST8
BAD Q92934
CREB1 P16220
IKK-complex SIGNOR-C14
BCL2 P10415
TRAF2 Q12933
SOS1 Q07889
TNF P01375
TRADD Q15628
BAK/BAX SIGNOR-C96
TNFRSF1A P19438
XIAP P98170
NFKBIA P25963
GRB2 P62993
NRAS P01111
MEK1/2 SIGNOR-PF25
Apoptosis SIGNOR-PH2
MAP3K7 O43318
BCL2L11 O43521
CASP7 P55210
FOXO3 O43524
RPS6KA1 Q15418
ERK1/2 SIGNOR-PF1
FOXO1 Q12778
CASP3 P42574
IKBKG Q9Y6K9
Survival SIGNOR-PH13
AKT SIGNOR-PF24