| + |
17beta-estradiol | up-regulates quantity 
precursor of
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269757 |
|
|
in vitro |
|
| pmid |
sentence |
| 8994190 |
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269761 |
|
|
in vitro |
|
| pmid |
sentence |
| 8099587 |
17 beta-HSD type 2 was capable of catalyzing the interconversion of testosterone and androstenedione as well as estradiol and estrone. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD17B1 | up-regulates quantity
chemical modification
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269760 |
|
|
in vitro |
|
| pmid |
sentence |
| 8994190 |
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HSD17B2 | up-regulates quantity
chemical modification
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269764 |
|
|
in vitro |
|
| pmid |
sentence |
| 8099587 |
17 beta-HSD type 2 was capable of catalyzing the interconversion of testosterone and androstenedione as well as estradiol and estrone. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
17beta-estradiol | up-regulates 
|
MAPK3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83280 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 11043579 |
Estrogen rapidly activates the mitogen-activated protein kinases, erk-1 and erk-2, via an as yet unknown mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SULT1E1 | up-regulates quantity
chemical modification
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269749 |
|
|
in vitro |
|
| pmid |
sentence |
| 7779757 |
HEST-1 maximally sulfates β-estradiol and estrone at concentrations of 20 nM. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
17beta-estradiol | up-regulates quantity
precursor of
|
4-hydroxy-17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269753 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 8790407 |
These studies demonstrate that human P450 1B1 is a catalytically efficient E2 4-hydroxylase that is likely to participate in endocrine regulation and the toxicity of estrogens. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
17beta-estradiol | up-regulates
chemical activation
|
ESR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154660 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17478088 |
Oestrogen receptors (er)alpha and beta modify the expression of genes involved in cell growth, proliferation and differentiation through binding to oestrogen response elements (eres) located in a number of gene promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Luminal Breast Cancer |
| + |
estrone | up-regulates quantity
precursor of
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269759 |
|
|
in vitro |
|
| pmid |
sentence |
| 8994190 |
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269763 |
|
|
in vitro |
|
| pmid |
sentence |
| 8099587 |
17 beta-HSD type 2 was capable of catalyzing the interconversion of testosterone and androstenedione as well as estradiol and estrone. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
17beta-estradiol | up-regulates activity
chemical activation
|
ESR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258592 |
|
|
in vitro |
|
| pmid |
sentence |
| 9048584 |
In total 37 substances were tested for both ER subtypes (Fig. 3 and Table 1). In Fig. 3 several examples of typical competitor curves obtained are shown. In all cases monophasic curves were obtained for compounds with significant affinity. . The present study is the first in which the ligand binding properties of both ER subtypes are measured separately, and caution is needed when comparing RBAs from this study with the previous studies involving mixtures of ER subtypes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
4-hydroxy-17beta-estradiol | up-regulates quantity
precursor of
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269755 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 8790407 |
These studies demonstrate that human P450 1B1 is a catalytically efficient E2 4-hydroxylase that is likely to participate in endocrine regulation and the toxicity of estrogens. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
17beta-estradiol | up-regulates
chemical activation
|
GPER1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269752 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 15705806 |
Competition binding assays of E2-Alexa 633 binding with 17β-estradiol demonstrated a Ki for 17β-estradiol of approximately 6.6 nM for GPR30 (Fig. 2F). These results demonstrate that a classic GPCR superfamily member directly binds a sex steroid hormone and that GPR30 is an estrogen-binding receptor. |Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160778 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18262661 |
Recent studies have revealed the contribution of a novel estrogen receptor gpr30, which belongs to the family of seven-transmembrane g-protein-coupled receptors, to many of the rapid biological responses to estrogen. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| + |
CYP19A1 | up-regulates quantity
chemical modification
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251528 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 395188 |
Studies show that aromatization (a reaction sequence unique in steroid biosynthesis) of androgens to estrogens is not limited to the female reproductive organs but also occurs in extragonadal tissue. Aromatization involves the loss of the angular C-19 methyl group and cis elimination of the 1beta and 2beta hydrogens from the androgen precursors, androstenedione and testosterone, to yield estrone and estradiol, respectively. In men, the production of estrone is 18 ug/day and is mainly extraglandular. Aromatase activity has also been shown in a variety of tissues in mammalian and other species. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Luminal Breast Cancer, Sex Hormone Biosynthesis |
| + |
17beta-estradiol | up-regulates activity
chemical activation
|
ESR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258591 |
|
|
in vitro |
|
| pmid |
sentence |
| 9048584 |
In total 37 substances were tested for both ER subtypes (Fig. 3 and Table 1). In Fig. 3 several examples of typical competitor curves obtained are shown. In all cases monophasic curves were obtained for compounds with significant affinity. . The present study is the first in which the ligand binding properties of both ER subtypes are measured separately, and caution is needed when comparing RBAs from this study with the previous studies involving mixtures of ER subtypes. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Luminal Breast Cancer |
| + |
17beta-estradiol | up-regulates quantity
precursor of
|
17beta-estradiol 3-sulfate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269750 |
|
|
in vitro |
|
| pmid |
sentence |
| 7779757 |
HEST-1 maximally sulfates β-estradiol and estrone at concentrations of 20 nM. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
17beta-estradiol 3-sulfate(1-) | up-regulates quantity
precursor of
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269748 |
|
|
in vitro |
|
| pmid |
sentence |
| 7779757 |
HEST-1 maximally sulfates β-estradiol and estrone at concentrations of 20 nM. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CYP1B1 | up-regulates quantity
chemical modification
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269756 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 8790407 |
These studies demonstrate that human P450 1B1 is a catalytically efficient E2 4-hydroxylase that is likely to participate in endocrine regulation and the toxicity of estrogens. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HSD17B11 | up-regulates quantity
chemical modification
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
17beta-estradiol | up-regulates
chemical activation
|
ESR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154663 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17478088 |
Oestrogen receptors (er)alpha and beta modify the expression of genes involved in cell growth, proliferation and differentiation through binding to oestrogen response elements (eres) located in a number of gene promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
17beta-estradiol | up-regulates
chemical activation
|
MAPK15 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83277 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 11043579 |
Estrogen rapidly activates the mitogen-activated protein kinases, erk-1 and erk-2, via an as yet unknown mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
17beta-estradiol | up-regulates
|
AKT2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97798 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12554767 |
Treatment of cells with estradiol resulted in phosphorylation of akt and a 9-fold increase in akt activity in 10 min. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
17beta-estradiol | up-regulates
|
Corticotropin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268726 |
|
|
|
|
| pmid |
sentence |
| 24631756 |
ACTH and corticosterone responses to the same acute stress stimulus are higher in the pro-estrus phase of the cycle, when the serum concentrations of estrogen are the highest |Moreover, Kirschbaum et al. conducted a double blind study of 32 men, showing that 100 mcg of estradiol/day for two days was sufficient to produce statistically significant increases in ACTH |
|
| Publications: |
1 |
| + |
testosterone | up-regulates quantity
precursor of
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
3.0
17beta-estradiol