| + |
ADCY3 | up-regulates quantity 
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265000 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
cAMP | up-regulates activity
chemical activation
|
PKA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY4 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY7 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI1 | down-regulates 
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
The G alpha I subunit inhibits adenylyl cyclase activity and therefore reduces cytoplasmic cAMP levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY1 | up-regulates
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Typically Gas stimulates adenylyl cyclase and increases levels of cyclic amp (camp), whereas galfai inhibits adenylyl cyclase and lowers camp levels, and members of the galfaq family bind to and activate phospholipase c (plc), which cleaves phosphatidylinositol bisphosphate (pip2) into diacylglycerol and inositol triphosphate (ip3). The gbeta subunits and ggamma subunits function as a dimer to activate many molecules, including phospholipases, ion channels and lipid kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
To further explore the role of camp signaling in the hippo pathway, we treated cells with forskolin, an activator of adenylyl cyclase that results in cAMP production. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
cAMP | up-regulates
chemical activation
|
PRKACA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198492 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
The cAMP signaling cascade can activate protein kinase a (PKA) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141786 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
Pge2 receptors are coupled to the G protein Gs, which causes accumulation of cyclic adenosine monophosphate (cAMP) and activates protein kinase a (PKA), we confirmed that PGE2 treatment or transfection of cells with the active catalytic subunit of PKA also stimulated the activity of a cAMP-responsive-element driven reporter gene (CRE-luc). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
cAMP | up-regulates quantity by expression 
transcriptional regulation
|
DIO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270243 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| + |
cAMP | up-regulates quantity by expression
transcriptional regulation
|
DIO2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267281 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| + |
GNAS | up-regulates quantity
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12145344 |
HETEROTRIMERIC G PROTEINS are essential for cell signaling throughout the body. The stimulatory G protein, Gs, couples activation of a host of different transmembrane receptors to adenylyl cyclase stimulation, leading to intracellular generation of cAMP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP | up-regulates quantity
precursor of
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267842 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY9 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265005 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
cAMP | down-regulates activity 
chemical inhibition
|
PRKAR2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258761 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY1 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
ADCY2 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDE1C | down-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
PDE1A and PDE1B preferentially hydrolyse cGMP, whereas PDE1C hydrolyses cAMP and cGMP with similar Km values |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY10 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
cAMP | down-regulates activity
chemical inhibition
|
PRKAR1B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
cAMP | down-regulates activity
chemical inhibition
|
PRKAR2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY6 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY8 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Adenylate_cyclase | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267844 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY5 | up-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
cAMP | down-regulates activity
chemical inhibition
|
PRKAR1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ENPP1 | down-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253018 |
|
|
|
|
| pmid |
sentence |
| 20923972 |
Phosphodiesterases Catalyze Hydrolysis of cAMP-bound to Regulatory Subunit of Protein Kinase A and Mediate Signal Termination |
|
| Publications: |
1 |
| + |
PDE1A | down-regulates quantity
chemical modification
|
cAMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253398 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
PDE1A and PDE1B preferentially hydrolyse cGMP, whereas PDE1C hydrolyses cAMP and cGMP with similar Km values |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
cAMP
