| + |
wortmannin | down-regulates 
chemical inhibition
|
PIK3CA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36557 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8162590 |
The microbial product wortmannin and some of its analogues have been shown to be potent inhibitors of phosphatidylinositol-3-kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7503989 |
Wortmannin inhibited the activity of partially purified pi3-kinase from calf thymus, as well as the pi3-kinase activity in anti-pi3-kinase p85 immunoprecipitates from rbl-2h3 cells, at a concentration as low as 1.0 nm and with ic50 values of 3.0 nm. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
wortmannin | down-regulates
chemical inhibition
|
PI3K |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8162590 |
The microbial product wortmannin and some of its analogues have been shown to be potent inhibitors of phosphatidylinositol-3-kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252663 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 7503989 |
Wortmannin inhibited the activity of partially purified pi3-kinase from calf thymus, as well as the pi3-kinase activity in anti-pi3-kinase p85 immunoprecipitates from rbl-2h3 cells, at a concentration as low as 1.0 nm and with ic50 values of 3.0 nm. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
wortmannin | down-regulates
chemical inhibition
|
PIK3C3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260730 |
|
|
Chlorocebus aethiops |
Vero Cell |
| pmid |
sentence |
| 22253445 |
From these results, we conclude that LY294002 and wortmannin inhibit SARS pseudovirus entry by targeting PI4KB and that PI4KB is involved in SARS-CoV S-mediated entry into VeroE6 cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
wortmannin | down-regulates
chemical inhibition
|
MYLK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-207791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
wortmannin
