| + |
PLCG2 | up-regulates quantity 
chemical modification
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
GPER1 | up-regulates 
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19549922 |
Gpr30 also stimulates the pi3k pathway, elevating cellular pip3 levels, which is also predicted to activate nr5a receptors by direct binding of pip3 to the ligand binding domain . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLCB1 | up-regulates quantity
chemical modification
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256497 |
|
|
in vitro |
|
| pmid |
sentence |
| 23880553 |
Phospholipase C (PLC) enzymes convert phosphatidylinositol-4,5-bisphosphate into the second messengers diacylglycerol and inositol-1,4,5-triphosphate. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Dopaminergic Synapse, Glutamatergic synapse, Oxytocin signaling, Thyroid Hormone Metabolism |
| + |
1D-myo-inositol 1,4,5-trisphosphate | down-regulates activity 
chemical inhibition
|
CAPZA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261842 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 12788695 |
We further measured the ability of ppIs phosphorylated in positions D-3 and D-4 to release the F-actin capping proteins CapZ and gelsolin from OG-permeabilized platelets (Fig. 7A). Ten percent of platelet CapZ and gelsolin is found in the OG-insoluble fraction (4). PI3,4,5P3 and PI3,4P2 release both CapZ and gelsolin from these preparations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1D-myo-inositol 1,4,5-trisphosphate | down-regulates activity
chemical inhibition
|
GSN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261840 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 12788695 |
We further measured the ability of ppIs phosphorylated in positions D-3 and D-4 to release the F-actin capping proteins CapZ and gelsolin from OG-permeabilized platelets (Fig. 7A). Ten percent of platelet CapZ and gelsolin is found in the OG-insoluble fraction (4). PI3,4,5P3 and PI3,4P2 release both CapZ and gelsolin from these preparations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1D-myo-inositol 1,4,5-trisphosphate | up-regulates
chemical activation
|
PRKCA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179291 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18593525 |
The hrh1 predominantly couples to g?q/11 proteins, leading to the activation of phospholipase c (plc) and subsequent release of the second messengers inositol trisphosphate (ip3) and diacylglycerol (dag) followed by the activation of pkc and the release of [ca2+]i. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, Thyroid Hormone Metabolism, VEGF Signaling |
| + |
PLCD4 | up-regulates
chemical modification
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39041 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8395015 |
Hydrolysis of phosphatidylinositol 4,5-bisphosphate (pip2) by phosphatidylinositol-specific phospholipase c (pi-plc) generates two second messengers, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9125218 |
A key pathway is the hydrolysis of PIP2 . This is mediated by PLC, and yields the two second messengers 1,4,5-IP3 and DAG |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | up-regulates quantity
precursor of
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
1D-myo-inositol 1,4,5-trisphosphate | up-regulates activity
chemical activation
|
ITPR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256239 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24646566 |
The key event in activation of fluid secretion is an increase in intracellular [ca2+] ([ca2+]i) triggered by ip3-induced release of ca2+ from er via the ip3r. ip3rs determine the site of initiation and the pattern of [ca2+]i signal in the cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse, Glutamatergic synapse, Oxytocin signaling, VEGF Signaling |
| + |
PLCG1 | up-regulates
chemical modification
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21918248 |
Phospholypase c is an enzyme which catalyzes the hydrolysis of phosphatidylinositol-4,5-biphosphate (p(4,5)p(2)) into second messangers inositol-1,4,5-triphosphate (ins(1,4,5)p3) and dag. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, VEGF Signaling |
3.0
1D-myo-inositol 1,4,5-trisphosphate