Summary

Name ORF4b
Full Name Non-structural protein ORF4b
Synonyms ORF4b |
Primary ID K9N643
Links - -
Type protein
Relations 2
Pathways COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA
Function Plays a role in the inhibition of host innate immunity by inhibiting the interaction between host IKBKE and MAVS. In turn, this inhibition prevents the production of host interferon beta. Additionally, inhibits host NF-kappa-B by interacting with host KPNA4 and thereby preventing the translocation of the NF-kappa-B complex into the nucleus by this importin (PubMed:29370303).

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Relations

Regulator Mechanism target score ℹ
+ ORF4bdown-regulates activity img/direct_inhibition.png binding IKBKE 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA
+ ORF4bdown-regulates activity img/direct_inhibition.png binding TBK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA