| + |
NAD(1-) | up-regulates quantity 
precursor of
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268113 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDH1 | down-regulates quantity 
chemical modification
|
NAD(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Malate is dehydrogenated to produce oxaloacetate by the enzyme Malate Dehydrogenase. In this reaction NAD is converted to NADH2. Oxaloacetate formed in this reaction reacts with acetyl-CoA to form citrate in order to start another round of the citric acid cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDH9A1 | down-regulates quantity
chemical modification
|
NAD(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11802770 |
Aldolytic cleavage of HTML yields 4-trimethylaminobutyraldehyde (TMABA) and glycine, a reaction catalysed by HTML aldolase (HTMLA; EC 4.1.2.‘X’). Dehydrogenation of TMABA by TMABA dehydrogenase (TMABA-DH; EC 1.2.1.47) results in the formation of 4-Ntrimethylaminobutyrate (butyrobetaine). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Carnitine biosynthesis |
| + |
NAD(1-) | up-regulates activity
binding
|
SIRT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10693811 |
Here we show that yeast and mouse Sir2 proteins are nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
NAMPT | up-regulates quantity
chemical modification
|
NAD(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238602 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12555668 |
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesi |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
MDH2 | down-regulates quantity
chemical modification
|
NAD(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Malate is dehydrogenated to produce oxaloacetate by the enzyme Malate Dehydrogenase. In this reaction NAD is converted to NADH2. Oxaloacetate formed in this reaction reacts with acetyl-CoA to form citrate in order to start another round of the citric acid cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NAD(1-)