| + |
ATP synthase | up-regulates quantity 
chemical modification
|
ATP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261410 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial (mt) ATP synthase, or complex V consists of two functional domains: F(1), situated in the mitochondrial matrix, and F(o), located in the inner mitochondrial membrane. Complex V uses the energy created by the proton electrochemical gradient to phosphorylate ADP to ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ATP | down-regulates 
chemical inhibition
|
PRKAG1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172822 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21399626 |
Atp promotes dephosphorylation of catalytic subunit, rendering the ampk enzyme inactive |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21680840 |
AMPK is an ___ heterotrimer activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ATP | down-regulates
chemical inhibition
|
AMPK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21399626 |
Atp promotes dephosphorylation of catalytic subunit, rendering the ampk enzyme inactive |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Adenylate_cyclase | down-regulates quantity
chemical modification
|
ATP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ATP | up-regulates quantity
precursor of
|
AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267837 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33961946 |
Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5′-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ADK | down-regulates quantity
chemical modification
|
ATP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267839 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33961946 |
Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5′-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ATP | up-regulates quantity
precursor of
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267842 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ATP | up-regulates
chemical activation
|
P2RX7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18827222 |
Pericellular ATP activates P2XRs on the T cell in an autocrine fashion (step 4) and perhaps also P2X7 receptors on the APC in a paracrine fashion resulting in IL-1beta processing and release (step 5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP | up-regulates quantity
precursor of
|
ADP(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33961946 |
Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5′-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
STOML2 | up-regulates quantity 
|
ATP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20359165 |
In addition, mitochondrial and whole-cell ATP levels in resting SLP-2hi T cells were significantly higher than those in SLP-2lo T cells (P < 0.05) (Fig. 7d). Such an increase in ATP levels in SLP-2hi T cells correlated with increased resistance to depletion of mitochondrial ATP with oligomycin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ATP