| + |
inosine | up-regulates quantity 
precursor of
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269734 |
|
|
in vitro |
|
| pmid |
sentence |
| 15926889 |
Adenosine deaminase (ADA; EC 3.5.4.4) catalyses the deamination of adenosine and 2′-deoxyadenosine to inosine and deoxyinosine. Two different isoenzymes of ADA designated as ADA1 and ADA2 were found in mammals and lower vertebrates |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
adenosine | up-regulates activity
binding, chemical activation
|
ADORA3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268422 |
|
|
in vitro |
|
| pmid |
sentence |
| 14662005 |
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled membrane receptors, designated A1, A2A, A2B and A3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257449 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 31160049 |
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
ADK | down-regulates quantity 
chemical modification
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33961946 |
Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5′-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
NT5E | up-regulates quantity
chemical modification
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269742 |
|
|
in vitro |
|
| pmid |
sentence |
| 31461341 |
Ecto-5'-nucleotidase [cluster of differentiation 73 (CD73)] is a ubiquitously expressed glycosylphosphatidylinositol-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate to adenosine. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
adenosine | up-regulates activity
binding, chemical activation
|
ADORA2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268421 |
|
|
in vitro |
|
| pmid |
sentence |
| 14662005 |
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled membrane receptors, designated A1, A2A, A2B and A3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257448 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 31160049 |
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
adenosine | up-regulates quantity
precursor of
|
AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18957298 |
Adenosine is an endogenous inhibitor of excitatory synaptic transmission with potent anticonvulsant properties in the mammalian brain. Given adenosine's important role in modulating synaptic transmission, several mechanisms exist to regulate its extracellular availability. One of these is the intracellular enzyme adenosine kinase (ADK), which phosphorylates adenosine to AMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
adenosine | up-regulates quantity
precursor of
|
ADP(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33961946 |
Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5′-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
adenosine | up-regulates activity
chemical activation, binding
|
ADORA2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257447 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 31160049 |
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268420 |
|
|
in vitro |
|
| pmid |
sentence |
| 14662005 |
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled membrane receptors, designated A1, A2A, A2B and A3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| + |
adenosine | up-regulates activity
chemical activation, binding
|
ADORA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257446 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 31160049 |
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268419 |
|
|
in vitro |
|
| pmid |
sentence |
| 14662005 |
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled membrane receptors, designated A1, A2A, A2B and A3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| + |
ADA | up-regulates quantity
chemical modification
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269735 |
|
|
in vitro |
|
| pmid |
sentence |
| 15926889 |
Adenosine deaminase (ADA; EC 3.5.4.4) catalyses the deamination of adenosine and 2′-deoxyadenosine to inosine and deoxyinosine. Two different isoenzymes of ADA designated as ADA1 and ADA2 were found in mammals and lower vertebrates |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AMP | up-regulates quantity
precursor of
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269741 |
|
|
in vitro |
|
| pmid |
sentence |
| 31461341 |
Ecto-5'-nucleotidase [cluster of differentiation 73 (CD73)] is a ubiquitously expressed glycosylphosphatidylinositol-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate to adenosine. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269738 |
|
|
in vitro |
|
| pmid |
sentence |
| 18940592 |
Specifically, PAP dephosphorylates extracellular adenosine monophosphate (AMP) to adenosine and activates A1-adenosine receptors in dorsal spinal cord. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| Pathways: | Nucleotide Biosynthesis |
| + |
adenosine | down-regulates
|
Excitatory_synaptic_transmission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265464 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18957298 |
Adenosine is an endogenous inhibitor of excitatory synaptic transmission with potent anticonvulsant properties in the mammalian brain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
adenosine | up-regulates quantity
precursor of
|
inosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269736 |
|
|
in vitro |
|
| pmid |
sentence |
| 15926889 |
Adenosine deaminase (ADA; EC 3.5.4.4) catalyses the deamination of adenosine and 2′-deoxyadenosine to inosine and deoxyinosine. Two different isoenzymes of ADA designated as ADA1 and ADA2 were found in mammals and lower vertebrates |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ACP3 | up-regulates quantity
chemical modification
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269739 |
|
|
in vitro |
|
| pmid |
sentence |
| 18940592 |
Specifically, PAP dephosphorylates extracellular adenosine monophosphate (AMP) to adenosine and activates A1-adenosine receptors in dorsal spinal cord. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
adenosine | down-regulates activity
chemical inhibition
|
PI4K2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258316 |
|
|
in vitro |
|
| pmid |
sentence |
| 21704602 |
Both PI4K2A and PI4K2B were inhibited by adenosine at concentrations that do not significantly inhibit PI4KA and PI4KB actitvity |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
adenosine | down-regulates activity
chemical inhibition
|
PI4K2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258317 |
|
|
in vitro |
|
| pmid |
sentence |
| 21704602 |
Both PI4K2A and PI4K2B were inhibited by adenosine at concentrations that do not significantly inhibit PI4KA and PI4KB actitvity |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
adenosine